GlycosylTransferase Family 104

Activities in FamilydTDP-β-L-Rhap : arginine α-L-rhamnosyltransferase (EC 2.4.1.-)
Mechanism Inverting
NoteLassak et al. identified EarP as EF-P arginine R32 specific rhamnosyl transferase in Shewanella oneidensis using dTDP-b-L-rhamnose as donor substrate (PMID=25686373). The results of this study were subsequently confirmed for Pseudomonas aeruginosa (PMID=26060278), Pseudomonas putida (PMID=28951478) and Neisseria meningitidis (PMID=26840407). In 2016, it has been shown for S. oneidensis (PMID=28451135) and P. aeruginosa (PMID=28451332) that the enzyme is an inverting glycosyltransferase, thus mediating the formation of an a-L-rhamnosidic linkage. A structural basis for the arginine glycosylation reaction was provided by Krafczyk, Macosek and coworkers by having solved the crystal structure of the GT-B folding EarP from P. putida and an accompanying biochemical analysis of the enzyme (PMID=28951478).
Statistics GenBank accession (983); Uniprot accession (0); PDB accession (1); 3D entries (1); cryst (0)
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Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 T228_11170   Pseudomonas aeruginosa LESlike7 AHK89050.1    
 HW04_01830   Pseudomonas aeruginosa M1608 ALY69766.1    
 PAM18_2111   Pseudomonas aeruginosa M18 AEO74595.1    
 A6752_25975   Pseudomonas aeruginosa M28A1 ARN49035.1    
 HW03_05100   Pseudomonas aeruginosa M37351 ALY76133.1    
 A6746_10720   Pseudomonas aeruginosa M8A1 ARN34831.1    
 A6747_18640   Pseudomonas aeruginosa M8A4 ARN42027.1    
 U769_10695   Pseudomonas aeruginosa MTB-1 AHB55375.1    
 AOY09_04197   Pseudomonas aeruginosa N15-01092 ALV79235.1    
 OB07_02124   Pseudomonas aeruginosa N17-1 AMU00497.1    
 NCGM1900_3461   Pseudomonas aeruginosa NCGM 1900 BAP22550.1    
 NCGM1984_2195   Pseudomonas aeruginosa NCGM 1984 BAP50174.1    
 NCGM2_3961   Pseudomonas aeruginosa NCGM2.S1 BAK90798.1    
 PA257_2461   Pseudomonas aeruginosa NCGM257 BAQ39064.1    
 ERS445055_02169   Pseudomonas aeruginosa NCTC10332 CKH23885.1    
 NHmuc_3395   Pseudomonas aeruginosa NHmuc APJ53385.1    
 CGU45_04630   Pseudomonas aeruginosa Ocean-1155 ASP10624.1    
 CGU46_30950   Pseudomonas aeruginosa Ocean-1175 ASP09096.1    
 PA1S_11155   Pseudomonas aeruginosa PA1 AHA16653.1    
 A9P90_25535   Pseudomonas aeruginosa PA121617 ANP62086.1    
 PA1R_gp0684   Pseudomonas aeruginosa PA1R AHA22452.1    
 AOD73_11150   Pseudomonas aeruginosa PA1RG ALE47990.1    
 BN889_03180   Pseudomonas aeruginosa PA38182 CDI91229.1    
 PSPA7_2303   Pseudomonas aeruginosa PA7 ABR83791.1    
 PA7790_01183   Pseudomonas aeruginosa PA7790 APB56575.1    
 PA8281_00058   Pseudomonas aeruginosa PA8281 AOX32485.1    
 PSA83_02224   Pseudomonas aeruginosa PA83 ASJ84459.1    
 PA96_2072   Pseudomonas aeruginosa PA96 AHW70566.1    
 AQ622_02134   Pseudomonas aeruginosa PAER4_119 APC72238.1    
 Y880_02577   Pseudomonas aeruginosa PAK ARI02503.1    
 dTDP-β-L-Rhap : arginine α-L-rhamnosyltransferase (EarP; PA2852) 2.4.1.- Pseudomonas aeruginosa PAO1 AAG06240.1    
 N297_2954   Pseudomonas aeruginosa PAO1-VE13 AGY73947.1    
 N296_2954   Pseudomonas aeruginosa PAO1-VE2 AGY67096.1    
 OU9_02897   Pseudomonas aeruginosa PAO1H2O AID74079.1    
 PAO1OR2128   Pseudomonas aeruginosa PAO1_Orsay CTQ37044.1    
 M801_2819   Pseudomonas aeruginosa PAO581 AGV59763.1    
 B7W86_11665   Pseudomonas aeruginosa PASGNDM345 ARI90884.1    
 B7W87_11670   Pseudomonas aeruginosa PASGNDM699 ARI97319.1    
 AXW93_10805   Pseudomonas aeruginosa PA_154197 ARC79315.1    
 AM599_11155   Pseudomonas aeruginosa PA_D1 AON06477.1    
 A6695_11155   Pseudomonas aeruginosa PA_D16 AON30449.1    
 A6681_11155   Pseudomonas aeruginosa PA_D2 AON12466.1    
 A6681_11155   Pseudomonas aeruginosa PA_D2 AON12466.1    
 A7329_11155   Pseudomonas aeruginosa PA_D21 AON36453.1    
 A7329_11155   Pseudomonas aeruginosa PA_D21 AON36453.1    
 A6701_11155   Pseudomonas aeruginosa PA_D22 AON42436.1    
 A6704_11160   Pseudomonas aeruginosa PA_D25 AON48450.1    
 A6704_11160   Pseudomonas aeruginosa PA_D25 AON48450.1    
 A7331_11150   Pseudomonas aeruginosa PA_D5 AON18453.1    
 A6688_13875   Pseudomonas aeruginosa PA_D9 AON24976.1    
 A6688_13875   Pseudomonas aeruginosa PA_D9 AON24976.1    
 A6748_01325   Pseudomonas aeruginosa Pb18 ARN50204.1    
 PSE305_30970c   Pseudomonas aeruginosa PSE305 CDO82231.1    
 BFV99_22015   Pseudomonas aeruginosa RIVM-EMC2982 ARG51910.1    
 M062_15285   Pseudomonas aeruginosa RP73 AGO40479.1    
 YH69_11240   Pseudomonas aeruginosa S04 90 AKF98563.1    
 HW02_24360   Pseudomonas aeruginosa S86968 ALY92199.1    
 SCVFeb_2148   Pseudomonas aeruginosa SCVFeb APJ40932.1    
 SCVJan_2148   Pseudomonas aeruginosa SCVJan APJ46551.1    
 A214_22745   Pseudomonas aeruginosa SJTD-1 ANI11202.1    
 HW01_05315   Pseudomonas aeruginosa T38079 ALY94769.1    
 HW00_22040   Pseudomonas aeruginosa T52373 ALZ03980.1    
 HV99_18170   Pseudomonas aeruginosa T63266 ALZ08769.1    
 PA14_27200   Pseudomonas aeruginosa UCBPP-PA14 ABJ12092.1    
 APT60_10755   Pseudomonas aeruginosa USDA-ARS-USMARC-41639 ALZ90799.1    
 ATC05_29010   Pseudomonas aeruginosa VA-134 ALP60908.1    
 P797_20555   Pseudomonas aeruginosa VRFPA04 AID85488.1    
 HV98_16925   Pseudomonas aeruginosa W16407 ALZ14233.1    
 HV97_15140   Pseudomonas aeruginosa W36662 ALZ19974.1    
 HV96_16870   Pseudomonas aeruginosa W45909 ALZ26392.1    
 HV95_07585   Pseudomonas aeruginosa W60856 ALY82785.1    
 HV94_12015   Pseudomonas aeruginosa X78812 ALZ31575.1    
 AI22_22715   Pseudomonas aeruginosa YL84 AHH51660.1    
 AWM79_21670   Pseudomonas agarici NCPPB 2472 AMB87752.1    
 A0T30_14025   Pseudomonas alcaligenes NEB 585 AMR67422.1    
 UYA_12005   Pseudomonas alcaliphila JAB1 APU32832.1    
 PSAKL28_14450   Pseudomonas alkylphenolica KL28 AIL60671.1    
 B5U27_20550   Pseudomonas amygdali pv. lachrymans NM002 ARA82267.1    
 SAMN04490179_4987   Pseudomonas antarctica BS2772 SDN59689.1    
 A7J50_1864   Pseudomonas antarctica PAMC 27494 ANF85285.1    
 SAMN04489798_5389   Pseudomonas arsenicoxydans CECT 7543 SDP32956.1    
 SAMN05216598_5590   Pseudomonas asplenii ATCC 23835 SDT41698.1    
 B1R45_08995   Pseudomonas azotoformans F77 AQT93405.1    
 SAMN04489799_6136   Pseudomonas azotoformans LMG 21611 SDP02828.1    
 AYR47_15745   Pseudomonas azotoformans S4 AMN79691.1    
 CL52_12150   Pseudomonas balearica DSM 6083 AJE15741.1    
 SAMN04490180_0109   Pseudomonas brassicacearum BS3663 SDP02296.1    
 CD58_08975   Pseudomonas brassicacearum DF41 AHL33017.1    
 A0U95_07880   Pseudomonas brassicacearum L13-6-12 AOS38679.1    
 AK973_1927   Pseudomonas brassicacearum LBUM300 ALQ02376.1    
 PSEBR_a1614   Pseudomonas brassicacearum subsp. brassicacearum NFM421 AEA67818.1    
 SAMN04490181_2598   Pseudomonas brenneri BS2771 SDU98582.1    
 SAMN04490182_0924   Pseudomonas cedrina BS2981 SDS18376.1    
 PCPL58_1659   Pseudomonas cerasi CZT28115.1    
 A3218_22095   Pseudomonas chlororaphis AMS16862.1    
 SAMN04489803_1118   Pseudomonas chlororaphis ATCC 13985 SDS30686.1    
 SAMN05216585_2780   Pseudomonas chlororaphis DSM 21509 SDS60153.1    
 SAMN04489802_1879   Pseudomonas chlororaphis LMG 21630 SDS63065.1    
 EY04_21550   Pseudomonas chlororaphis PA23 AIC21400.1    
 PCL1606_19110   Pseudomonas chlororaphis PCL1606 AKA23366.1    
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