Glycoside Hydrolase Family 5

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (11678); Uniprot accession (1922); PDB accession (209); 3D entries (74); cryst (0)
All (10301) Archaea (67) Bacteria (8107) Eukaryota (2005) Viruses (5) unclassified (117) Structure (74) Characterized (547)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | ... | 21 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 mannanase   Achaetomium sp. Xz-8 / Xz8 AHK22783.1     7
 secreted protein   Achlya hypogyna ATCC 48635 AIG55998.1    
 secreted protein   Achlya hypogyna ATCC 48635 AIG55999.1    
 secreted protein   Achlya hypogyna ATCC 48635 AIG56138.1    
 secreted protein   Achlya hypogyna ATCC 48635 AIG56220.1     12
 secreted protein   Achlya hypogyna ATCC 48635 AIG56251.1    
 secreted protein   Achlya hypogyna ATCC 48635 AIG56426.1    
 secreted protein   Achlya hypogyna ATCC 48635 AIG56430.1     31
 secreted protein   Achlya hypogyna ATCC 48635 AIG56483.1    
 β-1,6-glucanase (CG16) (peptide fragment) 3.2.1.75 Acremonium IMI 383068   P82288   15
 β-rutinosidase / α-L-rhamnosyl-β-glucosidase   Acremonium sp. DSM 24697 SES201 AMD11613.1     23
 β-1,6-glucanase (BGN6.1) 3.2.1.75 Acremonium sp. OXF C13 AAT97707.1 Q68GV7   15
 endo-β-mannanase (Man1)   Actinidia arguta ACN78662.1 C7A7X6   7
 glycoside hydrolase 5 (Eng-4)   Adineta ricciae AKC91348.1    
 glycoside hydrolase family 5 endoglucanase, partial (fragment)   Agaricus arvensis FB-AA-61 CDL74346.1     5
 β-mannanase (Cel4A) 3.2.1.78 Agaricus bisporus C54-CARB8 CAB76904.1
ABJ41267.1
Q9P893   7
 β-mannanase (Cel4;Cel4b) 3.2.1.78 Agaricus bisporus D649 CAA90423.1 Q92401   7
 exo-β-1,3-glucanase 1 (Exg1;AbEXG1) 3.2.1.58 Agaricus bisporus HORST U1 CAA63536.1 Q12539   9
 Exg2 / AbEXG2 (fragment)   Agaricus bisporus HORST U1 CAA63537.1 Q12540   9
 glycoside hydrolase family 5 endoglucanase, partial (fragment)   Agaricus comtulus FB-AC-01 CDL74349.1     5
 CEL4a mannanase (fragment)   Agaricus subrufescens WC837 AIU39657.1     7
 CEL4a mannanase (fragment)   Agaricus subrufescens WC837-S03 AIU39658.1     7
 glycoside hydrolase family 5 endoglucanase, partial (fragment)   Agaricus xanthodermus FB-AX-06 CDL74330.1     5
 ALNC14_005500 (Alnc14c3g505)   Albugo laibachii Nc14 CCA14407.1     20
 ALNC14_011460 (Alnc14c7g1004)   Albugo laibachii Nc14 CCA15003.1
CCA25494.1
    20
 ALNC14_020430 (Alnc14c16g1760)   Albugo laibachii Nc14 CCA15900.1    
 ALNC14_037790 (Alnc14c38g3295)   Albugo laibachii Nc14 CCA17636.1    
 ALNC14_057660 (Alnc14c75g5042)   Albugo laibachii Nc14 CCA19623.1
CCA22873.1
    20
 ALNC14_059470 (Alnc14c79g5216)   Albugo laibachii Nc14 CCA19804.1     20
 ALNC14_088050 (Alnc14c163g7812) (possible fragment)   Albugo laibachii Nc14 CCA22662.1     33
 ALNC14_096330   Albugo laibachii Nc14 CCA23489.1    
 ALNC14_100670 (Alnc14c213g8963)   Albugo laibachii Nc14 CCA23923.1     20
 ALNC14_127450 (Alnc14c394g11305)   Albugo laibachii Nc14 CCA26601.1     20
 ALNC14_136230 (Alnc14c546g12117)   Albugo laibachii Nc14 CCA27479.1     20
 ALNC14_001090 (Alnc14c1g102)   Albugo laibachii Nc14 CCA13966.1     12
 ALNC14_020040   Albugo laibachii Nc14 CCA15861.1    
 ALNC14_020040   Albugo laibachii Nc14 CCA15861.1    
 ALNC14_038900 (Alnc14c39g3396)   Albugo laibachii Nc14 CCA17747.1    
 ALNC14_068240 (Alnc14c101g6025)   Albugo laibachii Nc14 CCA20681.1    
 ALNC14_121230 (Alnc14c338g10754)   Albugo laibachii Nc14 CCA25979.1    
 ALNC14_127210   Albugo laibachii Nc14 CCA26577.1     33
 ALNC14_139410 (Alnc14c693g12405)   Albugo laibachii Nc14 CCA27797.1     33
 ORF (fragment)   Alternaria sp. 0602-001 2B PDA/MF06-192 CDL74328.1     5
 Man5   Alternaria sp. DW1 AKT45095.1     7
 EgL (fragment)   Amanita armillariiformis AEQ58924.1     5
 EgL (fragment)   Amanita manicata AEQ58922.1     5
 EgL (fragment)   Amanita prairiicola AEQ58918.1     5
 EgL (fragment)   Amanita prairiicola AEQ58919.1     5
 EgL (fragment)   Amanita sp. sp-Ridley-2 AEQ58916.1     5
 EgL (fragment)   Amanita subcaligata AEQ58923.1     5
 EgL (fragment)   Amanita thiersii AEQ58917.1     5
 EgL (fragment)   Amanita vittadinii AEQ58921.1     5
 cellulase / exo-β-glucanase 5B (AmCel-5B) 3.2.1.4 Anoplophora chinensis AFN89566.1     2
 cellulase (Eng)   Aphelenchoides besseyi AIK28470.2
AIK28470.1
    2
 cellulase (Eng-1)   Aphelenchoides fragariae AFD33558.1     2
 β-1,4-endoglucanase / cellulase (Eng-1;Afr-ENG-1) (fragment)   Aphelenchoides fragariae AFD33557.1     2
 Eng-3 (fragment)   Aphelenchoides fragariae AFI63769.1     2
 endo-β-1,4-glucanase (Aα-Eng-1)   Aphelenchus avenae BAI44493.1
BAI44494.1
C9K4V2   2
 endo-β-1,4-glucanase (Aα-Eng-2)   Aphelenchus avenae BAI44495.1
BAI44496.1
C9K4V4   2
 endo-β-1,4-mannanase (AkMan;AkManA) 3.2.1.78 Aplysia kurodai BAJ60954.1   3VUP[A,B] 10
 endoglucanase III (Ag-EGaseIII) 3.2.1.4 Apriona germari AAX18655.1 Q5DIE3   2
 glycoside hydrolase family 5 subfamily 2 (Gh5-6) 3.2.1.4 Apriona japonica AHI15751.1     2
 glycoside hydrolase family 5 subfamily 2 (Gh5-5)   Apriona japonica AHI15750.1     2
 glycoside hydrolase family 5 subfamily 2 (Gh5-1)   Apriona japonica AHI15746.1     2
 glycoside hydrolase family 5 subfamily 2 (Gh5-2)   Apriona japonica AHI15747.1     2
 glycoside hydrolase family 5 subfamily 2 (Gh5-3)   Apriona japonica AHI15748.1     2
 glycoside hydrolase family 5 subfamily 2 (Gh5-4)   Apriona japonica AHI15749.1     2
 At1g13130   Arabidopsis thaliana AAU05478.1
AAD31066.1
AEE28973.1
CAW49139.1
CAW49147.1
CAW50877.1
CAW50885.1
CBC20353.1
CBC20368.1
NP_172772.1
Q66GP7
Q9SAE6
  11
 At3g10900 (AtMan4)   Arabidopsis thaliana AAF19559.1
AEE74968.1
NP_187701.1
Q9SG95   7
 At3g10890 (AtMan3)   Arabidopsis thaliana AAF19560.1
AEE74967.1
NP_187700.1
Q9SG94   7
 At4g28320 (AtMan5)   Arabidopsis thaliana CAB79634.1
ABG48480.1
AEE85469.1
BAF00634.1
NP_194561.1
Q9M0H6   7
 At5g01930 (AtMan6)   Arabidopsis thaliana AAO64766.1
AED90411.1
BAE99339.1
CAB82763.1
NP_195813.1
Q9LZV3   7
 At3g30540 (AtManP) (probable fragment)   Arabidopsis thaliana NP_189675.1
AEE77650.1
BAB01021.1
Q9LW44   7
 At3g26140   Arabidopsis thaliana BAB02434.1
AEE77125.1
ANM63939.1
ANM63940.1
CAW49140.1
CAW50878.1
CBC20355.1
NP_189245.1
Q9LTM8   11
 At3g26130   Arabidopsis thaliana BAB02432.1
AEE77124.1
ANM65424.1
ANM65425.1
CAW49134.1
CAW50872.1
CBC20341.1
CBD33733.1
NP_189244.1
Q9LTN0   11
 endo-β-1,4-mannanase (AtMan5-1;AtMan1;At1g02310) 3.2.1.78 Arabidopsis thaliana AAN72165.1
AAG00883.1
AAL91241.1
AEE27414.1
ANM59069.1
NP_171733.1
NP_171733.2
Q9FZ29   7
 At5g17500   Arabidopsis thaliana CAC01894.1
AED92434.1
CAW49142.1
CAW50880.1
CBC20359.1
NP_197252.1
Q9LF52   11
 At5g16700   Arabidopsis thaliana CAC01834.1
AED92327.1
CAW49141.1
CAW50879.1
CBC20356.1
NP_197172.1
Q9LFE7   11
 β-mannanase 2 (AtMan2;AtMan5-2;At2g20680) 3.2.1.78 Arabidopsis thaliana AAP40422.1
AAD20927.1
ABG25077.1
AEC07056.1
BAF00487.1
NP_179660.2
Q7Y223
Q9SKU9
  7
 At5g66460 (AtMan7)   Arabidopsis thaliana BAB10922.1
AAN17429.1
AAP49511.1
AED98217.1
NP_201447.1
Q9FJZ3   7
 β-mannanase (PM;Man47;AtMAN47) 3.2.1.78 Armillariella tabescens EJLY2098 ABB88954.1 A1X5Y1   7
 EGX54367.1   Arthrobotrys oligospora ATCC 24927 EGX54367.1     7
 EGX54339.1   Arthrobotrys oligospora ATCC 24927 EGX54339.1     9
 EGX54106.1   Arthrobotrys oligospora ATCC 24927 EGX54106.1     9
 EGX52505.1   Arthrobotrys oligospora ATCC 24927 EGX52505.1     15
 EGX49995.1   Arthrobotrys oligospora ATCC 24927 EGX49995.1     49
 EGX49988.1   Arthrobotrys oligospora ATCC 24927 EGX49988.1     5
 EGX49194.1   Arthrobotrys oligospora ATCC 24927 EGX49194.1     5
 EGX49029.1   Arthrobotrys oligospora ATCC 24927 EGX49029.1     7
 EGX48467.1   Arthrobotrys oligospora ATCC 24927 EGX48467.1     9
 EGX48303.1   Arthrobotrys oligospora ATCC 24927 EGX48303.1     4
 EGX47949.1   Arthrobotrys oligospora ATCC 24927 EGX47949.1     5
 EGX47679.1   Arthrobotrys oligospora ATCC 24927 EGX47679.1     24
 EGX47422.1   Arthrobotrys oligospora ATCC 24927 EGX47422.1     12
 EGX46850.1   Arthrobotrys oligospora ATCC 24927 EGX46850.1     7
 EGX46484.1   Arthrobotrys oligospora ATCC 24927 EGX46484.1     22
 EGX45346.1   Arthrobotrys oligospora ATCC 24927 EGX45346.1     5
 EGX45164.1   Arthrobotrys oligospora ATCC 24927 EGX45164.1     22
 EGX45042.1   Arthrobotrys oligospora ATCC 24927 EGX45042.1     12
 EGX50094.1   Arthrobotrys oligospora ATCC 24927 EGX50094.1     27
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