Glycoside Hydrolase Family 5

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (11921); Uniprot accession (1922); PDB accession (209); 3D entries (74); cryst (0)
All (10543) Archaea (67) Bacteria (8307) Eukaryota (2044) Viruses (5) unclassified (120) Structure (74) Characterized (547)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | ... | 21 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 (1-4)-β-mannan endohydrolase (Man2) (fragment)   Eucalyptus pilularis BAM05593.1     7
 (1-4)-β-mannan endohydrolase (Man2) (fragment)   Eucalyptus pyrocarpa BAM05594.1     7
 unnamed protein product   Eutrema halophilum BAJ34043.1 E4MWR0   7
 Th18   Eutrema halophilum ABB45852.1 Q0ZR47   7
 ORF   Flammulina velutipes KACC 42777 ADX07304.1     5
 ORF   Flammulina velutipes KACC 42777 ADX07305.1     9
 ORF (fragment)   Flammulina velutipes KACC 42777 ADX07317.1     9
 ORF   Flammulina velutipes KACC 42777 ADX07321.1     9
 ORF   Flammulina velutipes KACC 42777 ADX07338.1     9
 FFUJ_01844   Fusarium fujikuroi IMI 58289 CCT61678.1     5
 FFUJ_01044   Fusarium fujikuroi IMI 58289 CCT62409.1     24
 FFUJ_02196   Fusarium fujikuroi IMI 58289 CCT65263.1     23
 FFUJ_02332   Fusarium fujikuroi IMI 58289 CCT65393.1    
 FFUJ_13562   Fusarium fujikuroi IMI 58289 CCT67355.1     12
 FFUJ_14767   Fusarium fujikuroi IMI 58289 CCT67754.1     5
 FFUJ_07722   Fusarium fujikuroi IMI 58289 CCT68897.1     12
 FFUJ_06131   Fusarium fujikuroi IMI 58289 CCT70180.1     9
 FFUJ_06400   Fusarium fujikuroi IMI 58289 CCT70427.1     15
 FFUJ_06648   Fusarium fujikuroi IMI 58289 CCT70659.1     22
 FFUJ_12776   Fusarium fujikuroi IMI 58289 CCT72882.1    
 FFUJ_10992   Fusarium fujikuroi IMI 58289 CCT74918.1     15
 FFUJ_11390   Fusarium fujikuroi IMI 58289 CCT75371.1     5
 FFUJ_11407   Fusarium fujikuroi IMI 58289 CCT75388.1     27
 FFUJ_06597   Fusarium fujikuroi IMI 58289 CCT70608.1     22
 FFUJ_08723   Fusarium fujikuroi IMI 58289 CCT71223.1     15
 FFUJ_03742   Fusarium fujikuroi IMI 58289 CCT64988.1     23
 FFUJ_03705   Fusarium fujikuroi IMI 58289 CCT65024.1     7
 glycoside hydrolase family 5 endoglucanase, partial (fragment)   Fusarium graminearum 0656-004 2 A WA/MF06-059 CDL74336.1     5
 FGRAMPH1_01T03899   Fusarium graminearum PH-1 SCB64278.1     15
 unnamed protein product   Fusarium graminearum PH-1 CEF73786.1     5
 unnamed protein product   Fusarium graminearum PH-1 CEF88748.1     12
 endo-β-1,4-glucanase (FgCel5A;FGSG_03795;FG03795) (Cel5A)   Fusarium graminearum PH-1 CEF78665.1     5
 unnamed protein product   Fusarium graminearum PH-1 CEF85597.1     22
 unnamed protein product   Fusarium graminearum PH-1 CEF85699.1     23
 unnamed protein product   Fusarium graminearum PH-1 CEF88482.1     7
 unnamed protein product   Fusarium graminearum PH-1 CEF85947.1     16
 FGRAMPH1_01T10411   Fusarium graminearum PH-1 SCB65636.1
CEF77008.1
    9
 unnamed protein product   Fusarium graminearum PH-1 CEF78819.1     22
 unnamed protein product   Fusarium graminearum PH-1 CEF79732.1     7
 unnamed protein product   Fusarium graminearum PH-1 CEF75026.1     12
 unnamed protein product   Fusarium graminearum PH-1 CEF76558.1     15
 unnamed protein product (fragment)   Fusarium graminearum PH-1 CEF72475.1     24
 β-1,6-galactanase (Gal1;FoGal1) 3.2.1.164 Fusarium oxysporum 12S BAF42338.1 A0ZSY6   16
 FOXB_04211 (fragment)   Fusarium oxysporum Fo5176 EGU85271.1     31
 glycoside hydrolase family 5 endoglucanase, partial (fragment)   Fusarium solani 0610-001 2 A WA/MF06-071 CDL74337.1     5
 β-1,4-endoglucanase (GlCel5A;GL28282) (Cel5A) 3.2.1.4 Ganoderma lucidum     5D8W[A,B]
5D8Z[A,B]
5
 glycoside hydrolase family protein 5 (Gh5-1)   Gastrophysa viridula ADU33333.1     10
 β-1,3-glucanase, partial   Glaciozyma antarctica PI12 AJA37480.1     9
 β-1 3-glucanase   Glaciozyma antarctica PI12 AJD14768.1     9
 psychrophilic β-mannanase (PMAN)   Glaciozyma antarctica PI12 AIC85594.1    
 β-1,4-endoglucanase (fragment)   Globodera pallida AER27800.1     2
 β-1,4-endoglucanase (fragment)   Globodera pallida AER27801.1     2
 β-1,4-endoglucanase (fragment)   Globodera pallida AER27802.1     2
 β-1,4-endoglucanase (fragment)   Globodera pallida AER27803.1     2
 β-1,4-endoglucanase (fragment)   Globodera pallida AER27804.1     2
 endo-β-1,4-glucanase (Eng-3)   Globodera rostochiensis AHW98762.1     2
 endo-β-1,4-glucanase (Eng1)   Globodera rostochiensis AHW98760.1     2
 endo-β-1,4-glucanase (Eng-2)   Globodera rostochiensis AHW98761.1     2
 β-1,4-endoglucanase (Eng-3) 3.2.1.4 Globodera rostochiensis RO-1 AAN03645.1
AAN03646.1
Q8MM42   2
 β-1,4-endoglucanase (Eng-4) 3.2.1.4 Globodera rostochiensis RO-1 AAN03647.1
AAN03648.1
Q8MM50   2
 endoglucanase 1 (Eng1;Eng-1;Gr-eng1;Gr-eng-1) 3.2.1.4 Globodera rostochiensis RO-1 AAC63988.1
AAC48325.1
O16028
Q7KQF7
  2
 endoglucanase 2 (Eng2;Eng-2) 3.2.1.4 Globodera rostochiensis RO-1 AAC48341.1
AAC63989.1
O44078
O77094
  2
 endo-β-1,4-glucanase 2 (Eng2)   Globodera tabacum solanacearum AAD56393.1 Q9U6M4   2
 endo-β-1,4-glucanase 1 (Eng1)   Globodera tabacum solanacearum AAD56392.1 Q9U6M5   2
 endo-β-1,4-glucanase (Cel5G) (Cel5G)   Gloeophyllum trabeum AEJ35166.1     5
 endo-β-1,4-glucanase (GtCel5A) (Cel5A) 3.2.1.4 Gloeophyllum trabeum ATCC 11539 ADH51728.1 D7REW1
P84194
  5
 β-mannanase (GLOTRDRAFT_110405) (Man5A) 3.2.1.78 Gloeophyllum trabeum ATCC 11539 / CBS900.73 EPQ57046.1     7
 ORF (fragment)   Gloeoporus dichrous 133/Gd CDL74355.1     5
 GmMAN1 (possible fragment)   Glycine max CAW50873.1
CBC20343.1
    11
 JCVI-FLGm-24C18   Glycine max ACU17987.1 C6T835   7
 unknown (fragment)   Glycine max ACU18247.1 C6T8U5   11
 JCVI-FLGm-24P8   Glycine max ACU18982.1 C6TAY0   7
 JCVI-FLGm-19N17   Glycine max ACU19893.1 C6TDJ1   7
 endo-β-1,4-mannanase (GmMan1) 3.2.1.78 Glycine max ABG88068.1 Q0PKY2   7
 GpGH5 / M427DRAFT_29612 3.2.1.- Gonapodya prolifera JEL478 KXS18720.1     34
 glycoside hydrolase family 5 endoglucanase, partial (Glu-1) (fragment)   Grifola frondosa 136 CDL74353.1
CDL74354.1
    5
 glycoside hydrolase family 5 endoglucanase, partial (fragment)   Gymnopilus junonius 137/K 89 CDL74351.1    
 endo-β-1,4-mannanase   Haliotis discus discus ACJ12612.1 B6VEZ3   10
 β-1,4-mannanase (ManHDD)   Haliotis discus discus BAI99559.1 D4QF63   10
 endo-β-1,4-mannanase (Man1;HdMan) 3.2.1.78 Haliotis discus hannai BAE78456.1 Q2MH89   10
 glycoside hydrolase family 5 endoglucanase, partial (fragment)   Hericium erinaceus 139/LM 03 CDL74357.1    
 ORF (fragment)   Heterobasidion annosum FB-HA-37 CDL74347.1     5
 endo-β-1,4-glucanase 1a (Eng1A;Eng-1A;Hα-eng-1a)   Heterodera avenae ACO55952.1
AFQ55438.1
AGH32769.1
D5FQ93   2
 endo-β-1,4-glucanase 2 (Eng2)   Heterodera avenae AFQ55680.1
AFQ55681.1
    2
 endo-β-1,4-glucanase 3 (Eng3)   Heterodera avenae AFQ55682.1
AFQ55683.1
    2
 β-1,4-endoglucanase-1 (fragment)   Heterodera cruciferae AJE31858.1     2
 endoglucanase 4 (Eng4;Eng-4) 3.2.1.4 Heterodera glycines AAK85303.1
AAP88024.1
Q7YZF3
Q95UR3
  2
 cellulase (Eng6;Eng-6;G26D05)   Heterodera glycines AAM50039.1
AAO25506.1
Q86DQ0   2
 cellulase (Eng5;Eng-5)   Heterodera glycines AAN32884.1
AAP97436.1
Q8ITJ4   2
 endoglucanase 1 (Eng1;Eng-1) 3.2.1.4 Heterodera glycines AAC15707.1
AAC48327.1
CAB42450.1
CAB59144.1
O18453   2
 endoglucanase 2 (Eng2;Eng-2) 3.2.1.4 Heterodera glycines AAC48326.1
AAC15708.1
CAB42449.1
CAB59143.1
O18454   2
 endoglucanase 3 (Eng3;Eng-3) 3.2.1.4 Heterodera glycines AAC33848.1
AAC33860.1
O77449   2
 β-1,4-endoglucanase-2 precursor (Eng2)   Heterodera koreana 01 ART34946.1     2
 endo-β-1,4-glucanase 1 (Eng1;Hssp19) (partial)   Heterodera schachtii CAC12958.1 Q9GRU6   2
 endo-β-1,4-glucanase 2 (Eng2;Hssp19)   Heterodera schachtii CAC12959.1 Q9GRU5   2
 β-1,4-endoglucanase (fragment)   Hirschmanniella gracilis AER27797.1
AER27799.1
    2
 β-1,4-endoglucanase (fragment)   Hirschmanniella gracilis AER27798.1     2
 β-1,4-endoglucanase (fragment)   Hirschmanniella loofi AER27793.1     2
 β-1,4-endoglucanase (fragment)   Hirschmanniella loofi AER27794.1     2
 β-1,4-endoglucanase (fragment)   Hirschmanniella loofi AER27795.1     2
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