Glycoside Hydrolase Family 5

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (11393); Uniprot accession (1922); PDB accession (208); 3D entries (73); cryst (0)
All (10017) Archaea (67) Bacteria (7846) Eukaryota (1982) Viruses (5) unclassified (117) Structure (73) Characterized (547)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | ... | 20 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 unnamed protein product   Fusarium graminearum PH-1 CEF88482.1     7
 unnamed protein product   Fusarium graminearum PH-1 CEF85947.1     16
 FGRAMPH1_01T10411   Fusarium graminearum PH-1 SCB65636.1
CEF77008.1
    9
 unnamed protein product   Fusarium graminearum PH-1 CEF78819.1     22
 unnamed protein product   Fusarium graminearum PH-1 CEF79732.1     7
 unnamed protein product   Fusarium graminearum PH-1 CEF75026.1     12
 unnamed protein product   Fusarium graminearum PH-1 CEF76558.1     15
 unnamed protein product (fragment)   Fusarium graminearum PH-1 CEF72475.1     24
 β-1,6-galactanase (Gal1;FoGal1) 3.2.1.164 Fusarium oxysporum 12S BAF42338.1 A0ZSY6   16
 FOXB_04211 (fragment)   Fusarium oxysporum Fo5176 EGU85271.1     31
 glycoside hydrolase family 5 endoglucanase, partial (fragment)   Fusarium solani 0610-001 2 A WA/MF06-071 CDL74337.1     5
 β-1,4-endoglucanase (GlCel5A;GL28282) (Cel5A) 3.2.1.4 Ganoderma lucidum     5D8W[A,B]
5D8Z[A,B]
5
 glycoside hydrolase family protein 5 (Gh5-1)   Gastrophysa viridula ADU33333.1     10
 β-1,3-glucanase, partial   Glaciozyma antarctica PI12 AJA37480.1     9
 β-1 3-glucanase   Glaciozyma antarctica PI12 AJD14768.1     9
 psychrophilic β-mannanase (PMAN)   Glaciozyma antarctica PI12 AIC85594.1    
 β-1,4-endoglucanase (fragment)   Globodera pallida AER27800.1     2
 β-1,4-endoglucanase (fragment)   Globodera pallida AER27801.1     2
 β-1,4-endoglucanase (fragment)   Globodera pallida AER27802.1     2
 β-1,4-endoglucanase (fragment)   Globodera pallida AER27803.1     2
 β-1,4-endoglucanase (fragment)   Globodera pallida AER27804.1     2
 endo-β-1,4-glucanase (Eng-3)   Globodera rostochiensis AHW98762.1     2
 endo-β-1,4-glucanase (Eng1)   Globodera rostochiensis AHW98760.1     2
 endo-β-1,4-glucanase (Eng-2)   Globodera rostochiensis AHW98761.1     2
 β-1,4-endoglucanase (Eng-3) 3.2.1.4 Globodera rostochiensis RO-1 AAN03645.1
AAN03646.1
Q8MM42   2
 β-1,4-endoglucanase (Eng-4) 3.2.1.4 Globodera rostochiensis RO-1 AAN03647.1
AAN03648.1
Q8MM50   2
 endoglucanase 1 (Eng1;Eng-1;Gr-eng1;Gr-eng-1) 3.2.1.4 Globodera rostochiensis RO-1 AAC63988.1
AAC48325.1
O16028
Q7KQF7
  2
 endoglucanase 2 (Eng2;Eng-2) 3.2.1.4 Globodera rostochiensis RO-1 AAC48341.1
AAC63989.1
O44078
O77094
  2
 endo-β-1,4-glucanase 2 (Eng2)   Globodera tabacum solanacearum AAD56393.1 Q9U6M4   2
 endo-β-1,4-glucanase 1 (Eng1)   Globodera tabacum solanacearum AAD56392.1 Q9U6M5   2
 endo-β-1,4-glucanase (Cel5G) (Cel5G)   Gloeophyllum trabeum AEJ35166.1     5
 endo-β-1,4-glucanase (GtCel5A) (Cel5A) 3.2.1.4 Gloeophyllum trabeum ATCC 11539 ADH51728.1 D7REW1
P84194
  5
 β-mannanase (GLOTRDRAFT_110405) (Man5A) 3.2.1.78 Gloeophyllum trabeum ATCC 11539 / CBS900.73 EPQ57046.1     7
 ORF (fragment)   Gloeoporus dichrous 133/Gd CDL74355.1     5
 GmMAN1 (possible fragment)   Glycine max CAW50873.1
CBC20343.1
    11
 JCVI-FLGm-24C18   Glycine max ACU17987.1 C6T835   7
 unknown (fragment)   Glycine max ACU18247.1 C6T8U5   11
 JCVI-FLGm-24P8   Glycine max ACU18982.1 C6TAY0   7
 JCVI-FLGm-19N17   Glycine max ACU19893.1 C6TDJ1   7
 endo-β-1,4-mannanase (GmMan1) 3.2.1.78 Glycine max ABG88068.1 Q0PKY2   7
 GpGH5 / M427DRAFT_29612 3.2.1.- Gonapodya prolifera JEL478 KXS18720.1     34
 glycoside hydrolase family 5 endoglucanase, partial (Glu-1) (fragment)   Grifola frondosa 136 CDL74353.1
CDL74354.1
    5
 glycoside hydrolase family 5 endoglucanase, partial (fragment)   Gymnopilus junonius 137/K 89 CDL74351.1    
 endo-β-1,4-mannanase   Haliotis discus discus ACJ12612.1 B6VEZ3   10
 β-1,4-mannanase (ManHDD)   Haliotis discus discus BAI99559.1 D4QF63   10
 endo-β-1,4-mannanase (Man1;HdMan) 3.2.1.78 Haliotis discus hannai BAE78456.1 Q2MH89   10
 glycoside hydrolase family 5 endoglucanase, partial (fragment)   Hericium erinaceus 139/LM 03 CDL74357.1    
 ORF (fragment)   Heterobasidion annosum FB-HA-37 CDL74347.1     5
 endo-β-1,4-glucanase 1a (Eng1A;Eng-1A;Hα-eng-1a)   Heterodera avenae ACO55952.1
AFQ55438.1
AGH32769.1
D5FQ93   2
 endo-β-1,4-glucanase 2 (Eng2)   Heterodera avenae AFQ55680.1
AFQ55681.1
    2
 endo-β-1,4-glucanase 3 (Eng3)   Heterodera avenae AFQ55682.1
AFQ55683.1
    2
 β-1,4-endoglucanase-1 (fragment)   Heterodera cruciferae AJE31858.1     2
 endoglucanase 4 (Eng4;Eng-4) 3.2.1.4 Heterodera glycines AAK85303.1
AAP88024.1
Q7YZF3
Q95UR3
  2
 cellulase (Eng6;Eng-6;G26D05)   Heterodera glycines AAM50039.1
AAO25506.1
Q86DQ0   2
 cellulase (Eng5;Eng-5)   Heterodera glycines AAN32884.1
AAP97436.1
Q8ITJ4   2
 endoglucanase 1 (Eng1;Eng-1) 3.2.1.4 Heterodera glycines AAC15707.1
AAC48327.1
CAB42450.1
CAB59144.1
O18453   2
 endoglucanase 2 (Eng2;Eng-2) 3.2.1.4 Heterodera glycines AAC48326.1
AAC15708.1
CAB42449.1
CAB59143.1
O18454   2
 endoglucanase 3 (Eng3;Eng-3) 3.2.1.4 Heterodera glycines AAC33848.1
AAC33860.1
O77449   2
 β-1,4-endoglucanase-2 precursor (Eng2)   Heterodera koreana 01 ART34946.1     2
 endo-β-1,4-glucanase 1 (Eng1;Hssp19) (partial)   Heterodera schachtii CAC12958.1 Q9GRU6   2
 endo-β-1,4-glucanase 2 (Eng2;Hssp19)   Heterodera schachtii CAC12959.1 Q9GRU5   2
 β-1,4-endoglucanase (fragment)   Hirschmanniella gracilis AER27797.1
AER27799.1
    2
 β-1,4-endoglucanase (fragment)   Hirschmanniella gracilis AER27798.1     2
 β-1,4-endoglucanase (fragment)   Hirschmanniella loofi AER27793.1     2
 β-1,4-endoglucanase (fragment)   Hirschmanniella loofi AER27794.1     2
 β-1,4-endoglucanase (fragment)   Hirschmanniella loofi AER27795.1     2
 β-1,4-endoglucanase (fragment)   Hirschmanniella loofi AER27796.1     2
 ORF (fragment)   Hirsutella thompsonii H3 AIK98137.1     27
 predicted protein   Hordeum vulgare subsp. vulgare BAK01092.1     5
 predicted protein   Hordeum vulgare subsp. vulgare BAJ97814.1     14
 predicted protein   Hordeum vulgare subsp. vulgare BAK05121.1     11
 predicted protein   Hordeum vulgare subsp. vulgare BAK05376.1     14
 NIASHv2104N09 (fragment)   Hordeum vulgare subsp. vulgare BAK01294.1     7
 predicted protein   Hordeum vulgare subsp. vulgare BAK00694.1     11
 predicted protein (fragment)   Hordeum vulgare subsp. vulgare BAK07818.1     14
 endo-β-1,4-mannanase (Man1;HvMAN1) 3.2.1.78 Hordeum vulgare subsp. vulgare BAK05001.1
ABC87082.1
Q2I011   7
 ORF (fragment)   Hordeum vulgare subsp. vulgare AGW47737.1     14
 cellulase, partial   Humicola grisea var. thermoidea APD14599.1     24
 endo-β-1,4-glucanase 3 (CMC3;Egl2) 3.2.1.4 Humicola grisea var. thermoidea IFO9854 BAA12676.1     5
 endo-β-1,4-glucanase IV (CMC3) 3.2.1.4 Humicola insolens ATCC 16454 CAA53631.1 Q12624   5
 β-mannanase (alkali-tolerant) (Man5A) 3.2.1.78 Humicola insolens Y1 ADZ99301.1     7
 endoglycoceramidase (EGCase) 3.2.1.123 Hydra magnipapillata BAD20464.1 Q6L6S1   27
 glycoside hydrolase family 5 endoglucanase, partial (fragment)   Hypholoma sp. 150 150/K 107 CDL74350.1     5
 endoglucanase II (EgII)   Hypocrea orientalis EU7-22 AFD50195.1     5
 ORF   Hypocrella siamensis MTCC 10142 ANH56493.1     5
 ORF   Hypocrella siamensis MTCC 10142 ANH56410.1     12
 ORF   Hypocrella siamensis MTCC 10142 ANH56505.1     9
 β-mannanase (Man1;HhMAN1) 3.2.1.78 Hypothenemus hampei ACU52526.1
ACU52527.1
C8CAP6   8
 cellulase   Inonotus hispidus Haeb08 AIY53679.1     5
 endoglucanase (EG)   Inonotus obliquus JL01 AMK37824.1     5
 Man5A   Irpex lacteus AGV52632.1     7
 Man5B (short fragment)   Irpex lacteus AGV52633.1     7
 endoglucanase (Cen1;En-1) 3.2.1.4 Irpex lacteus MC-2 BAD67544.1 Q5W7K4   5
 ORF (partial)   Isaria fumosorosea Ifr AsC AIK98138.1     27
 KAFR_0A01010 (Kafr0a01010)   Kazachstania africana CBS 2517 CCF55539.1     49
 KAFR_0A04770 (Kafr0a04770)   Kazachstania africana CBS 2517 CCF55912.1     9
 KAFR_0C00510 (Kafr0c00510)   Kazachstania africana CBS 2517 CCF57046.1     49
 KAFR_0C05910 (Kafr0c05910)   Kazachstania africana CBS 2517 CCF57582.1     9
 KAFR_0G00170 (Kafr0g00170)   Kazachstania africana CBS 2517 CCF59050.1     12
 KAFR_0G02350 (Kafr0g02350)   Kazachstania africana CBS 2517 CCF59269.1     9
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