Glycoside Hydrolase Family 5

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (11393); Uniprot accession (1922); PDB accession (208); 3D entries (73); cryst (0)
All (10017) Archaea (67) Bacteria (7846) Eukaryota (1982) Viruses (5) unclassified (117) Structure (73) Characterized (547)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | ... | 20 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 CNF02120   Cryptococcus neoformans var. neoformans JEC21 AAW44253.1
AAW44253.2
Q5KFD5   22
 CND00790   Cryptococcus neoformans var. neoformans JEC21 AAW43031.1
AAW43031.2
Q5KJ34   9
 CNE03150   Cryptococcus neoformans var. neoformans JEC21 AAW43562.1 Q5KGL9   9
 CNA07770   Cryptococcus neoformans var. neoformans JEC21 AAW41305.1 Q5KN45  
 CNL04840   Cryptococcus neoformans var. neoformans JEC21 AAW46509.1
AAW46508.1
Q5K8Q6   9
 CNA06030   Cryptococcus neoformans var. neoformans JEC21 AAW41138.1 Q5KNL9   12
 CNH02900   Cryptococcus neoformans var. neoformans JEC21 AAW45154.1 Q5KD09   50
 CNA03300   Cryptococcus neoformans var. neoformans JEC21 AAW40834.1 Q5KPC6   9
 CNH02490   Cryptococcus neoformans var. neoformans JEC21 AAW45118.1
AAW45117.1
Q5KCW8
Q5KCW9
  12
 carboxymethylcellulase (CsCMCase) 3.2.1.4 Cryptococcus sp. S-2 ABP02069.1 A4UU22   5
 endo-β-1,4-mannanase (Man;CaMan) 3.2.1.78 Cryptopygus antarcticus ABV68808.1 B4XC07 4OOU[A,B]
4OOZ[A,B]
10
 endo-β-mannanase (Man;CmMAN)   Cucumis melo subsp. melo ADN34185.1 E5GCI6   7
 endoglycoceramidase (EGCase) 3.2.1.123 Cyanea nozakii BAB16369.1
BAB16370.1
Q9GV15
Q9GV16
  27
 CYFA0S_02e07932g   Cyberlindnera fabianii YJS4271 CDR38887.1     49
 CYFA0S_03e01992g   Cyberlindnera fabianii YJS4271 CDR39305.1     12
 CYFA0S_06e03532g   Cyberlindnera fabianii YJS4271 CDR41190.1     9
 CYFA0S_09e02652g   Cyberlindnera fabianii YJS4271 CDR42395.1     9
 CYFA0S_38e00672g   Cyberlindnera fabianii YJS4271 CDR47857.1     22
 ORF (fragment)   Cylindrocarpon sp. 0629-017 3 A WA/MF06-299 CDL74333.1     5
 glycoside hydrolase family 5 endoglucanase, partial (fragment)   Cystoderma carcharias FB-CC-22 CDL74334.1    
 endo-β-mannanase (Man;DfMAN) (fragment)   Datura ferox AAO06964.1 Q8GTA2   7
 endo-β-mannanase (DcMan1) 3.2.1.78 Daucus carota AAN34823.1 Q8H6B4   7
 DEHA0F26378g   Debaryomyces hansenii CBS767 CAG89835.1 Q6BK51   49
 DEHA0D09196g   Debaryomyces hansenii CBS767 CAG86973.1 Q6BSJ3   9
 DEHA0F01716g   Debaryomyces hansenii CBS767 CAG88733.1 Q6BMZ4   9
 DEHA0G07095g   Debaryomyces hansenii CBS767 CAG90288.1 Q6BIZ4   22
 DEHA0D15136g   Debaryomyces hansenii CBS767 CAG87248.1 Q6BRU0   12
 DEHA0F01485g   Debaryomyces hansenii CBS767 CAG88722.1 Q6BN02   9
 mannosidase 1, partial   Diospyros kaki AOR05814.1     7
 endoglucanase (Eng1;Dα-Eng1) 3.2.1.4 Ditylenchus africanus ABY52965.1 B6CI25   2
 endo-β-1,4-glucanase (Eng-1B)   Ditylenchus destructor ACJ60676.1 D1FVA4   2
 endo-β-1,4-glucanase (Eng-2)   Ditylenchus destructor ACP20205.1 D6BL58   2
 endo-β-1,4-glucanase (Eng-1A)   Ditylenchus destructor ADW77528.1     2
 glucan 1,3-β-glucosidase   Drosera adelae BAW35423.1     14
 Esi_0054_0103   Ectocarpus siliculosus Ec 32 CBJ27054.1     33
 β-1,6-glucanase (GcnA) 3.2.1.75 Epichloe festucae FL1 ABK27195.1 A0FJV0   15
 β-1,6-glucanase (GcnA) 3.2.1.75 Epichloe festucae var. lolii LP19 ABK27199.1 A0FJV4   15
 ORF (fragment)   Epicoccum nigrum 0629-002 J 4 A B PDA/MF06-217 CDL74335.1     5
 cellulase (CelA)   Epidinium caudatum BAC57895.1 Q86S90  
 endoglucanase (Epi2)   Epidinium caudatum BAC57893.1 Q86S92   4
 endo-β-1,4-glucanase (Epi3) (probable fragment) 3.2.1.4 Epidinium caudatum BAA76394.1 Q9XXV3   4
 Cmc-01A (partial) (fragment)   Epidinium ecaudatum CAL91973.1 B7FBJ8   4
 cellulase (Cmc-08) (partial)   Epidinium ecaudatum CAL91968.1 B7FBJ3   1
 Cmc-02 (partial)   Epidinium ecaudatum CAL91969.1 B7FBJ4   4
 cellulase (Cmc-13) (fragment)   Epidinium ecaudatum CAL91971.1 B7FBJ6   4
 Cmc-01B (fragment)   Epidinium ecaudatum CAL91974.1 B7FBJ9   4
 CMCase (Cmc-06) (Cel5A) 3.2.1.4 Epidinium ecaudatum CAH69214.1
CAL91975.1
Q5F324   4
 Ecym_1266   Eremothecium cymbalariae DBVPG#7215 AET37508.1     12
 Ecym_3088   Eremothecium cymbalariae DBVPG#7215 AET38598.1     9
 Ecym_5128   Eremothecium cymbalariae DBVPG#7215 AET39907.1     49
 Ecym_5578   Eremothecium cymbalariae DBVPG#7215 AET40316.1     9
 AAR146W   Eremothecium gossypii ATCC 10895 AAS50513.1 Q75EC8   9
 AAR017W   Eremothecium gossypii ATCC 10895 AAS50382.1 Q75ER2   12
 ABL101C   Eremothecium gossypii ATCC 10895 AAS50670.1
NP_982846.1
Q75DX4   49
 AEL220C   Eremothecium gossypii ATCC 10895 AAS52465.1 Q758I2   9
 FAGOS_FAAR146W   Eremothecium gossypii FDAG1 AEY94800.1     9
 FAGOS_FABL101C   Eremothecium gossypii FDAG1 AEY94958.1     49
 FAGOS_FAAR017W   Eremothecium gossypii FDAG1 AEY94668.1     12
 FAGOS_FAEL220C   Eremothecium gossypii FDAG1 AEY96764.1     9
 AW171_hschr74460   Eremothecium sinecaudum ATCC 58844 AMD22423.1     9
 AW171_hschr84964   Eremothecium sinecaudum ATCC 58844 AMD22901.1     9
 AW171_hschr52916   Eremothecium sinecaudum ATCC 58844 AMD20986.1     49
 AW171_hschr63925   Eremothecium sinecaudum ATCC 58844 AMD21928.1     12
 Man1 (fragment)   Eucalyptus globulus subsp. globulus ABD47729.1 Q27U85   7
 Man2 (fragment)   Eucalyptus globulus subsp. globulus ABD47730.1
BAM05595.1
Q27U84   7
 Man3 (fragment)   Eucalyptus globulus subsp. globulus ABD47731.1 Q27U83   7
 (1-4)-β-mannan endohydrolase (Man2) (fragment)   Eucalyptus pilularis BAM05593.1     7
 (1-4)-β-mannan endohydrolase (Man2) (fragment)   Eucalyptus pyrocarpa BAM05594.1     7
 unnamed protein product   Eutrema halophilum BAJ34043.1 E4MWR0   7
 Th18   Eutrema halophilum ABB45852.1 Q0ZR47   7
 ORF   Flammulina velutipes KACC 42777 ADX07304.1     5
 ORF   Flammulina velutipes KACC 42777 ADX07305.1     9
 ORF (fragment)   Flammulina velutipes KACC 42777 ADX07317.1     9
 ORF   Flammulina velutipes KACC 42777 ADX07321.1     9
 ORF   Flammulina velutipes KACC 42777 ADX07338.1     9
 FFUJ_01844   Fusarium fujikuroi IMI 58289 CCT61678.1     5
 FFUJ_01044   Fusarium fujikuroi IMI 58289 CCT62409.1     24
 FFUJ_02196   Fusarium fujikuroi IMI 58289 CCT65263.1     23
 FFUJ_02332   Fusarium fujikuroi IMI 58289 CCT65393.1    
 FFUJ_13562   Fusarium fujikuroi IMI 58289 CCT67355.1     12
 FFUJ_14767   Fusarium fujikuroi IMI 58289 CCT67754.1     5
 FFUJ_07722   Fusarium fujikuroi IMI 58289 CCT68897.1     12
 FFUJ_06131   Fusarium fujikuroi IMI 58289 CCT70180.1     9
 FFUJ_06400   Fusarium fujikuroi IMI 58289 CCT70427.1     15
 FFUJ_06648   Fusarium fujikuroi IMI 58289 CCT70659.1     22
 FFUJ_12776   Fusarium fujikuroi IMI 58289 CCT72882.1    
 FFUJ_10992   Fusarium fujikuroi IMI 58289 CCT74918.1     15
 FFUJ_11390   Fusarium fujikuroi IMI 58289 CCT75371.1     5
 FFUJ_11407   Fusarium fujikuroi IMI 58289 CCT75388.1     27
 FFUJ_06597   Fusarium fujikuroi IMI 58289 CCT70608.1     22
 FFUJ_08723   Fusarium fujikuroi IMI 58289 CCT71223.1     15
 FFUJ_03742   Fusarium fujikuroi IMI 58289 CCT64988.1     23
 FFUJ_03705   Fusarium fujikuroi IMI 58289 CCT65024.1     7
 glycoside hydrolase family 5 endoglucanase, partial (fragment)   Fusarium graminearum 0656-004 2 A WA/MF06-059 CDL74336.1     5
 FGRAMPH1_01T03899   Fusarium graminearum PH-1 SCB64278.1     15
 unnamed protein product   Fusarium graminearum PH-1 CEF73786.1     5
 unnamed protein product   Fusarium graminearum PH-1 CEF88748.1     12
 endo-β-1,4-glucanase (FgCel5A;FGSG_03795;FG03795) (Cel5A)   Fusarium graminearum PH-1 CEF78665.1     5
 unnamed protein product   Fusarium graminearum PH-1 CEF85597.1     22
 unnamed protein product   Fusarium graminearum PH-1 CEF85699.1     23
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