Glycoside Hydrolase Family 5

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (11921); Uniprot accession (1922); PDB accession (209); 3D entries (74); cryst (0)
All (10543) Archaea (67) Bacteria (8307) Eukaryota (2044) Viruses (5) unclassified (120) Structure (74) Characterized (547)
| 1 | ... | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | ... | 21 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 β-1,4-endoglucanase Eng-1ii (fragment)   Meloidogyne incognita AAK21886.1 Q9BJY7   2
 β-1,4-endoglucanase Eng-1i (fragment)   Meloidogyne incognita AAK21885.1 Q9BJY8   2
 β-1,4-endoglucanase Eng-2b (fragment)   Meloidogyne incognita AAK21884.1 Q9BJY9  
 β-1,4-endoglucanase (Eng-2) 3.2.1.4 Meloidogyne incognita AAK21883.2 Q9BJZ0   2
 endo-β-1,4-glucanase (Eng-1A;Mi-eng-1) 3.2.1.4 Meloidogyne incognita AAK21882.1 Q9BJZ1   2
 β-1,4-endoglucanase (Eng-2) 3.2.1.4 Meloidogyne incognita AAK21881.1 Q9BJZ2   2
 β-1,4-endoglucanase-1, partial (Eng-1) (fragment)   Meloidogyne javanica AHX24638.1     2
 β-1,4-endoglucanase Eng-1ii (fragment)   Meloidogyne javanica AAK21895.1 Q9BJY1   2
 β-1,4-endoglucanase Eng-1i (fragment)   Meloidogyne javanica AAK21894.1 Q9BJY2   2
 cellulase (Eng-3)   Meloidogyne javanica HYN CAJ77137.1
ACA66271.1
A2VA30   2
 cellulase 5 (Cgh5A)   Mesosa myops AMA76414.1     2
 cellulase 5 (Cgh5D)   Mesosa myops AMA76418.1     2
 cellulase 5 (Cgh5F)   Mesosa myops AMA76419.1     2
 cellulase 5, partial (Cgh5G) (fragment)   Mesosa myops AMA76420.1    
 cellulase 5, partial (Cgh5E)   Mesosa myops AMA76417.1     2
 cellulase 5 (Cgh5B)   Mesosa myops AMA76415.1     2
 cellulase 5 (Cgh5C)   Mesosa myops AMA76416.1     2
 MAC_09197   Metarhizium acridum CQMa 102 EFY84753.1     15
 ORF (fragment)   Metarhizium reniforme IndGH96 AIK98136.1     27
 endo-β-mannanase   Metopus es CCAP 1653/2 ABR27262.1 A6MI38   41
 exo-β-1,3-glucanase   Meyerozyma caribbica AEP83833.1     9
 exo-β-1,3-glucanase (Exg1)   Meyerozyma guilliermondii K123-1 / M8 ACN18104.1
ADV90770.1
A5DN91   9
 exo-β-1,3-glucanase (fragment)   Meyerozyma guilliermondii M8 ABY47601.1 A9YX59   9
 ORF (fragment)   Microdochium bolleyi 0629-022 2 WA/MF06-285 CDL74339.1     5
 MICPUN_58085   Micromonas commoda sp. RCC299 ACO62742.1 C1E4L9   7
 MICPUN_83090 (fragment)   Micromonas commoda sp. RCC299 ACO64669.1 C1E9E6   7
 MICPUN_102881   Micromonas commoda sp. RCC299 ACO69881.1 C1FHU7  
 GNLVRS01_PISO0A03784g (Piso0_000184)   Millerozyma farinosa CBS 7064 CCE72597.1     9
 GNLVRS01_PISO0B03917g (Piso0_000184)   Millerozyma farinosa CBS 7064 CCE73161.1     9
 GNLVRS01_PISO0N05909g (Piso0_005010)   Millerozyma farinosa CBS 7064 CCE86515.1     49
 GNLVRS01_PISO0M05754g (Piso0_005010)   Millerozyma farinosa CBS 7064 CCE85414.1     49
 GNLVRS01_PISO0L01419g (Piso0_003735)   Millerozyma farinosa CBS 7064 CCE84194.1     12
 GNLVRS01_PISO0K01418g (Piso0_003735)   Millerozyma farinosa CBS 7064 CCE83163.1     12
 GNLVRS01_PISO0D12411g (Piso0_001166)   Millerozyma farinosa CBS 7064 CCE79126.1     9
 GNLVRS01_PISO0D12587g (Piso0_001174)   Millerozyma farinosa CBS 7064 CCE79134.1     9
 GNLVRS01_PISO0C12344g (Piso0_001166)   Millerozyma farinosa CBS 7064 CCE78540.1     9
 GNLVRS01_PISO0C12520g (Piso0_001174)   Millerozyma farinosa CBS 7064 CCE78548.1     9
 endo-β-1,4-mannosidase   Morus alba var. multicaulis AGG82699.1     7
 MA4_25J11.12   Musa acuminata ABF69949.1 Q1EPK8   7
 endo-β-1,4-mannanase (Man5A) 3.2.1.78 Mytilus edulis CAC81056.1 Q8WPJ2 2C0H[A] 10
 NCAS_0A08000   Naumovozyma castellii CBS 4309 type strain:CBS 4309 CCC67358.1     9
 NCAS_0D03110 (Ncas0d03110)   Naumovozyma castellii CBS 4309 type strain:CBS 4309 CCC69892.1     9
 NCAS_0F01050 (Ncas0f01050)   Naumovozyma castellii CBS 4309 type strain:CBS 4309 CCC70589.1     12
 NCAS_0H00760 (Ncas0h00760)   Naumovozyma castellii CBS 4309 type strain:CBS 4309 CCC71386.1     9
 NCAS_0I01650 (Ncas0i01650)   Naumovozyma castellii CBS 4309 type strain:CBS 4309 CCC71833.1     49
 EXG1 (fragment)   Naumovozyma castellii CBS4309 AAO32489.1 Q875Z0   9
 EXG1 (fragment)   Naumovozyma castellii CBS4309 AAO32490.1 Q875Y9  
 NDAI_0A07390 (Ndai0a07390)   Naumovozyma dairenensis CBS 421 type strain:CBS 421 CCD22893.1     49
 NDAI_0D00730 (Ndai0d00730)   Naumovozyma dairenensis CBS 421 type strain:CBS 421 CCD24387.1     9
 NDAI_0H00880 (Ndai0h00880)   Naumovozyma dairenensis CBS 421 type strain:CBS 421 CCD26262.1     9
 NDAI_0H01560 (Ndai0h01560)   Naumovozyma dairenensis CBS 421 type strain:CBS 421 CCD26330.1     12
 NDAI_0I01790 (Ndai0i01790)   Naumovozyma dairenensis CBS 421 type strain:CBS 421 CCD26748.1     9
 NECHADRAFT_90120   Nectria haematococca mpVI 77-13-4 EEU48583.1     24
 endo-β-1,4-glucanase A (CelA) 3.2.1.4 Neocallimastix frontalis AAC63094.1 Q01409   4
 endo-β-1,4-glucanase B (CelB) 3.2.1.4 Neocallimastix patriciarum AAE59927.1
CAA83238.1
Q12647   4
 endo-β-1,4-glucanase D (CelD;W5-CelD;W5C-P) (Cel5D) 3.2.1.4
3.2.1.4
3.2.1.73
3.2.1.73
Neocallimastix patriciarum W5 AAC06321.1
AEX92707.1
O59943   4
 endo-β-1,4-glucanase D (CelD;W5-CelD;W5C-P) (Cel5D) 3.2.1.4
3.2.1.4
3.2.1.73
3.2.1.73
Neocallimastix patriciarum W5 AAC06321.1 O59943   4
 endo-β-1,4-glucanase D (CelD;W5-CelD;W5C-P) (Cel5D) 3.2.1.4
3.2.1.4
3.2.1.73
3.2.1.73
Neocallimastix patriciarum W5 AAC06321.1 O59943   4
 cellulase (fragment)   Neocallimastix sp. GMLF1 ADQ12983.1 E5FVN2   4
 β-1,6-glucanase 3.2.1.75 Neotyphodium sp. FCB-2002 AAN04103.1 Q8NJN4   15
 GH5 cellulase (Ncsp38)   Nephotettix cincticeps BAQ94505.1     40
 endo-β-1,4-glucanase (GH5-1;EG2;NCU00762) 3.2.1.4 Neurospora crassa OR74A CAE81955.1
ABZ29259.1
XP_324942.1
Q7SDR1   5
 NCU08412.1   Neurospora crassa OR74A XP_329458.1
EAA34048.1
    7
 NCU03254.1   Neurospora crassa OR74A XP_330690.1     24
 NCU02233.1   Neurospora crassa OR74A XP_331009.1 Q7S4G1   12
 NCU05882.1   Neurospora crassa OR74A XP_325737.1 Q7S526   16
 NCU03254   Neurospora crassa OR74A EAA35171.2     24
 NCU03914 (Ncrα-Bgl501)   Neurospora crassa OR74A XP_323233.1
CAB91690.1
CAB91690.2
Q1K5Z7
Q9P5K7
  9
 endo-β-1,4-mannanase (Man5) (partial)   Neurospora sitophila CCI55471.1   4AWE[A] 7
 endo-β-1,4-glucanase I (EGaseI)   Oncideres albomarginata chamela ADI24131.1 D7P694   2
 endo-β-1,4-glucanase (CelA) 3.2.1.4 Orpinomyces joyonii 19-2 AAC49731.1 P87211   2
 endo-β-1,4-glucanase (CelB2) (fragment) 3.2.1.4 Orpinomyces joyonii SG4 AAB69348.1 O13334   4
 endo-β-1,4-glucanase (CelB29) 3.2.1.4 Orpinomyces joyonii SG4 AAB69347.1 O13333   4
 EG5, partial   Orpinomyces sp. C1A ANS13827.1     4
 CelE (fragment)   Orpinomyces sp. FCT 2 ACY25184.1 D0V738   4
 endoglucanase (CelB)   Orpinomyces sp. LT-3 AEO51792.1     4
 β-mannanase (ManA) 3.2.1.78 Orpinomyces sp. PC-2 AAL01213.1 Q96V96   7
 endo-β-1,4-glucanase B (CelB) 3.2.1.4 Orpinomyces sp. PC-2 AAD04193.1
AAE59925.1
P78719   4
 endo-β-1,4-glucanase E (CelE) 3.2.1.4 Orpinomyces sp. PC-2 AAC05164.1 Q9HFE0   4
 unnamed protein product   Oryza sativa CAW50874.1
CBC20345.1
    11
 H0510A06.1   Oryza sativa Indica Group CAH67676.1
CAH66881.1
    11
 H0510A06.2   Oryza sativa Indica Group CAH67677.1
CAH66882.1
    11
 OSIGBa0158F13.11   Oryza sativa Indica Group CAH66880.1     11
 OSNPB_040276300 (Os04g0276300) (fragment)   Oryza sativa Japonica Group BAS88352.1    
 OSNPB_100164700 (Os10g0164700) (fragment)   Oryza sativa Japonica Group BAT10030.1     7
 Os03g0828500   Oryza sativa Japonica Group AAL79758.1
ABF99676.1
BAF13691.1
BAS87176.1
Q10B67   7
 Os03g0828300   Oryza sativa Japonica Group AAL79761.1
BAF13690.1
BAS87175.1
A3APA9
Q0DM48
  7
 exo-β-1,3-glucosidase (GH5BG;Os10g0370500) 3.2.1.58 Oryza sativa Japonica Group AAM08614.1
AAM08821.1
AAP53379.1
BAF26372.1
BAG89316.1
BAT10560.1
Q8RU06   14
 Os10g0370800   Oryza sativa Japonica Group AAM08620.1
AAP53385.1
BAF26375.1
BAT10564.1
NP_001064461.1
Q8RU51   14
 Os10g0370800   Oryza sativa Japonica Group AAM08620.1
AAP53385.1
BAF26375.1
BAT10564.1
NP_001064461.1
Q8RU51   14
 Os10g0370800   Oryza sativa Japonica Group AAM08620.1
AAP53385.1
BAF26375.1
BAT10564.1
BAT10565.1
NP_001064461.1
Q8RU51   14
 Os01g0663300   Oryza sativa Japonica Group BAB91747.1
BAF05699.1
BAS73552.1
A2ZW94
Q0JKM9
Q8LR27
  7
 Os04g0480900   Oryza sativa Japonica Group BAF15019.1
BAG98948.1
BAS89738.1
CAD41088.2
CAW49144.1
CAW50875.1
CAW50882.1
CBC20347.1
CBC20363.1
A3AUX3
Q7XUQ6
Q7XUQ7
Q7XUQ8
  11
 Os04g0481000   Oryza sativa Japonica Group CBC20365.1
BAF15020.1
BAS89739.1
CAD41089.2
CAW49145.1
CAW50883.1
Q7XUQ5
Q7XUQ6
  11
 Os04g0481200   Oryza sativa Japonica Group CAD41090.2
BAF15021.1
BAS89740.1
CAW49146.1
CAW50884.1
CBC20366.1
Q7XUQ4
Q7XUQ5
Q7XUQ6
  11
 Os08g0484100   Oryza sativa Japonica Group BAD10703.1
BAD09304.1
BAF23993.1
Q6YTT8   14
 Os02g0596200   Oryza sativa Japonica Group BAD16839.1
BAD21617.1
BAF09234.1
BAS79555.1
CAW49143.1
CAW50881.1
CBC20360.1
Q6ZI46   11
 Os02g0766900   Oryza sativa Japonica Group BAD17320.1
BAD17132.1
BAF10140.1
BAS81070.1
A3ABP6
Q6Z310
  7
 Os06g0311600   Oryza sativa Japonica Group BAD61770.1
BAF19398.1
BAS97441.1
Q0DCM5   7
 OSJNBb0006B22.2 or OSJNBb0059K16.9   Oryza sativa Japonica Group AAV44080.1
AAV44120.1
BAS93345.1
Q5W6G0   7
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