GlycosylTransferase Family 104

Activities in FamilydTDP-β-L-Rhap : arginine α-L-rhamnosyltransferase (EC 2.4.1.-)
Mechanism Inverting
NoteLassak et al. identified EarP as EF-P arginine R32 specific rhamnosyl transferase in Shewanella oneidensis using dTDP-b-L-rhamnose as donor substrate (PMID=25686373). The results of this study were subsequently confirmed for Pseudomonas aeruginosa (PMID=26060278), Pseudomonas putida (PMID=28951478) and Neisseria meningitidis (PMID=26840407). In 2016, it has been shown for S. oneidensis (PMID=28451135) and P. aeruginosa (PMID=28451332) that the enzyme is an inverting glycosyltransferase, thus mediating the formation of an a-L-rhamnosidic linkage. A structural basis for the arginine glycosylation reaction was provided by Krafczyk, Macosek and coworkers by having solved the crystal structure of the GT-B folding EarP from P. putida and an accompanying biochemical analysis of the enzyme (PMID=28951478).
Statistics GenBank accession (2176); Uniprot accession (0); PDB accession (9); 3D entries (3); cryst (0)
All (2172) Bacteria (2172) Structure (3) Characterized (4)
| 1 | ... | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | ... | 22 |
Protein Name EC#OrganismGenBank UniprotPDB/3D
 GBP346_A2951   Burkholderia pseudomallei MSHR346 ACQ98320.1    
 DP55_812   Burkholderia pseudomallei MSHR346 AIP11006.1    
 BGI46_12640   Burkholderia pseudomallei MSHR3763 APZ25613.1    
 X978_1298   Burkholderia pseudomallei MSHR3965 AIV84815.1    
 BGI47_12635   Burkholderia pseudomallei MSHR4083 APZ19421.1    
 BG17_3154   Burkholderia pseudomallei MSHR491 AJX23819.1    
 BBQ_886   Burkholderia pseudomallei MSHR511 AHG35337.1    
 BBX_1421   Burkholderia pseudomallei MSHR520 AHK66344.1    
 DP65_2775   Burkholderia pseudomallei MSHR5848 AIP39325.1    
 DP63_1667   Burkholderia pseudomallei MSHR5855 AIP23568.1    
 DR56_2169   Burkholderia pseudomallei MSHR5858 AIP47348.1    
 BGI52_12965   Burkholderia pseudomallei MSHR5864 APZ13390.1    
 Y028_3362   Burkholderia pseudomallei MSHR62 AIV71486.1    
 BH02_1083   Burkholderia pseudomallei MSHR668 AJX87868.1    
 BGI49_12865   Burkholderia pseudomallei MSHR6755 APY99803.1    
 BGI50_12605   Burkholderia pseudomallei MSHR7929 APY93679.1    
 BG19_2281   Burkholderia pseudomallei MSHR840 AJX72092.1    
 BBS_2495   Burkholderia pseudomallei NAU20B-16 AHE32498.1    
 BBU_3137   Burkholderia pseudomallei NAU35A-3 AIS86426.1    
 BBJ_408   Burkholderia pseudomallei NCTC 13178 AHE28090.1    
 BBK_2532   Burkholderia pseudomallei NCTC 13179 AGZ29845.1    
 DP47_3238   Burkholderia pseudomallei Pasteur 52237 AJX61220.1    
 BG24_2186   Burkholderia pseudomallei PB08298010 AJX95987.1    
 DP45_01594   Burkholderia pseudomallei BEJ AJX38120.1    
 X988_2369   Burkholderia pseudomallei TSV 48 AIV49048.1    
 X994_12   Burkholderia pseudomallei sp. TSV202 AIV78556.1    
 X994_12   Burkholderia pseudomallei sp. TSV202 AIV78556.1    
 BK015_05740   Burkholderia pseudomallei VB976100 APD34716.1    
 BK015_05740   Burkholderia pseudomallei VB976100 APD34716.1    
 UQ47_12600   Burkholderia pseudomallei vgh07 AJW53805.1    
 AM256_12770   Burkholderia pseudomallei vgh16R ALB94390.1    
 AM256_12770   Burkholderia pseudomallei vgh16R ALB94390.1    
 AM257_12795   Burkholderia pseudomallei vgh16W ALC00462.1    
 ABD05_11325   Burkholderia pyrrocinia DSM 10685 AKM00747.1    
 CUJ89_05845   Burkholderia pyrrocinia mHSR5 AXF20073.1    
 BW21_1356   Burkholderia sp. 2002721687 AJY41476.1    
 bAD24_I16580   Burkholderia sp. AD24 ASL45094.1    
 WS70_05575   Burkholderia sp. BDU6 AOJ01365.1    
 WS71_18495   Burkholderia sp. BDU8 AOJ09348.1    
 AQ610_06150   Burkholderia sp. Bp5365 MSMB43 ALX42051.1    
 BC1001_2527   Burkholderia sp. CCGE1001 ADX55943.1    
 BC1003_2498   Burkholderia sp. CCGE1003 ADN58451.1    
 FAZ95_15630 (EarP)   Burkholderia sp. DHOD12 QCP50457.1    
 AC233_12975   Burkholderia sp. HB1 ALE55481.1    
 DCN14_20090 (EarP)   Burkholderia sp. IDO3 AXK64955.1    
 DM992_15885 (EarP)   Burkholderia sp. JP2-270 AWV00824.1    
 FFI87_005460 (EarP)   Burkholderia sp. KBS0801 QDW49836.1    
 A9R05_11000   Burkholderia sp. KK1 AQG99292.1    
 WS66_23120   Burkholderia sp. LA-2-3-30-S1-D2 AOI98515.1    
 WS78_05085   Burkholderia sp. MSMB0266 AOJ68200.1    
 WS86_06280   Burkholderia sp. MSMB0852 AOJ80270.1    
 WS87_11850   Burkholderia sp. MSMB0856 AOJ87320.1    
 WT60_06240   Burkholderia sp. MSMB617WGS AOK46495.1    
 AYM40_14595   Burkholderia sp. OLGA172 ANB73447.1    
 AXG89_00960   Burkholderia sp. PAMC 26561 AME25060.1    
 AX768_10695   Burkholderia sp. PAMC 28687 AMM14494.1    
 BRPE67_ACDS19480   Burkholderia sp. RPE67 BAO87003.1    
 BTHE68_17660   Burkholderia sp. THE68 BBU28032.1    
 BSTAB16_1339   Burkholderia stabilis VBB11214.1    
 BBJ41_06430   Burkholderia stabilis ATCC BAA-67 AOR67211.1    
 BSFP_031050   Burkholderia stabilis FERMP-21014 BAX60250.1    
 BG87_1636   Burkholderia thailandensis 2002721643 AJX99042.1    
 BTQ_2183   Burkholderia thailandensis 2002721723 AHI73531.1    
 DR62_114   Burkholderia thailandensis 2003015869 AIP62945.1    
 BTM_2930   Burkholderia thailandensis 34 AJY27502.1    
 G9462_11375 (EarP)   Burkholderia thailandensis BPM QIO12546.1    
 BTN_3347   Burkholderia thailandensis E254 AIT20860.1    
 DR63_597   Burkholderia thailandensis E264 AIP27084.1    
 BTH_I1738   Burkholderia thailandensis E264 E264; ATCC 700388 ABC38454.1    
 BTJ_134   Burkholderia thailandensis E444 AHI78522.1    
 A8H31_30165 (EarP)   Burkholderia thailandensis FDAARGOS_237 AVR11337.1    
 A8H32_12380 (EarP)   Burkholderia thailandensis FDAARGOS_238 AVR25801.1    
 A8H35_12295   Burkholderia thailandensis FDAARGOS_241 AWY59080.1    
 A8H36_16140   Burkholderia thailandensis FDAARGOS_242 AWY69386.1    
 CO709_25555   Burkholderia thailandensis FDAARGOS_426 ATF36345.1    
 BTL_1431   Burkholderia thailandensis H0587 AHI64025.1    
 BTI_1209   Burkholderia thailandensis MSMB121 AGK49145.1    
 BTHA_1523   Burkholderia thailandensis MSMB59 AIS94309.1    
 BTRA_1655   Burkholderia thailandensis USAMRU Malaysia #20 AIC87121.1    
 BW23_589   Burkholderia ubonensis MSMB22 AJX15743.1    
 A8H33_16715 (EarP)   Burkholderia vietnamiensis FDAARGOS_239 AVR15124.1    
 E1O_07430   Burkholderiales bacterium GJ-E10 BAP87874.1    
 A4V04_03335   Burkholderiales bacterium YL45 ANU65567.1    
 SBC1_24320   Caballeronia sp. SBC1 QIN62418.1    
 SBC2_25730   Caballeronia sp. SBC2 QIE24526.1    
 CAP2UW1_1557   Candidatus Accumulibacter phosphatis clade IIA str. UW-1 ACV34872.1    
 CKBE_00327   Candidatus Kinetoplastibacterium blastocrithidii (ex Strigomonas culicis) AFZ83516.1    
 BCUE_0401   Candidatus Kinetoplastibacterium blastocrithidii TCC012E AGF49613.1    
 CKCE_0787   Candidatus Kinetoplastibacterium crithidii (ex Angomonas deanei ATCC 30255) AFZ83189.1    
 CDEE_0404   Candidatus Kinetoplastibacterium crithidii TCC036E AGF47465.1    
 CDSE_0401   Candidatus Kinetoplastibacterium desouzaii TCC079E AGF46726.1    
 ST1E_0444   Candidatus Kinetoplastibacterium galatii TCC219 AGF48887.1    
 CONE_0387   Candidatus Kinetoplastibacterium oncopeltii TCC290E AGF48187.1    
 CKSOR_00172   Candidatus Kinetoplastibacterium sorsogonicusi MF-08 AWD32302.1    
 BN1208_0682   Candidatus Methylopumilus planktonicus MMS-10A-171 CEZ19568.1    
 FIT69_03090   Candidatus Methylopumilus planktonicus MMS-VB-116 QDD01574.1    
 FIT66_03320   Candidatus Methylopumilus planktonicus MMS-VB-14 QDD08206.1    
 FIT68_03125   Candidatus Methylopumilus planktonicus MMS-VI-155 QDD00251.1    
 FIT67_03315   Candidatus Methylopumilus planktonicus MMS-VI-180 QDD06870.1    
 FIT63_03100   Candidatus Methylopumilus planktonicus MMS-VI-228 QDD23302.1    

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