Glycoside Hydrolase Family 5

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (12681); Uniprot accession (1922); PDB accession (213); 3D entries (75); cryst (0)
All (11302) Archaea (67) Bacteria (9025) Eukaryota (2084) Viruses (6) unclassified (120) Structure (75) Characterized (547)
| 1 | ... | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | ... | 21 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 ORF (fragment)   Lacazia loboi 33-RPGB ABW86806.1 B5KRK5   9
 ORF (fragment)   Lacazia loboi 4-RPM ABW86812.1 B5KRL1   9
 LACBIDRAFT_292256   Laccaria bicolor S238N-H82 EDR14294.1     30
 LACBIDRAFT_294893 (fragment)   Laccaria bicolor S238N-H82 EDR05274.1     30
 EXG1   Lachancea kluyveri CBS3082 AAO32563.1 Q875R9   9
 KLTH0F13706g   Lachancea thermotolerans CBS 6340 CAR24346.1     12
 KLTH0C07414g   Lachancea thermotolerans CBS 6340 CAR22109.1     49
 KLTH0H06974g   Lachancea thermotolerans CBS 6340 CAR30320.1     9
 endo-β-1,4-mannanase (Man1) 3.2.1.78 Lactuca sativa CAC51690.3 Q93X40   7
 ORF   Lagenidium giganteum ARSEF 373 AIK98135.1     27
 β-1,6-glucanase (Glu1)   Lecanicillium fungicola 150-1 AAO63562.1 Q7ZA48   15
 exo-β-1,3-glucanase (Exg1) 3.2.1.58 Lentinula edodes H600 BAD97445.1
BAD97446.1
Q53UH0   9
 glycoside hydrolase family 5 endoglucanase, partial (fragment)   Lentinula edodes M-LE-777 CDL74352.1    
 Man7 / LesaMAN7 (fragment)   Lepidium sativum AED01931.1     7
 ORF   Leptosphaeria maculans JN3 CBX90804.1 E4ZHH1   16
 ORF   Leptosphaeria maculans JN3 CBX91472.1 E4ZJ41   9
 ORF   Leptosphaeria maculans JN3 CBX91659.1 E4ZK64   49
 ORF   Leptosphaeria maculans JN3 CBX91913.1 E5R4E5   5
 ORF   Leptosphaeria maculans JN3 CBX93149.1 E4ZPC4   7
 ORF   Leptosphaeria maculans JN3 CBX94583.1 E4ZSZ5   4
 ORF   Leptosphaeria maculans JN3 CBX96078.1 E4ZWV2   7
 ORF   Leptosphaeria maculans JN3 CBX96356.1 E4ZYB1   9
 ORF   Leptosphaeria maculans JN3 CBX97550.1 E5A2B5   9
 ORF   Leptosphaeria maculans JN3 CBX97708.1 E5A1Z1   16
 ORF   Leptosphaeria maculans JN3 CBX97977.1 E5A3V3   12
 ORF   Leptosphaeria maculans JN3 CBY01903.1 E5AFB4   7
 ORF (fragment)   Leptosphaeria maculans JN3 CBX91542.1 E4ZJB1   9
 ORF (fragment)   Leptosphaeria maculans JN3 CBY00459.1 E5A9W8   16
 ORF (fragment)   Leptosphaeria maculans JN3 CBY00460.1 E5A9W9   16
 endocellulase (Cel5A)   Leucoagaricus gongylophorus Ae322 CDJ79817.1     5
 endocellulase (Cel5B)   Leucoagaricus gongylophorus Ae322 CDJ79818.1     5
 β-mannosidase   Lichtheimia corymbifera CGMCC 4974 AMB61311.1     7
 LRAMOSA05721   Lichtheimia ramosa CDS13545.1     7
 LRAMOSA05754   Lichtheimia ramosa CDS13578.1     12
 LRAMOSA07974   Lichtheimia ramosa CDS05446.1     12
 LRAMOSA09953   Lichtheimia ramosa CDS08592.1     27
 LRAMOSA10401   Lichtheimia ramosa CDS09041.1     50
 LRAMOSA04528   Lichtheimia ramosa CDS12333.1     7
 LRAMOSA07070   Lichtheimia ramosa CDS04115.1     9
 LRAMOSA08274   Lichtheimia ramosa CDS05746.1     9
 LRAMOSA09878   Lichtheimia ramosa CDS08517.1     7
 EgL (fragment)   Limacella glischra AEQ58911.1     5
 glycoside hydrolase family 5 endoglucanase, partial (fragment)   Limacella guttata FB-LG-51 CDL74327.1    
 EgL (fragment)   Limacella illinita AEQ58912.1     5
 GH5A   Limnoria quadripunctata ADE58567.1 D5IEF5   10
 GH5C   Limnoria quadripunctata ADE58568.1 D5IEF6   10
 GH5E   Limnoria quadripunctata ADE58569.1 D5IEF7   10
 ORF   Lolium perenne ARJ57515.1     15
 ORF   Lolium perenne ARJ57513.1     15
 ORF   Lolium perenne ARJ57514.1     15
 unknown   Lotus japonicus AFK43830.1     7
 unknown   Lotus japonicus AFK46805.1     7
 unknown (fragment)   Lotus japonicus AFK34066.1     7
 unknown   Lotus japonicus AFK35120.1     14
 unknown (fragment)   Lotus japonicus AFK38496.1     14
 unknown   Lotus japonicus AFK46453.1     11
 unknown (fragment)   Lotus japonicus AFK48266.1     11
 endo-β-1,4-glucanase 1 (Egl1) 3.2.1.4 Macrophomina phaseolina AAB51451.1 Q12638   5
 endo-β-1,4-glucanase 2 (Egl2) 3.2.1.4 Macrophomina phaseolina AAB03889.1 Q12637   5
 MG07846.4 (fragment)   Magnaporthe oryzae 70-15 XP_367942.1     22
 MG05844.4   Magnaporthe oryzae 70-15 XP_369620.1     7
 MG06512.4   Magnaporthe oryzae 70-15 XP_369997.1 G4N6W3   9
 MG00319.4   Magnaporthe oryzae 70-15 XP_368925.1 G4NCZ5   5
 MG00530.4   Magnaporthe oryzae 70-15 XP_368714.1 G4NBI5   24
 MG00882.4   Magnaporthe oryzae 70-15 XP_368362.1 G4NDR4   12
 MG03374.4   Magnaporthe oryzae 70-15 XP_360831.1 G4N8V8   16
 MG05381.4   Magnaporthe oryzae 70-15 XP_360006.1 G4MKY3   16
 MG09342.4 (fragment)   Magnaporthe oryzae 70-15 XP_364584.1 G4NI55   7
 MG10083.4   Magnaporthe oryzae 70-15 XP_365863.1 G4N908   5
 MG09433.4   Magnaporthe oryzae 70-15 XP_364493.1     22
 MGG_06402   Magnaporthe oryzae 70-15 XP_003717168.1
XP_369887.1
    11
 MGG_10423   Magnaporthe oryzae 70-15 XP_003719440.1
XP_366204.1
    16
 MGL_0748   Malassezia globosa CBS 7966 EDP44941.1     50
 MSYG_3070   Malassezia sympodialis ATCC 42132 SHO78723.1     50
 MSYG_2409 (fragment)   Malassezia sympodialis ATCC 42132 SHO78067.1     12
 MSYG_2412   Malassezia sympodialis ATCC 42132 SHO78070.1     50
 MSYG_4240   Malassezia sympodialis ATCC 42132 SHO79887.1     50
 MSYG_4116   Malassezia sympodialis ATCC 42132 SHO79766.1     9
 MSYG_3905   Malassezia sympodialis ATCC 42132 SHO79555.1     50
 MSYG_3512 (fragment)   Malassezia sympodialis ATCC 42132 SHO79163.1     9
 endo-β-mannanase (Man2;MdMAN2)   Malus domestica ACN78664.1 C7A7X8   7
 endo-β-mannanase (Man3;MdMAN3)   Malus domestica ACN78665.1 C7A7X9   7
 endo-β-mannanase (Man1;MdMAN1)   Malus domestica ACN78663.1 C7A7X7   7
 glycoside hydrolase family 5 endoglucanase, partial (fragment)   Marasmius oreades FB-MO-71 CDL74348.1     5
 unknown   Medicago truncatula AFK33638.1     14
 unknown   Medicago truncatula AFK42423.1     14
 MtrDRAFT_AC149642g20v1   Medicago truncatula ABD32354.1 Q2HTU0   11
 MtrDRAFT_AC145165g35v2   Medicago truncatula ABP02833.1
ABE91798.1
ABE91799.1
    14
 MtrDRAFT_AC137669g17v2   Medicago truncatula ABO79647.1     7
 MtrDRAFT_AC141435g4v2 + MtrDRAFT_AC141435g5v2 (fragments)   Medicago truncatula ABO80563.1
ABO80564.1
    11
 MtrDRAFT_AC147959g9v1   Medicago truncatula ABP03047.1
AFK37837.1
    14
 MtrDRAFT_AC147959g24v1   Medicago truncatula ABP03049.1     14
 MtrDRAFT_AC147959g10v1   Medicago truncatula ABP03050.1     14
 BN887_02050   Melanopsichium pennsylvanicum 4 CDI51178.1     9
 BN887_01986   Melanopsichium pennsylvanicum 4 CDI51074.1     50
 BN887_02040   Melanopsichium pennsylvanicum 4 CDI51196.1     12
 BN887_00859   Melanopsichium pennsylvanicum 4 CDI51800.1     9
 BN887_05784 (fragment)   Melanopsichium pennsylvanicum 4 CDI52106.1     50
 BN887_04738   Melanopsichium pennsylvanicum 4 CDI54550.1     12
 BN887_04978   Melanopsichium pennsylvanicum 4 CDI55234.1     9
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