Glycoside Hydrolase Family 5

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (11690); Uniprot accession (1922); PDB accession (209); 3D entries (74); cryst (0)
All (10313) Archaea (67) Bacteria (8119) Eukaryota (2005) Viruses (5) unclassified (117) Structure (74) Characterized (547)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | ... | 21 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 EGX46126.1 (fragment)   Arthrobotrys oligospora ATCC 24927 EGX46126.1     5
 EGX45355.1   Arthrobotrys oligospora ATCC 24927 EGX45355.1     7
 endoglucanase II   Aspergillus aculeatus AAN16396.1
AAN75019.1
Q8J0N5
Q8J135
  5
 endoglucanase 2 (Cmc2;FII-CMCase;FII CM-cellulase) 3.2.1.4 Aspergillus aculeatus F-50 BAA29030.1 O74169   5
 β-mannanase (Man1) 3.2.1.78 Aspergillus aculeatus KSM 510 / MRC11624 AAA67426.1 Q00012   7
 endo-β-1,4-glucanase V (FV CM-cellulase;Cel1) 3.2.1.4 Aspergillus aculeatus WO 94/14953 AAC08587.1 O59951   5
 β-mannanase (Man5P1;NFIA_113780) 3.2.1.78 Aspergillus fischeri NRRL 181 NRRL 181 / P1 XP_001262744.1     7
 endo-β-1,4-mannosidase (ManAF)   Aspergillus flavus UKM-1 ADZ75457.1     7
 glucosylceramidase / EGCase related protein 1 (EGCrP1) 3.2.1.45 Aspergillus fumigatus BAL46041.1     12
 AFUA_1G03600 (Exg1;Afum-Bgl501)   Aspergillus fumigatus Af293 EAL88072.1 Q4WK60   9
 endo-β-1,4-mannanase (Man I;Man II;AFUA_8G07030;Afu8g07030) 3.2.1.78 Aspergillus fumigatus Af293 EAL85463.1 Q4WBS1   7
 endo-β-1,4-mannanase (ManF;Man I;Man II) (partial) 3.2.1.78 Aspergillus fumigatus IMI 385708 ACH58410.1
ACH58411.1
B5LZ77
B5LZ78
Q4WBS1
  7
 endoglucanase (CenA)   Aspergillus fumigatus WL002 AOY41714.1     5
 endoglucanase / cellulase (Egl2) 3.2.1.4 Aspergillus fumigatus Z5 ADX78144.1     5
 endoglucanase / cellulase (Egl3) 3.2.1.4 Aspergillus fumigatus Z5 ADX78145.1     5
 endo-β-1,4-glucanase C (EglC) (Cel5B) 3.2.1.4 Aspergillus kawachii BAB62319.1 Q96WQ8   5
 endo-β-1,4-glucanase A (EglA) (Cel5A) 3.2.1.4 Aspergillus kawachii BAB62317.1 Q96WR0   5
 endo-β-1,4-glucanase A (EglA; AN1285.2) 3.2.1.4 Aspergillus nidulans FGSC A4 EAA65878.1
ABF50848.1
BAA82592.1
Q5BDU5   5
 AN2709.2 (frameshift)   Aspergillus nidulans FGSC A4 EAA63111.1 C8VKA9
Q5B9S1
  7
 AN8068.2   Aspergillus nidulans FGSC A4 EAA59690.1 C8V683
Q5AUG2
  4
 AN7639.2   Aspergillus nidulans FGSC A4 EAA61825.1 Q5AVP1   7
 endo-β-1,4-glucanase (AN5214.2) 3.2.1.4 Aspergillus nidulans FGSC A4 ABF50872.1
EAA62395.1
Q1HFS8   5
 exo-β-1,3-glucanase (Anid-Bgl502;AN7533) 3.2.1.58 Aspergillus nidulans FGSC A4 EAA62113.1
ABF50886.1
C8VBL9
Q5AVZ7
  9
 AN1332.2   Aspergillus nidulans FGSC A4 EAA65515.1 C8VS48
Q5BDP8
  23
 AN9166.2   Aspergillus nidulans FGSC A4 EAA61999.1 C8VK26
Q5ARB4
  16
 AN9276.2   Aspergillus nidulans FGSC A4 EAA66343.1 Q5AR04   7
 AN4052 (Anid-Bgl501)   Aspergillus nidulans FGSC A4 EAA59523.1
XP_408189.1
Q5B5X8   9
 AN3013.2   Aspergillus nidulans FGSC A4 EAA63584.1 C8VIW0
Q5B8W7
  12
 endo-β-1,4-mannanase (ManA;AnMan5A;AN3358) (Man5A) 3.2.1.78 Aspergillus nidulans FGSC A4 ABF50863.1
EAA63326.1
Q5B7X2   7
 β-1,6-glucanase (Anid-Bgl503;AN3777) 3.2.1.75 Aspergillus nidulans FGSC A4 EAA59985.1
ABF50867.1
C8V716
Q5B6Q3
  15
 endo-β-1,4-mannanase (ManB;AnMan5B;AN3297) (Man5B) 3.2.1.78 Aspergillus nidulans FGSC A4 ABF50861.1
EAA63265.1
Q5B833   7
 endo-β-1,4-mannanase (ManC;AnMan5C;AN6427;ANID_06427) (Man5C) 3.2.1.78 Aspergillus nidulans FGSC A4 EAA58449.1
ABF50878.1
Q5AZ53   7
 β-mannanase (Man5;Man5XZ3) (partial) 3.2.1.78 Aspergillus nidulans XZ3 AGG69666.1     7
 β-mannanase, partial   Aspergillus niger AKC57288.1     7
 ORF (fragment)   Aspergillus niger AMY96372.1     16
 endo-β-1,4-mannanase   Aspergillus niger 128 ADK88903.1 D9ZKR5   7
 β-mannanase   Aspergillus niger BCC4525 AJZ68815.1     7
 β-mannanase   Aspergillus niger BCC4525 AJZ68815.2     7
 β-mannanase   Aspergillus niger BCC4525 AJZ68815.2     7
 endoglucanase B (EglB) 3.2.1.4 Aspergillus niger BCRC 31494 ACT68011.1 O74706   5
 endo-β-1,4-mannanase (ManBK) (partial) 3.2.1.78 Aspergillus niger BK 01 ACJ06979.1 B6V876 3WH9[A,B] 7
 endo-β-1,4-glucanase B (EglB) 3.2.1.4 Aspergillus niger CBS 120.49 / N400 AAE60102.1
AAE84292.1
CAA03653.1
CAA03658.1
CAA11965.1
O74706   5
 An01g11670   Aspergillus niger CBS 513.88 CAK44069.1 A2QAI8   5
 endo-β-1,6-galactanase (An03g01050) 3.2.1.164 Aspergillus niger CBS 513.88 CAK38078.1 A2QFW8   16
 β-mannanase (An05g01320) (Man5A) 3.2.1.78 Aspergillus niger CBS 513.88 CAK96471.1 A2QKT4   7
 An06g02060   Aspergillus niger CBS 513.88 CAK48049.1 A2QLQ4   23
 endo-β-1,4-glucanase B (EglB;An07g08950) 3.2.1.4 Aspergillus niger CBS 513.88 CAK45103.1 A2QPC3   5
 An08g01100   Aspergillus niger CBS 513.88 CAK39791.1 A2QQ32   23
 An11g07660   Aspergillus niger CBS 513.88 CAK45960.1 A2QX52   9
 An16g02100   Aspergillus niger CBS 513.88 CAL00434.1 A2R731   12
 endo-β-1,4-glucanase (EglA;An16g06800)   Aspergillus niger CBS 513.88 CAK42930.1 A2R8E0   5
 An18g04100 (P2) 3.2.1.58 Aspergillus niger CBS 513.88 CAK43212.1 A2RAR6   9
 endo-β-1,4-glucanase (Eg1)   Aspergillus niger DL08 AHY00945.1     5
 endo-β-1,4-glucanase (Eng1;EgI;AnCel5A) 3.2.1.4 Aspergillus niger IFO31125 AAG50051.1 O74706
Q9C3Z7
5I77[A]
5I78[A,B]
5I79[A,B]
5
 endo-β-1,4-mannanase (AnMan5A) (acidic) (Man5A) 3.2.1.78 Aspergillus niger LW-1 / E-30 AEY76082.1
AEP84473.1
    7
 exo-β-1,3-glucanase (Exg1;ExgA) 3.2.1.58 Aspergillus oryzae CBS 12559 CAC07551.1
AHH92832.1
CAD97460.1
Q7Z9L3   9
 endo-β-1,4-glucanase (CelE) 3.2.1.4 Aspergillus oryzae KBN616 BAD72778.1 Q2UPQ4
Q5TKT6
  5
 AO090009000373   Aspergillus oryzae RIB40 BAE54842.1 Q2UUC3   49
 AO090005001389   Aspergillus oryzae RIB40 BAE56314.1 Q2UQ51   12
 AO090005001553 (EglA)   Aspergillus oryzae RIB40 BAE56461.1 Q2UPQ4   5
 AO090001000604   Aspergillus oryzae RIB40 BAE57108.1
ABX90782.1
Q2UMV7   9
 exo-β-1,3-glucanase (Exg1;AO090003000990) 3.2.1.58 Aspergillus oryzae RIB40 BAE58099.1 Q7Z9L3   9
 AO090003001341 + AO090003001342 (fragments)   Aspergillus oryzae RIB40 BAE58401.1
BAE58402.1
    4
 AO090012000006   Aspergillus oryzae RIB40 BAE60253.1 Q2UDW2   27
 AO090012000046 (frameshift)   Aspergillus oryzae RIB40 BAE60287.1 Q2UDS8   16
 AO090012000917   Aspergillus oryzae RIB40 BAE61018.1 Q2UBP7   23
 AO090038000444 (ManD)   Aspergillus oryzae RIB40 BAE64232.1 Q2U2I3   7
 AO090011000715   Aspergillus oryzae RIB40 BAE65168.1 Q2TZU7   5
 AO090011000757   Aspergillus oryzae RIB40 BAE65206.1 Q2TZQ9   15
 AO090010000122 (ManG)   Aspergillus oryzae RIB40 BAE66031.1 Q2TXJ2   7
 AO090005000423 (fragment)   Aspergillus oryzae RIB40 BAE55488.1 Q2USH7   22
 endo-β-1,4-mannanase (partial) 3.2.1.78 Aspergillus sp. T16 AHA38074.1     7
 β-mannanase (MANN) 3.2.1.78 Aspergillus sulphureus ABC59553.1 Q2LE69   7
 ATEG_01374   Aspergillus terreus NIH2624 EAU38131.1     31
 endoglucanase   Aspergillus terreus SUK-1 AAW68436.2
AAW68436.1
Q5G1M1   5
 endo-β-1,4-glucanase (AuCel5A) (Cel5A)   Aspergillus usamii E001 AEY76081.1     5
 β-mannanase (AuMan5A) (Man5A) 3.2.1.78 Aspergillus usamii E001 / YL-01-78 ADZ99027.1     7
 cellulase / CMCase (Cmc1) 3.2.1.4 Aureobasidium pullulans 98 ACH69873.1
ACH63253.1
B5M6A4   22
 endo-β-1,4-glucanase (Egl;ApCel5A) (Cel5A) 3.2.1.4 Aureobasidium pullulans ATCC 62921 / NRRL Y-2311-1 AEM23896.1     5
 ORF (fragment)   Auxenochlorella protothecoides 0710 AFX97746.1     7
 Bathy08g02370   Bathycoccus prasinos RCC1105 CCO17574.1     7
 Bathy18g00620 (fragment)   Bathycoccus prasinos RCC1105 CCO20705.1     7
 Bathy18g00630 (fragment)   Bathycoccus prasinos RCC1105 CCO20718.1     7
 Bathy14g01780   Bathycoccus prasinos RCC1105 CCO19655.1     7
 Bathy01g00860   Bathycoccus prasinos RCC1105 CCO13990.1     32
 endo-β-1,4-mannanase 2 (S48) (fragment)   Biomphalaria glabrata AAV91524.1 Q5DL75   10
 endo-β-1,4-mannanase 1 (S58)   Biomphalaria glabrata AAV91523.1 Q5DL76   10
 exo-β-1,3-glucanase (Exg2) 3.2.1.58 Bipolaris zeicola AAF65310.1 Q9P8N7   9
 endo-β-1,4-glucanase   Bispora antennata AFY98622.1     5
 endo-β-1,4-mannanase (Man5) 3.2.1.78 Bispora antennata CBS 126.38 AFJ68087.1     7
 endo-β-1,4-mannanase 5A (Man5A) 3.2.1.78 Bispora sp. MEY-1 ACH56965.1 B5LXD7   7
 β-1,3-glucanase 1 (Glc-1)   Blumeria graminis AAL26905.1 Q96V64   9
 endo-β-1,4-glucanase (Cel5A)   Botrytis cinerea SAS56 AAT40313.1 Q6IVV6   5
 glycoside hydrolase family 5 protein (Bofut4_p065480.1)   Botrytis cinerea T4 CCD33736.1     23
 glycoside hydrolase family 5 protein (Bofut4_p064210.1)   Botrytis cinerea T4 CCD33819.1     9
 glycoside hydrolase family 5 protein (Bofut4_p097750.1)   Botrytis cinerea T4 CCD34874.1     9
 glycoside hydrolase family 5 protein (Bofut4_p061530.1)   Botrytis cinerea T4 CCD43943.1     7
 glycoside hydrolase family 5 protein (Bofut4_p118670.1)   Botrytis cinerea T4 CCD46317.1     16
 glycoside hydrolase family 5 protein (Bofut4_p037170.1)   Botrytis cinerea T4 CCD47737.1     49
 glycoside hydrolase family 5 protein (Bofut4_p002560.1)   Botrytis cinerea T4 CCD52809.1     22
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