Glycoside Hydrolase Family 5

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (11393); Uniprot accession (1922); PDB accession (208); 3D entries (73); cryst (0)
All (10017) Archaea (67) Bacteria (7846) Eukaryota (1982) Viruses (5) unclassified (117) Structure (73) Characterized (547)
| 1 | ... | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | ... | 20 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 endo-β-1,4-mannosidase   Morus alba var. multicaulis AGG82699.1     7
 MA4_25J11.12   Musa acuminata ABF69949.1 Q1EPK8   7
 endo-β-1,4-mannanase (Man5A) 3.2.1.78 Mytilus edulis CAC81056.1 Q8WPJ2 2C0H[A] 10
 NCAS_0A08000   Naumovozyma castellii CBS 4309 type strain:CBS 4309 CCC67358.1     9
 NCAS_0D03110 (Ncas0d03110)   Naumovozyma castellii CBS 4309 type strain:CBS 4309 CCC69892.1     9
 NCAS_0F01050 (Ncas0f01050)   Naumovozyma castellii CBS 4309 type strain:CBS 4309 CCC70589.1     12
 NCAS_0H00760 (Ncas0h00760)   Naumovozyma castellii CBS 4309 type strain:CBS 4309 CCC71386.1     9
 NCAS_0I01650 (Ncas0i01650)   Naumovozyma castellii CBS 4309 type strain:CBS 4309 CCC71833.1     49
 EXG1 (fragment)   Naumovozyma castellii CBS4309 AAO32489.1 Q875Z0   9
 EXG1 (fragment)   Naumovozyma castellii CBS4309 AAO32490.1 Q875Y9  
 NDAI_0A07390 (Ndai0a07390)   Naumovozyma dairenensis CBS 421 type strain:CBS 421 CCD22893.1     49
 NDAI_0D00730 (Ndai0d00730)   Naumovozyma dairenensis CBS 421 type strain:CBS 421 CCD24387.1     9
 NDAI_0H00880 (Ndai0h00880)   Naumovozyma dairenensis CBS 421 type strain:CBS 421 CCD26262.1     9
 NDAI_0H01560 (Ndai0h01560)   Naumovozyma dairenensis CBS 421 type strain:CBS 421 CCD26330.1     12
 NDAI_0I01790 (Ndai0i01790)   Naumovozyma dairenensis CBS 421 type strain:CBS 421 CCD26748.1     9
 NECHADRAFT_90120   Nectria haematococca mpVI 77-13-4 EEU48583.1     24
 endo-β-1,4-glucanase A (CelA) 3.2.1.4 Neocallimastix frontalis AAC63094.1 Q01409   4
 endo-β-1,4-glucanase B (CelB) 3.2.1.4 Neocallimastix patriciarum AAE59927.1
CAA83238.1
Q12647   4
 endo-β-1,4-glucanase D (CelD;W5-CelD;W5C-P) (Cel5D) 3.2.1.4
3.2.1.4
3.2.1.73
3.2.1.73
Neocallimastix patriciarum W5 AAC06321.1
AEX92707.1
O59943   4
 endo-β-1,4-glucanase D (CelD;W5-CelD;W5C-P) (Cel5D) 3.2.1.4
3.2.1.4
3.2.1.73
3.2.1.73
Neocallimastix patriciarum W5 AAC06321.1 O59943   4
 endo-β-1,4-glucanase D (CelD;W5-CelD;W5C-P) (Cel5D) 3.2.1.4
3.2.1.4
3.2.1.73
3.2.1.73
Neocallimastix patriciarum W5 AAC06321.1 O59943   4
 cellulase (fragment)   Neocallimastix sp. GMLF1 ADQ12983.1 E5FVN2   4
 β-1,6-glucanase 3.2.1.75 Neotyphodium sp. FCB-2002 AAN04103.1 Q8NJN4   15
 GH5 cellulase (Ncsp38)   Nephotettix cincticeps BAQ94505.1     40
 endo-β-1,4-glucanase (GH5-1;EG2;NCU00762) 3.2.1.4 Neurospora crassa OR74A CAE81955.1
ABZ29259.1
XP_324942.1
Q7SDR1   5
 NCU08412.1   Neurospora crassa OR74A XP_329458.1
EAA34048.1
    7
 NCU03254.1   Neurospora crassa OR74A XP_330690.1     24
 NCU02233.1   Neurospora crassa OR74A XP_331009.1 Q7S4G1   12
 NCU05882.1   Neurospora crassa OR74A XP_325737.1 Q7S526   16
 NCU03254   Neurospora crassa OR74A EAA35171.2     24
 NCU03914 (Ncrα-Bgl501)   Neurospora crassa OR74A XP_323233.1
CAB91690.1
CAB91690.2
Q1K5Z7
Q9P5K7
  9
 endo-β-1,4-mannanase (Man5) (partial)   Neurospora sitophila CCI55471.1   4AWE[A] 7
 endo-β-1,4-glucanase I (EGaseI)   Oncideres albomarginata chamela ADI24131.1 D7P694   2
 endo-β-1,4-glucanase (CelA) 3.2.1.4 Orpinomyces joyonii 19-2 AAC49731.1 P87211   2
 endo-β-1,4-glucanase (CelB2) (fragment) 3.2.1.4 Orpinomyces joyonii SG4 AAB69348.1 O13334   4
 endo-β-1,4-glucanase (CelB29) 3.2.1.4 Orpinomyces joyonii SG4 AAB69347.1 O13333   4
 EG5, partial   Orpinomyces sp. C1A ANS13827.1     4
 CelE (fragment)   Orpinomyces sp. FCT 2 ACY25184.1 D0V738   4
 endoglucanase (CelB)   Orpinomyces sp. LT-3 AEO51792.1     4
 β-mannanase (ManA) 3.2.1.78 Orpinomyces sp. PC-2 AAL01213.1 Q96V96   7
 endo-β-1,4-glucanase B (CelB) 3.2.1.4 Orpinomyces sp. PC-2 AAD04193.1
AAE59925.1
P78719   4
 endo-β-1,4-glucanase E (CelE) 3.2.1.4 Orpinomyces sp. PC-2 AAC05164.1 Q9HFE0   4
 unnamed protein product   Oryza sativa CAW50874.1
CBC20345.1
    11
 H0510A06.1   Oryza sativa Indica Group CAH67676.1
CAH66881.1
    11
 H0510A06.2   Oryza sativa Indica Group CAH67677.1
CAH66882.1
    11
 OSIGBa0158F13.11   Oryza sativa Indica Group CAH66880.1     11
 OSNPB_040276300 (Os04g0276300) (fragment)   Oryza sativa Japonica Group BAS88352.1    
 OSNPB_100164700 (Os10g0164700) (fragment)   Oryza sativa Japonica Group BAT10030.1     7
 Os03g0828500   Oryza sativa Japonica Group AAL79758.1
ABF99676.1
BAF13691.1
BAS87176.1
Q10B67   7
 Os03g0828300   Oryza sativa Japonica Group AAL79761.1
BAF13690.1
BAS87175.1
A3APA9
Q0DM48
  7
 exo-β-1,3-glucosidase (GH5BG;Os10g0370500) 3.2.1.58 Oryza sativa Japonica Group AAM08614.1
AAM08821.1
AAP53379.1
BAF26372.1
BAG89316.1
BAT10560.1
Q8RU06   14
 Os10g0370800   Oryza sativa Japonica Group AAM08620.1
AAP53385.1
BAF26375.1
BAT10564.1
NP_001064461.1
Q8RU51   14
 Os10g0370800   Oryza sativa Japonica Group AAM08620.1
AAP53385.1
BAF26375.1
BAT10564.1
NP_001064461.1
Q8RU51   14
 Os10g0370800   Oryza sativa Japonica Group AAM08620.1
AAP53385.1
BAF26375.1
BAT10564.1
BAT10565.1
NP_001064461.1
Q8RU51   14
 Os01g0663300   Oryza sativa Japonica Group BAB91747.1
BAF05699.1
BAS73552.1
A2ZW94
Q0JKM9
Q8LR27
  7
 Os04g0480900   Oryza sativa Japonica Group BAF15019.1
BAG98948.1
BAS89738.1
CAD41088.2
CAW49144.1
CAW50875.1
CAW50882.1
CBC20347.1
CBC20363.1
A3AUX3
Q7XUQ6
Q7XUQ7
Q7XUQ8
  11
 Os04g0481000   Oryza sativa Japonica Group CBC20365.1
BAF15020.1
BAS89739.1
CAD41089.2
CAW49145.1
CAW50883.1
Q7XUQ5
Q7XUQ6
  11
 Os04g0481200   Oryza sativa Japonica Group CAD41090.2
BAF15021.1
BAS89740.1
CAW49146.1
CAW50884.1
CBC20366.1
Q7XUQ4
Q7XUQ5
Q7XUQ6
  11
 Os08g0484100   Oryza sativa Japonica Group BAD10703.1
BAD09304.1
BAF23993.1
Q6YTT8   14
 Os02g0596200   Oryza sativa Japonica Group BAD16839.1
BAD21617.1
BAF09234.1
BAS79555.1
CAW49143.1
CAW50881.1
CBC20360.1
Q6ZI46   11
 Os02g0766900   Oryza sativa Japonica Group BAD17320.1
BAD17132.1
BAF10140.1
BAS81070.1
A3ABP6
Q6Z310
  7
 Os06g0311600   Oryza sativa Japonica Group BAD61770.1
BAF19398.1
BAS97441.1
Q0DCM5   7
 OSJNBb0006B22.2 or OSJNBb0059K16.9   Oryza sativa Japonica Group AAV44080.1
AAV44120.1
BAS93345.1
Q5W6G0   7
 Os05g0244500   Oryza sativa Japonica Group AAV43969.1
BAF16925.1
BAS92988.1
Q5W708   14
 Os11g0118200 (fragment)   Oryza sativa Japonica Group BAF27440.1
BAG97285.1
BAT12428.1
B7EY38
Q2RBB1
  7
 endo-β-1,4-mannanase 8 (OsMan8;Os12g0117300;LOC_Os12g02520)   Oryza sativa Japonica Group ABA95648.1
BAF29018.1
BAT15617.1
A3CED8
Q0IQJ7
Q2QYI9
  7
 Os01g0746700   Oryza sativa Japonica Group BAB56016.1
BAC05600.1
BAF06144.1
BAS74321.1
Q0JJD4   7
 OSTLU_4036 (fragment)   Ostreococcus lucimarinus CCE9901 ABO94548.1 A4RSG2   7
 OSTLU_3863 (fragment)   Ostreococcus lucimarinus CCE9901 ABO95765.1 A4RVU7   7
 OSTLU_26901   Ostreococcus lucimarinus CCE9901 ABO99132.1 A4S5W1   32
 OSTLU_92070   Ostreococcus lucimarinus CCE9901 ABO94043.1 A4RQL3   32
 OSTLU_42201 (fragment)   Ostreococcus lucimarinus CCE9901 ABP00730.1 A4SAC9   7
 Ot01g00930   Ostreococcus tauri OTTH0595 CAL50004.1 Q01GZ0   32
 Ot20g00120   Ostreococcus tauri OTTH0595 CAL56661.1 Q00S04   7
 Ot04g01830   Ostreococcus tauri OTTH0595 CAL51581.1 Q01B66   7
 Ot12g02510   Ostreococcus tauri OTTH0595 CAL57343.1 Q00XQ8   32
 Ot02g07200   Ostreococcus tauri OTTH0595 CAL52595.1 Q01DK8   7
 ORF (fragment)   Paecilomyces reniformis IndGH96 AIK98136.1     27
 immunodominant antigen gp43, partial (fragment)   Paracoccidioides brasiliensis ASO96830.1     9
 immunodominant antigen gp43, partial (fragment)   Paracoccidioides brasiliensis ASO96831.1     9
 Gp43 (fragment)   Paracoccidioides brasiliensis AEJ22066.1     9
 immunodominant antigen Gp43 (fragment)   Paracoccidioides brasiliensis ACF72730.1
ACF72731.1
ACF72732.1
ACF72733.1
ACF72734.1
ACF72735.1
ACF72736.1
ACF72737.1
ACF72738.1
ACF72739.1
ACF72740.1
ACF72741.1
ACF72742.1
ACF72743.1
B5AQR3  
 immunodominant antigen Gp43 (fragment)   Paracoccidioides brasiliensis ACF72744.1
ACF72745.1
B5AQS7   9
 Gp43 (fragment)   Paracoccidioides brasiliensis (VARIOUS STRAINS) AAY58372.1
AAY58373.1
AAY58374.1
AAY58375.1
AAY58376.1
AAY58377.1
AAY58378.1
AAY58379.1
AAY58380.1
AAY58381.1
AAY58382.1
AAY58383.1
AAY58384.1
AAY58385.1
AAY58386.1
AAY58387.1
AAY58388.1
AAY58389.1
AAY58390.1
AAY58391.1
AAY58392.1
AAY58393.1
AAY58394.1
AAY58395.1
AAY58396.1
AAY58397.1
AAY58398.1
AAY58399.1
AAY58400.1
AAY58401.1
AAY58402.1
AAY58403.1
AAY58404.1
AAY58405.1
AAY58406.1
AAY58407.1
AAY58408.1
AAY58409.1
AAY58410.1
AAY58411.1
AAY58412.1
AAY58413.1
AAY58414.1
AAY58415.1
AAY58416.1
AAY58417.1
AAY58418.1
AAY58419.1
AAY58420.1
AAY58421.1
AAY58422.1
AAY58423.1
AAY58424.1
AAY58425.1
AAY58426.1
AAY58427.1
AAY58428.1
AAY58429.1
AAY58430.1
AAY58431.1
AAY58432.1
AAY58433.1
AAY58434.1
AAY58435.1
AAY58436.1
Q30MW3  
 43 kDa glycoprotein (Gp43) (fragment)   Paracoccidioides brasiliensis (VARIOUS STRAINS) BAB12200.2
BAB12200.1
BAF62830.1
BAF62831.1
BAF62832.1
BAF62834.1
BAF62836.1
BAF62837.1
BAF62838.1
BAF62839.1
BAF62840.1
BAF62841.1
BAF62842.1
BAF62843.1
BAF62844.1
BAF62845.1
BAF62846.1
BAF62847.1
BAF62848.1
BAF62849.1
BAF62850.1
BAF62851.1
BAF62852.1
Q7LW78
Q9HDD7
 
 Gp43 (fragment)   Paracoccidioides brasiliensis ATCC 60855 AAT46286.1 Q6GWY1  
 GP43 (fragment)   Paracoccidioides brasiliensis B12 ABC94844.1
ABC94845.1
ABC94846.1
ABC94847.1
ABC94848.1
ABC94849.1
ABC94850.1
ABC94851.1
Q30MW3  
 GP43 (fragment)   Paracoccidioides brasiliensis B17 ABC94852.1
ABC94853.1
ABC94854.1
ABC94855.1
ABC94856.1
ABC94857.1
ABC94858.1
ABC94859.1
Q30MW3  
 GP43 (fragment)   Paracoccidioides brasiliensis B18 ABC94828.1
ABC94829.1
ABC94830.1
ABC94831.1
ABC94832.1
ABC94833.1
ABC94834.1
ABC94835.1
Q30MU7  
 gp43   Paracoccidioides brasiliensis B339 AAC49253.1
AAC49253.2
AAG36698.1
BAF62835.1
Q01575   9
 GP43 (fragment)   Paracoccidioides brasiliensis B7 ABC94836.1
ABC94837.1
ABC94838.1
ABC94839.1
ABC94840.1
ABC94841.1
ABC94842.1
ABC94843.1
Q30MU2  
 43 kDa secreted glycoprotein (fragment)   Paracoccidioides brasiliensis CABBASOUS AAT39126.1 Q6IVV1  
 43 kDa secreted glycoprotein (fragment)   Paracoccidioides brasiliensis DASYPUS AAT39127.1 Q6IVV1  
 immunodominant antigen Gp43, partial (fragment)   Paracoccidioides brasiliensis EPM106 ALT83500.1     9
 immunodominant antigen Gp43, partial (fragment)   Paracoccidioides brasiliensis EPM127 ALT83501.1     9
 immunodominant antigen Gp43, partial (fragment)   Paracoccidioides brasiliensis EPM155 ALT83503.1     9
 immunodominant antigen Gp43, partial (fragment)   Paracoccidioides brasiliensis EPM29 ALT83491.1     9
 immunodominant antigen Gp43, partial (fragment)   Paracoccidioides brasiliensis EPM35 ALT83492.1     9
 immunodominant antigen Gp43, partial (fragment)   Paracoccidioides brasiliensis EPM54 ALT83493.1     9
 immunodominant antigen Gp43, partial (fragment)   Paracoccidioides brasiliensis EPM60 ALT83494.1     9
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