Glycoside Hydrolase Family 5

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (11393); Uniprot accession (1922); PDB accession (208); 3D entries (73); cryst (0)
All (10017) Archaea (67) Bacteria (7846) Eukaryota (1982) Viruses (5) unclassified (117) Structure (73) Characterized (547)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | ... | 20 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 glycoside hydrolase family 5 protein (Bofut4_p141060.1)   Botrytis cinerea T4 CCD56844.1     15
 glycoside hydrolase family 5 protein (Bofut4_p067310.1) (fragment)   Botrytis cinerea T4 CCD43323.1     12
 glycoside hydrolase family 5 protein (Bofut4_p059260.1)   Botrytis cinerea T4 CCD44346.1     5
 glycoside hydrolase family 5 protein, partial sequence (Bofut4_p041740.1) (fragment)   Botrytis cinerea T4 CCD46563.1     9
 glycoside hydrolase family 5 protein, partial sequence (Bofut4_p041750.1) (fragment)   Botrytis cinerea T4 CCD46564.1     9
 glycoside hydrolase family 5 protein (Bofut4_p114590.1)   Botrytis cinerea T4 CCD46753.1     4
 glycoside hydrolase family 5 protein (Bofut4_p112910.1) (fragment)   Botrytis cinerea T4 CCD47981.1     5
 cel5A, endo-β-1,4-glucanase precursor (Bofut4_p020810.1)   Botrytis cinerea T4 CCD51775.1     5
 BofuT4P67000004001   Botrytis cinerea T4 CCD53723.2     7
 CmacGH5-3 / Gh5-3   Callosobruchus maculatus ADU33273.1     10
 CmacGH5-4 / Gh5-4   Callosobruchus maculatus ADU33274.1     10
 CmacGH5-1 / Gh5-1   Callosobruchus maculatus ADU33271.1     10
 CmacGH5-2 / Gh5-2   Callosobruchus maculatus ADU33272.1     10
 β-glucosidase 1 GH5 family (GH5BG1;CsGH5BG1) 3.2.1.21 Camellia sinensis ARU79086.1     14
 β-glucosidase 2 GH5 family (Gh5bg2)   Camellia sinensis ARU79087.1     14
 β-glucosidase 3 GH5 family (Gh5bg3)   Camellia sinensis ARU79088.1     14
 exo-β-1,3-glucanase (Xog;Xog1;Exg;Ca49c10.05) 3.2.1.58 Candida albicans CAA39908.1
AAV05307.1
CAA21969.1
P29717 1CZ1[A]
1EQC[A]
1EQP[A]
2PB1[A]
2PBO[A]
2PC8[A]
2PF0[A]
3N9K[A]
3O6A[A]
4M80[A]
4M81[A]
4M82[A]
9
 Sequence 15038 from patent US 6747137   Candida albicans AAV03081.1     12
 Sequence 17110 from patent US 6747137   Candida albicans AAV05153.1     49
 CAALFM_C114060WA   Candida albicans SC5314 AOW27007.1     49
 CAALFM_C206840WA (Spr1)   Candida albicans SC5314 AOW27685.1     9
 CAALFM_C102990CA (Xog1)   Candida albicans SC5314 AOW25980.1     9
 CAALFM_C102630CA (Exg2)   Candida albicans SC5314 AOW25944.1     9
 CAALFM_C505360CA   Candida albicans SC5314 AOW29940.1     12
 CD36_02790   Candida dubliniensis CD36 CAX44539.1 B9W780   9
 CD36_02450   Candida dubliniensis CD36 CAX44505.1 B9W746   9
 CD36_13040   Candida dubliniensis CD36 CAX45661.1 B9WA23   49
 CD36_21140   Candida dubliniensis CD36 CAX43895.1 B9WBX3   9
 CD36_54960   Candida dubliniensis CD36 CAX41875.1 B9WI78   12
 CAGL0M08756g   Candida glabrata CBS 138 CAG62702.1 Q6FJ68   9
 CAGL0I00484g   Candida glabrata CBS 138 CAG60211.1 Q6FR70   9
 CAGL0H10120g   Candida glabrata CBS 138 CAG60170.1 Q6FRA7   49
 CAGL0L09493g   Candida glabrata CBS 138 CAG62156.1 Q6FKQ8   12
 CAGL0G09515g   Candida glabrata CBS 138 CAG59700.1 Q6FSM1   9
 SAMEA4029010_CIC11G00000004496   [Candida] intermedia CBS 141442 SGZ57837.1     12
 SAMEA4029010_CIC11G00000001192   [Candida] intermedia CBS 141442 SGZ51338.1     9
 SAMEA4029010_CIC11G00000004413   [Candida] intermedia CBS 141442 SGZ55089.1     22
 SAMEA4029010_CIC11G00000000726   [Candida] intermedia CBS 141442 SGZ55355.1     49
 SAMEA4029010_CIC11G00000005718   [Candida] intermedia CBS 141442 SGZ53994.1     9
 SAMEA4029009_CIC11G00000005169   [Candida] intermedia PYCC 4715 SGZ55230.1     49
 SAMEA4029009_CIC11G00000000955   [Candida] intermedia PYCC 4715 SGZ52553.1     9
 SAMEA4029009_CIC11G00000002079   [Candida] intermedia PYCC 4715 SGZ53783.1     9
 SAMEA4029009_CIC11G00000004340   [Candida] intermedia PYCC 4715 SGZ58843.1     12
 SAMEA4029009_CIC11G00000001608   [Candida] intermedia PYCC 4715 SGZ54933.1     22
 exo-β-1,3-glucanase (Exg1) 3.2.1.58 Candida oleophila AAM21469.1 Q8NKF9   9
 CORT_0B07870   Candida orthopsilosis Co 90-125 CCG22492.1     9
 CORT_0B07220   Candida orthopsilosis Co 90-125 CCG22429.1     9
 CORT_0F00270   Candida orthopsilosis Co 90-125 CCG24256.1     12
 CORT_0G00460   Candida orthopsilosis Co 90-125 CCG24736.1     49
 CPAR2_100160   Candida parapsilosis CDC317 CCE39978.1     12
 CPAR2_104400   Candida parapsilosis CDC317 CCE40404.1     9
 CPAR2_106000   Candida parapsilosis CDC317 CCE40564.1     9
 CPAR2_106620   Candida parapsilosis CDC317 CCE40627.1     9
 CPAR2_700340   Candida parapsilosis CDC317 CCE45030.1     49
 CHGG_09153 (Cglo-Bgl501)   Chaetomium globosum CBS 148.51 EAQ85139.1     9
 β-mannanase (CsMan5A) (Man5A) 3.2.1.78 Chaetomium sp. CQ31 ADW82104.1     7
 mannanase (fragment)   Cherax quadricarinatus AIN40245.1     10
 ManB (fragment)   Chlorella vulgaris C-169 BAA99563.1 Q9LRG5   7
 cellulase (CelA;CsCelA) 3.2.1.4 Ciboria shiraiana AIC79156.1     5
 glycoside hydrolase family 5 endoglucanase, partial (fragment)   Cladosporium sp. 0629-033 2 WA Aa/MF06-304 CDL74329.1     5
 ORF (fragment)   Clonostachys rosea 0628-013 3 PDA/MF06-095 CDL74338.1     5
 Eg8-20   Clonostachys rosea f. catenulata HL-1-1 AFK10489.1     5
 ORF   Coccidioides posadasii ABA54914.1 Q3HYB8   12
 endo-β-1,4-mannanase (ManA;CaMANA) 3.2.1.78 Coffea arabica CAC08208.1
AAX01860.1
Q9FT02   7
 endo-β-1-4-mannanase (ManB;CaMANB) 3.2.1.78 Coffea arabica CAC08442.1 Q9FT03   7
 ORF (fragment)   Colletotrichum coccodes 0629-022 1 A PDA/MF06-283 CDL74331.1     5
 ORF (fragment)   Colletotrichum coccodes 0629-022 1 A PDA/MF06-283 CDL74332.1     5
 CC1G_04257   Coprinopsis cinerea okayama7#130 EAU88551.2     30
 CC1G_02860   Coprinopsis cinerea okayama7#130 EAU93630.1     30
 ORF   Coptotermes formosanus AGM32066.1     2
 ORF (fragment)   Coptotermes formosanus AGM32347.1     2
 ORF (fragment)   Coptotermes formosanus AGM32171.1     1
 ORF (fragment)   Coptotermes formosanus AGM32296.1    
 ORF (fragment)   Coptotermes formosanus AGM32613.1     1
 ORF   Coptotermes formosanus AGM32918.1    
 ORF (fragment)   Coptotermes formosanus AGM33006.1     2
 ORF (fragment)   Coptotermes formosanus AGM33013.1     1
 CGB_E4160W   Cryptococcus gattii WM276 ADV22545.1     9
 CGB_A6500C   Cryptococcus gattii WM276 ADV19799.1     12
 CGB_L3610C   Cryptococcus gattii WM276 ADV25348.1     50
 CGB_B3770C   Cryptococcus gattii WM276 ADV20345.1     9
 CGB_D2240C   Cryptococcus gattii WM276 ADV21668.1     9
 CGB_F4310C   Cryptococcus gattii WM276 ADV23065.1     9
 CGB_J1490W   Cryptococcus gattii WM276 ADV24619.1     9
 CGB_L3160C   Cryptococcus gattii WM276 ADV25373.1     12
 CGB_A9170W   Cryptococcus gattii WM276 ADV19959.1    
 CGB_F3670W   Cryptococcus gattii WM276 ADV22976.1     22
 β-glucocerebrosidase (EGCrP1;CNAG_00623) 3.2.1.45 Cryptococcus neoformans var. grubii H99 BAL46040.1
AFR92751.1
AFR92751.2
    12
 CNAG_02225   Cryptococcus neoformans var. grubii H99 AFR95595.1     9
 CNAG_05652   Cryptococcus neoformans var. grubii H99 AFR99083.1     50
 CNAG_00373   Cryptococcus neoformans var. grubii H99 AFR92508.1     9
 CNAG_05138   Cryptococcus neoformans var. grubii H99 AFR94403.1
AFR94403.2
    9
 CNAG_00939 (fragment)   Cryptococcus neoformans var. grubii H99 AFR95190.1     9
 CNAG_05766   Cryptococcus neoformans var. grubii H99 AFR96086.2
AFR96086.1
    22
 CNAG_05803   Cryptococcus neoformans var. grubii H99 AFR96122.1     9
 steryl β-glucosidase (EGCrP2;CNAG_05607) (vacuolar) 3.2.1.104 Cryptococcus neoformans var. grubii H99 AFR99035.1     12
 CNAG_00799   Cryptococcus neoformans var. grubii H99 AFR92930.1    
 exo-β-1,3-glucanase (fragment)   Cryptococcus neoformans var. neoformans AAM26269.1 Q8NKG2   9
 cellulase (CelC)   Cryptococcus neoformans var. neoformans 309 CAP67 CAD31110.1 Q8NIP0   9
 CNF01760   Cryptococcus neoformans var. neoformans JEC21 AAW44208.1
AAW44208.2
Q5KFH2   9
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