GlycosylTransferase Family 104

Activities in FamilydTDP-β-L-Rhap : arginine α-L-rhamnosyltransferase (EC 2.4.1.-)
Mechanism Inverting
NoteLassak et al. identified EarP as EF-P arginine R32 specific rhamnosyl transferase in Shewanella oneidensis using dTDP-b-L-rhamnose as donor substrate (PMID=25686373). The results of this study were subsequently confirmed for Pseudomonas aeruginosa (PMID=26060278), Pseudomonas putida (PMID=28951478) and Neisseria meningitidis (PMID=26840407). In 2016, it has been shown for S. oneidensis (PMID=28451135) and P. aeruginosa (PMID=28451332) that the enzyme is an inverting glycosyltransferase, thus mediating the formation of an a-L-rhamnosidic linkage. A structural basis for the arginine glycosylation reaction was provided by Krafczyk, Macosek and coworkers by having solved the crystal structure of the GT-B folding EarP from P. putida and an accompanying biochemical analysis of the enzyme (PMID=28951478).
Statistics GenBank accession (1018); Uniprot accession (0); PDB accession (1); 3D entries (1); cryst (0)
All (1021) Bacteria (1021) Structure (1) Characterized (4)
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Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 HMPREF0409_00860   Fusobacterium nucleatum subsp. animalis 4_8 AGM23324.1    
 FSDG_00303   Fusobacterium nucleatum subsp. animalis 7_1 EEO41744.1    
 CBG60_07525   Fusobacterium nucleatum subsp. animalis ChDC F332 ASG31071.1    
 RN98_07355   Fusobacterium nucleatum subsp. animalis KCOM 1279 ALF17996.1    
 RO08_03275   Fusobacterium nucleatum subsp. animalis KCOM 1325 ALF21343.1    
 FN0719   Fusobacterium nucleatum subsp. nucleatum ATCC 25586 AAL94915.1    
 RO05_07035   Fusobacterium nucleatum subsp. nucleatum ChDC F316 KCOM 1322 ALF24132.1    
 RN84_06835   Fusobacterium nucleatum subsp. nucleatum ChDC F317 ASG26569.1    
 RN95_01605   Fusobacterium nucleatum subsp. nucleatum KCOM 1250 ALF25187.1    
 RO02_02465   Fusobacterium nucleatum subsp. polymorphum ChDC F306 ALM93517.1    
 RN93_06580   Fusobacterium nucleatum subsp. polymorphum ChDC F319 ALQ42467.1    
 CBG50_05980   Fusobacterium nucleatum subsp. polymorphum KCOM 1260 (=ChDC F218) ASC02897.1    
 CBG61_03570   Fusobacterium nucleatum subsp. polymorphum KCOM 1275 ASG28104.1    
 ERS445057_01527   Fusobacterium nucleatum subsp. polymorphum NCTC10562 CKH00579.1    
 HMPREF0405_01054   Fusobacterium nucleatum subsp. vincentii 3_1_27 EFG34775.1    
 HMPREF0946_00201   Fusobacterium nucleatum subsp. vincentii 3_1_36A2 EEU32128.1    
 RN99_05270   Fusobacterium nucleatum subsp. vincentii ChDC F8 KCOM 1231 ALF19899.1    
 CS401_00945   Fusobacterium nucleatum subsp. vincentii KCOM 2931 ATV05475.1    
 CTM72_11395   Fusobacterium periodonticum KCOM 1261 ATV60255.1    
 CTM64_05695   Fusobacterium periodonticum KCOM 1262 ATV35583.1    
 CTM74_06665   Fusobacterium periodonticum KCOM 1263 ATV61523.1    
 CTM78_03340   Fusobacterium periodonticum KCOM 1277 ATV63508.1    
 CTM86_05635   Fusobacterium periodonticum KCOM 1282 ATV66115.1    
 CTM68_09285   Fusobacterium periodonticum KCOM 1283 ATV57849.1    
 CTM92_02110   Fusobacterium periodonticum KCOM 2305 ATV67522.1    
 CTM98_06525   Fusobacterium periodonticum KCOM 2555 ATV70327.1    
 CTN00_02480   Fusobacterium periodonticum KCOM 2653 ATV71944.1    
 AXF16_08685   Fusobacterium sp. oral taxon 203 W7671 ASS40151.1    
 FV113G1_21700   Fusobacterium varium Fv113-g1 BBA51820.1    
 Galf_0622   Gallionella capsiferriformans ES-2 ADL54664.1    
 A9404_12485   Halothiobacillus sp. LS2 ANJ68083.1    
 F506_14895   Herbaspirillum hiltneri N3 AKZ63781.1    
 Hrubri_3079   Herbaspirillum rubrisubalbicans M1 ALU90248.1    
 Hsc_3017   Herbaspirillum seropedicae AU14040 AON55293.1    
 Hsero_3062   Herbaspirillum seropedicae SmR1 ADJ64550.1    
 ACP92_15365   Herbaspirillum seropedicae Z67 AKN66478.1    
 hmeg3_15085   Herbaspirillum sp. meg3 ASU39482.1    
 HEAR0987   Herminiimonas arsenicoxydans CAL61169.1    
 LPB072_14130   Hydrogenophaga crassostreae LPB0072 AOW13809.1    
 Q5W_08510   Hydrogenophaga sp. PBC AOS82130.1    
 BSY239_2183   Hydrogenophaga sp. RAC07 AOF87336.1    
 Ilyop_2608   Ilyobacter polytropus DSM 2926 ADO84365.1    
 GJA_1540   Janthinobacterium agaricidamnosum NBRC 102515 = DSM 9628 CDG82185.1    
 YQ44_17350   Janthinobacterium sp. 1_2014MBL_MicDiv APA69256.1    
 VN23_20625   Janthinobacterium sp. B9-8 AMC36823.1    
 BZG29_10525   Janthinobacterium sp. LM6 AQR68727.1    
 mma_1125   Janthinobacterium sp. Marseille ABR89496.1    
 CNX70_11165   Janthinobacterium svalbardensis PAMC 27463 ATD60664.1    
 BJP62_06870   Jeongeupia sp. USM3 AOY00193.1    
 LHGZ1_0702   Laribacter hongkongensis HLGZ1 ASJ23533.1    
 LHK_00709   Laribacter hongkongensis HLHK9 ACO73702.1    
 Lcho_1933   Leptothrix cholodnii SP-6 ACB34200.1    
 L103DPR2_02131   Limnohabitans sp. 103DPR2 ALK92521.1    
 L63ED372_01090   Limnohabitans sp. 63ED37-2 ALK88304.1    
 A8C75_17640   Marinobacterium aestuarii ST58-10 ANG64114.1    
 CR152_18490   Massilia sp. B2 ATQ76298.1    
 ACZ75_01495   Massilia sp. NR 4-1 AKU20394.1    
 AM586_19130   Massilia sp. WG5 ALK97996.1    
 Mpe_A1961   Methylibium petroleiphilum PM1 ABM94919.1    
 ACJ67_09590   Methylophilus sp. TWE2 AKR43651.1    
 Mmol_1427   Methylotenera mobilis JLW8 ACT48333.1    
 BSY238_2900   Methyloversatilis sp. RAC08 AOF83569.1    
 Msip34_1237   Methylovorus glucosetrophus SIP3-4 ACT50483.1    
 MPQ_1309   Methylovorus sp. MP688 ADQ84472.1    
 MICA_189   Micavibrio aeruginosavorus ARL-13 AEP08535.1    
 A11S_186   Micavibrio aeruginosavorus EPB AGH97022.1    
 ABE85_04820   Mitsuaria sp. 7 ANH67062.1    
 SAMEA4076741_00798   Neisseria gonorrhoeae NCTC13798 SNU90350.1    
 SAMEA4076765_00998   Neisseria gonorrhoeae NCTC13799 SNU83057.1    
 SAMEA4076768_00766   Neisseria gonorrhoeae NCTC13800 SNV70311.1    
 BZG33_04435   Neisseria gonorrhoeae RIVM0610 ASQ72518.1    
 BZG34_02515   Neisseria gonorrhoeae RIVM0640 ASQ74809.1    
 AN159_01890   Neisseria meningitidis 331401 AOT28671.1    
 AT729_01340   Neisseria meningitidis 38277 APY29691.1    
 DE8669_1805   Neisseria meningitidis DE8669 ANW88179.1    
 NMBM01240149_1151   Neisseria meningitidis M01-240149 ADY97729.1    
 M0579_01841   Neisseria meningitidis M0579 AKM93292.1    
 A6L17_02345   Neisseria meningitidis M07149 ANX29444.1    
 A6L20_01955   Neisseria meningitidis M07161 ANX81367.1    
 A6L21_04345   Neisseria meningitidis M07162 ANX17255.1    
 A6L22_10285   Neisseria meningitidis M07165 AOA35605.1    
 A6L23_02765   Neisseria meningitidis M07999 AOA36525.1    
 A6L24_06625   Neisseria meningitidis M08000 ANX94659.1    
 A6L25_04835   Neisseria meningitidis M08001 ANX34023.1    
 A6L26_08470   Neisseria meningitidis M09261 ANX61683.1    
 A6L27_10190   Neisseria meningitidis M09293 ANX26619.1    
 LD07_09765   Neisseria meningitidis M10208 AIZ27067.1    
 A6L28_07645   Neisseria meningitidis M12752 ANX19903.1    
 A6L29_04890   Neisseria meningitidis M22160 ANX79795.1    
 A6L30_00055   Neisseria meningitidis M22189 ANX26975.1    
 A6L31_01070   Neisseria meningitidis M22191 ANX97878.1    
 A6L32_10240   Neisseria meningitidis M22718 ANX16082.1    
 A6L33_01530   Neisseria meningitidis M22722 ANX56360.1    
 A6L35_02465   Neisseria meningitidis M22745 ANX44032.1    
 A6L36_11025   Neisseria meningitidis M22747 AOA39996.1    
 A6L37_01630   Neisseria meningitidis M22748 ANX35556.1    
 A6L38_04665   Neisseria meningitidis M22759 ANX69351.1    
 A6L40_00660   Neisseria meningitidis M22769 ANX41649.1    
 A6L41_04825   Neisseria meningitidis M22772 ANX40273.1    
 A6L44_08010   Neisseria meningitidis M22797 AOA43572.1    
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