Glycoside Hydrolase Family 5

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (11393); Uniprot accession (1922); PDB accession (208); 3D entries (73); cryst (0)
All (10017) Archaea (67) Bacteria (7846) Eukaryota (1982) Viruses (5) unclassified (117) Structure (73) Characterized (547)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | ... | 79 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 CNX65_09135   Actinosynnema pretiosum X47 ATE53439.1     8
 CNX65_21150   Actinosynnema pretiosum X47 ATE55482.1     51
 CNX65_20680   Actinosynnema pretiosum X47 ATE55400.1     19
 ADH66_12235   Acutalibacter muris KB18 ASB41357.1     2
 ADH66_17150   Acutalibacter muris KB18 ASB42229.1     46
 AEQU_0542   Adlercreutzia equolifaciens DSM 19450 BAN76511.1     2
 AH4AK4_4038   Aeromonas hydrophila 4AK4 AHE51437.1     13
 AH4AK4_4042 (fragment)   Aeromonas hydrophila 4AK4 AHE51441.1     13
 B224_0634   Aeromonas media WS AHX59726.1     13
 B224_4215   Aeromonas media WS AHX62313.1     13
 Arad_4741   Agrobacterium radiobacter K84 ACM28380.1 B9JE34   46
 Arad_12368   Agrobacterium radiobacter K84 ACM31353.1 B9JQD4   12
 Arad_0393 (EgL)   Agrobacterium radiobacter K84 ACM25096.1 B9J6Z0   5
 BSY240_3431 (fragment)   Agrobacterium sp. RAC06 AOG10505.1     5
 Avi_6012   Agrobacterium vitis S4 ACM39029.1 B9K2D1   5
 ATC03_16595   Agromyces aureus AR33 ANJ28089.1     29
 ATC03_16080   Agromyces aureus AR33 ANJ28000.1     51
 SAMN04489721_1976   Agromyces flavus CPCC 202695 SDS82590.1     22
 APS56_15690   Algibacter alginicilyticus HZ22 ALJ06487.1     42
 β-1,4-mannanase   Alicyclobacillus acidocaldarius AAT47714.1     8
 endoglucanase (Glu1E)   Alicyclobacillus tengchongensis CGMCC 1504 AJD08472.1     37
 Alfi_1086   Alistipes finegoldii DSM 17242 AFL77440.1    
 Alfi_1589   Alistipes finegoldii DSM 17242 AFL77928.1     2
 AL1_13890   Alistipes shahii WAL 8301 CBK63843.1 D4ILN1  
 CDL62_06395   Alkalitalea saponilacus DSM 24412 ASB48785.1     21
 CDL62_08210   Alkalitalea saponilacus DSM 24412 ASB49124.1     26
 CDL62_05055   Alkalitalea saponilacus DSM 24412 ASB48549.1     46
 CDL62_01845   Alkalitalea saponilacus DSM 24412 ASB47982.1     25
 CDL62_01880   Alkalitalea saponilacus DSM 24412 ASB47989.1    
 CDL62_06245   Alkalitalea saponilacus DSM 24412 ASB48762.1     21
 CDL62_13665   Alkalitalea saponilacus DSM 24412 ASB50110.1     4
 SAMN04489726_7161   Allokutzneria albata DSM 44149 SDN55869.1     51
 SAMN04489726_1598   Allokutzneria albata DSM 44149 SDM43426.1    
 SAMN04489726_6883   Allokutzneria albata DSM 44149 SDN49924.1     43
 SAMN04489726_7657   Allokutzneria albata DSM 44149 SDN66578.1     2
 glycosyl hydrolase family 5_53 domain-containing protein   Alteromonadaceae bacterium Bs02 AIF91557.1     53
 glycosyl hydrolase family 5_8 and glycosyl hydrolase family 6 domain-containing protein   Alteromonadaceae bacterium Bs02 AIF91556.1     8
 glycosyl hydrolase family 5_2 domain-containing protein   Alteromonadaceae bacterium Bs08 AIF91547.1     2
 glycosyl hydrolase family 5_53 domain-containing protein   Alteromonadaceae bacterium Bs08 AIF91548.1     53
 glycosyl hydrolase family 5_8 domain-containing protein, partial   Alteromonadaceae bacterium Bs08 AIF91546.1     8
 glycosyl hydrolase family 5_53 domain-containing protein   Alteromonadaceae bacterium Bs08 AIF91545.1     53
 glycosyl hydrolase family GH5_53 domain-containing protein   Alteromonadaceae bacterium Bs12 AIF91526.1     53
 glycosyl hydrolase family 5_2 domain-containing protein   Alteromonadaceae bacterium Bs12 AIF91536.1     2
 glycosyl hydrolase family 5_53 domain-containing protein   Alteromonadaceae bacterium Bs12 AIF91542.1     53
 glycosyl hydrolase family 5_8 domain-containing protein   Alteromonadaceae bacterium Bs12 AIF91534.1     8
 glycosyl hydrolase family 5_53 domain-containing protein   Alteromonadaceae bacterium Bsc2 AIF91521.1     53
 AV939_12175   Alteromonas sp. Mac1 AMJ87257.1     41
 AV940_11940   Alteromonas sp. Mac2 AMJ91120.1     41
 A6F57_02120   Alteromonas stellipolaris PQQ-44 ANB24109.1     41
 AA2016_1400   Aminobacter aminovorans KCTC 2477 AMS40334.1    
 AA2016_1944   Aminobacter aminovorans KCTC 2477 AMS40874.1     48
 AXY_08250   Amphibacillus xylanus NBRC 15112 BAM46957.1     8
 AJAP_23210   Amycolatopsis japonica MG417-CF17 AIG77495.1     51
 AJAP_19810 (Cele2)   Amycolatopsis japonica MG417-CF17 AIG76823.1     2
 AJAP_11650 (Cele1)   Amycolatopsis japonica MG417-CF17 AIG75215.1     2
 SAMN04489733_2631   Amycolatopsis keratiniphila FH 1893 SDU27618.1     51
 SAMN04489733_0211   Amycolatopsis keratiniphila FH 1893 SDT99530.1     2
 SAMN04489733_1943   Amycolatopsis keratiniphila FH 1893 SDU19440.1     2
 BB31_41955   Amycolatopsis lurida NRRL 2430 AJK59464.1     2
 BB31_05885   Amycolatopsis lurida NRRL 2430 AJK53007.1     2
 B737_4049   Amycolatopsis mediterranei RB AGT84713.1     2
 B737_7271   Amycolatopsis mediterranei RB AGT87932.1     4
 B737_5130   Amycolatopsis mediterranei RB AGT85794.1     1
 B737_8016   Amycolatopsis mediterranei RB AGT88677.1     40
 B737_2653   Amycolatopsis mediterranei RB AGT83317.1     18
 B737_7302   Amycolatopsis mediterranei RB AGT87963.1     8
 B737_2348   Amycolatopsis mediterranei RB AGT83012.1     43
 RAM_38105   Amycolatopsis mediterranei S699 AEK46088.1
AFO80835.1
    8
 RAM_20880   Amycolatopsis mediterranei S699 AEK42656.1
AFO77585.1
    2
 RAM_13630   Amycolatopsis mediterranei S699 AEK41214.1
AFO76188.1
    18
 RAM_37950   Amycolatopsis mediterranei S699 AEK46057.1
AFO80804.1
    4
 RAM_41810   Amycolatopsis mediterranei S699 AEK46829.1
AFO81548.1
    40
 RAM_26450   Amycolatopsis mediterranei S699 AEK43767.1
AFO78666.1
    1
 RAM_12075   Amycolatopsis mediterranei S699 AEK40905.1
AFO75883.1
    43
 AMED_2374   Amycolatopsis mediterranei U32 ADJ44170.1 D8HUX2   43
 AMED_2681   Amycolatopsis mediterranei U32 ADJ44476.1 D8HY34   18
 AMED_4097   Amycolatopsis mediterranei U32 ADJ45874.1 D8HQ52   2
 AMED_5192   Amycolatopsis mediterranei U32 ADJ46955.1 D8I1M4   1
 AMED_7382   Amycolatopsis mediterranei U32 ADJ49096.1 D8I9C9   4
 AMED_7413   Amycolatopsis mediterranei U32 ADJ49127.1 D8I9G0   8
 AMED_8139   Amycolatopsis mediterranei U32 ADJ49840.1 D8HLV8   40
 SD37_27170   Amycolatopsis orientalis B-37 ANN18940.1     2
 SD37_17825   Amycolatopsis orientalis B-37 ANN17321.1     4
 SD37_19870   Amycolatopsis orientalis B-37 ANN17680.1     2
 SD37_21965   Amycolatopsis orientalis B-37 ANN21935.1     1
 SD37_23615   Amycolatopsis orientalis B-37 ANN18328.1     43
 SD37_16955   Amycolatopsis orientalis B-37 ANN17163.1     8
 SD37_26450   Amycolatopsis orientalis B-37 ANN22051.1     40
 AORI_3215   Amycolatopsis orientalis HCCB10007 AGM05800.1     51
 AORI_3875   Amycolatopsis orientalis HCCB10007 AGM06460.1     2
 AORI_5568   Amycolatopsis orientalis HCCB10007 AGM08151.1     2
 endo-β-1,4-glucanase (End2)   Anabaena laxa RPAN8 / CCC 381 ADE22239.1 D5KTA0  
 ANA_C11786   Anabaena sp. 90 AFW94547.1    
 ANT_03660   Anaerolinea thermophila UNI-1 BAJ62400.1     37
 ANT_22130   Anaerolinea thermophila UNI-1 BAJ64239.1     12
 ANT_18750   Anaerolinea thermophila UNI-1 BAJ63901.1     25
 BEQ56_08495   Anaerolineaceae bacterium oral taxon 439 W11661 AOH43511.1     4
 Anae109_4201   Anaeromyxobacter sp. Fw109-5 ABS28379.1 A7HI33  
 Anae109_3225   Anaeromyxobacter sp. Fw109-5 ABS27420.1 A7HFC4  
 GFC28_925   Anoxybacillus sp. B2M1 ANB56319.1     22
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