GlycosylTransferase Family 104

Activities in FamilydTDP-β-L-Rhap : arginine α-L-rhamnosyltransferase (EC 2.4.1.-)
Mechanism Inverting
NoteLassak et al. identified EarP as EF-P arginine R32 specific rhamnosyl transferase in Shewanella oneidensis using dTDP-b-L-rhamnose as donor substrate (PMID=25686373). The results of this study were subsequently confirmed for Pseudomonas aeruginosa (PMID=26060278), Pseudomonas putida (PMID=28951478) and Neisseria meningitidis (PMID=26840407). In 2016, it has been shown for S. oneidensis (PMID=28451135) and P. aeruginosa (PMID=28451332) that the enzyme is an inverting glycosyltransferase, thus mediating the formation of an a-L-rhamnosidic linkage. A structural basis for the arginine glycosylation reaction was provided by Krafczyk, Macosek and coworkers by having solved the crystal structure of the GT-B folding EarP from P. putida and an accompanying biochemical analysis of the enzyme (PMID=28951478).
Statistics GenBank accession (2363); Uniprot accession (0); PDB accession (9); 3D entries (3); cryst (0)
All (2355) Bacteria (2355) Structure (3) Characterized (4)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | ... | 24 |
Protein Name EC#OrganismGenBank UniprotPDB/3D
 I6I07_17200 (EarP)   Achromobacter deleyi FDAARGOS_1050 QQB32421.1    
 FOC80_14645 (EarP)   Achromobacter denitrificans FDAARGOS_786 QKH50603.1    
 FOC81_06850 (EarP)   Achromobacter denitrificans FDAARGOS_787 QKQ46418.1    
 FOC82_12500 (EarP)   Achromobacter denitrificans FDAARGOS_788 QKH42253.1    
 EC609_22080 (EarP)   Achromobacter denitrificans PheN1 QCS64917.1    
 B9P52_21365   Achromobacter denitrificans PR1 ASC66662.1    
 APT56_19715   Achromobacter denitrificans USDA-ARS-USMARC-56712 ALX85242.1    
 CE205_10405   Achromobacter insolitus AB2 AXA71002.1    
 BUW96_11410   Achromobacter insolitus DSM 23807 APX75426.1    
 MC81_13695 (EarP)   Achromobacter insolitus FDAARGOS_88 AVG40365.1    
 E2544_10255 (EarP)   Achromobacter insolitus LCu2 QEK92168.1    
 NCTC13520_01927   Achromobacter insolitus NCTC13520 VEG67368.1    
 FOC84_23670 (EarP)   Achromobacter pestifer FDAARGOS_790 QKH37765.1    
 AruCF_1672   Achromobacter ruhlandii SCCH3:ACH 33-1365 AOU92563.1    
 C2U31_25835   Achromobacter sp. AONIH1 AUT49116.1    
 DVB37_17935 (EarP)   Achromobacter sp. B7 AYD65594.1    
 CVS48_23545   Achromobacter spanius DSM 23806 AUA58725.1    
 CLM73_18400   Achromobacter spanius MYb73 AVJ28926.1    
 NCTC13519_04640   Achromobacter spanius NCTC13519 VEE59131.1    
 ELS24_19970 (EarP)   Achromobacter spanius UQ283 AZS80531.1    
 AXYL_04438   Achromobacter xylosoxidans A8 ADP17757.1    
 F0U64_20180 (EarP)   Achromobacter xylosoxidans AX1 QEQ24524.1    
 LH59_19750   Achromobacter xylosoxidans C54 AIR52889.1    
 AL504_28445   Achromobacter xylosoxidans FDAARGOS_147 AMG39583.1    
 AL509_04290 (EarP)   Achromobacter xylosoxidans FDAARGOS_150 AUZ18583.1    
 AL520_16945   Achromobacter xylosoxidans FDAARGOS_162 AMG45899.1    
 FOC83_08915 (EarP)   Achromobacter xylosoxidans FDAARGOS_789 QKQ53069.1    
 I6H41_12060 (EarP)   Achromobacter xylosoxidans FDAARGOS_984 QQE59670.1    
 IAG39_10850 (EarP)   Achromobacter xylosoxidans GD03 QNP87964.1    
 HPS43_00975 (EarP)   Achromobacter xylosoxidans GN008 QKI74063.1    
 HPS44_04525 (EarP)   Achromobacter xylosoxidans GN050 QKI68951.1    
 Axylo_2213   Achromobacter xylosoxidans MN001 AKP89709.1    
 AX27061_4294   Achromobacter xylosoxidans NBRC 15126 = ATCC 27061 AHC48753.1    
 ERS451415_04314   Achromobacter xylosoxidans NCTC10807 CKH89803.1    
 NCTC10808_04254   Achromobacter xylosoxidans NCTC10808 SQG76418.1    
 NH44784_060491   Achromobacter xylosoxidans NH44784-1996 CCH09990.1    
 CE206_21885   Achromobacter xylosoxidans SOLR10 AXA78907.1    
 C8245_23245 (EarP)   Acidovorax avenae subsp. avenae AA81_1 AVS68192.1    
 C8247_07070 (fragment)   Acidovorax avenae subsp. avenae AA99_2 AVS70219.1    
 Acav_1679   Acidovorax avenae subsp. avenae ATCC 19860 ADX45597.1    
 C8237_06915 (fragment)   Acidovorax avenae subsp. avenae INDB2 AVS80853.1    
 C8238_07230 (fragment)   Acidovorax avenae subsp. avenae KL3 AVS88061.1    
 C8232_04725 (EarP)   Acidovorax avenae subsp. avenae MDB1 AVS95650.1    
 C8243_07290 (EarP)   Acidovorax avenae subsp. avenae NCT3 AVT02325.1    
 C8242_06750 (EarP)   Acidovorax avenae subsp. avenae QHB1 AVT09234.1    
 C7Y68_07805 (fragment)   Acidovorax avenae subsp. avenae SH7 AVT19936.1    
 CBP34_07870   Acidovorax carolinensis NA3 ART51601.1    
 C8240_07465 (fragment)   Acidovorax cattleyae CAT98_1 AVS76333.1    
 C8240_07460 (fragment)   Acidovorax cattleyae CAT98_1 AVS73895.1    
 Aave_1649   Acidovorax citrulli AAC00-1 ABM32236.1    
 CQB05_12510   Acidovorax citrulli KACC17005 ATG94747.1    
 APS58_3346   Acidovorax citrulli M6 QCX12109.1    
 Dtpsy_2361   Acidovorax ebreus TPSY ACM33798.1    
 H9L24_01230 (EarP)   Acidovorax monticola KACC 19171 QNP59666.1    
 HUK68_11615 (EarP)   Acidovorax sp. 16-35-5 QKV53482.1    
 G7045_07790 (EarP)   Acidovorax sp. HDW3 QIL44173.1    
 EXV95_01745 (EarP)   Acidovorax sp. JMULE5 QLA79500.1    
 Ajs_2874   Acidovorax sp. JS42 ABM43015.1    
 C380_15150   Acidovorax sp. KKS102 AFU46727.1    
 CBP33_07975   Acidovorax sp. NA2 ART48071.1    
 CBP36_08545   Acidovorax sp. P4 ART58891.1    
 BSY15_4119   Acidovorax sp. RAC01 AOG22616.1    
 I6G90_10815 (EarP)   Aeromonas allosaccharophila FDAARGOS_933 QPR52978.1    
 BOQ57_16535   Aeromonas aquatica MX16A APJ16434.1    
 GWG05_05230 (EarP)   Aeromonas caviae 1507-17068 QLL83768.1    
 GWG10_05470 (EarP)   Aeromonas caviae 1605-27183 QLL87750.1    
 GWC92_15665 (EarP)   Aeromonas caviae 1607-10029 QLL81628.1    
 VI35_05210   Aeromonas caviae 8LM ATP89830.1    
 JC965_01770 (EarP)   Aeromonas caviae Aero21 QQA61293.1    
 JH254_19135 (EarP)   Aeromonas caviae Aero52 QQM75475.1    
 MC60_018725   Aeromonas caviae FDAARGOS_72 AUU23793.1
 ACGSH8M1_010990   Aeromonas caviae GSH8M-1 BBG88433.1    
 KAM329_10230   Aeromonas caviae KAM329 BCM74471.1    
 KAM376_31690   Aeromonas caviae KAM376 BCR30163.1    
 NCTC12244_03127   Aeromonas caviae NCTC12244 SQH60631.1    
 C0708_01400   Aeromonas caviae R25-2 AXB07697.1    
 C1C92_00820   Aeromonas caviae R25-6 AXA99701.1    
 C1C91_02835   Aeromonas caviae T25-39 AXB04114.1    
 FCM34_05415 (EarP)   Aeromonas caviae WCW1-2 QDO74851.1    
 WP3S18E02_33050   Aeromonas caviae WP3-S18-ESBL-02 BBR11644.1    
 WP5W18E02_32340   Aeromonas caviae WP5-W18-ESBL-02 BBS18197.1    
 WP8S17E03_09710   Aeromonas caviae WP8-S17-ESBL-03 BBT20546.1    
 WP8S18C01_10810   Aeromonas caviae WP8-S18-CRE-01 BBT52118.1    
 CK627_09595   Aeromonas dhakensis KN-Mc-6U21 ASX11018.1    
 NCTC12917_01092   Aeromonas encheleia NCTC12917 VEG95556.1    
 E4630_05520 (EarP)   Aeromonas hydrophila 23-C-23 QBX75089.1    
 FT673_03595 (EarP)   Aeromonas hydrophila 2359 QNF23877.1    
 AH4AK4_1106   Aeromonas hydrophila 4AK4 AHE48576.1    
 VU14_05525   Aeromonas hydrophila AH10 AKA16358.1    
 TK34_16320   Aeromonas hydrophila AHNIH1 ANT68895.1    
 RY45_16635   Aeromonas hydrophila AL06-06 AJQ55630.1    
 V428_17935   Aeromonas hydrophila AL09-71 AHX33855.1    
 HQK30_16090 (EarP)   Aeromonas hydrophila B11 QKG00644.1    
 AhyD4_05500   Aeromonas hydrophila D4 ALZ79078.1    
 AHGSH82_010640   Aeromonas hydrophila GSH8-2 BBG83919.1    
 A9258_05290   Aeromonas hydrophila GYK1 ANR99066.1    
 GQR50_05700 (EarP)   Aeromonas hydrophila HX-3 QGZ72051.1    
 V469_05325   Aeromonas hydrophila J-1 AJE35366.1    
 AS145_05540   Aeromonas hydrophila JBN2301 ALQ62377.1    
 KAM330_11330   Aeromonas hydrophila KAM330 BCK62144.1    

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