Glycoside Hydrolase Family 5

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (13513); Uniprot accession (1922); PDB accession (214); 3D entries (76); cryst (0)
All (12129) Archaea (93) Bacteria (9771) Eukaryota (2138) Viruses (7) unclassified (120) Structure (76) Characterized (549)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | ... | 98 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 AMIS_52810   Actinoplanes missouriensis 431 BAL90501.1     2
 AMIS_66390   Actinoplanes missouriensis 431 BAL91859.1    
 AMIS_9970   Actinoplanes missouriensis 431 BAL86217.1     4
 AMIS_23050   Actinoplanes missouriensis 431 BAL87525.1     8
 AMIS_23960   Actinoplanes missouriensis 431 BAL87616.1    
 AMIS_49860   Actinoplanes missouriensis 431 BAL90206.1     4
 AMIS_38990   Actinoplanes missouriensis 431 BAL89119.1     1
 AMIS_40420   Actinoplanes missouriensis 431 BAL89262.1     8
 L083_0808   Actinoplanes sp. N902-109 AGL14318.1     18
 L083_3363 (CelA)   Actinoplanes sp. N902-109 AGL16873.1     40
 L083_3484   Actinoplanes sp. N902-109 AGL16994.1     1
 L083_3663 (BglC)   Actinoplanes sp. N902-109 AGL17173.1     2
 L083_4706   Actinoplanes sp. N902-109 AGL18216.1     4
 L083_5388   Actinoplanes sp. N902-109 AGL18898.1     8
 ACWT_6045   Actinoplanes sp. SE50 ATO85460.1     2
 ACWT_5047   Actinoplanes sp. SE50 ATO84462.1     2
 ACWT_6771   Actinoplanes sp. SE50 ATO86186.1    
 ACWT_6205   Actinoplanes sp. SE50 ATO85620.1     40
 ACWT_5998   Actinoplanes sp. SE50 ATO85413.1     4
 ACWT_3970   Actinoplanes sp. SE50 ATO83385.1     1
 ACWT_2150   Actinoplanes sp. SE50 ATO81565.1    
 ACWT_2785   Actinoplanes sp. SE50 ATO82200.1    
 ACWT_3746   Actinoplanes sp. SE50 ATO83161.1    
 ACWT_4871   Actinoplanes sp. SE50 ATO84286.1    
 ACPL_4099   Actinoplanes sp. SE50/110 AEV84994.1
SLM00792.1
    1
 ACPL_5001   Actinoplanes sp. SE50/110 AEV85890.1
SLM01696.1
   
 ACPL_5177 (BglC)   Actinoplanes sp. SE50/110 AEV86064.1
SLM01872.1
    2
 ACPL_6130   Actinoplanes sp. SE50/110 AEV87015.1
SLM02825.1
    4
 ACPL_6177 (BglC)   Actinoplanes sp. SE50/110 AEV87062.1
SLM02872.1
    2
 ACPL_6337 (CelA)   Actinoplanes sp. SE50/110 AEV87219.1
SLM03033.1
    40
 ACPL_2275   Actinoplanes sp. SE50/110 AEV83172.1
SLL98973.1
   
 ACPL_2761   Actinoplanes sp. SE50/110 AEV83656.1
SLL99607.1
   
 ACPL_3874   Actinoplanes sp. SE50/110 AEV84769.1
SLM00568.1
   
 ACPL_6902   Actinoplanes sp. SE50/110 AEV87784.1
SLM03600.1
   
 SAMN04489717_0883   Actinopolymorpha singaporensis DSM 22024 SDR87823.1     7
 SAMN04489717_1670   Actinopolymorpha singaporensis DSM 22024 SDS11517.1     4
 SAMN04489717_2988   Actinopolymorpha singaporensis DSM 22024 SDS53076.1     1
 CDG81_12880   Actinopolyspora erythraea YIM 90600 ASU79031.1     19
 CDG81_11150   Actinopolyspora erythraea YIM 90600 ASU78741.1    
 CDG81_11260   Actinopolyspora erythraea YIM 90600 ASU78759.1     19
 Amir_1830   Actinosynnema mirum DSM 43827 ACU35778.1 C6WE35   8
 Amir_4131   Actinosynnema mirum DSM 43827 ACU37986.1 C6WH67   19
 Amir_4152   Actinosynnema mirum DSM 43827 ACU38007.1 C6WH88   8
 Amir_4607   Actinosynnema mirum DSM 43827 ACU38440.1 C6WLP7   18
 Amir_2781   Actinosynnema mirum DSM 43827 ACU36714.1 C6WP45   4
 Amir_3216   Actinosynnema mirum DSM 43827 ACU37124.1 C6W8M5   1
 Amir_3335   Actinosynnema mirum DSM 43827 ACU37240.1 C6W9M3   4
 Amir_4225   Actinosynnema mirum DSM 43827 ACU38080.1 C6WHG1   51
 Amir_6164   Actinosynnema mirum DSM 43827 ACU39971.1 C6WHM2   43
 asmnew07   Actinosynnema pretiosum subsp. auranticum ATCC 31565 AEC53450.1     1
 CNX65_14080   Actinosynnema pretiosum X47 ATE54282.1     4
 CNX65_22910   Actinosynnema pretiosum X47 ATE55778.1     18
 CNX65_20775   Actinosynnema pretiosum X47 ATE55417.1     8
 CNX65_16395   Actinosynnema pretiosum X47 ATE54663.1     1
 CNX65_30350   Actinosynnema pretiosum X47 ATE57059.1     43
 CNX65_09135   Actinosynnema pretiosum X47 ATE53439.1     8
 CNX65_21150   Actinosynnema pretiosum X47 ATE55482.1     51
 CNX65_20680   Actinosynnema pretiosum X47 ATE55400.1     19
 ADH66_12235   Acutalibacter muris KB18 ASB41357.1     2
 ADH66_17150   Acutalibacter muris KB18 ASB42229.1     46
 AEQU_0542   Adlercreutzia equolifaciens DSM 19450 BAN76511.1     2
 AH4AK4_4038   Aeromonas hydrophila 4AK4 AHE51437.1     13
 AH4AK4_4042 (fragment)   Aeromonas hydrophila 4AK4 AHE51441.1     13
 B224_0634   Aeromonas media WS AHX59726.1     13
 B224_4215   Aeromonas media WS AHX62313.1     13
 Arad_4741   Agrobacterium radiobacter K84 ACM28380.1 B9JE34   46
 Arad_12368   Agrobacterium radiobacter K84 ACM31353.1 B9JQD4   12
 Arad_0393 (EgL)   Agrobacterium radiobacter K84 ACM25096.1 B9J6Z0   5
 BSY240_3431 (fragment)   Agrobacterium sp. RAC06 AOG10505.1     5
 Avi_6012   Agrobacterium vitis S4 ACM39029.1 B9K2D1   5
 ATC03_16595   Agromyces aureus AR33 ANJ28089.1     29
 ATC03_16080   Agromyces aureus AR33 ANJ28000.1     51
 SAMN04489721_1976   Agromyces flavus CPCC 202695 SDS82590.1     22
 C7S18_08240   Ahniella affigens D13 AVP97183.1    
 APS56_15690   Algibacter alginicilyticus HZ22 ALJ06487.1     42
 β-1,4-mannanase   Alicyclobacillus acidocaldarius AAT47714.1     8
 endoglucanase (Glu1E)   Alicyclobacillus tengchongensis CGMCC 1504 AJD08472.1     37
 Alfi_1086   Alistipes finegoldii DSM 17242 AFL77440.1    
 Alfi_1589   Alistipes finegoldii DSM 17242 AFL77928.1     2
 AL1_13890   Alistipes shahii WAL 8301 CBK63843.1 D4ILN1  
 CDL62_06395   Alkalitalea saponilacus DSM 24412 ASB48785.1     21
 CDL62_08210   Alkalitalea saponilacus DSM 24412 ASB49124.1     26
 CDL62_05055   Alkalitalea saponilacus DSM 24412 ASB48549.1     46
 CDL62_01845   Alkalitalea saponilacus DSM 24412 ASB47982.1     25
 CDL62_01880   Alkalitalea saponilacus DSM 24412 ASB47989.1    
 CDL62_06245   Alkalitalea saponilacus DSM 24412 ASB48762.1     21
 CDL62_13665   Alkalitalea saponilacus DSM 24412 ASB50110.1     4
 SAMN04489726_7161   Allokutzneria albata DSM 44149 SDN55869.1     51
 SAMN04489726_1598   Allokutzneria albata DSM 44149 SDM43426.1    
 SAMN04489726_6883   Allokutzneria albata DSM 44149 SDN49924.1     43
 SAMN04489726_7657   Allokutzneria albata DSM 44149 SDN66578.1     2
 glycosyl hydrolase family 5_53 domain-containing protein   Alteromonadaceae bacterium Bs02 AIF91557.1     53
 glycosyl hydrolase family 5_8 and glycosyl hydrolase family 6 domain-containing protein   Alteromonadaceae bacterium Bs02 AIF91556.1     8
 glycosyl hydrolase family 5_2 domain-containing protein   Alteromonadaceae bacterium Bs08 AIF91547.1     2
 glycosyl hydrolase family 5_53 domain-containing protein   Alteromonadaceae bacterium Bs08 AIF91548.1     53
 glycosyl hydrolase family 5_8 domain-containing protein, partial   Alteromonadaceae bacterium Bs08 AIF91546.1     8
 glycosyl hydrolase family 5_53 domain-containing protein   Alteromonadaceae bacterium Bs08 AIF91545.1     53
 glycosyl hydrolase family GH5_53 domain-containing protein   Alteromonadaceae bacterium Bs12 AIF91526.1     53
 glycosyl hydrolase family 5_2 domain-containing protein   Alteromonadaceae bacterium Bs12 AIF91536.1     2
 glycosyl hydrolase family 5_53 domain-containing protein   Alteromonadaceae bacterium Bs12 AIF91542.1     53
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