GlycosylTransferase Family 104

Activities in FamilydTDP-β-L-Rhap : arginine α-L-rhamnosyltransferase (EC 2.4.1.-)
Mechanism Inverting
NoteLassak et al. identified EarP as EF-P arginine R32 specific rhamnosyl transferase in Shewanella oneidensis using dTDP-b-L-rhamnose as donor substrate (PMID=25686373). The results of this study were subsequently confirmed for Pseudomonas aeruginosa (PMID=26060278), Pseudomonas putida (PMID=28951478) and Neisseria meningitidis (PMID=26840407). In 2016, it has been shown for S. oneidensis (PMID=28451135) and P. aeruginosa (PMID=28451332) that the enzyme is an inverting glycosyltransferase, thus mediating the formation of an a-L-rhamnosidic linkage. A structural basis for the arginine glycosylation reaction was provided by Krafczyk, Macosek and coworkers by having solved the crystal structure of the GT-B folding EarP from P. putida and an accompanying biochemical analysis of the enzyme (PMID=28951478).
Statistics GenBank accession (1215); Uniprot accession (0); PDB accession (5); 3D entries (2); cryst (0)
All (1217) Bacteria (1217) Structure (2) Characterized (4)
| 1 | ... | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 A6704_11160   Pseudomonas aeruginosa PA_D25 AON48450.1    
 A6704_11160   Pseudomonas aeruginosa PA_D25 AON48450.1    
 A7331_11150   Pseudomonas aeruginosa PA_D5 AON18453.1    
 A6688_13875   Pseudomonas aeruginosa PA_D9 AON24976.1    
 A6688_13875   Pseudomonas aeruginosa PA_D9 AON24976.1    
 A6748_01325   Pseudomonas aeruginosa Pb18 ARN50204.1    
 CWI21_11555   Pseudomonas aeruginosa PB350 AUA76735.1    
 CWI23_11305   Pseudomonas aeruginosa PB353 AUA89020.1    
 CWI22_11305   Pseudomonas aeruginosa PB354 AUA82937.1    
 CWI20_11555   Pseudomonas aeruginosa PB367 AUB01360.1    
 CWI24_11315   Pseudomonas aeruginosa PB368 AUA95109.1    
 CWI25_11130   Pseudomonas aeruginosa PB369 AUA70547.1    
 B8B76_11465   Pseudomonas aeruginosa PPF-1 AVZ33882.1    
 PSE305_30970c   Pseudomonas aeruginosa PSE305 CDO82231.1    
 BFV99_22015   Pseudomonas aeruginosa RIVM-EMC2982 ARG51910.1    
 M062_15285   Pseudomonas aeruginosa RP73 AGO40479.1    
 YH69_11240   Pseudomonas aeruginosa S04 90 AKF98563.1    
 HW02_24360   Pseudomonas aeruginosa S86968 ALY92199.1    
 SCVFeb_2148   Pseudomonas aeruginosa SCVFeb APJ40932.1    
 SCVJan_2148   Pseudomonas aeruginosa SCVJan APJ46551.1    
 A214_22745   Pseudomonas aeruginosa SJTD-1 ANI11202.1    
 HW01_05315   Pseudomonas aeruginosa T38079 ALY94769.1    
 HW00_22040   Pseudomonas aeruginosa T52373 ALZ03980.1    
 HV99_18170   Pseudomonas aeruginosa T63266 ALZ08769.1    
 PA14_27200   Pseudomonas aeruginosa UCBPP-PA14 ABJ12092.1    
 APT60_10755   Pseudomonas aeruginosa USDA-ARS-USMARC-41639 ALZ90799.1    
 ATC05_29010   Pseudomonas aeruginosa VA-134 ALP60908.1    
 P797_20555   Pseudomonas aeruginosa VRFPA04 AID85488.1    
 HV98_16925   Pseudomonas aeruginosa W16407 ALZ14233.1    
 HV97_15140   Pseudomonas aeruginosa W36662 ALZ19974.1    
 HV96_16870   Pseudomonas aeruginosa W45909 ALZ26392.1    
 HV95_07585   Pseudomonas aeruginosa W60856 ALY82785.1    
 DBA97_11825 (EarP)   Pseudomonas aeruginosa WCHPA075019 AVZ18962.1    
 HV94_12015   Pseudomonas aeruginosa X78812 ALZ31575.1    
 AI22_22715   Pseudomonas aeruginosa YL84 AHH51660.1    
 AWM79_21670   Pseudomonas agarici NCPPB 2472 AMB87752.1    
 A0T30_14025   Pseudomonas alcaligenes NEB 585 AMR67422.1    
 UYA_12005   Pseudomonas alcaliphila JAB1 APU32832.1    
 PSAKL28_14450   Pseudomonas alkylphenolica KL28 AIL60671.1    
 B5U27_20550   Pseudomonas amygdali pv. lachrymans NM002 ARA82267.1    
 BKM19_021680 (EarP)   Pseudomonas amygdali pv. morsprunorum R15244 AVB17509.1    
 SAMN04490179_4987   Pseudomonas antarctica BS2772 SDN59689.1    
 A7J50_1864   Pseudomonas antarctica PAMC 27494 ANF85285.1    
 SAMN04489798_5389   Pseudomonas arsenicoxydans CECT 7543 SDP32956.1    
 SAMN05216598_5590   Pseudomonas asplenii ATCC 23835 SDT41698.1    
 BKM03_20925 (EarP)   Pseudomonas avellanae R2leaf AVB23196.1    
 B1R45_08995   Pseudomonas azotoformans F77 AQT93405.1    
 SAMN04489799_6136   Pseudomonas azotoformans LMG 21611 SDP02828.1    
 AYR47_15745   Pseudomonas azotoformans S4 AMN79691.1    
 CL52_12150   Pseudomonas balearica DSM 6083 AJE15741.1    
 SAMN04490180_0109   Pseudomonas brassicacearum BS3663 SDP02296.1    
 CD58_08975   Pseudomonas brassicacearum DF41 AHL33017.1    
 A0U95_07880   Pseudomonas brassicacearum L13-6-12 AOS38679.1    
 AK973_1927   Pseudomonas brassicacearum LBUM300 ALQ02376.1    
 PSEBR_a1614   Pseudomonas brassicacearum subsp. brassicacearum NFM421 AEA67818.1    
 SAMN04490181_2598   Pseudomonas brenneri BS2771 SDU98582.1    
 SAMN04490182_0924   Pseudomonas cedrina BS2981 SDS18376.1    
 PCPL58_1659   Pseudomonas cerasi CZT28115.1    
 PL963_01692   Pseudomonas cerasi SOS17937.1    
 A3218_22095   Pseudomonas chlororaphis AMS16862.1    
 SAMN04489803_1118   Pseudomonas chlororaphis ATCC 13985 SDS30686.1    
 SAMN05216585_2780   Pseudomonas chlororaphis DSM 21509 SDS60153.1    
 SAMN04489802_1879   Pseudomonas chlororaphis LMG 21630 SDS63065.1    
 CXP47_21195   Pseudomonas chlororaphis Lzh-T5 AUG42286.1    
 EY04_21550   Pseudomonas chlororaphis PA23 AIC21400.1    
 PCL1606_19110   Pseudomonas chlororaphis PCL1606 AKA23366.1    
 JM49_09620   Pseudomonas chlororaphis subsp. aurantiaca JD37 AIS11933.1    
 PCAU_4264   Pseudomonas chlororaphis subsp. aurantiaca StFRB508 BAV76473.1    
 C6Q18_21235 (EarP)   Pseudomonas chlororaphis subsp. piscium ZJU60 AVO60366.1    
 VM99_16010   Pseudomonas chlororaphis UFB2 AKJ99500.1    
 PCH70_37340 (fragment)   Pseudomonas cichorii JBC1 AHF68887.1    
 PcP3B5_20330   Pseudomonas citronellolis P3B5 AMO75483.1    
 A9C11_10075   Pseudomonas citronellolis SJTE-3 ANI14310.1    
 SAMN04490183_2848   Pseudomonas corrugata BS3649 SDU99756.1    
 AXG94_24025   Pseudomonas corrugata RM1-1-4 AOE64705.1    
 LK03_21225   Pseudomonas cremoricolorata ND07 AIR91619.1    
 PSEEN1561   Pseudomonas entomophila L48 CAK14423.1    
 SAMN05216591_2808   Pseudomonas extremaustralis DSM 17835 SDF38869.1    
 SAMN04490184_5263   Pseudomonas extremorientalis BS2774 SDP84921.1    
 C0J56_08900   Pseudomonas fluorescens 2P24 AUM69002.1    
 PflA506_1761   Pseudomonas fluorescens A506 AFJ59796.1    
 SAMN04488487_4059   Pseudomonas fluorescens ATCC 13525 SNY11427.1    
 PSF113_1695   Pseudomonas fluorescens F113 AEV61719.1    
 C1C98_09015   Pseudomonas fluorescens FR1 AUO45590.1    
 AO356_03165   Pseudomonas fluorescens FW300-N2C3 ALI05820.1    
 TK06_12410   Pseudomonas fluorescens FW300-N2E2 AMZ71859.1    
 AO353_19075   Pseudomonas fluorescens FW300-N2E3 ALI03082.1    
 AYK59_13255   Pseudomonas fluorescens KENGFT3 AMS21069.1    
 A7319_08145   Pseudomonas fluorescens L111 AOE72794.1    
 A7318_07590   Pseudomonas fluorescens L228 AOE78460.1    
 A7317_08155   Pseudomonas fluorescens L321 AOE66979.1    
 VO64_4826   Pseudomonas fluorescens LBUM223 AKA85372.1    
 AK972_4111   Pseudomonas fluorescens LBUM636 AMW84911.1    
 DBV33_19570 (EarP)   Pseudomonas fluorescens MS82 AWA40680.1    
 B723_26320   Pseudomonas fluorescens NCIMB 11764 AKV09717.1    
 NCTC10038_01938   Pseudomonas fluorescens NCTC10038 SQF90539.1    
 PF1751_v1c16820   Pseudomonas fluorescens PCL1751 AJP51385.1    
 Pfl01_4000   Pseudomonas fluorescens Pf0-1 ABA75737.1    
 PFLUOLIPICF7_28385   Pseudomonas fluorescens PICF7 AJZ96853.1    
 BH711_04000   Pseudomonas fluorescens Pt14 AOS73119.1    
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