GlycosylTransferase Family 104

Activities in FamilydTDP-β-L-Rhap : arginine α-L-rhamnosyltransferase (EC 2.4.1.-)
Mechanism Inverting
NoteLassak et al. identified EarP as EF-P arginine R32 specific rhamnosyl transferase in Shewanella oneidensis using dTDP-b-L-rhamnose as donor substrate (PMID=25686373). The results of this study were subsequently confirmed for Pseudomonas aeruginosa (PMID=26060278), Pseudomonas putida (PMID=28951478) and Neisseria meningitidis (PMID=26840407). In 2016, it has been shown for S. oneidensis (PMID=28451135) and P. aeruginosa (PMID=28451332) that the enzyme is an inverting glycosyltransferase, thus mediating the formation of an a-L-rhamnosidic linkage. A structural basis for the arginine glycosylation reaction was provided by Krafczyk, Macosek and coworkers by having solved the crystal structure of the GT-B folding EarP from P. putida and an accompanying biochemical analysis of the enzyme (PMID=28951478).
Statistics GenBank accession (983); Uniprot accession (0); PDB accession (1); 3D entries (1); cryst (0)
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Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 B9P52_21365   Achromobacter denitrificans PR1 ASC66662.1    
 APT56_19715   Achromobacter denitrificans USDA-ARS-USMARC-56712 ALX85242.1    
 BUW96_11410   Achromobacter insolitus DSM 23807 APX75426.1    
 AruCF_1672   Achromobacter ruhlandii SCCH3:ACH 33-1365 AOU92563.1    
 AXYL_04438   Achromobacter xylosoxidans A8 ADP17757.1    
 LH59_19750   Achromobacter xylosoxidans C54 AIR52889.1    
 AL504_28445   Achromobacter xylosoxidans FDAARGOS_147 AMG39583.1    
 AL520_16945   Achromobacter xylosoxidans FDAARGOS_162 AMG45899.1    
 Axylo_2213   Achromobacter xylosoxidans MN001 AKP89709.1    
 AX27061_4294   Achromobacter xylosoxidans NBRC 15126 = ATCC 27061 AHC48753.1    
 ERS451415_04314   Achromobacter xylosoxidans NCTC10807 CKH89803.1    
 NH44784_060491   Achromobacter xylosoxidans NH44784-1996 CCH09990.1    
 Acav_1679   Acidovorax avenae subsp. avenae ATCC 19860 ADX45597.1    
 Aave_1649   Acidovorax citrulli AAC00-1 ABM32236.1    
 Dtpsy_2361   Acidovorax ebreus TPSY ACM33798.1    
 Ajs_2874   Acidovorax sp. JS42 ABM43015.1    
 C380_15150   Acidovorax sp. KKS102 AFU46727.1    
 CBP33_07975   Acidovorax sp. NA2 ART48071.1    
 CBP34_07870   Acidovorax sp. NA3 ART51601.1    
 CBP36_08545   Acidovorax sp. P4 ART58891.1    
 BSY15_4119   Acidovorax sp. RAC01 AOG22616.1    
 BOQ57_16535   Aeromonas aquatica MX16A APJ16434.1    
 CK627_09595   Aeromonas dhakensis KN-Mc-6U21 ASX11018.1    
 AH4AK4_1106   Aeromonas hydrophila 4AK4 AHE48576.1    
 VU14_05525   Aeromonas hydrophila AH10 AKA16358.1    
 TK34_16320   Aeromonas hydrophila AHNIH1 ANT68895.1    
 RY45_16635   Aeromonas hydrophila AL06-06 AJQ55630.1    
 V428_17935   Aeromonas hydrophila AL09-71 AHX33855.1    
 AhyD4_05500   Aeromonas hydrophila D4 ALZ79078.1    
 A9258_05290   Aeromonas hydrophila GYK1 ANR99066.1    
 V469_05325   Aeromonas hydrophila J-1 AJE35366.1    
 AS145_05540   Aeromonas hydrophila JBN2301 ALQ62377.1    
 AHML_17280   Aeromonas hydrophila ML09-119 AGM45224.1    
 U876_05305   Aeromonas hydrophila NJ-35 AKJ33562.1    
 V429_17970   Aeromonas hydrophila pc104A AHX70656.1    
 AHA_3226   Aeromonas hydrophila subsp. hydrophila ATCC 7966 ABK36714.1    
 AI20_03210   Aeromonas hydrophila YL17 AHV34243.1    
 B224_0950   Aeromonas media WS AHX59952.1    
 CE456_18820   Aeromonas salmonicida S121 ASI24364.1    
 CE463_18815   Aeromonas salmonicida S44 ASI28683.1    
 CE462_17765   Aeromonas salmonicida S68 ASI32813.1    
 BHG40_21070   Aeromonas salmonicida subsp. masoucida RFAS1 ATD40134.1    
 ASA_1087 (fragment)   Aeromonas salmonicida subsp. salmonicida A449 ABO89209.1    
 WL1483_3566   Aeromonas schubertii WL1483 ALP42985.1    
 O23A_p0258   Aeromonas sp. O23A ARW81010.1    
 WM43_17745   Aeromonas veronii AVNIH1 ANB54366.1    
 B565_0929   Aeromonas veronii B565 AEB48964.1    
 A6033_08690   Aeromonas veronii CB51 ANB68669.1    
 AMS64_06385   Aeromonas veronii TH0426 AMQ42031.1    
 CDA61_05255   Alcaligenes faecalis BDB4 ASC91871.1    
 AFA_04775   Alcaligenes faecalis JQ135 ASR91379.1    
 ALFP_1020   Alcaligenes faecalis P156 ARP52907.1    
 Alide_2792   Alicycliphilus denitrificans BC ADV00523.1    
 Alide2_1677   Alicycliphilus denitrificans K601 AEB84067.1    
 BXU06_14985   Aquaspirillum sp. LM1 AQR66203.1    
 dqs_0095   Azoarcus olearius DQS4 ANQ83178.1    
 azo0085   Azoarcus sp. BH72 CAL92703.1    
 AZKH_0036   Azoarcus sp. KH32C BAL22388.1    
 ACG10_06205   Azotobacter chroococcum B3 ASL25950.1    
 Achr_27570   Azotobacter chroococcum NCIMB 8003 AJE22180.1    
 AvCA_15270   Azotobacter vinelandii CA AGK15295.1    
 AvCA6_15270   Azotobacter vinelandii CA6 AGK19950.1    
 Avin_15270   Azotobacter vinelandii DJ ATCC BAA-1303 ACO77742.1    
 D521_1412   beta proteobacterium CB AGG33981.1    
 BWI17_11830   Betaproteobacteria bacterium GR16-43 APV50319.1    
 B0B51_19955   blood disease bacterium A2-HR MARDI AQW32153.1    
 BDB_mp60173   blood disease bacterium R229 CCA83008.1    
 BAV2517   Bordetella avium 197N CAJ50127.1    
 BAU08_07900   Bordetella bronchialis AU17976 ANN71266.1    
 BAU06_07670   Bordetella bronchialis AU3182 ANN66184.1    
 BN112_1674   Bordetella bronchiseptica 253 CCJ53591.1    
 AL472_10680   Bordetella bronchiseptica ATCC:BAA-588D-5 AMG88199.1    
 BBB44_08625   Bordetella bronchiseptica I328 AOB26300.1    
 BN115_1743   Bordetella bronchiseptica MO149 CCJ58499.1    
 BB1841   Bordetella bronchiseptica RB50 CAE32338.1    
 BBS798_1742   Bordetella bronchiseptica S798 BAO68468.1    
 CAL15_11235   Bordetella genomosp. 13 AU7206 ARP94900.1    
 CAL11_15215   Bordetella genomosp. 6 AU22978 ARP77405.1    
 CAL12_08150   Bordetella genomosp. 8 AU19157 ARP84422.1    
 CAL14_14630   Bordetella genomosp. 9 AU14267 ARP91370.1    
 CAL13_15105   Bordetella genomosp. 9 AU17164 ARP87389.1    
 ACR54_03551   Bordetella hinzii F582 AKQ56841.1    
 ACR55_03464   Bordetella hinzii H568 AKQ61308.1    
 SAMEA4040645_01066   Bordetella hinzii NCTC13200 SNV69074.1    
 D558_0800   Bordetella holmesii 44057 AIT25480.1    
 F783_014480   Bordetella holmesii F627 AMD49863.1    
 H558_03600   Bordetella holmesii H558 AMD44657.1    
 BBB42_15405   Bordetella holmesii H903 AOB36756.1    
 BPP2391   Bordetella parapertussis 12822 CAE37688.1    
 BN117_1544   Bordetella parapertussis Bpp5 CCJ48877.1    
 BBB43_12065   Bordetella parapertussis H904 AOB39488.1    
 Q425_15670   Bordetella pertussis 137 AJB26274.1    
 BN118_1020   Bordetella pertussis 18323 CCJ62445.1    
 AL474_04545   Bordetella pertussis ATCC:BAA-1335D-5 AMG21806.1    
 B1838_1990   Bordetella pertussis B1838 ALH49409.1    
 B1865_1784   Bordetella pertussis B1865 ALH52682.1    
 B1917_1785   Bordetella pertussis B1917 AIW92171.1    
 B1920_1865   Bordetella pertussis B1920 AIW95725.1    
 BBB38_10270   Bordetella pertussis B202 ANT93366.1    
 ADU61_07860   Bordetella pertussis B203 ANT89313.1    
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