GlycosylTransferase Family 104

Activities in FamilydTDP-β-L-Rhap : arginine α-L-rhamnosyltransferase (EC 2.4.1.-)
Mechanism Inverting
NoteLassak et al. identified EarP as EF-P arginine R32 specific rhamnosyl transferase in Shewanella oneidensis using dTDP-b-L-rhamnose as donor substrate (PMID=25686373). The results of this study were subsequently confirmed for Pseudomonas aeruginosa (PMID=26060278), Pseudomonas putida (PMID=28951478) and Neisseria meningitidis (PMID=26840407). In 2016, it has been shown for S. oneidensis (PMID=28451135) and P. aeruginosa (PMID=28451332) that the enzyme is an inverting glycosyltransferase, thus mediating the formation of an a-L-rhamnosidic linkage. A structural basis for the arginine glycosylation reaction was provided by Krafczyk, Macosek and coworkers by having solved the crystal structure of the GT-B folding EarP from P. putida and an accompanying biochemical analysis of the enzyme (PMID=28951478).
Statistics GenBank accession (1018); Uniprot accession (0); PDB accession (1); 3D entries (1); cryst (0)
All (1021) Bacteria (1021) Structure (1) Characterized (4)
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Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 A6L45_03645   Neisseria meningitidis M22801 ANX48398.1    
 A6L52_11005   Neisseria meningitidis M23413 ANX55884.1    
 A6L61_00650   Neisseria meningitidis M24730 ANX45797.1    
 A6L64_09590   Neisseria meningitidis M25070 ANX59808.1    
 A6L66_10270   Neisseria meningitidis M25073 AOA46060.1    
 A6L67_10255   Neisseria meningitidis M25074 AOA48179.1    
 A6L77_08195   Neisseria meningitidis M25087 ANX71998.1    
 A6L86_05405   Neisseria meningitidis M25419 ANX88169.1    
 A6L93_08660   Neisseria meningitidis M25438 ANX53413.1    
 A6L95_05290   Neisseria meningitidis M25456 ANX86079.1    
 A6L96_08315   Neisseria meningitidis M25459 ANX78285.1    
 A6L97_07410   Neisseria meningitidis M25462 ANX63563.1    
 A6M04_02510   Neisseria meningitidis M25472 ANX66902.1    
 A6M07_02630   Neisseria meningitidis M25476 ANX83552.1    
 CQR35_05455   Neisseria meningitidis M26263 ATL34055.1    
 CQR34_08690   Neisseria meningitidis M26417 ATL36868.1    
 A6M08_10200   Neisseria meningitidis M27559 ANX66126.1    
 LA24_06615   Neisseria meningitidis M7124 AIZ20363.1    
  dTDP-β-L-Rhap : arginine α-L-rhamnosyltransferase (EarP; SO_2329) 2.4.1.- Neisseria meningitidis NIID280 BAU19337.1    
 LA50_01220   Neisseria meningitidis NM3686 AIZ17325.1    
 NMBNZ0533_0987   Neisseria meningitidis NZ-05/33 ADZ03424.1    
 CGZ65_07170   Neisseria sp. 10022 ATD65143.1    
 BG910_00290   Neisseria sp. 10023 ASK26391.1    
 CGZ77_08235   Neisseria sp. KEM232 ASP17731.1    
 SAMEA4504057_01613   Neisseria zoodegmatis NCTC12230 SNU80102.1    
 AAW31_07340   Nitrosomonas communis Nm2 AKH39509.1    
 NE0898   Nitrosomonas europaea ATCC 19718 CAD84809.1    
 Neut_1303   Nitrosomonas eutropha C91 ABI59553.1    
 NAL212_2416   Nitrosomonas sp. AL212 ADZ27232.1    
 Nit79A3_2025   Nitrosomonas sp. Is79A3 AEJ01816.1    
 ATY38_00515   Nitrosomonas ureae Nm10 ALQ49855.1    
 SAMN06296273_1123   Nitrosomonas ureae Nm15 SNX59685.1    
 ODI_R2902   Orrella dioscoreae SOE50698.1    
 ADJ79_09350   Ottowia sp. oral taxon 894 W10237 AKU67370.1    
 BRW83_1049   Oxalobacter formigenes HC-1 ARQ45797.1    
 BRW84_04900   Oxalobacter formigenes OXCC13 ARQ78027.1    
 PAEH1_12265   Paenalcaligenes hominis 15S00501 AQS52113.1    
 AA956_21440   Pandoraea apista AU2161 AKI63800.1    
 AT395_20840   Pandoraea apista DSM 16535 ALS68240.1    
 XM39_04120   Pandoraea apista TF80G25 AKH71527.1    
 SG18_04120   Pandoraea apista TF81F4 AJE97551.1    
 AB870_07020   Pandoraea faecigallinarum DSM 23572 AKM32614.1    
 AT302_03605   Pandoraea norimbergensis DSM 11628 ALS58992.1    
 MB84_00055   Pandoraea oxalativorans DSM 23570 AKC71988.2    
 U875_03550   Pandoraea pnomenusa 3kgm AHB04582.2    
 LV28_09780   Pandoraea pnomenusa DSM 16536 AIU26793.1    
 A6P55_07110   Pandoraea pnomenusa MCB032 ANC44020.1    
 X636_05940   Pandoraea pnomenusa RB-44 AHB75032.1    
 DA70_20600   Pandoraea pnomenusa RB38 AHN76597.1    
 RO07_04100   Pandoraea pulmonicola DSM 16583 AJC23045.2    
 NA29_24960   Pandoraea sputorum DSM 21091 AJC18388.1    
 SAMEA4530655_04181   Pandoraea sputorum NCTC13161 SNU88303.1    
 PATSB16_31100   Pandoraea thiooxydans ATSB16 APR96448.1    
 ABW99_12655   Pandoraea thiooxydans DSM 25325 AKJ68929.1    
 UC34_20150   Pandoraea vervacti NS15 AJP59975.2    
 ATN79_04885   Paraburkholderia caribensis Bcrs1W AMV42018.1    
 K788_0005565   Paraburkholderia caribensis MBA4 ALL65921.1    
 AN416_13580   Paraburkholderia caribensis MWAP64 ALP63510.1    
 OI25_2531   Paraburkholderia fungorum ATCC BAA-463 AJZ58081.1    
 BUPH_03102 (fragment)   Paraburkholderia phenoliruptrix BR3459a AFT86676.1    
 Bphy_0850   Paraburkholderia phymatum STM815 ACC70039.1    
 Bphyt_2890   Paraburkholderia phytofirmans PsJN ACD17284.1    
 RBRH_02437   Paraburkholderia rhizoxinica HKI 454 CBW74328.1    
 CJU94_10490   Paraburkholderia sp. BN5 ASW00353.1    
 BTO02_15155   Paraburkholderia sp. SOS3 APR37718.1    
 BJG93_01725   Paraburkholderia sprentiae WSM5005 APA84261.1    
 DR64_3257   Paraburkholderia xenovorans LB400 AIP31817.1    
 Bxe_A1094   Paraburkholderia xenovorans LB400 ABE31852.1    
 AT984_06585   Paucibacter sp. KCTC 42545 ALT79680.1    
 SAMEA2665130_01755   Plesiomonas shigelloides NCTC10360 SBT61264.1    
 Pnap_1626   Polaromonas naphthalenivorans CJ2 ABM36940.1    
 Bpro_3073   Polaromonas sp. JS666 ABE44987.1    
 AAW51_2046   [Polyangium] brachysporum DSM 7029 AKJ28737.1    
 AOC25_02595   Polynucleobacter asymbioticus MWH-RechtKol4 APC00588.1    
 A4F89_02590   Polynucleobacter asymbioticus MWH-RechtKolB APB98303.1    
 Pnuc_0414   Polynucleobacter asymbioticus QLW-P1DMWA-1 ABP33634.1    
 AOC10_02260   Polynucleobacter asymbioticus Tro8F10W22 APC05435.1    
 CL55_00015090   Polynucleobacter duraquae MWH-MoK4 AKD25842.1    
 Pnec_0422   Polynucleobacter necessarius STIR1 ACB43698.1    
 A8O14_02095   Polynucleobacter wuianus QLW-P1FAT50C-4 ANI98990.1    
 PTUN_b0402   Pseudoalteromonas tunicata D2 ATC96794.1    
 PA14OR_2194   Pseudomonas aeruginosa SCM62097.1    
 BMR72_10180   Pseudomonas aeruginosa APB64713.1    
 BMR72_10180   Pseudomonas aeruginosa APB64713.1    
 PERCYII10_2123   Pseudomonas aeruginosa SIP52384.1    
 AU380_17875   Pseudomonas aeruginosa 12-4-4(59) ALU49575.1    
 CD800_26170   Pseudomonas aeruginosa 1207 ASD12355.1    
 CDG41_11615   Pseudomonas aeruginosa 124 ASA28827.1    
 CD797_11935   Pseudomonas aeruginosa 127 ASD03217.1    
 CDL16_12260   Pseudomonas aeruginosa 58 ASA14938.1    
 PA8380_22890   Pseudomonas aeruginosa 8380 BAR67123.1    
 CD796_11690   Pseudomonas aeruginosa 84 ASC97109.1    
 AES1R_26415   Pseudomonas aeruginosa AES-1R ALT75129.1    
 BGV84_10760   Pseudomonas aeruginosa ATCC 15692 AOP57602.1    
 A4W92_27310   Pseudomonas aeruginosa ATCC 27853 AMX90581.1    
 ACG06_10730   Pseudomonas aeruginosa ATCC 27853 ANT75767.1    
 G655_10545   Pseudomonas aeruginosa B136-33 AGI81032.1    
 A6R75_21255   Pseudomonas aeruginosa BAMC 07-48 ANA72553.1    
 YQ19_12925   Pseudomonas aeruginosa Carb01 63 AKE69083.1    
 AOU28_09350   Pseudomonas aeruginosa Cu1510 ALS11775.1    
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