Glycoside Hydrolase Family 5

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (13367); Uniprot accession (1922); PDB accession (214); 3D entries (76); cryst (0)
All (11985) Archaea (92) Bacteria (9640) Eukaryota (2127) Viruses (6) unclassified (120) Structure (76) Characterized (549)
| 1 | ... | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | ... | 22 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 BN887_02040   Melanopsichium pennsylvanicum 4 CDI51196.1     12
 BN887_00859   Melanopsichium pennsylvanicum 4 CDI51800.1     9
 BN887_05784 (fragment)   Melanopsichium pennsylvanicum 4 CDI52106.1     50
 BN887_04738   Melanopsichium pennsylvanicum 4 CDI54550.1     12
 BN887_04978   Melanopsichium pennsylvanicum 4 CDI55234.1     9
 BN887_04322   Melanopsichium pennsylvanicum 4 CDI55906.1     16
 BN887_01891   Melanopsichium pennsylvanicum 4 CDI56177.1     9
 BN887_03423   Melanopsichium pennsylvanicum 4 CDI56700.1    
 Mard-eng-1 (fragment)   Meloidogyne ardenensis AER27760.1     2
 β-1,4-endoglucanase-1, partial (Eng-1) (fragment)   Meloidogyne arenaria AHX24636.1     2
 β-1,4-endoglucanase Eng-1ii (fragment)   Meloidogyne arenaria AAK21893.1 Q9BJY3   2
 β-1,4-endoglucanase Eng-1i (fragment)   Meloidogyne arenaria AAK21892.1 Q9BJY4   2
 β-1,4-endoglucanase (fragment)   Meloidogyne artiellia AER27761.1     2
 β-1,4-endoglucanase (fragment)   Meloidogyne chitwoodi AER27805.1     2
 β-1,4-endoglucanase (fragment)   Meloidogyne chitwoodi AER27807.1     2
 endo-β-1,4-glucanase   Meloidogyne chitwoodi Mc-eng-2 AER27806.1     2
 β-1,4-endoglucanase (fragment)   Meloidogyne hapla AAP33282.1 Q86BU9  
 β-1,4-endoglucanase-1, partial (Eng-1) (fragment)   Meloidogyne hapla AHX24637.1     2
 β-1,4-endoglucanase Eng-1i (fragment)   Meloidogyne hapla AAK21891.1
AAS48572.1
Q9BJY5   2
 β-1,4-endoglucanase-1, partial (Eng-1) (fragment)   Meloidogyne hispanica AHX24640.1     2
 β-1,4-endoglucanase (fragment)   Meloidogyne ichinohei AER27762.1     2
 β-1,4-endoglucanase (fragment)   Meloidogyne ichinohei AER27763.1     2
 endo-β-1,4-glucanase 1 (Eng-1) 3.2.1.4 Meloidogyne incognita AAD45868.1 Q9UA57   2
 cellulase (Eng4)   Meloidogyne incognita AAR37375.1 Q5QJ65   2
 cellulase (Eng3;Eng-1)   Meloidogyne incognita AAR37374.1
AHX24639.1
Q5QJ66   2
 β-1,4-endoglucanase Eng-1vi (fragment)   Meloidogyne incognita AAK21890.1 Q9BH59   2
 β-1,4-endoglucanase Eng-1v (fragment)   Meloidogyne incognita AAK21889.1 Q9BJY6   2
 β-1,4-endoglucanase Eng-1iv (fragment)   Meloidogyne incognita AAK21888.1 Q9BH59   2
 β-1,4-endoglucanase Eng-1iii (fragment)   Meloidogyne incognita AAK21887.1 Q9BH59   2
 β-1,4-endoglucanase Eng-1ii (fragment)   Meloidogyne incognita AAK21886.1 Q9BJY7   2
 β-1,4-endoglucanase Eng-1i (fragment)   Meloidogyne incognita AAK21885.1 Q9BJY8   2
 β-1,4-endoglucanase Eng-2b (fragment)   Meloidogyne incognita AAK21884.1 Q9BJY9  
 β-1,4-endoglucanase (Eng-2) 3.2.1.4 Meloidogyne incognita AAK21883.2 Q9BJZ0   2
 endo-β-1,4-glucanase (Eng-1A;Mi-eng-1) 3.2.1.4 Meloidogyne incognita AAK21882.1 Q9BJZ1   2
 β-1,4-endoglucanase (Eng-2) 3.2.1.4 Meloidogyne incognita AAK21881.1 Q9BJZ2   2
 β-1,4-endoglucanase-1, partial (Eng-1) (fragment)   Meloidogyne javanica AHX24638.1     2
 β-1,4-endoglucanase Eng-1ii (fragment)   Meloidogyne javanica AAK21895.1 Q9BJY1   2
 β-1,4-endoglucanase Eng-1i (fragment)   Meloidogyne javanica AAK21894.1 Q9BJY2   2
 cellulase (Eng-3)   Meloidogyne javanica HYN CAJ77137.1
ACA66271.1
A2VA30   2
 cellulase 5 (Cgh5A)   Mesosa myops AMA76414.1     2
 cellulase 5 (Cgh5D)   Mesosa myops AMA76418.1     2
 cellulase 5 (Cgh5F)   Mesosa myops AMA76419.1     2
 cellulase 5, partial (Cgh5G) (fragment)   Mesosa myops AMA76420.1    
 cellulase 5, partial (Cgh5E)   Mesosa myops AMA76417.1     2
 cellulase 5 (Cgh5B)   Mesosa myops AMA76415.1     2
 cellulase 5 (Cgh5C)   Mesosa myops AMA76416.1     2
 MAC_09197   Metarhizium acridum CQMa 102 EFY84753.1     15
 ORF (fragment)   Metarhizium reniforme IndGH96 AIK98136.1     27
 endo-β-mannanase   Metopus es CCAP 1653/2 ABR27262.1 A6MI38   41
 exo-β-1,3-glucanase   Meyerozyma caribbica AEP83833.1     9
 exo-β-1,3-glucanase (Exg1)   Meyerozyma guilliermondii K123-1 / M8 ACN18104.1
ADV90770.1
A5DN91   9
 exo-β-1,3-glucanase (fragment)   Meyerozyma guilliermondii M8 ABY47601.1 A9YX59   9
 ORF (fragment)   Microdochium bolleyi 0629-022 2 WA/MF06-285 CDL74339.1     5
 MICPUN_58085   Micromonas commoda sp. RCC299 ACO62742.1 C1E4L9   7
 MICPUN_83090 (fragment)   Micromonas commoda sp. RCC299 ACO64669.1 C1E9E6   7
 MICPUN_102881   Micromonas commoda sp. RCC299 ACO69881.1 C1FHU7  
 GNLVRS01_PISO0A03784g (Piso0_000184)   Millerozyma farinosa CBS 7064 CCE72597.1     9
 GNLVRS01_PISO0B03917g (Piso0_000184)   Millerozyma farinosa CBS 7064 CCE73161.1     9
 GNLVRS01_PISO0N05909g (Piso0_005010)   Millerozyma farinosa CBS 7064 CCE86515.1     49
 GNLVRS01_PISO0M05754g (Piso0_005010)   Millerozyma farinosa CBS 7064 CCE85414.1     49
 GNLVRS01_PISO0L01419g (Piso0_003735)   Millerozyma farinosa CBS 7064 CCE84194.1     12
 GNLVRS01_PISO0K01418g (Piso0_003735)   Millerozyma farinosa CBS 7064 CCE83163.1     12
 GNLVRS01_PISO0D12411g (Piso0_001166)   Millerozyma farinosa CBS 7064 CCE79126.1     9
 GNLVRS01_PISO0D12587g (Piso0_001174)   Millerozyma farinosa CBS 7064 CCE79134.1     9
 GNLVRS01_PISO0C12344g (Piso0_001166)   Millerozyma farinosa CBS 7064 CCE78540.1     9
 GNLVRS01_PISO0C12520g (Piso0_001174)   Millerozyma farinosa CBS 7064 CCE78548.1     9
 endo-β-1,4-mannosidase   Morus alba var. multicaulis AGG82699.1     7
 MA4_25J11.12   Musa acuminata ABF69949.1 Q1EPK8   7
 endo-β-1,4-mannanase (Man5A) 3.2.1.78 Mytilus edulis CAC81056.1 Q8WPJ2 2C0H[A] 10
 NCAS_0A08000   Naumovozyma castellii CBS 4309 type strain:CBS 4309 CCC67358.1     9
 NCAS_0D03110 (Ncas0d03110)   Naumovozyma castellii CBS 4309 type strain:CBS 4309 CCC69892.1     9
 NCAS_0F01050 (Ncas0f01050)   Naumovozyma castellii CBS 4309 type strain:CBS 4309 CCC70589.1     12
 NCAS_0H00760 (Ncas0h00760)   Naumovozyma castellii CBS 4309 type strain:CBS 4309 CCC71386.1     9
 NCAS_0I01650 (Ncas0i01650)   Naumovozyma castellii CBS 4309 type strain:CBS 4309 CCC71833.1     49
 EXG1 (fragment)   Naumovozyma castellii CBS4309 AAO32489.1 Q875Z0   9
 EXG1 (fragment)   Naumovozyma castellii CBS4309 AAO32490.1 Q875Y9  
 NDAI_0A07390 (Ndai0a07390)   Naumovozyma dairenensis CBS 421 type strain:CBS 421 CCD22893.1     49
 NDAI_0D00730 (Ndai0d00730)   Naumovozyma dairenensis CBS 421 type strain:CBS 421 CCD24387.1     9
 NDAI_0H00880 (Ndai0h00880)   Naumovozyma dairenensis CBS 421 type strain:CBS 421 CCD26262.1     9
 NDAI_0H01560 (Ndai0h01560)   Naumovozyma dairenensis CBS 421 type strain:CBS 421 CCD26330.1     12
 NDAI_0I01790 (Ndai0i01790)   Naumovozyma dairenensis CBS 421 type strain:CBS 421 CCD26748.1     9
 NECHADRAFT_90120   Nectria haematococca mpVI 77-13-4 EEU48583.1     24
 endo-β-1,4-glucanase A (CelA) 3.2.1.4 Neocallimastix frontalis AAC63094.1 Q01409   4
 endo-β-1,4-glucanase B (CelB) 3.2.1.4 Neocallimastix patriciarum AAE59927.1
CAA83238.1
Q12647   4
 endo-β-1,4-glucanase D (CelD;W5-CelD;W5C-P) (Cel5D) 3.2.1.4
3.2.1.4
3.2.1.73
3.2.1.73
Neocallimastix patriciarum W5 AAC06321.1
AEX92707.1
O59943   4
 endo-β-1,4-glucanase D (CelD;W5-CelD;W5C-P) (Cel5D) 3.2.1.4
3.2.1.4
3.2.1.73
3.2.1.73
Neocallimastix patriciarum W5 AAC06321.1 O59943   4
 endo-β-1,4-glucanase D (CelD;W5-CelD;W5C-P) (Cel5D) 3.2.1.4
3.2.1.4
3.2.1.73
3.2.1.73
Neocallimastix patriciarum W5 AAC06321.1 O59943   4
 cellulase (fragment)   Neocallimastix sp. GMLF1 ADQ12983.1 E5FVN2   4
 β-1,6-glucanase 3.2.1.75 Neotyphodium sp. FCB-2002 AAN04103.1 Q8NJN4   15
 GH5 cellulase (Ncsp38)   Nephotettix cincticeps BAQ94505.1     40
 endo-β-1,4-glucanase (GH5-1;EG2;NCU00762) 3.2.1.4 Neurospora crassa OR74A CAE81955.1
ABZ29259.1
XP_324942.1
Q7SDR1   5
 NCU08412.1   Neurospora crassa OR74A XP_329458.1
EAA34048.1
    7
 NCU03254.1   Neurospora crassa OR74A XP_330690.1     24
 NCU02233.1   Neurospora crassa OR74A XP_331009.1 Q7S4G1   12
 NCU05882.1   Neurospora crassa OR74A XP_325737.1 Q7S526   16
 NCU03254   Neurospora crassa OR74A EAA35171.2     24
 NCU03914 (Ncrα-Bgl501)   Neurospora crassa OR74A XP_323233.1
CAB91690.1
CAB91690.2
Q1K5Z7
Q9P5K7
  9
 endo-β-1,4-mannanase (Man5) (partial)   Neurospora sitophila CCI55471.1   4AWE[A] 7
 endo-β-1,4-glucanase I (EGaseI)   Oncideres albomarginata chamela ADI24131.1 D7P694   2
 endo-β-1,4-glucanase (CelA) 3.2.1.4 Orpinomyces joyonii 19-2 AAC49731.1 P87211   2
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