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Glycoside Hydrolase Family 5

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-); lichenase / endo-β-1,3-1,4-glucanase (EC 3.2.1.73); β-glycosidase (EC 3.2.1.-); endo-β-1,3-glucanase / laminarinase (EC 3.2.1.39); β-N-acetylhexosaminidase (EC 3.2.1.52); chitosanase (EC 3.2.1.132); β-D-galactofuranosidase (EC 3.2.1.146); β-galactosylceramidase (EC 3.2.1.46); ; β-rutinosidase /α-L-rhamnose-(1,6)-β-D-glucosidase (EC 3.2.1.-); α-L-arabinofuranosidase (EC 3.2.1.55); glucomannan-specific endo-β-1,4-glucanase (EC 3.2.1.-); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168)
Mechanism Retaining e
ClanGH-A
3D Structure Status( β / α ) 8 barrel
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
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Statistics GenBank accession (28301); Uniprot accession (672); PDB accession (290); 3D entries (107); cryst (0)
Summary
Download GH5 (26769) Taxonomic display Structure (107) Characterized (614)
| 1 | 2 |
Archaea
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 Subf
 endo-β-1,4-glucanase (EGPh;EglB;TCel3;PH1171) 3.2.1.4 Pyrococcus horikoshii OT3 AAQ31833.1
AAQ31832.1
BAA30271.1
NP_143072.1		 O58925
2ZUM[A] 1.95
2ZUN[A,B,C] β-D-Glcp-(1-4)-α-D-Glcp-(1-4)-GLU
β-D-Glcp-(1-4)-β-D-Glcp
 2.00
3AXX[A,B,C] β-D-Glcp-(1-4)-β-D-Glcp
 1.90
3QHM[A,B,C] β-D-Glcp-(1-4)-β-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
 2.01
3QHN[A,B,C] β-D-Glcp-(1-4)-β-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
 1.99
3QHO[A,B,C] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
 1.65
3VVG[A,B,C] 1.90
3W6L[A,B,C] 1.75
3W6M[A,B,C] 1.95
4DM1[A,B,C] 1.75
4DM2[A,B,C] 1.95
1
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 Subf
 glucomannanase (AceceDRAFT_0142) 3.2.1.- Acetivibrio cellulolyticus WP_010248927.1 A0A5S8WF61
6MQ4[A] 1.40
4
 endo-β-1,4-glucanase E (CelE;EgE) (Cel5C) 3.2.1.4
3.2.1.8
3.2.1.-		 Acetivibrio thermocellus AAA23224.1 P10477
4IM4[A,B,C,D,E,F] 2.42
4
 bifunctional endo-β-1,4-glucanase / β-1,4-xylanase H (CelH;EgH;CtCelH;CtCel5E;Cthe_1472) (Lic26A;Cel5E) 3.2.1.4
3.2.1.8		 Acetivibrio thermocellus ATCC 27405 ABN52701.1
CCF82162.1		 H6SHY4
P16218
4U3A[A,B] 2.42
4U5I[A,B] β-D-Xylp-(1-4)-β-D-Xylp
 2.50
4U5K[A,B] β-D-Glcp-(1-4)-β-D-Glcp
 2.65
5BYW[A,B,C,D,E] 2.60
25
 xylanase (M6;CtM6;CtXyl5A;Cthe_2193) (arabinoxylan-specific) (Xyl5A) 3.2.1.- Acetivibrio thermocellus ATCC 27405 ABN53395.1 A3DHG6
2Y8K[A] 1.47
5AK1[A] 2.64
5G56[A] 2.64
5LA0[A] α-L-Arap
 1.65
5LA1[A] β-D-Xylp
 1.90
5LA2[A,B] β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp-(1-4)[α-L-Araf-(1-3)]-α-D-Xylp
β-L-Arap
 1.65
34
 endo-β-1,4-glucanase C (LC2;CelC;EgC) (Cel5B) 3.2.1.4 Acetivibrio thermocellus NCIB 10682EL AAA23220.1 P07985
P0C2S3
1CEC[A] 2.15
1CEN[A] β-D-Glcp-(1-4)-β-D-Glcp
 2.30
1CEO[A] 1.90
37
 endo-β-1,4-glucanase E1 (EGAc;EGI;TcE1;Acel_0614) (Cel5A) 3.2.1.4 Acidothermus cellulolyticus 11B AAA75477.1
ABH84883.1
ABK52387.1
ACW33392.1
CAD42489.1
CAR96693.1		 P54583
1C0D[A,B] 2.40
1ECE[A,B] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
 2.40
1VRX[A,B] 2.40
1
 endoglucanase (BlCel5B; BLi01882; BL01230) (Cel5B) 3.2.1.4 Bacillus licheniformis DSM 13 = ATCC 14580 AAU40777.1
AAU23417.1		 Q65JI7
4YZP[A] 1.70
4YZT[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
 1.67
4
 cellulase (BCE103)   Bacillus sp. (in: firmicutes) CBS 670.93 CAB59165.1
AAV25061.1
CAB58698.1
CAD82873.1		  
1LF1[A] 1.70
2
 cellulase (CelB) 3.2.1.4 Bacillus sp. BG-CS10 ADD62401.1 D4P8C6
5E09[A] 2.35
5E0C[A] 2.35
5XRC[A,B,C] 2.90
4
 β-mannanase (Amn5) (Man5A) 3.2.1.78 Bacillus sp. JAMB-602 BAD99527.1 Q4W8M3
1WKY[A] 1.65
8
 endo-β-1,4-glucanase K (Egl-K) 3.2.1.4 Bacillus sp. KSM-635 AAA22304.1 P19424
1G01[A] 1.90
1G0C[A] β-D-Glcp-(1-4)-α-D-Glcp
 1.90
2
 β-mannanase (ManA;MAN330) (Man5A) 3.2.1.78 Bacillus sp. N16-5 AAT06599.1
AML27065.1		 Q5YEX6
3JUG[A] 1.60
8
 endo-β-1,4-glucanase (EglS;BglC;Gld;BSU18130;BsCel5;BsCel5A) (Cel5A) 3.2.1.4 Bacillus subtilis subsp. subtilis str. 168 CAA82317.1
AEJ76923.1
AIY93123.1
AQR81804.1
AQR86018.1
CAA97610.1
CAB13696.2
NP_389695.1		 A0A6M3ZBL5
G1DE47
P10475
3PZT[A,B] 1.97
3PZU[A,B] 2.10
3PZV[A,B,C,D] 2.87
2
 endo-xyloglucanase (CelA; BoGH5A; BoGH5; BACOVA_02653; Bovatus_03072) 3.2.1.151 Bacteroides ovatus ATCC 8483 ALJ47680.1 A7LXT7
3ZMR[A,B] α-D-Xylp-(1-6)-β-D-Glcp-(1-4)[α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)[α-D-Xylp-(1-6)]-β-D-Glcp-(1-1)-<non_carb>
α-D-Xylp-(1-6)-β-D-Glcp-(1-4)[α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)[α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-GLU
 1.43
4
 endo-cellulase (AC2aCel5A) (Cel5A) 3.2.1.4 Bacteroidetes bacterium AC2a AIJ19564.1 A0A076MPD7
4YHE[A,B] 1.85
4
 β-mannosidase active on Man-β-1,4-GlcNAc (BLD_0195)   Bifidobacterium longum DJO10A ACD97641.1  
6MOY[A,B] β-D-GlcpNAc
 2.50
6MP2[A,B] 1.98
6MP7[A,B] β-D-GlcpNAc
 1.75
6MPA[A,B] β-D-GlcpNAc
 1.90
6MPC[A,B] 1.80
18
 Blon_2377   Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088 ACJ53432.1  
7LQX[A] 1.30
18
 β-1,4-mannosidase (BlGH5_18; HMPREF0175_1989) 3.2.1.25 Bifidobacterium longum subsp. longum ATCC 55813 EEI79871.1 C2GY91
7LR1[A,B,C,D] 1.80
7LR2[A,B,C,D] β-D-GlcpNAc
 2.40
7LR6[A,B,C,D] β-D-Manp-(1-4)-β-D-GlcpNAc
 2.30
18
 bpr_I1710 (Cel5C)   Butyrivibrio proteoclasticus B316 ADL34447.1  
4NF7[A] 2.11
4
 endomannanase / endoglucanase (ManB) (Man5B) 3.2.1.78 Caldanaerobius polysaccharolyticus KMTHCJ AGA35556.1
ADK22147.1		 D9J0D7
3W0K[A,B] 1.60
36
 endoglucanase (Csac_0678) 3.2.1.4 Caldicellulosiruptor saccharolyticus DSM 8903 ABP66297.1 A4XHB2
5ECU[A] 1.50
2
 β-1,3-1,4-glucanase / lichenase (F32EG5) 3.2.1.6 Caldicellulosiruptor sp. F32 AGM71677.1 R9RX81
4X0V[A,B,C,D,E,F,G,H] 2.80
5H4R[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
 1.70
4
 endo-xyloglucanase (CjGH5D; CJA_3010) (Cel5D) 3.2.1.151 Cellvibrio japonicus Ueda107 ACE84905.1 B3PD52
5OYC[A,B] 1.60
5OYD[A,B] α-D-Xylp-(1-6)-β-D-Glcp-(1-4)[α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)[α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-<non_carb>
β-D-Glcp-(1-4)[α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)[α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-<non_carb>
 2.10
5OYE[A,B] α-D-Xylp-(1-6)[β-D-Glcp-(1-4)]-β-D-Glcp-(1-4)[α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)-β-D-Glcp
α-D-Xylp-(1-6)[β-D-Glcp-(1-4)]-β-D-Glcp-(1-4)[β-D-Galp-(1-2)-α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)-β-D-Glcp
 1.90
6HA9[A,B] α-D-Xylp-(1-6)-β-D-Glcp-(1-4)[α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)[α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)-β-D-Glcp2F-(1-1)-<non_carb>
α-D-Xylp-(1-6)[β-D-Glcp-(1-4)]-β-D-Glcp-(1-4)[α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)-β-D-Glcp2F-(1-1)-<non_carb>
 2.00
6HAA[A,B] α-D-Xylp-(1-6)-β-D-Glcp-(1-4)[α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)[α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)-α-D-Glcp2F-(1-4)-GLU
α-D-Xylp-(1-6)[β-D-Glcp-(1-4)]-β-D-Glcp-(1-4)[α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)-α-D-Glcp2F-(1-4)-GLU
 1.70
4
 β-mannosidase 5A (Man5A) (Man5A) 3.2.1.25 Cellvibrio mixtus NCIMB 8633 AAS19695.1 Q6QT42
1UUQ[A] 1.5
1UZ4[A] <carb_like_IFL>
 1.71
7ODJ[A]
7
 CDIF28668_02723 3.2.1.4 Clostridioides difficile DSM 28668 AXU72614.1 A0A5Q9L120
6UJE[A] 1.75
6UJF[A] β-D-Glcp
 2.00
25
 glucomannanase (CAC0826) 3.2.1.151
3.2.1.-		 Clostridium acetobutylicum ATCC 824 AAK78802.1
NP_347462.1		 Q97KU0
6PZ7[A] 1.25
4
 endo-β-1,4-glucanase / xylanase D (EngD) 3.2.1.4
3.2.1.8		 Clostridium cellulovorans ATCC 35269 AAA23233.1 P28623
3ICG[A,B,C,D] 2.10
3NDY[A,B,C,D] 2.10
3NDZ[A,B,C,D] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
 2.08
4
 endo-β-1,4-glucanase E / dual cellulase-mannanase (EngE) 3.2.1.4
3.2.1.-		 Clostridium cellulovorans ATCC 35269 AAD39739.1 D9SV64
Q9XD99
6UI3[A] 1.30
4
 endo-β-1,4-glucanase (CelA) 3.2.1.4 Clostridium longisporum AAC37035.1 P54937
6Q1I[A,B] 1.35
4
 exo-β-1,4-mannosidase (CaMan5_18; PAZ_c15370) 3.2.1.25 Cutibacterium acnes 266 AEE72695.1 A0A2B7I7A6
6GVB[A,B,C,D] 1.80
18
 periplasmic endoglucanase 5B (CHU_2103) (Cel5B) 3.2.1.4 Cytophaga hutchinsonii ATCC 33406 ABG59366.1 A0A6N4ST27
Q11T98
5IHS[A] 1.10
2
 endo-β-1,4-glucanase Z (CelZ;EgZ;Dda3937_02793) (Cel5A=Cel5Z) 3.2.1.4 Dickeya dadantii 3937 ADM99099.1
CAA68604.1		 P07103
1EGZ[A,B,C] 2.30
2
 endo-β-1,4-glucanase (FnCel5A;Fnod_1560) (Cel5A) 3.2.1.4 Fervidobacterium nodosum Rt17-B1 ABS61403.1
ADD73709.1		 A7HNC0
D4PEB3
3NCO[A,B] 1.50
3RJX[A] 2.40
3RJY[A] α-D-Glcp
 2.20
25
 endoglucanase (BcelFp; Ferpe_1841) 3.2.1.4 Fervidobacterium pennivorans DSM 9078 AFG35892.1  
6KDD[A] 1.92
25
 endo-β-1,4-glucanase (CelA;GsCelA) 3.2.1.4 Geobacillus sp. 70PC53 ACJ60856.1 C5H6X3
4XZB[A] 1.62
4XZW[A] 1.50
2
 β-glucanase (CelB; BhCel5B; BH0603) (Cel5B) 3.2.1.4 Halalkalibacterium halodurans C-125 BAB04322.1
NP_241469.1		 Q9KF82
4V2X[A] 1.64
4
 endo-β-1,4-glucanase (MtGlu5; Mtai_v1c27890)   Meiothermus taiwanensis WR-220 AWR88013.1  
7VT4[A,B] 1.93
7VT5[A] 1.46
7VT6[A] β-D-Glcp
 1.53
7VT7[A] β-D-Glcp-(1-4)-β-D-Glcp
 1.53
7VT8[A] β-D-Glcp
 2.99
25
 endo-β-1,4-glucanase (MtGlu5; Mtai_v1c27890) 3.2.1.4 Meiothermus taiwanensis WR-220 AWR88013.1  
7VT4[A,B] 1.93
7VT5[A] 1.46
7VT6[A] β-D-Glcp
 1.53
7VT7[A] β-D-Glcp-(1-4)-β-D-Glcp
 1.53
7VT8[A] β-D-Glcp
 2.99
25
 β-mannosidase (Op5Man5; OPIT5_10225) 3.2.1.25 Opitutaceae bacterium TAV5 AHF90519.1 W0J1H8
7BOB[A,B,C] 2.20
 xyloglucanase (XG5; PpXG5) 3.2.1.151 Paenibacillus pabuli AAR65335.1 H9KVH3
2JEP[A,B] 1.4
2JEQ[A] α-D-Xylp-(1-6)[β-D-Glcp-(1-4)]-β-D-Glcp-(1-4)[β-D-Galp-(1-2)-α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)-β-D-Glcp
 1.94
4
 endo-xyloglucanase (Bacsa_0886) 3.2.1.151 Phocaeicola salanitronis DSM 18170 ADY35478.1 F0R2T3
6WQY[A] 1.05
4
  Endoglycoceramidase (EGALC, REQ_10740) 3.2.1.46 Prescottella equi 103S CBH47174.1 A0A3S5Y3Q1
E4WE20
6JYZ[A] 1.35
29
 endoglycoceramidase I (EGCase I; 103S_EGCase I; REQ_38260) 3.2.1.123 Prescottella equi 103S CBH49814.1 A0A3S5YBC7
5CCU[A,B] 2.11
5DVG[A] β-D-Galp-(1-3)-β-D-GalpNAc-(1-4)[α-D-Neup5Ac-(2-3)]-β-D-Galp-(1-4)-β-D-Glcp-(1-1)-<non_carb>
 2.15
5J14[A,B] α-D-Neup5Ac-(2-3)-β-D-Galp-(1-4)-β-D-Glcp-(1-1)-<non_carb>
β-D-Galp-(1-4)-β-D-Glcp-(1-1)-<non_carb>
 1.92
5J7Z[A,B] β-D-Galp-(1-3)-β-D-GalpNAc-(1-4)[α-D-Neup5Ac-(2-3)]-β-D-Galp-(1-4)-β-D-Glcp-(1-1)-<non_carb>
 2.15
 mixed-linkage β-glucanase/xyloglucanase (Orf4; CMCase; PbrCel5A; PBR_0368) (Cel5A) 3.2.1.151
3.2.1.73		 Prevotella bryantii B14 AAC97596.1
AAA22909.1		 D8DY19
O06842
Q44878
3L55[A,B] 1.60
3VDH[A,B] 1.62
5D9M[A,B] α-D-Xylp-(1-6)-β-D-Glcp-(1-4)[α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)[α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)-α-D-Glcp
α-D-Xylp-(1-6)-β-D-Glcp-(1-4)[α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)[α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)[α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)[α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)[α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)-α-D-Glcp
 1.90
5D9N[A,B] α-D-Xylp-(1-6)-β-D-Glcp-(1-4)[α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)[α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)-β-D-Glcp
 1.86
5D9O[A,B] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
 1.55
5D9P[A,B] α-D-Xylp-(1-6)-β-D-Glcp-(1-4)[α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)[α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-<non_carb>
α-D-Xylp-(1-6)-β-D-Glcp-(1-4)[α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)[α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)-β-D-Glcp1N-(1-1)-<non_carb>
 1.80
6D2W[A,B] 2.10
4
 endoglucanase (CelG) (Cel5G) 3.2.1.4 Pseudoalteromonas haloplanktis A23 CAA76775.1 O86099
1TVN[A,B] 1.41
1TVP[A,B] β-D-Glcp-(1-4)-β-D-Glcp
 1.60
2
 endoglycoceramidase II (EGCase II; M777_EGCase II) 3.2.1.123 Rhodococcus sp. (in: high G+C Gram-positive bacteria) M-777 AAB67050.1 O33853
2OSW[A,B] 1.60
2OSX[A] α-D-Neup5Ac-(2-3)-β-D-Galp-(1-4)-β-D-Glcp-(1-1)-<non_carb>
 1.10
2OSY[A,B] β-D-Galp-(1-4)-α-D-Glcp-(1-4)-GLU
 2.10
2OYK[A,B] β-D-Glcp-(1-1)-<non_carb>
 1.50
2OYL[A,B] β-D-Glcp-(1-1)-<non_carb>
 1.80
2OYM[A,B] <carb_like_MNI>
 1.86
28
 endo-β-1,4-glucanase A (CelA; Cca; RceCel5A; Ccel_1099) (Cel5A) 3.2.1.4 Ruminiclostridium cellulolyticum H10 AAA23221.1
AAA51444.1
ACL75458.1		 P17901
1EDG[A] 1.60
4
 glucomannanase (RUM_05520) 3.2.1.- Ruminococcus champanellensis 18P13 = JCM 17042 CBL16772.1 D4LAX7
6WQP[A,B] 1.60
6WQV[A,B,C,D] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-α-D-Glcp
 1.45
4
 glucomannanase (RfGH5-1/2) 3.2.1.- Ruminococcus flavefaciens WP_009984467.1 A0A8I3B056
6XSU[A,B] 1.41
4
 endo-β-1,4-glucanase 5F (SdGluc5_26A;Sde_1572) (Cel5F) 3.2.1.4 Saccharophagus degradans 2-40 ABD80834.1 Q21KE5
5A8M[A,B,C] 1.86
5A8N[A] 2.05
5A8O[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
 2.30
5A8P[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-3)-β-D-Glcp
 2.20
5A8Q[A] β-D-Glcp-(1-3)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
 1.90
5A94[A,B,C,D,E,F] β-D-Glcp-(1-3)-β-D-Glcp-(1-4)-β-D-Glcp
 1.99
5A95[A,B,C] β-D-Glcp-(1-3)-β-D-Glcp-(1-4)-β-D-Glcp
 1.35
26
 β-mannanase 5A (BaMan5A) (Man5A) 3.2.1.78 Salipaludibacillus agaradhaerens AAN27517.1
AAN27518.1
AAQ31837.1
AAQ79152.1
AAQ79153.1
ABC13790.1
ABC13791.1		 G1K3N4
Q5YEX6
2WHJ[A] 1.78
2WHL[A] β-D-Manp-(1-4)-β-D-Manp-(1-4)-α-D-Manp
 1.40
8
 endo-β-1,4-glucanase 5A (Cel5A) 3.2.1.4 Salipaludibacillus agaradhaerens AAC19169.1 O85465
1A3H[A] 1.57
1E5J[A] β-D-Glcp-(1-4)-α-D-Glcp4S-(1-4)-β-D-Glcp4S-(1-4)-β-D-Glcp-(1-1)-methyl
 1.85
1H11[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-α-D-Glcp2F-(1-4)-GLU
 1.08
1H2J[A] β-D-Glcp-(1-4)-α-D-Glcp2F-(1-4)-GLU
 1.15
1H5V[A] β-D-Glcp-(1-4)-β-D-Glcp4S-(1-4)-β-D-Glcp4S-(1-4)-β-D-Glcp4S-(1-4)-α-D-Glcp4S-(1-1)-methyl
 1.1
1HF5[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-α-D-Glcp2F-(1-4)-GLU
 1.10
1HF6[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-1)-<non_carb>
 1.15
1HF7[A] β-D-Glcp-(1-4)-α-D-Glcp2F-(1-4)-GLU
β-D-Glcp-(1-4)-β-D-Glcp2F-(1-1)-<non_carb>
 1.10
1OCQ[A] β-D-Glcp-(1-4)-<carb_like_IFM>
<carb_like_IFM>
 1.08
1QHZ[A] 1.95
1QI0[A] β-D-Glcp-(1-4)-β-D-Glcp
 2.10
1QI2[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-α-D-Glcp2F-(1-4)-GLU
 1.75
1W3K[A] β-D-Glcp-(1-1)-<non_carb>
<carb_like_OXZ>
 1.2
1W3L[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-1)-<non_carb>
<carb_like_OXZ>
 1.04
2A3H[A] β-D-Glcp-(1-4)-β-D-Glcp
 2.00
2V38[A] β-D-Glcp-(1-1)-<non_carb>
<carb_like_IFL>
 1.50
3A3H[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-α-D-Glcp
 1.64
4A3H[A] β-D-Glcp-(1-4)-β-D-Glcp2F-(1-1)-<non_carb>
 1.65
5A3H[A] β-D-Glcp-(1-4)-α-D-Glcp2F-(1-4)-GLU
 1.82
6A3H[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-α-D-Glcp2F-(1-4)-GLU
 1.68
7A3H[A] 0.95
8A3H[A] β-D-Glcp-(1-1)-<non_carb>
 0.97
2
 β-1,4-mannosidase (ScGH5_18; SCATT_p07120) 3.2.1.25 Streptantibioticus cattleyicolor NRRL 8057 = DSM 46488 AEW98905.1 F8JJ04
7LR7[A] β-D-GlcpNAc
 1.95
7LR8[A,B] β-D-Manp-(1-4)-β-D-GlcpNAc
 1.60
18
 β-mannanase (SACTE_2347) 3.2.1.78 Streptomyces sp. SirexAA-E AEN10237.1
WP_014046222.1		 G2NHM6
4FK9[A] 1.06
8
 β-mannanase (Man;StMan) 3.2.1.78 Streptomyces thermolilacinus NBRC14274 BAK26781.1 F5HR99
3WSU[A,B] 1.60
4Y7E[A,B] β-D-Manp-(1-4)-β-D-Manp-(1-4)-β-D-Manp
β-D-Manp-(1-4)-β-D-Manp-(1-4)-β-D-Manp-(1-4)-β-D-Manp
 1.50
8
 endo-β-1,4-glucanase (Cel5A ; Ps_Cel5A; PST_2494) 3.2.1.4 Stutzerimonas stutzeri A1501 ABP80146.1 A4VME5
4LX4[A,B,C,D] 1.56
6R2J[A,B,C,D] β-D-Glcp-(1-4)-β-D-Glcp
 1.44
5
 endo-β-1,4-glucosidase 3.2.1.73 Teredinibacter sp. WAK85940.1  
8C10[A] 1.00
2
 endo-β-1,4-glucanase / celulase (CelDZ1a) 3.2.1.4 Thermoanaerobacterium sp. A57Txylan ALX38276.1 A0A0U4EBH5
I3VS73
5FIP[A,B,C,D] 1.88
2
 β-mannanase Q1.1 (Man) (partial) 3.2.1.78 Thermobifida fusca KW3 CAA06924.1 Q9ZF13
2MAN[A] β-D-Manp-(1-4)-D-1-deoxy-Manp
 1.90
3MAN[A] β-D-Manp-(1-4)-β-D-Manp-(1-4)-D-1-deoxy-Manp
 1.60
1BQC[A] 1.50
8
 endo-β-1,4-glucanase 5A (E5;CelE;TfCel5A;Tfu_0901) (Cel5A) 3.2.1.4 Thermobifida fusca YX AAZ54939.1
AAC09379.1		 Q01786
Q47RH8
2CKR[A,B] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
 1.77
2CKS[A,B] 1.6
2
 THTE_1171   Thermogutta terrifontis R1 ASV73773.1  
8AG9[A] 1.56
8ANX[A]
8B3Y[A] 1.25
 endoglucanase / β-mannanase (Tm_Cel5A; TmCel5A; TM1751) (Cel5A) 3.2.1.4
3.2.1.78		 Thermotoga maritima MSB8 AAD36816.1
AGL50683.1
AHD18355.1
AKE29506.1
NP_229549.1		 Q9X273
R4P461
3AMC[A,B] 1.40
3AMD[A,B,C,D] 2.00
3AMG[A,B] β-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp
 2.40
3AOF[A,B] β-D-Manp-(1-4)-β-D-Manp-(1-4)-β-D-Manp
 1.29
3AZR[A,B] β-D-Glcp
β-D-Glcp-(1-4)-α-D-Glcp
 1.71
3AZS[A,B] β-D-Manp-(1-4)-β-D-Manp-(1-4)-α-D-Manp
 1.69
3AZT[A,B,C,D] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-α-D-Glcp
 1.80
3MMU[A,B,C,D,E,F,G,H] 2.20
3MMW[A,B,C,D] 1.85
25
 endo-mannanase (Man/Cel5B; TM1752;TM_1752) (Cel5B) 3.2.1.78 Thermotoga maritima MSB8 AAD36817.1
AGL50684.1
AHD18354.1
AKE29507.1
NP_229550.1		 Q9X274
R4P1V9
1VJZ[A] 2.05
7EC9[A,B] <carb_like_NOJ>
 1.80
7EFZ[A,B] 1.69
36
 endo-β-1,4-mannanase (Man;TpMan;TpManGH5;Tpet_1542) 3.2.1.78 Thermotoga petrophila RKU-1 ABQ47550.1
YP_001245126.1		 A5IMX7
3PZ9[A] 1.42
3PZG[A] 1.40
3PZI[A] β-D-Glcp
 1.55
3PZM[A] 1.50
3PZN[A] 1.50
3PZO[A] α-D-Glcp-(1-4)-α-D-Glcp
 1.55
3PZQ[A] α-D-Glcp-(1-4)-α-D-Glcp
 1.92
6TN6[A] 1.45
7
 cellulase 5R (Cel5R;Cel5R_FS) 3.2.1.4 uncultured bacterium AND74761.1 A0A172PZJ4
5I2U[A,B] 2.20
2
 endo-β-1,4-glucanase (CelE2, partial) 3.2.1.4 uncultured bacterium ANN44164.1  
8FC0[A,B,C,D,E,F,G,H] 2.10
1
 endoglucanase (RBcel1) 3.2.1.4 uncultured bacterium ACO55737.1 C1JI15
4EE9[A] 1.38
4M24[A] β-D-Glcp-(1-4)-β-D-Glcp
 1.39
5LJF[A,B] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
 1.73
6ZZ3[A,B,C,D] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-α-D-Glcp-(1-4)-GLU
 2.10
7P6G[A,B] 1.49
7P6H[A,B] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-α-D-Glcp
 1.73
7P6I[A] 1.47
7P6J[A,B,C,D] β-D-Glcp-(1-4)-β-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-α-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-α-D-Glcp-(1-4)-GLU
β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-α-D-Glcp-(1-4)-GLU
 1.75
5
 xyloglucan-specific endo-β-1,4-glucanase (XEG5A) (Xeg5A) 3.2.1.151 uncultured bacterium ACZ54907.1 D2K7Z0
4W84[A,B] 1.79
4W85[A,B] β-D-Glcp
 1.92
4W86[A,B] β-D-Glcp
 2.64
4W87[A,B] α-D-Xylp-(1-6)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
 2.15
4W88[A,B] β-D-Galp-(1-2)-α-D-Xylp-(1-6)[α-D-Xylp-(1-6)-β-D-Glcp-(1-4)]-β-D-Glcp-(1-4)-β-D-Glcp
β-D-Galp-(1-2)-α-D-Xylp-(1-6)[β-D-Glcp-(1-4)]-β-D-Glcp
 1.58
4W89[A,B] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-α-D-Glcp
 2.40
4
 exo-xyloglucanase (XEG5B) (Xeg5B) 3.2.1.150 uncultured bacterium ADB44000.1 D2XML9
4W8A[A] 1.72
4W8B[A] α-D-Xylp-(1-6)-β-D-Glcp-(1-4)[α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)-β-D-Glcp
α-D-Xylp-(1-6)-β-D-Glcp-(1-4)[α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)[β-D-Galp-(1-2)-α-D-Xylp-(1-6)]-β-D-Glcp-(1-4)-α-D-Glcp
 1.15
4
 β-1,3-glucanase (mrbExg5) 3.2.1.58 uncultured bacterium QPA36577.1 A0A873QLE9
6ZB8[A,B] 1.35
6ZB9[A,B] 2.50
44
 endo-β-1,4-glucanase (YBcontig310-00424-17) 3.2.1.4 uncultured bacterium ADU86909.1 H2BCH8
6XSO[A,B] 1.50
4
 endoglucanase / cellulase (cMGL504) (Cel5A) 3.2.1.4 uncultured bacterium AFJ05146.1 I6PLH5
4HTY[A] 2.00
4HU0[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
 2.38
26
 cellulase (CelE1) 3.2.1.4 uncultured bacterium AHA42547.2
AHA42547.1		 A0A0R5P8X1
V5KYY9
4M1R[A,B] 1.80
2
 endo-β-1,4-glucanase (EngXCA;EngA) (frameshift) 3.2.1.4 Xanthomonas campestris pv. campestris CAC18529.1
AAA27612.1		 P19487
Q9EVR6
4TUF[A,B,C,D] 2.70
1
 XAC0029 (XacEgl5B)   Xanthomonas citri pv. citri str. 306 AAM34921.1
NP_640385.1
WP_011050033.1		  
5HOS[A] 1.60
5
 XAC0030 (Egl)   Xanthomonas citri pv. citri str. 306 AAM34922.1
NP_640386.1		  
4W7U[A] 1.48
4W7V[A] β-D-Glcp-(1-4)-β-D-Glcp
 1.43
4W7W[A] β-D-Glcp-(1-4)-β-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-α-D-Glcp
 1.05
5HNN[A,B,C] 1.63
5HPC[A] 2.60
5
 endo-β-1,3-1,4-glucanase (EngA; ZgEngA; zobellia_208) 3.2.1.6 Zobellia galactanivorans DsijT CAZ94281.1 G0L8Z3
6GL0[A,B,C] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-α-D-Glcp
 2.20
6GL2[A] 1.96
4
Eukaryota
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 Subf
 endo-β-1,4-mannanase (AkMan;AkManA) 3.2.1.78 Aplysia kurodai BAJ60954.1 E5RSM0
3VUP[A,B] 1.05
10
 glucosylceramidase / EGCase related protein 1 (EGCrP1) 3.2.1.45 Aspergillus fumigatus BAL46041.1 H1AE13
8EXD[A,B,C,D] 3.80
12
 endo-β-1,4-mannanase (ManBK) (partial) 3.2.1.78 Aspergillus niger BK 01 ACJ06979.1 B6V876
3WH9[A,B] 1.57
7
 endo-β-1,4-glucanase (Eng1; EgI; AnCel5A) 3.2.1.4 Aspergillus niger IFO31125 AAG50051.1 O74706
Q9C3Z7
5I77[A] β-D-GlcpNAc
 1.80
5I78[A,B] 1.58
5I79[A,B] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
 2.35
5
 β-rutinosidase (AnRut) 3.2.1.168 Aspergillus niger K2    
6I1A[B] 1.27
6I1A[A] 1.27
23
 rutinosidase / 6-O-α-L-rhamnosyl-β-glucosidase (AoRut; AO090012000917) 3.2.1.- Aspergillus oryzae RIB40 BAE61018.1 A0A1S9DRB1
Q2UBP7
6LA0[A,B] 1.75
23
 exo-β-1,3-glucanase (Xog;Xog1;Exg;Ca49c10.05) 3.2.1.58 Candida albicans CAA39908.1
AAV05307.1
CAA21969.1		 P29717
1CZ1[A] 1.85
1EQC[A] <carb_like_CTS>
 1.85
1EQP[A] 1.90
2PB1[A] α-D-Glcp2F-(1-4)-GLU
β-D-Glcp2F-(1-1)-<non_carb>
 1.90
2PBO[A] 1.85
2PC8[A] β-D-Glcp
 1.80
2PF0[A] 1.90
3N9K[A] β-D-Glcp-(1-3)-β-D-Glcp
β-D-Glcp-(1-3)-β-D-Glcp-(1-3)-β-D-Glcp
 1.70
3O6A[A] 2.00
4M80[A] 1.86
4M81[A] α-D-Glcp1F
β-D-Glcp-(1-1)-<non_carb>
 1.86
4M82[A] β-D-Glcp
β-D-Glcp-(1-6)-β-D-Glcp-(1-1)-<non_carb>
 1.59
9
 steryl β-glucosidase (EGCrP2;CNAG_05607) (vacuolar) 3.2.1.104 Cryptococcus neoformans var. grubii H99 AFR99035.1 J9W473
7LPO[A,B,C,D] 2.13
7LPP[A,B,C,D] 2.85
7LPQ[A,B,C,D] 2.32
12
 endo-β-1,4-mannanase (Man;CaMan) 3.2.1.78 Cryptopygus antarcticus ABV68808.1 B4XC07
4OOU[A,B] 2.36
4OOZ[A,B] β-D-Manp
β-D-Manp-(1-4)-β-D-Manp-(1-4)-β-D-Manp-(1-4)-β-D-Manp
β-D-Manp-(1-4)-β-D-Manp-(1-4)-β-D-Manp-(1-4)-β-D-Manp-(1-4)-β-D-Manp
 2.60
10
 endo-1,4-β-mannanase 3.2.1.78 Eisenia fetida BBB35836.1 A0A2Z5VGG0
5Y6T[A] 1.70
10
 endo-β-1,4-glucanase (GlCel5A; GL28282) (Cel5A) 3.2.1.4 Ganoderma lucidum QDK64599.1 A0A1A9TAJ1
5D8W[A,B] 2.86
5D8Z[A,B] β-D-Glcp-(1-4)-β-D-Glcp
 2.70
5
 endo-β-1,4-mannanase (Man5A) 3.2.1.78 Mytilus edulis CAC81056.1 Q8WPJ2
2C0H[A] 1.6
10
 endo-β-1,4-mannanase (Man5; CsMan5) (partial) 3.2.1.78 Neurospora sitophila DSM 16514 CCI55471.1  
4AWE[A] 1.40
7
 BCR36DRAFT_398243   Piromyces finnis ORX48147.1  
8GHX[A,B]
8GHY[A,B]
4
 endoglucanase A (CelA;EglA) (partial) 3.2.1.4 Piromyces rhizinflatus 2301 AAF00074.2 Q9URH5
3AYR[A] 2.00
3AYS[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
 2.20
4
 endo-β-1,4-mannanase (PaMan5A;Pa_6_490) (Man5A) 3.2.1.78 Podospora anserina S mat+ CAP71606.1
ADO14134.1
CDP31001.1		 B2B3C0
3ZIZ[A] 1.40
7
 β-mannanase (RmMan5B) (Man5B) 3.2.1.78 Rhizomucor miehei CAU432 AGV01048.1 A0A075C6T6
4LYP[A,B] 1.28
4LYQ[A] β-D-Manp-(1-4)-β-D-Manp-(1-4)-α-D-Lyxp
 2.00
4LYR[A] 2.50
4NRR[A,B] β-D-Manp-(1-4)-β-D-Fruf
 2.40
4NRS[A,B] β-D-Manp-(1-4)-α-D-Manp
 2.57
7
 β-mannanase (RmMan5A) (Man5A) 3.2.1.78 Rhizomucor miehei CAU432 / CGMCC 4967 AGC24277.1 L7SVX1
4L3M[A] 2.26
4QP0[A] 2.30
7
 exo-β-1,3-glucanase 1 / flavonoid β-glucosidase (Exg1;Bgl1;Scw6;YLR300W) 3.2.1.21
3.2.1.58		 Saccharomyces cerevisiae S288c AAA34599.1
AAB67345.1
AAT93088.1
NP_013403.1		 P23776
1H4P[A,B] 1.75
9
 endo-β-mannanase 4a / mannan transglycosylase/hydrolase (Man4;LeMan4;LeMAN4a;LeMAN4i;MTH) 3.2.1.78 Solanum lycopersicum AAK97760.1
AAK56557.1
AAK97759.2		 Q8L5J1
Q8RVL3
Q93WT4
1RH9[A] 1.50
7
 β-mannanase 3.2.1.78 Talaromyces trachyspermus ATCC 24792 BAP19029.1 A0A077JNB5
A0A087WNH1
3WFL[A] 1.60
7
 endoglucanase 2 (EG2;EGIIa) (partial) (Cel5A) 3.2.1.4 Talaromyces verruculosus B221-151   A0A1U7Q1U3
5L9C[A,B,C,D] β-D-Glcp-(1-4)-β-D-Glcp
 1.85
6T9F[A,B,C,D] 2.25
6T9G[A,B,C,D] 2.30
6TPC[A,C] 1.52
6YON[A,B,C,D] 2.60
5I6S[A] 2.10
5
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