Glycoside Hydrolase Family 5

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (13708); Uniprot accession (1922); PDB accession (214); 3D entries (76); cryst (0)
All (12318) Archaea (93) Bacteria (9958) Eukaryota (2140) Viruses (7) unclassified (120) Structure (76) Characterized (549)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | ... | 22 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 ORF (fragment)   Coptotermes formosanus AGM32613.1     1
 ORF   Coptotermes formosanus AGM32918.1    
 ORF (fragment)   Coptotermes formosanus AGM33006.1     2
 ORF (fragment)   Coptotermes formosanus AGM33013.1     1
 ORF (partial)   Cordyceps fumosorosea Ifr AsC AIK98138.1     27
 A9K55_008696   Cordyceps militaris ATCC 34164 ATY62578.1     15
 A9K55_000635   Cordyceps militaris ATCC 34164 ATY67020.1     27
 A9K55_009287   Cordyceps militaris ATCC 34164 ATY62125.1     5
 A9K55_003598   Cordyceps militaris ATCC 34164 ATY58494.1     24
 A9K55_000717   Cordyceps militaris ATCC 34164 ATY66476.1     9
 A9K55_005048   Cordyceps militaris ATCC 34164 ATY64700.1     12
 A9K55_008189   Cordyceps militaris ATCC 34164 ATY62039.1     11
 CGB_E4160W   Cryptococcus gattii WM276 ADV22545.1     9
 CGB_A6500C   Cryptococcus gattii WM276 ADV19799.1     12
 CGB_L3610C   Cryptococcus gattii WM276 ADV25348.1     50
 CGB_B3770C   Cryptococcus gattii WM276 ADV20345.1     9
 CGB_D2240C   Cryptococcus gattii WM276 ADV21668.1     9
 CGB_F4310C   Cryptococcus gattii WM276 ADV23065.1     9
 CGB_J1490W   Cryptococcus gattii WM276 ADV24619.1     9
 CGB_L3160C   Cryptococcus gattii WM276 ADV25373.1     12
 CGB_A9170W   Cryptococcus gattii WM276 ADV19959.1    
 CGB_F3670W   Cryptococcus gattii WM276 ADV22976.1     22
 β-glucocerebrosidase (EGCrP1;CNAG_00623) 3.2.1.45 Cryptococcus neoformans var. grubii H99 BAL46040.1
AFR92751.1
AFR92751.2
    12
 CNAG_02225   Cryptococcus neoformans var. grubii H99 AFR95595.1     9
 CNAG_05652   Cryptococcus neoformans var. grubii H99 AFR99083.1     50
 CNAG_00373   Cryptococcus neoformans var. grubii H99 AFR92508.1     9
 CNAG_05138   Cryptococcus neoformans var. grubii H99 AFR94403.1
AFR94403.2
    9
 CNAG_00939 (fragment)   Cryptococcus neoformans var. grubii H99 AFR95190.1     9
 CNAG_05766   Cryptococcus neoformans var. grubii H99 AFR96086.2
AFR96086.1
    22
 CNAG_05803   Cryptococcus neoformans var. grubii H99 AFR96122.1     9
 steryl β-glucosidase (EGCrP2;CNAG_05607) (vacuolar) 3.2.1.104 Cryptococcus neoformans var. grubii H99 AFR99035.1     12
 CNAG_00799   Cryptococcus neoformans var. grubii H99 AFR92930.1    
 CKF44_000834 (fragment)   Cryptococcus neoformans var. grubii KN99 AUB24953.1     9
 CKF44_000537   Cryptococcus neoformans var. grubii KN99 AUB22216.1     12
 CKF44_005183   Cryptococcus neoformans var. grubii KN99 AUB25961.1     22
 CKF44_005217   Cryptococcus neoformans var. grubii KN99 AUB26004.1     9
 CKF44_004606   Cryptococcus neoformans var. grubii KN99 AUB24055.1     9
 CKF44_000313   Cryptococcus neoformans var. grubii KN99 AUB21944.1     9
 CKF44_005075   Cryptococcus neoformans var. grubii KN99 AUB29314.1     50
 CKF44_000704   Cryptococcus neoformans var. grubii KN99 AUB22412.1    
 CKF44_005031   Cryptococcus neoformans var. grubii KN99 AUB29264.1     12
 CKF44_002007   Cryptococcus neoformans var. grubii KN99 AUB25420.1     9
 exo-β-1,3-glucanase (fragment)   Cryptococcus neoformans var. neoformans AAM26269.1 Q8NKG2   9
 cellulase (CelC)   Cryptococcus neoformans var. neoformans 309 CAP67 CAD31110.1 Q8NIP0   9
 CNF01760   Cryptococcus neoformans var. neoformans JEC21 AAW44208.1
AAW44208.2
Q5KFH2   9
 CNF02120   Cryptococcus neoformans var. neoformans JEC21 AAW44253.1
AAW44253.2
Q5KFD5   22
 CND00790   Cryptococcus neoformans var. neoformans JEC21 AAW43031.1
AAW43031.2
Q5KJ34   9
 CNE03150   Cryptococcus neoformans var. neoformans JEC21 AAW43562.1 Q5KGL9   9
 CNA07770   Cryptococcus neoformans var. neoformans JEC21 AAW41305.1 Q5KN45  
 CNL04840   Cryptococcus neoformans var. neoformans JEC21 AAW46509.1
AAW46508.1
Q5K8Q6   9
 CNA06030   Cryptococcus neoformans var. neoformans JEC21 AAW41138.1 Q5KNL9   12
 CNH02900   Cryptococcus neoformans var. neoformans JEC21 AAW45154.1 Q5KD09   50
 CNA03300   Cryptococcus neoformans var. neoformans JEC21 AAW40834.1 Q5KPC6   9
 CNH02490   Cryptococcus neoformans var. neoformans JEC21 AAW45118.1
AAW45117.1
Q5KCW8
Q5KCW9
  12
 carboxymethylcellulase (CsCMCase) 3.2.1.4 Cryptococcus sp. S-2 ABP02069.1 A4UU22   5
 ORF   Cryptomeria japonica var. sinensis BBE74942.1     11
 endo-β-1,4-mannanase (Man;CaMan) 3.2.1.78 Cryptopygus antarcticus ABV68808.1 B4XC07 4OOU[A,B]
4OOZ[A,B]
10
 endo-β-mannanase (Man;CmMAN)   Cucumis melo subsp. melo ADN34185.1 E5GCI6   7
 endoglycoceramidase (EGCase) 3.2.1.123 Cyanea nozakii BAB16369.1
BAB16370.1
Q9GV15
Q9GV16
  27
 CYFA0S_02e07932g   Cyberlindnera fabianii YJS4271 CDR38887.1     49
 CYFA0S_03e01992g   Cyberlindnera fabianii YJS4271 CDR39305.1     12
 CYFA0S_06e03532g   Cyberlindnera fabianii YJS4271 CDR41190.1     9
 CYFA0S_09e02652g   Cyberlindnera fabianii YJS4271 CDR42395.1     9
 CYFA0S_38e00672g   Cyberlindnera fabianii YJS4271 CDR47857.1     22
 ORF (fragment)   Cylindrocarpon sp. 0629-017 3 A WA/MF06-299 CDL74333.1     5
 glycoside hydrolase family 5 endoglucanase, partial (fragment)   Cystoderma carcharias FB-CC-22 CDL74334.1    
 endo-β-mannanase (Man;DfMAN) (fragment)   Datura ferox AAO06964.1 Q8GTA2   7
 endo-β-mannanase (DcMan1) 3.2.1.78 Daucus carota AAN34823.1 Q8H6B4   7
 DEHA0F26378g   Debaryomyces hansenii CBS767 CAG89835.1 Q6BK51   49
 DEHA0D09196g   Debaryomyces hansenii CBS767 CAG86973.1 Q6BSJ3   9
 DEHA0F01716g   Debaryomyces hansenii CBS767 CAG88733.1 Q6BMZ4   9
 DEHA0G07095g   Debaryomyces hansenii CBS767 CAG90288.1 Q6BIZ4   22
 DEHA0D15136g   Debaryomyces hansenii CBS767 CAG87248.1 Q6BRU0   12
 DEHA0F01485g   Debaryomyces hansenii CBS767 CAG88722.1 Q6BN02   9
 mannosidase 1, partial   Diospyros kaki AOR05814.1     7
 endoglucanase (Eng1;Dα-Eng1) 3.2.1.4 Ditylenchus africanus ABY52965.1 B6CI25   2
 endo-β-1,4-glucanase (Eng-1B)   Ditylenchus destructor ACJ60676.1 D1FVA4   2
 endo-β-1,4-glucanase (Eng-2)   Ditylenchus destructor ACP20205.1 D6BL58   2
 endo-β-1,4-glucanase (Eng-1A)   Ditylenchus destructor ADW77528.1     2
 glucan 1,3-β-glucosidase   Drosera adelae BAW35423.1     14
 Esi_0054_0103   Ectocarpus siliculosus Ec 32 CBJ27054.1     33
 endo-1,4-β-mannanase   Eisenia fetida BBB35836.1   5Y6T[A] 10
 β-1,6-glucanase (GcnA) 3.2.1.75 Epichloe festucae FL1 ABK27195.1 A0FJV0   15
 β-1,6-glucanase (GcnA) 3.2.1.75 Epichloe festucae var. lolii LP19 ABK27199.1 A0FJV4   15
 ORF (fragment)   Epicoccum nigrum 0629-002 J 4 A B PDA/MF06-217 CDL74335.1     5
 cellulase (CelA)   Epidinium caudatum BAC57895.1 Q86S90  
 endoglucanase (Epi2)   Epidinium caudatum BAC57893.1 Q86S92   4
 endo-β-1,4-glucanase (Epi3) (probable fragment) 3.2.1.4 Epidinium caudatum BAA76394.1 Q9XXV3   4
 Cmc-01A (partial) (fragment)   Epidinium ecaudatum CAL91973.1 B7FBJ8   4
 cellulase (Cmc-08) (partial)   Epidinium ecaudatum CAL91968.1 B7FBJ3   1
 Cmc-02 (partial)   Epidinium ecaudatum CAL91969.1 B7FBJ4   4
 cellulase (Cmc-13) (fragment)   Epidinium ecaudatum CAL91971.1 B7FBJ6   4
 Cmc-01B (fragment)   Epidinium ecaudatum CAL91974.1 B7FBJ9   4
 CMCase (Cmc-06) (Cel5A) 3.2.1.4 Epidinium ecaudatum CAH69214.1
CAL91975.1
Q5F324   4
 Ecym_1266   Eremothecium cymbalariae DBVPG#7215 AET37508.1     12
 Ecym_3088   Eremothecium cymbalariae DBVPG#7215 AET38598.1     9
 Ecym_5128   Eremothecium cymbalariae DBVPG#7215 AET39907.1     49
 Ecym_5578   Eremothecium cymbalariae DBVPG#7215 AET40316.1     9
 AAR146W   Eremothecium gossypii ATCC 10895 AAS50513.1 Q75EC8   9
 AAR017W   Eremothecium gossypii ATCC 10895 AAS50382.1 Q75ER2   12
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