Glycoside Hydrolase Family 5

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (11690); Uniprot accession (1922); PDB accession (209); 3D entries (74); cryst (0)
All (10313) Archaea (67) Bacteria (8119) Eukaryota (2005) Viruses (5) unclassified (117) Structure (74) Characterized (547)
| 1 | ... | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | ... | 82 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 B2258_1115   Bifidobacterium breve NCFB 2258 AHJ21311.1     18
 B2258_1417   Bifidobacterium breve NCFB 2258 AHJ21603.1     44
 BS27_1462   Bifidobacterium breve S27 AHJ25238.1     44
 BS27_1164   Bifidobacterium breve S27 AHJ24964.1     18
 Bbr_1144   Bifidobacterium breve UCC2003 ABE95822.1     18
 Bbr_1438   Bifidobacterium breve UCC2003 ABE96110.1     44
 BBCT_1303   Bifidobacterium catenulatum DSM 16992 = JCM 1194 = LMG 11043 BAR02271.1     44
 BBCT_1301   Bifidobacterium catenulatum DSM 16992 = JCM 1194 = LMG 11043 BAR02269.1     44
 BcFMB_00600   Bifidobacterium choerinum FMB-1 ATU19681.1     2
 BDP_1678   Bifidobacterium dentium Bd1 ADB10270.1 D2Q5Q5   44
 BDP_1679   Bifidobacterium dentium Bd1 ADB10271.1 D2Q5Q6   44
 BDP_2147   Bifidobacterium dentium Bd1 ADB10705.1 D2Q7E3   4
 BDP_2148   Bifidobacterium dentium Bd1 ADB10706.1 D2Q7E4   4
 BBDE_2018   Bifidobacterium dentium JCM 1195 = DSM 20436 BAQ28012.1     4
 BBDE_1592   Bifidobacterium dentium JCM 1195 = DSM 20436 BAQ27586.1     44
 BBDE_1593   Bifidobacterium dentium JCM 1195 = DSM 20436 BAQ27587.1     44
 BBDE_2017   Bifidobacterium dentium JCM 1195 = DSM 20436 BAQ28011.1     4
 BBKW_1501   Bifidobacterium kashiwanohense JCM 15439 = DSM 21854 BAQ29636.1     44
 AH68_07950   Bifidobacterium kashiwanohense PV20-2 AIZ14998.1     44
 AH68_07940   Bifidobacterium kashiwanohense PV20-2 AIZ14996.1     44
 BL105A_1466   Bifidobacterium longum 105-A BAP84090.1     44
 BL105A_1220   Bifidobacterium longum 105-A BAP83849.1     18
 B624_1382   Bifidobacterium longum 35624 AOL10833.1     44
 BBG7_1331   Bifidobacterium longum BG7 ALE36519.1     18
 BBG7_1592   Bifidobacterium longum BG7 ALE36779.1     44
 GS08_07990   Bifidobacterium longum BXY01 AIF91045.1     44
 GS08_06665   Bifidobacterium longum BXY01 AIF90798.1     18
 BLD_1938 (BglC)   Bifidobacterium longum DJO10A ACD99383.1     44
 BLD_0195   Bifidobacterium longum DJO10A ACD97641.1 B3DQP5   18
 BL1333   Bifidobacterium longum NCC2705 AAN25133.1
NP_696497.1
Q8G4P5   18
 BL1761   Bifidobacterium longum NCC2705 AAN25544.1
NP_696908.1
Q8G3J8   44
 SAMN04489749_0603   Bifidobacterium longum Su859 SDO39948.1     44
 SAMN04489749_0829   Bifidobacterium longum Su859 SDO44614.1     18
 BLIF_1312   Bifidobacterium longum subsp. infantis 157F BAJ71452.1     18
 BLIF_1557   Bifidobacterium longum subsp. infantis 157F BAJ71695.1     44
 Blon_0621   Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088 ACJ51728.1 B7GPJ8   44
 Blon_2377   Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088 ACJ53432.1 B7GNS6   18
 BLIJ_2448   Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088 BAJ70025.1     18
 BLIJ_0626   Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088 BAJ68219.1     44
 RY67_1342   Bifidobacterium longum subsp. infantis BT1 ALE09362.1     44
 RY67_1643   Bifidobacterium longum subsp. infantis BT1 ALE09655.1     18
 RY67_518   Bifidobacterium longum subsp. infantis BT1 ALE08581.1     18
 BL1206_1618   Bifidobacterium longum subsp. longum AH1206 AOP01655.1     44
 BBMN68_220   Bifidobacterium longum subsp. longum BBMN68 ADQ02913.1 E4R1Y2   18
 BBMN68_1793   Bifidobacterium longum subsp. longum BBMN68 ADQ02850.1 E4R3Z1   44
 BBL306_1348   Bifidobacterium longum subsp. longum CCUG30698 ALO74877.1     18
 BBL306_1734   Bifidobacterium longum subsp. longum CCUG30698 ALO75263.1     44
 BIL_02210   Bifidobacterium longum subsp. longum F8 CBK69899.1 D6DBM8   44
 BIL_06980   Bifidobacterium longum subsp. longum F8 CBK70291.1 D6DCS0   18
 BLGT_06810   Bifidobacterium longum subsp. longum GT15 AIW44813.1     18
 BLGT_08000   Bifidobacterium longum subsp. longum GT15 AIW44128.1     44
 BLLJ_1498 (possible fragment)   Bifidobacterium longum subsp. longum JCM 1217 BAJ67165.1     44
 BLJ_1536   Bifidobacterium longum subsp. longum JDM301 ADH00979.1 D6ZVS3   44
 BLJ_1281   Bifidobacterium longum subsp. longum JDM301 ADH00732.1 D6ZV26   18
 BLNIAS_00618   Bifidobacterium longum subsp. longum KACC 91563 AEI96988.1     44
 B8809_1374   Bifidobacterium longum subsp. longum NCIMB8809 ALO73045.1     44
 B8809_1134   Bifidobacterium longum subsp. longum NCIMB8809 ALO72805.1     18
 BIP_14810   Bifidobacterium pseudocatenulatum D2CA CBK72652.1     44
 BIP_14830 (fragment)   Bifidobacterium pseudocatenulatum D2CA CBK72654.1    
 BBPC_1381   Bifidobacterium pseudocatenulatum DSM 20438 = JCM 1200 = LMG 10505 BAR04059.1     44
 BBPC_1383   Bifidobacterium pseudocatenulatum DSM 20438 = JCM 1200 = LMG 10505 BAR04061.1     44
 Bgl2 (fragment)   Bifidobacterium scardovii BAA-773 ACV66983.1 C9DIJ3  
 BBSC_1812   Bifidobacterium scardovii JCM 12489 = DSM 13734 BAQ31892.1     18
 BBSC_1966   Bifidobacterium scardovii JCM 12489 = DSM 13734 BAQ32046.1     44
 D805_0070 (fragment)   Bifidobacterium thermophilum RBL67 AGH40337.1     44
 D805_1196   Bifidobacterium thermophilum RBL67 AGH41463.1     2
 D805_0646   Bifidobacterium thermophilum RBL67 AGH40913.1     2
 B5J99_11580   Blastomonas fulva T2 ASR52020.1    
 BSY18_469   Blastomonas sp. RAC04 AOF99486.1    
 ADH70_005020   Blautia coccoides YL58 ASU28285.1     44
 A4V09_06660   Blautia sp. YL58 ANU75476.1     44
 B0B51_10750   blood disease bacterium A2-HR MARDI AQW31539.1     5
 endoglucanase (fragment)   blood disease bacterium R223 AAY33899.1 Q4U4W3   5
 BDB_120007 (EgL)   blood disease bacterium R229 CCA80961.1     5
 Egl (fragment)   blood disease bacterium R229 MAFF301552 ADD24725.1 D3XCB3   5
 endoglucanase (fragment)   blood disease bacterium R233 AAY33903.1 Q4U4V9   5
 endoglucanase (fragment)   blood disease bacterium R506 AAY33900.1 Q4U4W2   5
 endoglucanase (fragment)   blood disease bacterium T520 AAS46799.1 Q5DSS9   5
 endoglucanase (fragment)   blood disease bacterium T633 AAS46800.1 Q5DSS8   5
 endoglucanase (fragment)   blood disease bacterium Y1 AAY33917.1 Q4U4U5   5
 AXW83_21500   Bosea sp. PAMC 26642 AMJ62536.1    
 AXW83_03360   Bosea sp. PAMC 26642 AMJ59468.1    
 BHK69_14820   Bosea vaviloviae Vaf18 AOO81558.1    
 Bfae_10930   Brachybacterium faecium DSM 4810 ACU84941.1 C7MBG8   18
 CFK41_16325   Brachybacterium ginsengisoli DCY80 ATG56168.1     46
 CFK41_08345   Brachybacterium ginsengisoli DCY80 ATG54776.1     18
 BH708_13780   Brachybacterium sp. P6-10-X1 APX33606.1     18
 BH708_03855   Brachybacterium sp. P6-10-X1 APX32004.1     18
 CFK38_00380   Brachybacterium sp. VM2412 ATG50144.1    
 CFK38_10445   Brachybacterium sp. VM2412 ATG51890.1     18
 CFK39_10330   Brachybacterium sp. VR2415 ASK66143.1    
 CFK39_00935   Brachybacterium sp. VR2415 ASK64645.1     18
 NK6_7446   Bradyrhizobium diazoefficiens NK6 BAR60597.1     25
 AAV28_13865   Bradyrhizobium diazoefficiens USDA 110 AND88774.1     25
 blr3367   Bradyrhizobium diazoefficiens USDA 110 NP_770007.1
BAC48632.1
Q89PW3   25
 BD122_29925   Bradyrhizobium diazoefficiens USDA 122 APO54584.1     25
 RN69_31130   Bradyrhizobium japonicum E109 AJA64257.1     25
 BKD09_RS33400   Bradyrhizobium japonicum J5 APG13256.1     25
 BJS_06698   Bradyrhizobium japonicum SEMIA 5079 AHY51746.1     25
 BJ6T_64240   Bradyrhizobium japonicum USDA 6 BAL11673.1     25
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