Glycoside Hydrolase Family 5

Activities in Familyendo-β-1,4-glucanase / cellulase (EC; endo-β-1,4-xylanase (EC; β-glucosidase (EC; β-mannosidase (EC; β-glucosylceramidase (EC; glucan β-1,3-glucosidase (EC; licheninase (EC; exo-β-1,4-glucanase / cellodextrinase (EC; glucan endo-1,6-β-glucosidase (EC; mannan endo-β-1,4-mannosidase (EC; cellulose β-1,4-cellobiosidase (EC; steryl β-glucosidase (EC; endoglycoceramidase (EC; chitosanase (EC; β-primeverosidase (EC; xyloglucan-specific endo-β-1,4-glucanase (EC; endo-β-1,6-galactanase (EC; hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC; β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Mechanism Retaining
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (13088); Uniprot accession (1922); PDB accession (213); 3D entries (75); cryst (0)
All (11706) Archaea (92) Bacteria (9369) Eukaryota (2119) Viruses (6) unclassified (120) Structure (75) Characterized (548)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | ... | 94 |
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 ACG10_17745   Azotobacter chroococcum B3 ASL27949.1     45
 Achr_34060   Azotobacter chroococcum NCIMB 8003 AJE22811.1     45
 AvCA_07130   Azotobacter vinelandii CA AGK15534.1     45
 AvCA6_07130   Azotobacter vinelandii CA6 AGK19467.1     45
 Avin_07130   Azotobacter vinelandii DJ ATCC BAA-1303 ACO76963.1 C1DLL5   45
 endo-β-1,4-glucanase (Egl-1139) / III-3A (Cel5A) Bacillus akibai / KSM-1139 BAA00045.1
P06564   2
 endoglucanase (EG-I-1)   Bacillus akibai I-1 AFI25187.1     2
 CSE15_08310   Bacillus altitudinis P-10 ATP93954.1     7
 CFN77_08490   Bacillus altitudinis SGAir0031 ATH72233.1     7
 cellulase   Bacillus amyloliquefaciens 157 AVC04903.1     2
 BAALB65_09790   Bacillus amyloliquefaciens ALB65 AWM44312.1     2
 DDT09_09835   Bacillus amyloliquefaciens ALB69 AWM48134.1     2
 DDT10_09310   Bacillus amyloliquefaciens ALB79 AWM51868.1     2
 endoglucanase   Bacillus amyloliquefaciens AMS1 AKS29707.1     2
 A1R12_09055   Bacillus amyloliquefaciens B15 AMR50503.1     2
 endo-β-1,4-glucanase (EgL)   Bacillus amyloliquefaciens BY-5 AMW90767.1     2
 U471_18630   Bacillus amyloliquefaciens CC178 AGZ56565.1     2
 endo-β-1,4-glucanase   Bacillus amyloliquefaciens IARI-SP-2 AGW99978.1     2
 KSO_010315   Bacillus amyloliquefaciens IT-45 AGF27558.1     2
 KHU1_1621   Bacillus amyloliquefaciens KHG19 AJK65578.1     2
 SB45_09085   Bacillus amyloliquefaciens L-H15 AJH24169.1     2
 XM40_09090   Bacillus amyloliquefaciens L-S60 AKD22364.1     2
 U722_09575   Bacillus amyloliquefaciens LFB112 AHC42348.1     2
 BSF20_16750   Bacillus amyloliquefaciens LM2303 APH49957.1     2
 cellulase (fragment)   Bacillus amyloliquefaciens MBAA3 AHJ80840.1     2
 AVM03_03620   Bacillus amyloliquefaciens MBE1283 ALV01512.1     2
 endo-1,4-β-glucanase precursor   Bacillus amyloliquefaciens MN-13 AVI57374.1     2
 endo-1,4-β-glucanase precursor   Bacillus amyloliquefaciens MN-8 AVI57373.1     2
 endoglucanase (EglS)   Bacillus amyloliquefaciens PK1 AUB45039.1     2
 endoglucanase (EglII) Bacillus amyloliquefaciens PSM 3.1 ADC54852.1 D3Y2F0   2
 AS588_06260   Bacillus amyloliquefaciens S499 AMP31635.1     2
 cellulase   Bacillus amyloliquefaciens T3 AWB51882.1     2
 BAMY6614_13370   Bacillus amyloliquefaciens UMAF6614 AMQ74283.1     2
 BAMY6639_00620   Bacillus amyloliquefaciens UMAF6639 AMQ71229.1     2
 endoglucanase A (EngA)   Bacillus amyloliquefaciens UMAS1002 AAL99668.1 Q8RPQ6   2
 BSO20_02700   Bacillus amyloliquefaciens WS-8 APQ49018.1     2
 BAMY_08970   Bacillus amyloliquefaciens Y14 APB82271.1     2
 MUS_2161 (BglC)   Bacillus amyloliquefaciens Y2 AFJ62120.1     2
 BaGK_15910 (fragment)   Bacillus atrophaeus GQJK17 ASS72344.1     2
 D068_cds30840 (fragment)   Bacillus atrophaeus UCMB-5137 AKL85635.1     2
 CY96_16600   Bacillus bombysepticus str. Wang AHX19543.1     48
 Bcell_1191   Bacillus cellulosilyticus DSM 2522 ADU29456.1 D2LUH5   4
 Bcell_3371   Bacillus cellulosilyticus DSM 2522 ADU31613.1 D2LQZ8   2
 endo-β-1,4-glucanase A (CelA;EgA;Bcell_0438) Bacillus cellulosilyticus DSM 2522 ADU28720.1
 endo-β-1,4-glucanase B (CelB;EgB;Bcell_0437) Bacillus cellulosilyticus DSM 2522 ADU28719.1
D2LVP0   2
 endo-β-1,4-glucanase C (CelC;EgC;Cel2;Bcell_3370) Bacillus cellulosilyticus DSM 2522 ADU31612.1
 B5E38_0519   Bacillus cereus 25 ARO58138.1     48
 DA68_13320   Bacillus cereus A1 ANE86586.1     48
 BCB4264_A3539   Bacillus cereus B4264 ACK60962.1 B7H8S5   48
 WR51_17990   Bacillus cereus CMCC P0011 ANC14724.1     48
 WR47_17990   Bacillus cereus CMCC P0021 ANC08907.1     48
 BA203_16885   Bacillus cereus D12_2 ASI75731.1     48
 FORC60_3446   Bacillus cereus FORC60 AVR33277.1     48
 FORC5_3317   Bacillus cereus FORC_005 AKE17854.1     48
 FORC13_4232   Bacillus cereus FORC_013 ALZ63293.1     48
 FORC47_3413   Bacillus cereus FORC_047 ASL66258.1     48
 FORC48_3449   Bacillus cereus FORC_048 ASI84531.1     48
 BCG9842_B1694   Bacillus cereus G9842 ACK97616.1 B7IRG0   48
 endo-β-1,4-glucanase (fragment)   Bacillus cereus IARI-SP-7 AGW99984.1     2
 BA204_16740   Bacillus cereus K8 ASJ49621.1     48
 BA201_17330   Bacillus cereus M13 ASK17637.1     48
 C1T25_10255   Bacillus cereus MBGJa3 AUZ28685.1     2
 CSW12_10225   Bacillus cereus MLY1 AUB63409.1     48
 ACN91_10355   Bacillus cereus NJ-W ALC55172.1     48
 C2I25_21980   Bacillus cereus TG1-6 AVP48902.1     48
 cellulase   Bacillus cereus Y5 AGK07581.1     48
 β-mannanase   Bacillus circulans AAS48170.1 Q6QHT4   8
 β-mannanase (TM1) Bacillus circulans AAT39478.1 Q6IUP2   8
 β-mannanase (Man1;ManB48) Bacillus circulans CGMCC 1416 AAX87002.1 Q49HI4   8
 β-mannanase (Man5A) Bacillus circulans CGMCC1554 AAX87003.1 Q0IJR6   8
 β-mannanase (G) Bacillus circulans K-1 BAA25878.1 O66185   8
 BC8716_04830   Bacillus clausii DSM 8716 AST98531.1     8
 DB29_01746   Bacillus clausii ENTPro ALA52574.1     8
 ABC0320   Bacillus clausii KSM-K16 BAD62862.1 Q5WL93   8
 BGM20_03610   Bacillus gibsonii FJAT-10019 AOL29768.1     2
 BGLY_1877   Bacillus glycinifermentans SCA85700.1     7
 BGLY_1876   Bacillus glycinifermentans SCA85699.1     4
 BGLY_2367 (Bglc2)   Bacillus glycinifermentans SCA86190.1     2
 COP00_03840   Bacillus glycinifermentans KBN06P03352 ATH91857.1     2
 β-glucanase (CelB;BhCel5B;BH0603) (Cel5B) Bacillus halodurans C-125 BAB04322.1
Q9KF82 4V2X[A] 4
 Cellulase (fragment)   Bacillus halodurans TSPV1 ALL28250.1     4
 BleG1_0468   Bacillus lehensis G1 AIC93076.1     54
 endo-β-1,4-glucanase, partial   Bacillus licheniformis AIY72754.1     2
 endo-β-1,4-glucanase, partial   Bacillus licheniformis AIY72755.1     2
 endo-β-1,4-glucanase, partial   Bacillus licheniformis AIY72756.1     2
 endo-β-1,4-glucanase (Egl01) Bacillus licheniformis AIY72753.1     2
 BL14DL4_04368   Bacillus licheniformis 14ADL4 AVI49505.1     4
 BL14DL4_00305   Bacillus licheniformis 14ADL4 AVI45571.1     2
 BL14DL4_04369   Bacillus licheniformis 14ADL4 AVI49506.1     7
 CPQ91_09265   Bacillus licheniformis ATCC 9789 ATI76022.1     7
 CPQ91_09260   Bacillus licheniformis ATCC 9789 ATI76021.1     4
 CPQ91_10290   Bacillus licheniformis ATCC 9789 ATI78443.1     2
 BL1202_02034   Bacillus licheniformis BL1202 AOP14982.1     4
 BL1202_02035   Bacillus licheniformis BL1202 AOP14983.1     7
 BL1202_02293   Bacillus licheniformis BL1202 AOP15241.1     2
 BLi01883 / BL01229   Bacillus licheniformis DSM 13 = ATCC 14580 AAU40778.1
Q65JI6   7
 endoglucanase (BlCel5B;BLi01882;BL01230) (Cel5B) Bacillus licheniformis DSM 13 = ATCC 14580 AAU40777.1
Q65JI7 4YZP[A]
 endo-β-1,4-glucanase C (BglC;BLi02088;BL01471) (Cel5A) Bacillus licheniformis DSM 13 = ATCC 14580 AAU23613.2
 endo-β-1,4-glucanase (CelA)   Bacillus licheniformis F11 CAJ70714.1 Q1EM84   2
 CelB   Bacillus licheniformis F11 CAJ70720.1 Q5K2M0   4

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