Glycoside Hydrolase Family 5

Known Activitieschitosanase (EC 3.2.1.132); β-mannosidase (EC 3.2.1.25); endo-β-1,4-glucanase / cellulase (EC 3.2.1.4); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); endo-β-1,4-xylanase (EC 3.2.1.8); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); β-1,3-mannanase (EC 3.2.1.-); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); mannan transglycosylase (EC 2.4.1.-); endo-β-1,6-galactanase (EC 3.2.1.164); endoglycoceramidase (EC 3.2.1.123); β-primeverosidase (EC 3.2.1.149); β-glucosylceramidase (EC 3.2.1.45); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); β-glucosidase (EC 3.2.1.21); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; New: many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (6182); Uniprot accession (1922); PDB accession (140); 3D entries (50); cryst (1)
All (4901) Archaea (51) Bacteria (3532) Eukaryota (1205) Viruses (2) unclassified (111) Structure (50 - 1 cryst) Characterized (402) Subfamilies (4234)


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AFMB - CNRS - Université d'Aix-Marseille