GlycosylTransferase Family 104

Activities in FamilydTDP-β-L-Rhap : arginine α-L-rhamnosyltransferase (EC 2.4.1.-)
Mechanism Inverting
NoteLassak et al. identified EarP as EF-P arginine R32 specific rhamnosyl transferase in Shewanella oneidensis using dTDP-b-L-rhamnose as donor substrate (PMID=25686373). The results of this study were subsequently confirmed for Pseudomonas aeruginosa (PMID=26060278), Pseudomonas putida (PMID=28951478) and Neisseria meningitidis (PMID=26840407). In 2016, it has been shown for S. oneidensis (PMID=28451135) and P. aeruginosa (PMID=28451332) that the enzyme is an inverting glycosyltransferase, thus mediating the formation of an a-L-rhamnosidic linkage. A structural basis for the arginine glycosylation reaction was provided by Krafczyk, Macosek and coworkers by having solved the crystal structure of the GT-B folding EarP from P. putida and an accompanying biochemical analysis of the enzyme (PMID=28951478).
Statistics GenBank accession (1018); Uniprot accession (0); PDB accession (1); 3D entries (1); cryst (0)
All (1021) Bacteria (1021) Structure (1) Characterized (4)
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Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 PFL_4265   Pseudomonas protegens Pf-5 AAY93521.1    
 PPSAL_1985   Pseudomonas pseudoalcaligenes CDR91212.1    
 BN5_2010   Pseudomonas pseudoalcaligenes CECT 5344 CECT5344 CDM40582.1    
 KF707C_23380   Pseudomonas pseudoalcaligenes KF707 = NBRC 110670 BAU74026.1    
 SAMN04490201_2142   Pseudomonas psychrophila BS3667 SDU50741.1    
 BJP27_03000   Pseudomonas psychrotolerans PRS08-11306 APQ10523.1    
 AWT69_001456   Pseudomonas putida 1A00316 AMK30093.1    
 KKK_18355   Pseudomonas putida B6-2 ANC82854.1    
 PPUBIRD1_3757   Pseudomonas putida BIRD-1 ADR61346.1    
 DW66_1781   Pseudomonas putida DLL-E4 AHZ76300.1    
 T1E_0932   Pseudomonas putida DOT-T1E AFO46790.1    
 CR511_07240   Pseudomonas putida E41 ATP43868.1    
 CR512_06980   Pseudomonas putida E46 ATP49123.1    
 Pput_3857   Pseudomonas putida F1 ABQ79981.1    
 PputGB1_1432   Pseudomonas putida GB-1 ABY97339.1    
 L483_06805   Pseudomonas putida H8234 AGN78283.1    
 B479_07225   Pseudomonas putida HB3267 PC9 AGA72361.1    
 IEC33019_0484   Pseudomonas putida IEC33019 ANY86085.1    
 Q5O_19325   Pseudomonas putida JB AOX10443.1    
 KF715C_ch15580   Pseudomonas putida KF715 BAW22131.1    
 dTDP-β-L-Rhap : arginine α-L-rhamnosyltransferase (EarP; PP_1857) 2.4.1.- Pseudomonas putida KT2440 SKB80791.1
AAN67476.1
  5NV8[A]
 SAMN05216501_4882   Pseudomonas putida N1R SIS17489.1    
 PP4_39260   Pseudomonas putida NBRC 14164 BAN55779.1    
 YSA_02040   Pseudomonas putida ND6 AFK67873.1    
 AB688_20745   Pseudomonas putida PC2 ANC04399.1    
 BG030_07120   Pseudomonas putida PP112420 APE97831.1    
 RPPX_16740   Pseudomonas putida S12 AJA14938.1    
 N805_15300   Pseudomonas putida S13.1.2 AJQ48489.1    
 PPS_1494   Pseudomonas putida S16 AEJ12069.1    
 A210_19935   Pseudomonas putida SJTE-1 ANI04812.1    
 PputW619_1467   Pseudomonas putida W619 ACA71972.1    
 SAMN04490202_0909   Pseudomonas reinekei BS3776 SDO44405.1    
 PCA10_33620   Pseudomonas resinovorans NBRC 106553 BAN49094.1    
 LT40_01725   Pseudomonas rhizosphaerae DSM 16299 AIS16183.1    
 SAMN04490209_3256   Pseudomonas rhodesiae BS2777 SDV10305.1    
 PSPPH_3649   Pseudomonas savastanoi pv. phaseolicola 1448A AAZ37214.1    
 PSA3335_22135   Pseudomonas savastanoi pv. savastanoi NCPPB 3335 ARD14694.1    
 SAMN05216363_1171   Pseudomonas sihuiensis KCTC 32246 SDU78752.1    
 PMA3_07675   Pseudomonas silesiensis A3 ANJ55044.1    
 PS417_08475   Pseudomonas simiae WCS417 AIB35613.1    
 SAMN05428955_5137   Pseudomonas sp. 7SR1 SIS27180.1    
 SAMN05216504_4567   Pseudomonas sp. A214 SIS11041.1    
 H681_15715   Pseudomonas sp. ATCC 13867 AGI25011.1    
 SAMN05216509_1527   Pseudomonas sp. B10 SIR31473.1    
 AA042_03265   Pseudomonas sp. BS-2016 AU1044 AOZ11783.1    
 SAMN04490210_3952   Pseudomonas sp. bs2935 SDS86989.1    
 CCOS191_3813   Pseudomonas sp. CCOS 191 CRI58349.1    
 PDR5_40680   Pseudomonas sp. DR 5-09 ANI55798.1    
 BL240_04225   Pseudomonas sp. DRA525 APO80737.1    
 CRN80_28570   Pseudomonas sp. FDAARGOS_380 ATN13325.1    
 C163_07010   Pseudomonas sp. FGI182 AHD13493.1    
 PGR6_16250   Pseudomonas sp. GR 6-02 ANI59198.1    
 CS390_17675   Pseudomonas sp. HLS-6 ATR84230.1    
 AA098_07930   Pseudomonas sp. JY-Q ANI33425.1    
 LAB08_0825   Pseudomonas sp. LAB-08 BAV26095.1    
 BHQ29_11225   Pseudomonas sp. LPH1 AQZ33803.1    
 B9K09_09550   Pseudomonas sp. M30-35 ARU88197.1    
 TO66_22340   Pseudomonas sp. MRSN12121 AJO79863.1    
 AWU82_24025   Pseudomonas sp. MS586 AMQ86271.1    
 MT1_1847 (fragment)   Pseudomonas sp. MT-1 BAP79025.1    
 CI807_15620   Pseudomonas sp. NS1(2017) ASV37554.1    
 POS17_4339   Pseudomonas sp. Os17 BAQ76033.1    
 PST29_4311   Pseudomonas sp. St29 BAQ82200.1    
 PSCI_0330   Pseudomonas sp. StFLB209 BAP41032.1    
 THL1_2302   Pseudomonas sp. TCU-HL1 AOE84850.1    
 U771_09640   Pseudomonas sp. TKP AHC34471.1    
 PYEL_05870   Pseudomonas sp. URMO17WK12:I11 CRN04850.1    
 PSHI_45250   Pseudomonas sp. URMO17WK12:I11 CRL51345.1    
 PputUW4_01424   Pseudomonas sp. UW4 AFY18630.1    
 PVLB_06905   Pseudomonas sp. VLB120 AGZ34184.1    
 PD374_09275   Pseudomonas sp. WCS374 AIB41254.1    
 SAMN05216496_2066   Pseudomonas sp. Z003-0.4C(8344-21) SDS64582.1    
 UIB01_08535   Pseudomonas stutzeri 19SMN4 AHY42531.1    
 CH92_13975   Pseudomonas stutzeri 28a24 AHL76142.1    
 PST_2513 (fragment)   Pseudomonas stutzeri A1501 ABP80165.1    
 A458_13345   Pseudomonas stutzeri CCUG 29243 AFM33900.1    
 PSTAB_2423   Pseudomonas stutzeri CGMCC 1.1803 AEJ05704.1    
 PSJM300_06125   Pseudomonas stutzeri DSM 10701 AFN77299.1    
 PSTAA_2621   Pseudomonas stutzeri DSM 4166 AEA84502.1    
 Psest_1798   Pseudomonas stutzeri RCH2 AGA86344.1    
 AB691_1663 (fragment)   Pseudomonas stutzeri SLG510A3-8 AKN26566.1    
 SAMN05216475_3519   Pseudomonas synxantha LMG 2190 SDU45995.1    
 SAMN05421724_2633   Pseudomonas syringae 31R1 SDS94955.1    
 N018_07280   Pseudomonas syringae CC1557 AHG40062.1    
 B1R35_10265   Pseudomonas syringae pv. actinidiae CRAFRU 12.29 AQX62237.1    
 B1F85_25685   Pseudomonas syringae pv. actinidiae CRAFRU 14.08 AQX68363.1    
 NZ708_09040   Pseudomonas syringae pv. actinidiae ICMP 18708 AOE59956.1    
 IYO_009055   Pseudomonas syringae pv. actinidiae ICMP 18884 AKT29669.1    
 JN853_09300   Pseudomonas syringae pv. actinidiae ICMP 9853 AQL40478.1    
 CT122_09605   Pseudomonas syringae pv. actinidiae MAFF212063 ATV20864.1    
 PsaNZ45_09595   Pseudomonas syringae pv. actinidiae NZ-45 APQ00918.1    
 PsaNZ47_09035   Pseudomonas syringae pv. actinidiae NZ-47 APQ06664.1    
 ACA40_17920   Pseudomonas syringae pv. lapsa ATCC 10859 ALU61642.1    
 PsyrB_18735   Pseudomonas syringae pv. syringae B301D AKF47208.1    
 Psyr_3629   Pseudomonas syringae pv. syringae B728a AAY38661.1    
 PsyrH_08270   Pseudomonas syringae pv. syringae HS191 AKF50463.1    
 PSYRMG_08645   Pseudomonas syringae UMAF0158 ALD97210.1    
 SAMN04490204_2275   Pseudomonas thivervalensis BS3779 SDF90390.1    
 B5P22_29365   Pseudomonas tolaasii 2192T ARB31247.1    
 SAMN04490205_3018   Pseudomonas trivialis BS3111 SDS60601.1    
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