GlycosylTransferase Family 104

Activities in FamilydTDP-β-L-Rhap : arginine α-L-rhamnosyltransferase (EC 2.4.1.-)
Mechanism Inverting
NoteLassak et al. identified EarP as EF-P arginine R32 specific rhamnosyl transferase in Shewanella oneidensis using dTDP-b-L-rhamnose as donor substrate (PMID=25686373). The results of this study were subsequently confirmed for Pseudomonas aeruginosa (PMID=26060278), Pseudomonas putida (PMID=28951478) and Neisseria meningitidis (PMID=26840407). In 2016, it has been shown for S. oneidensis (PMID=28451135) and P. aeruginosa (PMID=28451332) that the enzyme is an inverting glycosyltransferase, thus mediating the formation of an a-L-rhamnosidic linkage. A structural basis for the arginine glycosylation reaction was provided by Krafczyk, Macosek and coworkers by having solved the crystal structure of the GT-B folding EarP from P. putida and an accompanying biochemical analysis of the enzyme (PMID=28951478).
Statistics GenBank accession (1215); Uniprot accession (0); PDB accession (5); 3D entries (2); cryst (0)
All (1217) Bacteria (1217) Structure (2) Characterized (4)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | ... | 13 |
Protein Name EC#OrganismGenBank UniprotPDB/3D
 B9P52_21365   Achromobacter denitrificans PR1 ASC66662.1    
 APT56_19715   Achromobacter denitrificans USDA-ARS-USMARC-56712 ALX85242.1    
 BUW96_11410   Achromobacter insolitus DSM 23807 APX75426.1    
 MC81_13695 (EarP)   Achromobacter insolitus FDAARGOS_88 AVG40365.1    
 AruCF_1672   Achromobacter ruhlandii SCCH3:ACH 33-1365 AOU92563.1    
 C2U31_25835   Achromobacter sp. AONIH1 AUT49116.1    
 CVS48_23545   Achromobacter spanius DSM 23806 AUA58725.1    
 CLM73_18400   Achromobacter spanius MYb73 AVJ28926.1    
 AXYL_04438   Achromobacter xylosoxidans A8 ADP17757.1    
 LH59_19750   Achromobacter xylosoxidans C54 AIR52889.1    
 AL504_28445   Achromobacter xylosoxidans FDAARGOS_147 AMG39583.1    
 AL509_04290 (EarP)   Achromobacter xylosoxidans FDAARGOS_150 AUZ18583.1    
 AL520_16945   Achromobacter xylosoxidans FDAARGOS_162 AMG45899.1    
 Axylo_2213   Achromobacter xylosoxidans MN001 AKP89709.1    
 AX27061_4294   Achromobacter xylosoxidans NBRC 15126 = ATCC 27061 AHC48753.1    
 ERS451415_04314   Achromobacter xylosoxidans NCTC10807 CKH89803.1    
 NCTC10808_04254   Achromobacter xylosoxidans NCTC10808 SQG76418.1    
 NH44784_060491   Achromobacter xylosoxidans NH44784-1996 CCH09990.1    
 C8245_23245 (EarP)   Acidovorax avenae subsp. avenae AA81_1 AVS68192.1    
 C8247_07070 (fragment)   Acidovorax avenae subsp. avenae AA99_2 AVS70219.1    
 Acav_1679   Acidovorax avenae subsp. avenae ATCC 19860 ADX45597.1    
 C8237_06915 (fragment)   Acidovorax avenae subsp. avenae INDB2 AVS80853.1    
 C8238_07230 (fragment)   Acidovorax avenae subsp. avenae KL3 AVS88061.1    
 C8232_04725 (EarP)   Acidovorax avenae subsp. avenae MDB1 AVS95650.1    
 C8243_07290 (EarP)   Acidovorax avenae subsp. avenae NCT3 AVT02325.1    
 C8242_06750 (EarP)   Acidovorax avenae subsp. avenae QHB1 AVT09234.1    
 C7Y68_07805 (fragment)   Acidovorax avenae subsp. avenae SH7 AVT19936.1    
 CBP34_07870   Acidovorax carolinensis NA3 ART51601.1    
 C8240_07465 (fragment)   Acidovorax cattleyae CAT98_1 AVS76333.1    
 C8240_07460 (fragment)   Acidovorax cattleyae CAT98_1 AVS73895.1    
 Aave_1649   Acidovorax citrulli AAC00-1 ABM32236.1    
 CQB05_12510   Acidovorax citrulli KACC17005 ATG94747.1    
 Dtpsy_2361   Acidovorax ebreus TPSY ACM33798.1    
 Ajs_2874   Acidovorax sp. JS42 ABM43015.1    
 C380_15150   Acidovorax sp. KKS102 AFU46727.1    
 CBP33_07975   Acidovorax sp. NA2 ART48071.1    
 CBP36_08545   Acidovorax sp. P4 ART58891.1    
 BSY15_4119   Acidovorax sp. RAC01 AOG22616.1    
 BOQ57_16535   Aeromonas aquatica MX16A APJ16434.1    
 VI35_05210   Aeromonas caviae 8LM ATP89830.1    
 MC60_018725   Aeromonas caviae FDAARGOS_72 AUU23793.1    
 NCTC12244_03127   Aeromonas caviae NCTC12244 SQH60631.1    
 CK627_09595   Aeromonas dhakensis KN-Mc-6U21 ASX11018.1    
 AH4AK4_1106   Aeromonas hydrophila 4AK4 AHE48576.1    
 VU14_05525   Aeromonas hydrophila AH10 AKA16358.1    
 TK34_16320   Aeromonas hydrophila AHNIH1 ANT68895.1    
 RY45_16635   Aeromonas hydrophila AL06-06 AJQ55630.1    
 V428_17935   Aeromonas hydrophila AL09-71 AHX33855.1    
 AhyD4_05500   Aeromonas hydrophila D4 ALZ79078.1    
 A9258_05290   Aeromonas hydrophila GYK1 ANR99066.1    
 V469_05325   Aeromonas hydrophila J-1 AJE35366.1    
 AS145_05540   Aeromonas hydrophila JBN2301 ALQ62377.1    
 C7K70_17045 (EarP)   Aeromonas hydrophila KN-Mc-1R2 AVP85611.1    
 AHML_17280   Aeromonas hydrophila ML09-119 AGM45224.1    
 U876_05305   Aeromonas hydrophila NJ-35 AKJ33562.1    
 V429_17970   Aeromonas hydrophila pc104A AHX70656.1    
 AHA_3226   Aeromonas hydrophila subsp. hydrophila ATCC 7966 ABK36714.1    
 C1A23_19615 (EarP)   Aeromonas hydrophila subsp. hydrophila WCHAH045096 AWA07638.1    
 AI20_03210   Aeromonas hydrophila YL17 AHV34243.1    
 B224_0950   Aeromonas media WS AHX59952.1    
 C7N77_19505 (EarP)   Aeromonas rivipollensis KN-Mc-11N1 AVP95142.1    
 CHQ57_16175   Aeromonas salmonicida A527 ATU98799.1    
 CE456_18820   Aeromonas salmonicida S121 ASI24364.1    
 CE463_18815   Aeromonas salmonicida S44 ASI28683.1    
 CE462_17765   Aeromonas salmonicida S68 ASI32813.1    
 BHG40_21070   Aeromonas salmonicida subsp. masoucida RFAS1 ATD40134.1    
 Asalp_35960   Aeromonas salmonicida subsp. pectinolytica 34mel ATP10688.1    
 ASA_1087 (fragment)   Aeromonas salmonicida subsp. salmonicida A449 ABO89209.1    
 WL1483_3566   Aeromonas schubertii WL1483 ALP42985.1    
 C2U37_13105   Aeromonas sp. ASNIH1 AUZ80490.1    
 C3F36_16500   Aeromonas sp. ASNIH2 AUY10924.1    
 C2U39_05645   Aeromonas sp. ASNIH3 AUV11710.1    
 C2U40_04265   Aeromonas sp. ASNIH4 AUZ74097.1    
 C2U30_08085   Aeromonas sp. ASNIH5 AUT41676.1    
 C2U47_15670   Aeromonas sp. ASNIH7 AUV17820.1    
 CK910_10895   Aeromonas sp. CA23 ATL98929.1    
 CK911_12260   Aeromonas sp. CU5 ATL93508.1    
 O23A_p0258   Aeromonas sp. O23A ARW81010.1    
 WM43_17745   Aeromonas veronii AVNIH1 ANB54366.1    
 B565_0929   Aeromonas veronii B565 AEB48964.1    
 A6033_08690   Aeromonas veronii CB51 ANB68669.1    
 AMS64_06385   Aeromonas veronii TH0426 AMQ42031.1    
 CVS41_05235   Aeromonas veronii X11 ATY76585.1    
 CVS42_04580   Aeromonas veronii X12 ATY80179.1    
 CA948_10045   Alcaligenes aquatilis BU33N AWG36946.1    
 CDA61_05255   Alcaligenes faecalis BDB4 ASC91871.1    
 CPY64_03795   Alcaligenes faecalis DSM 30030 ATI01703.1    
 AFA_04775   Alcaligenes faecalis JQ135 ASR91379.1    
 ALFP_1020   Alcaligenes faecalis P156 ARP52907.1    
 Alide_2792   Alicycliphilus denitrificans BC ADV00523.1    
 Alide2_1677   Alicycliphilus denitrificans K601 AEB84067.1    
 DEH84_06740 (EarP)   Aquabacterium olei NBRC 110486 AWI53161.1    
 BXU06_14985   Aquaspirillum sp. LM1 AQR66203.1    
 CEW87_05820   Azoarcus communis TSNA42 AWI78919.1    
 CEW83_14490   Azoarcus communis TSPY31 AWI76274.1    
 dqs_0095   Azoarcus olearius DQS4 ANQ83178.1    
 azo0085   Azoarcus sp. BH72 CAL92703.1    
 AZKH_0036   Azoarcus sp. KH32C BAL22388.1    
 C0099_00110   Azoarcus sp. SY39 AUN93474.1    
 Dsui_2468   Azospira oryzae PS AEV26826.1    

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