GlycosylTransferase Family 104

Activities in FamilydTDP-β-L-Rhap : arginine α-L-rhamnosyltransferase (EC 2.4.1.-)
Mechanism Inverting
NoteLassak et al. identified EarP as EF-P arginine R32 specific rhamnosyl transferase in Shewanella oneidensis using dTDP-b-L-rhamnose as donor substrate (PMID=25686373). The results of this study were subsequently confirmed for Pseudomonas aeruginosa (PMID=26060278), Pseudomonas putida (PMID=28951478) and Neisseria meningitidis (PMID=26840407). In 2016, it has been shown for S. oneidensis (PMID=28451135) and P. aeruginosa (PMID=28451332) that the enzyme is an inverting glycosyltransferase, thus mediating the formation of an a-L-rhamnosidic linkage. A structural basis for the arginine glycosylation reaction was provided by Krafczyk, Macosek and coworkers by having solved the crystal structure of the GT-B folding EarP from P. putida and an accompanying biochemical analysis of the enzyme (PMID=28951478).
Statistics GenBank accession (983); Uniprot accession (0); PDB accession (1); 3D entries (1); cryst (0)
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Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 CBG50_05980   Fusobacterium nucleatum subsp. polymorphum KCOM 1260 (=ChDC F218) ASC02897.1    
 CBG61_03570   Fusobacterium nucleatum subsp. polymorphum KCOM 1275 ASG28104.1    
 ERS445057_01527   Fusobacterium nucleatum subsp. polymorphum NCTC10562 CKH00579.1    
 HMPREF0405_01054   Fusobacterium nucleatum subsp. vincentii 3_1_27 EFG34775.1    
 HMPREF0946_00201   Fusobacterium nucleatum subsp. vincentii 3_1_36A2 EEU32128.1    
 RN99_05270   Fusobacterium nucleatum subsp. vincentii ChDC F8 KCOM 1231 ALF19899.1    
 AXF16_08685   Fusobacterium sp. oral taxon 203 W7671 ASS40151.1    
 FV113G1_21700   Fusobacterium varium Fv113-g1 BBA51820.1    
 Galf_0622   Gallionella capsiferriformans ES-2 ADL54664.1    
 A9404_12485   Halothiobacillus sp. LS2 ANJ68083.1    
 F506_14895   Herbaspirillum hiltneri N3 AKZ63781.1    
 Hrubri_3079   Herbaspirillum rubrisubalbicans M1 ALU90248.1    
 Hsc_3017   Herbaspirillum seropedicae AU14040 AON55293.1    
 Hsero_3062   Herbaspirillum seropedicae SmR1 ADJ64550.1    
 ACP92_15365   Herbaspirillum seropedicae Z67 AKN66478.1    
 hmeg3_15085   Herbaspirillum sp. meg3 ASU39482.1    
 HEAR0987   Herminiimonas arsenicoxydans CAL61169.1    
 LPB072_14130   Hydrogenophaga crassostreae LPB0072 AOW13809.1    
 Q5W_08510   Hydrogenophaga sp. PBC AOS82130.1    
 BSY239_2183   Hydrogenophaga sp. RAC07 AOF87336.1    
 Ilyop_2608   Ilyobacter polytropus DSM 2926 ADO84365.1    
 GJA_1540   Janthinobacterium agaricidamnosum NBRC 102515 = DSM 9628 CDG82185.1    
 YQ44_17350   Janthinobacterium sp. 1_2014MBL_MicDiv APA69256.1    
 VN23_20625   Janthinobacterium sp. B9-8 AMC36823.1    
 BZG29_10525   Janthinobacterium sp. LM6 AQR68727.1    
 mma_1125   Janthinobacterium sp. Marseille ABR89496.1    
 CNX70_11165   Janthinobacterium svalbardensis PAMC 27463 ATD60664.1    
 BJP62_06870   Jeongeupia sp. USM3 AOY00193.1    
 LHGZ1_0702   Laribacter hongkongensis HLGZ1 ASJ23533.1    
 LHK_00709   Laribacter hongkongensis HLHK9 ACO73702.1    
 Lcho_1933   Leptothrix cholodnii SP-6 ACB34200.1    
 L103DPR2_02131   Limnohabitans sp. 103DPR2 ALK92521.1    
 L63ED372_01090   Limnohabitans sp. 63ED37-2 ALK88304.1    
 A8C75_17640   Marinobacterium aestuarii ST58-10 ANG64114.1    
 ACZ75_01495   Massilia sp. NR 4-1 AKU20394.1    
 AM586_19130   Massilia sp. WG5 ALK97996.1    
 Mpe_A1961   Methylibium petroleiphilum PM1 ABM94919.1    
 ACJ67_09590   Methylophilus sp. TWE2 AKR43651.1    
 Mmol_1427   Methylotenera mobilis JLW8 ACT48333.1    
 BSY238_2900   Methyloversatilis sp. RAC08 AOF83569.1    
 Msip34_1237   Methylovorus glucosetrophus SIP3-4 ACT50483.1    
 MPQ_1309   Methylovorus sp. MP688 ADQ84472.1    
 MICA_189   Micavibrio aeruginosavorus ARL-13 AEP08535.1    
 A11S_186   Micavibrio aeruginosavorus EPB AGH97022.1    
 ABE85_04820   Mitsuaria sp. 7 ANH67062.1    
 SAMEA4076741_00798   Neisseria gonorrhoeae NCTC13798 SNU90350.1    
 SAMEA4076765_00998   Neisseria gonorrhoeae NCTC13799 SNU83057.1    
 SAMEA4076768_00766   Neisseria gonorrhoeae NCTC13800 SNV70311.1    
 BZG33_04435   Neisseria gonorrhoeae RIVM0610 ASQ72518.1    
 BZG34_02515   Neisseria gonorrhoeae RIVM0640 ASQ74809.1    
 AN159_01890   Neisseria meningitidis 331401 AOT28671.1    
 AT729_01340   Neisseria meningitidis 38277 APY29691.1    
 DE8669_1805   Neisseria meningitidis DE8669 ANW88179.1    
 NMBM01240149_1151   Neisseria meningitidis M01-240149 ADY97729.1    
 M0579_01841   Neisseria meningitidis M0579 AKM93292.1    
 A6L17_02345   Neisseria meningitidis M07149 ANX29444.1    
 A6L20_01955   Neisseria meningitidis M07161 ANX81367.1    
 A6L21_04345   Neisseria meningitidis M07162 ANX17255.1    
 A6L22_10285   Neisseria meningitidis M07165 AOA35605.1    
 A6L23_02765   Neisseria meningitidis M07999 AOA36525.1    
 A6L24_06625   Neisseria meningitidis M08000 ANX94659.1    
 A6L25_04835   Neisseria meningitidis M08001 ANX34023.1    
 A6L26_08470   Neisseria meningitidis M09261 ANX61683.1    
 A6L27_10190   Neisseria meningitidis M09293 ANX26619.1    
 LD07_09765   Neisseria meningitidis M10208 AIZ27067.1    
 A6L28_07645   Neisseria meningitidis M12752 ANX19903.1    
 A6L29_04890   Neisseria meningitidis M22160 ANX79795.1    
 A6L30_00055   Neisseria meningitidis M22189 ANX26975.1    
 A6L31_01070   Neisseria meningitidis M22191 ANX97878.1    
 A6L32_10240   Neisseria meningitidis M22718 ANX16082.1    
 A6L33_01530   Neisseria meningitidis M22722 ANX56360.1    
 A6L35_02465   Neisseria meningitidis M22745 ANX44032.1    
 A6L36_11025   Neisseria meningitidis M22747 AOA39996.1    
 A6L37_01630   Neisseria meningitidis M22748 ANX35556.1    
 A6L38_04665   Neisseria meningitidis M22759 ANX69351.1    
 A6L40_00660   Neisseria meningitidis M22769 ANX41649.1    
 A6L41_04825   Neisseria meningitidis M22772 ANX40273.1    
 A6L44_08010   Neisseria meningitidis M22797 AOA43572.1    
 A6L45_03645   Neisseria meningitidis M22801 ANX48398.1    
 A6L52_11005   Neisseria meningitidis M23413 ANX55884.1    
 A6L61_00650   Neisseria meningitidis M24730 ANX45797.1    
 A6L64_09590   Neisseria meningitidis M25070 ANX59808.1    
 A6L66_10270   Neisseria meningitidis M25073 AOA46060.1    
 A6L67_10255   Neisseria meningitidis M25074 AOA48179.1    
 A6L77_08195   Neisseria meningitidis M25087 ANX71998.1    
 A6L86_05405   Neisseria meningitidis M25419 ANX88169.1    
 A6L93_08660   Neisseria meningitidis M25438 ANX53413.1    
 A6L95_05290   Neisseria meningitidis M25456 ANX86079.1    
 A6L96_08315   Neisseria meningitidis M25459 ANX78285.1    
 A6L97_07410   Neisseria meningitidis M25462 ANX63563.1    
 A6M04_02510   Neisseria meningitidis M25472 ANX66902.1    
 A6M07_02630   Neisseria meningitidis M25476 ANX83552.1    
 A6M08_10200   Neisseria meningitidis M27559 ANX66126.1    
 LA24_06615   Neisseria meningitidis M7124 AIZ20363.1    
  dTDP-β-L-Rhap : arginine α-L-rhamnosyltransferase (EarP; SO_2329) 2.4.1.- Neisseria meningitidis NIID280 BAU19337.1    
 LA50_01220   Neisseria meningitidis NM3686 AIZ17325.1    
 NMBNZ0533_0987   Neisseria meningitidis NZ-05/33 ADZ03424.1    
 CGZ65_07170   Neisseria sp. 10022 ATD65143.1    
 BG910_00290   Neisseria sp. 10023 ASK26391.1    
 CGZ77_08235   Neisseria sp. KEM232 ASP17731.1    
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