Glycoside Hydrolase Family 5

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (13367); Uniprot accession (1922); PDB accession (214); 3D entries (76); cryst (0)
All (11985) Archaea (92) Bacteria (9640) Eukaryota (2127) Viruses (6) unclassified (120) Structure (76) Characterized (549)
| 1 | ... | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | ... | 22 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 JCVI-FLGm-19N17   Glycine max ACU19893.1 C6TDJ1   7
 endo-β-1,4-mannanase (GmMan1) 3.2.1.78 Glycine max ABG88068.1 Q0PKY2   7
 GpGH5 / M427DRAFT_29612 3.2.1.- Gonapodya prolifera JEL478 KXS18720.1     34
 glycoside hydrolase family 5 endoglucanase, partial (Glu-1) (fragment)   Grifola frondosa 136 CDL74353.1
CDL74354.1
    5
 glycoside hydrolase family 5 endoglucanase, partial (fragment)   Gymnopilus junonius 137/K 89 CDL74351.1    
 endo-β-1,4-mannanase   Haliotis discus discus ACJ12612.1 B6VEZ3   10
 β-1,4-mannanase (ManHDD)   Haliotis discus discus BAI99559.1 D4QF63   10
 endo-β-1,4-mannanase (Man1;HdMan) 3.2.1.78 Haliotis discus hannai BAE78456.1 Q2MH89   10
 glycoside hydrolase family 5 endoglucanase, partial (fragment)   Hericium erinaceus 139/LM 03 CDL74357.1    
 ORF (fragment)   Heterobasidion annosum FB-HA-37 CDL74347.1     5
 ORF   Heterodera avenae AVA09688.1     2
 endo-β-1,4-glucanase 1a (Eng1A;Eng-1A;Hα-eng-1a)   Heterodera avenae ACO55952.1
AFQ55438.1
AGH32769.1
D5FQ93   2
 endo-β-1,4-glucanase 2 (Eng2)   Heterodera avenae AFQ55680.1
AFQ55681.1
    2
 endo-β-1,4-glucanase 3 (Eng3)   Heterodera avenae AFQ55682.1
AFQ55683.1
    2
 β-1,4-endoglucanase-1 (fragment)   Heterodera cruciferae AJE31858.1     2
 endoglucanase 4 (Eng4;Eng-4) 3.2.1.4 Heterodera glycines AAK85303.1
AAP88024.1
Q7YZF3
Q95UR3
  2
 cellulase (Eng6;Eng-6;G26D05)   Heterodera glycines AAM50039.1
AAO25506.1
Q86DQ0   2
 cellulase (Eng5;Eng-5)   Heterodera glycines AAN32884.1
AAP97436.1
Q8ITJ4   2
 endoglucanase 1 (Eng1;Eng-1) 3.2.1.4 Heterodera glycines AAC15707.1
AAC48327.1
CAB42450.1
CAB59144.1
O18453   2
 endoglucanase 2 (Eng2;Eng-2) 3.2.1.4 Heterodera glycines AAC48326.1
AAC15708.1
CAB42449.1
CAB59143.1
O18454   2
 endoglucanase 3 (Eng3;Eng-3) 3.2.1.4 Heterodera glycines AAC33848.1
AAC33860.1
O77449   2
 β-1,4-endoglucanase-2 precursor (Eng2)   Heterodera koreana 01 ART34946.1     2
 endo-β-1,4-glucanase 1 (Eng1;Hssp19) (partial)   Heterodera schachtii CAC12958.1 Q9GRU6   2
 endo-β-1,4-glucanase 2 (Eng2;Hssp19)   Heterodera schachtii CAC12959.1 Q9GRU5   2
 β-1,4-endoglucanase (fragment)   Hirschmanniella gracilis AER27797.1
AER27799.1
    2
 β-1,4-endoglucanase (fragment)   Hirschmanniella gracilis AER27798.1     2
 β-1,4-endoglucanase (fragment)   Hirschmanniella loofi AER27793.1     2
 β-1,4-endoglucanase (fragment)   Hirschmanniella loofi AER27794.1     2
 β-1,4-endoglucanase (fragment)   Hirschmanniella loofi AER27795.1     2
 β-1,4-endoglucanase (fragment)   Hirschmanniella loofi AER27796.1     2
 ORF (fragment)   Hirsutella thompsonii H3 AIK98137.1     27
 predicted protein   Hordeum vulgare subsp. vulgare BAK01092.1     5
 predicted protein   Hordeum vulgare subsp. vulgare BAJ97814.1     14
 predicted protein   Hordeum vulgare subsp. vulgare BAK05121.1     11
 predicted protein   Hordeum vulgare subsp. vulgare BAK05376.1     14
 NIASHv2104N09 (fragment)   Hordeum vulgare subsp. vulgare BAK01294.1     7
 predicted protein   Hordeum vulgare subsp. vulgare BAK00694.1     11
 predicted protein (fragment)   Hordeum vulgare subsp. vulgare BAK07818.1     14
 endo-β-1,4-mannanase (Man1;HvMAN1) 3.2.1.78 Hordeum vulgare subsp. vulgare BAK05001.1
ABC87082.1
Q2I011   7
 ORF (fragment)   Hordeum vulgare subsp. vulgare AGW47737.1     14
 cellulase, partial   Humicola grisea var. thermoidea APD14599.1     24
 endo-β-1,4-glucanase 3 (CMC3;Egl2) 3.2.1.4 Humicola grisea var. thermoidea IFO9854 BAA12676.1     5
 endo-β-1,4-glucanase IV (CMC3) 3.2.1.4 Humicola insolens ATCC 16454 CAA53631.1 Q12624   5
 β-mannanase (alkali-tolerant) (Man5A) 3.2.1.78 Humicola insolens Y1 ADZ99301.1     7
 endoglycoceramidase (EGCase) 3.2.1.123 Hydra magnipapillata BAD20464.1 Q6L6S1   27
 glycoside hydrolase family 5 endoglucanase, partial (fragment)   Hypholoma sp. 150 150/K 107 CDL74350.1     5
 endoglucanase II (EgII)   Hypocrea orientalis EU7-22 AFD50195.1     5
 ORF   Hypocrella siamensis MTCC 10142 ANH56493.1     5
 ORF   Hypocrella siamensis MTCC 10142 ANH56410.1     12
 ORF   Hypocrella siamensis MTCC 10142 ANH56505.1     9
 β-mannanase (Man1;HhMAN1) 3.2.1.78 Hypothenemus hampei ACU52526.1
ACU52527.1
C8CAP6   8
 cellulase   Inonotus hispidus Haeb08 AIY53679.1     5
 endoglucanase (EG)   Inonotus obliquus JL01 AMK37824.1     5
 Man5A   Irpex lacteus AGV52632.1     7
 Man5B (short fragment)   Irpex lacteus AGV52633.1     7
 endoglucanase (Cen1;En-1) 3.2.1.4 Irpex lacteus MC-2 BAD67544.1 Q5W7K4   5
 KAFR_0A01010 (Kafr0a01010)   Kazachstania africana CBS 2517 CCF55539.1     49
 KAFR_0A04770 (Kafr0a04770)   Kazachstania africana CBS 2517 CCF55912.1     9
 KAFR_0C00510 (Kafr0c00510)   Kazachstania africana CBS 2517 CCF57046.1     49
 KAFR_0C05910 (Kafr0c05910)   Kazachstania africana CBS 2517 CCF57582.1     9
 KAFR_0G00170 (Kafr0g00170)   Kazachstania africana CBS 2517 CCF59050.1     12
 KAFR_0G02350 (Kafr0g02350)   Kazachstania africana CBS 2517 CCF59269.1     9
 KAFR_0K01030 (Kafr0k01030)   Kazachstania africana CBS 2517 CCF60459.1     12
 KNAG_0B03180 (Knag0b03180)   Kazachstania naganishii CBS 8797 type strain:CBS 8797 CCK68759.1     9
 KNAG_0E03600 (Knag0e03600)   Kazachstania naganishii CBS 8797 type strain:CBS 8797 CCK70617.1     12
 KNAG_0F03220 (Knag0f03220)   Kazachstania naganishii CBS 8797 type strain:CBS 8797 CCK70984.1     9
 KNAG_0J00880 (Knag0j00880)   Kazachstania naganishii CBS 8797 type strain:CBS 8797 CCK72170.1     49
 KNAG_0M00890 (Knag0m00890)   Kazachstania naganishii CBS 8797 type strain:CBS 8797 CCK72942.1     9
 KLLA0F18788g   Kluyveromyces lactis NRRL Y-1140 CAG98630.1 Q6CJG7   49
 KLLA0C05324g   Kluyveromyces lactis NRRL Y-1140 CAH01288.1
CAA86949.1
Q12628   9
 KLLA0B11704g   Kluyveromyces lactis NRRL Y-1140 CAH02444.1 Q6CVI8   12
 KLMA_40105   Kluyveromyces marxianus DMKU3-1042 BAO40129.1     49
 KLMA_10234   Kluyveromyces marxianus DMKU3-1042 BAO37856.1     9
 KLMA_70317   Kluyveromyces marxianus DMKU3-1042 BAO42165.1     12
 KMAR_10210   Kluyveromyces marxianus NBRC 1777 BAP69418.1     9
 KMAR_70289   Kluyveromyces marxianus NBRC 1777 BAP73573.1     12
 KMAR_40114   Kluyveromyces marxianus NBRC 1777 BAP71622.1     49
 ORF (fragment)   Koerneria sudhausi SB413 ADY92762.1     2
 ATY40_BA7502724 (Exg1)   Komagataella pastoris ATCC 28485 ANZ75686.1     9
 ATY40_BA7504625 (Spr1)   Komagataella pastoris ATCC 28485 ANZ77526.1     9
 ATY40_BA7502971 (Yir007W)   Komagataella pastoris ATCC 28485 ANZ75469.1     12
 ATY40_BA7500992   Komagataella pastoris ATCC 28485 ANZ74575.1     49
 exo-β-1,3-glucanase (Eg;Exg1) 3.2.1.58 Komagataella pastoris X-33 AAY28969.1 Q2TCV2   9
 AT249_GQ6705072 (Spr1)   Komagataella phaffii ATCC 76273 AOA64999.1     9
 AT249_GQ6704659 (Yir007W)   Komagataella phaffii ATCC 76273 AOA65127.1     12
 AT249_GQ6700497 (Exg1)   Komagataella phaffii ATCC 76273 AOA62628.1     9
 BQ9382_C4-1440 (Acib2eukg772300)   Komagataella phaffii CBS 7435 SOP83200.1     9
 BQ9382_C2-4535 (Acib2eukg770258)   Komagataella phaffii CBS 7435 SOP81159.1     9
 PP7435_Chr1-0852   Komagataella phaffii CBS 7435 CCA36990.1
SOP79548.1
    49
 PP7435_Chr2-0842 (fragment)   Komagataella phaffii CBS 7435 CCA38524.1     9
 PP7435_Chr4-0271 (Exg2)   Komagataella phaffii CBS 7435 CCA40446.1     9
 PP7435_Chr4-0672   Komagataella phaffii CBS 7435 CCA40830.1
SOP83608.1
    12
 PAS_chr2-1_0454 (Exg;Exg1) 3.2.1.58 Komagataella phaffii GS115 CAY69081.1
AOA67579.1
C4R0Q7   9
 PAS_chr1-4_0082   Komagataella phaffii GS115 CAY67911.1
AOA65441.1
C4QXD8   49
 PAS_chr4_0692   Komagataella phaffii GS115 CAY71953.1
AOA70150.1
C4R8M8   9
 PAS_chr4_0321   Komagataella phaffii GS115 CAY71564.1
AOA70086.1
C4R7I9   12
 AT249_GQ6702105   Komagataella phaffii WT AOA60792.1     49
 ORF (fragment)   Lacazia loboi 10-RMS ABW86801.1
ABW86803.1
ABW86804.1
ABW86805.1
ABW86807.1
ABW86808.1
ABW86809.1
ABW86810.1
ABW86811.1
ABW86813.1
ABW86814.1
ABW86815.1
ABW86816.1
ABW86817.1
ABW86821.1
B5KRK0   9
 ORF (fragment)   Lacazia loboi 11-A ABW86819.1 B5KRL8   9
 ORF (fragment)   Lacazia loboi 12-S2 ABW86802.1 B5KRK1   9
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