GlycosylTransferase Family 104

Activities in FamilydTDP-β-L-Rhap : arginine α-L-rhamnosyltransferase (EC 2.4.1.-)
Mechanism Inverting
NoteLassak et al. identified EarP as EF-P arginine R32 specific rhamnosyl transferase in Shewanella oneidensis using dTDP-b-L-rhamnose as donor substrate (PMID=25686373). The results of this study were subsequently confirmed for Pseudomonas aeruginosa (PMID=26060278), Pseudomonas putida (PMID=28951478) and Neisseria meningitidis (PMID=26840407). In 2016, it has been shown for S. oneidensis (PMID=28451135) and P. aeruginosa (PMID=28451332) that the enzyme is an inverting glycosyltransferase, thus mediating the formation of an a-L-rhamnosidic linkage. A structural basis for the arginine glycosylation reaction was provided by Krafczyk, Macosek and coworkers by having solved the crystal structure of the GT-B folding EarP from P. putida and an accompanying biochemical analysis of the enzyme (PMID=28951478).
Statistics GenBank accession (1018); Uniprot accession (0); PDB accession (1); 3D entries (1); cryst (0)
All (1021) Bacteria (1021) Structure (1) Characterized (4)
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Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 DP47_3238   Burkholderia pseudomallei Pasteur 52237 AJX61220.1    
 BG24_2186   Burkholderia pseudomallei PB08298010 AJX95987.1    
 DP45_01594   Burkholderia pseudomallei BEJ AJX38120.1    
 X988_2369   Burkholderia pseudomallei TSV 48 AIV49048.1    
 X994_12   Burkholderia pseudomallei sp. TSV202 AIV78556.1    
 X994_12   Burkholderia pseudomallei sp. TSV202 AIV78556.1    
 BK015_05740   Burkholderia pseudomallei VB976100 APD34716.1    
 BK015_05740   Burkholderia pseudomallei VB976100 APD34716.1    
 UQ47_12600   Burkholderia pseudomallei vgh07 AJW53805.1    
 AM256_12770   Burkholderia pseudomallei vgh16R ALB94390.1    
 AM256_12770   Burkholderia pseudomallei vgh16R ALB94390.1    
 AM257_12795   Burkholderia pseudomallei vgh16W ALC00462.1    
 ABD05_11325   Burkholderia pyrrocinia DSM 10685 AKM00747.1    
 BW21_1356   Burkholderia sp. 2002721687 AJY41476.1    
 bAD24_I16580   Burkholderia sp. AD24 ASL45094.1    
 AQ610_06150   Burkholderia sp. Bp5365 MSMB43 ALX42051.1    
 BC1001_2527   Burkholderia sp. CCGE1001 ADX55943.1    
 BC1002_2121   Burkholderia sp. CCGE1002 ADG16180.1    
 BC1003_2498   Burkholderia sp. CCGE1003 ADN58451.1    
 AC233_12975   Burkholderia sp. HB1 ALE55481.1    
 A9R05_11000   Burkholderia sp. KK1 AQG99292.1    
 WS78_05085   Burkholderia sp. MSMB0266 AOJ68200.1    
 WS86_06280   Burkholderia sp. MSMB0852 AOJ80270.1    
 WT60_06240   Burkholderia sp. MSMB617WGS AOK46495.1    
 AYM40_14595   Burkholderia sp. OLGA172 ANB73447.1    
 AXG89_00960   Burkholderia sp. PAMC 26561 AME25060.1    
 AX768_10695   Burkholderia sp. PAMC 28687 AMM14494.1    
 BRPE64_ACDS19570   Burkholderia sp. RPE64 BAN23711.1    
 BRPE67_ACDS19480   Burkholderia sp. RPE67 BAO87003.1    
 BBJ41_06430   Burkholderia stabilis ATCC BAA-67 AOR67211.1    
 BSFP_031050   Burkholderia stabilis FERMP-21014 BAX60250.1    
 BG87_1636   Burkholderia thailandensis 2002721643 AJX99042.1    
 BTQ_2183   Burkholderia thailandensis 2002721723 AHI73531.1    
 DR62_114   Burkholderia thailandensis 2003015869 AIP62945.1    
 BTM_2930   Burkholderia thailandensis 34 AJY27502.1    
 BTN_3347   Burkholderia thailandensis E254 AIT20860.1    
 DR63_597   Burkholderia thailandensis E264 AIP27084.1    
 BTH_I1738   Burkholderia thailandensis E264 E264; ATCC 700388 ABC38454.1    
 BTJ_134   Burkholderia thailandensis E444 AHI78522.1    
 CO709_25555   Burkholderia thailandensis FDAARGOS_426 ATF36345.1    
 BTL_1431   Burkholderia thailandensis H0587 AHI64025.1    
 BTI_1209   Burkholderia thailandensis MSMB121 AGK49145.1    
 BTHA_1523   Burkholderia thailandensis MSMB59 AIS94309.1    
 BTRA_1655   Burkholderia thailandensis USAMRU Malaysia #20 AIC87121.1    
 BW23_589   Burkholderia ubonensis MSMB22 AJX15743.1    
 E1O_07430   Burkholderiales bacterium GJ-E10 BAP87874.1    
 A4V04_03335   Burkholderiales bacterium YL45 ANU65567.1    
 CAP2UW1_1557   Candidatus Accumulibacter phosphatis clade IIA str. UW-1 ACV34872.1    
 CKBE_00327   Candidatus Kinetoplastibacterium blastocrithidii (ex Strigomonas culicis) AFZ83516.1    
 BCUE_0401   Candidatus Kinetoplastibacterium blastocrithidii TCC012E AGF49613.1    
 CKCE_0787   Candidatus Kinetoplastibacterium crithidii (ex Angomonas deanei ATCC 30255) AFZ83189.1    
 CDEE_0404   Candidatus Kinetoplastibacterium crithidii TCC036E AGF47465.1    
 CDSE_0401   Candidatus Kinetoplastibacterium desouzaii TCC079E AGF46726.1    
 ST1E_0444   Candidatus Kinetoplastibacterium galatii TCC219 AGF48887.1    
 CONE_0387   Candidatus Kinetoplastibacterium oncopeltii TCC290E AGF48187.1    
 BN1208_0682   Candidatus Methylopumilus planktonicus MMS-10A-171 CEZ19568.1    
 BN1209_0702   Candidatus Methylopumilus turicensis MMS-10A-171 CEN55746.1    
 CJA_2148   Cellvibrio japonicus Ueda107 ACE85380.1    
 CBR65_01855   Cellvibrio sp. PSBB006 ARU26277.1    
 B0D95_06595   Cellvibrio sp. PSBB023 AQT59789.1    
 BKX93_19850   Chromobacterium vaccinii 21-1 AOZ52021.1    
 CRN81_06365   Chromobacterium violaceum CV1192 ATP28044.1    
 CR207_06380   Chromobacterium violaceum CV1197 ATP31954.1    
 LT85_1848   Collimonas arenae Cal35 AIY41006.1    
 CAter282_1630   Collimonas arenae Ter282 AMP09412.1    
 CFU_2766   Collimonas fungivorans Ter331 AEK62593.1    
 CFter6_3478   Collimonas fungivorans Ter6 AMO96111.1    
 CPter291_1865   Collimonas pratensis Ter291 AMP14131.1    
 CPter91_1834   Collimonas pratensis Ter91 AMP04207.1    
 SRAA_0998   Comamonadaceae bacterium A1 BAO80852.1    
 SMCB_0900   Comamonadaceae bacterium B1 BAO83128.1    
 MA05_12370   Comamonas aquatica CJG ANY62736.1    
 B5M06_00270   Comamonas kerstersii 8943 AQZ96936.1    
 CCO03_08165   Comamonas serinivorans DSM 26136 ARU04649.1    
 CtCNB1_1669   Comamonas testosteroni CNB-2 ACY32415.1    
 O987_10480   Comamonas testosteroni TK102 AIJ46220.1    
 RR42_m2842   Cupriavidus basilensis 4G11 AJG20216.1    
 CR3_1843   Cupriavidus gilardii CR3 ALD91056.1    
 Rmet_2411   Cupriavidus metallidurans CH34 ABF09288.1    
 A2G96_15970   Cupriavidus nantongensis X1 AMR79114.1    
 CNE_1c24320   Cupriavidus necator N-1 AEI77751.1    
 BJN34_13670   Cupriavidus necator NH9 AQV94924.1    
 BKK80_15505   Cupriavidus sp. USMAA1020 AOZ07065.1    
 BKK79_17445   Cupriavidus sp. USMAA2-4 AOY93389.1    
 BKK81_14555   Cupriavidus sp. USMAHM13 AOZ00319.1    
 RALTA_A2049   Cupriavidus taiwanensis LMG 19424 CAQ69989.1    
 Csp_E36710 (fragment)   Curvibacter putative symbiont of Hydra magnipapillata CBA26583.1    
 AEP_00819   Curvibacter sp. AEP1-3 ARV17776.1    
 Daro_2036   Dechloromonas aromatica RCB AAZ46781.1    
 Dsui_2468   Dechlorosoma suillum PS AEV26826.1    
 CHL79_21215   Delftia acidovorans RAY209 ATH14767.1    
 Daci_2872   Delftia acidovorans SPH-1 ABX35510.1    
 DelCs14_3860   Delftia sp. Cs1-4 AEF90848.1    
 BO996_13265   Delftia sp. HK171 APE48745.1    
 BI380_09090   Delftia tsuruhatensis CM13 AOV05859.1    
 BA022_01890   Diaphorobacter polyhydroxybutyrativorans SL-205 ASI67438.1    
 SAMEA4412678_01032   Eikenella corrodens NCTC10596 SNW08453.1    
 RN87_06485   Fusobacterium hwasookii ChDC F174 ALQ40178.1    
 RN92_07115   Fusobacterium hwasookii ChDC F206 ALQ35674.1    
 RN97_05600   Fusobacterium hwasookii ChDC F300 ALQ37693.1    
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