Glycoside Hydrolase Family 5

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (13847); Uniprot accession (1922); PDB accession (214); 3D entries (76); cryst (0)
All (12457) Archaea (93) Bacteria (10095) Eukaryota (2141) Viruses (7) unclassified (121) Structure (76) Characterized (550)
| 1 | ... | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | ... | 101 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 HD73_3790   Bacillus thuringiensis serovar kurstaki str. HD73 AGE79368.1     48
 DF16_orf02442 (BglC)   Bacillus thuringiensis serovar kurstaki str. YBT-1520 AIM30857.1     48
 YBT1520_18690   Bacillus thuringiensis serovar kurstaki str. YBT-1520 AHZ52363.1     48
 SD98_18215   Bacillus thuringiensis serovar morrisoni BGSC 4AA1 AJQ62320.1     48
 H175_ch3513   Bacillus thuringiensis serovar thuringiensis str. IS5056 AGG02225.1     48
 BG07_1333   Bacillus thuringiensis str. Al Hakam AJI15237.1     48
 BG07_59 (fragment)   Bacillus thuringiensis str. Al Hakam AJI17850.1     48
 YBT1518_19285   Bacillus thuringiensis YBT-1518 AHA72997.1     48
 XI92_25155   Bacillus thuringiensis YC-10 AKJ62307.1     48
 BVH75_15275   Bacillus thuringiensis YGD22-03 ARX69947.1     48
 BVH75_30260   Bacillus thuringiensis YGD22-03 ARX70213.1     28
 AQ980_12375   Bacillus thuringiensis YWC2-8 ALL61887.1     48
 B9C48_09240   Bacillus vallismortis NBIF-001 ARM28000.1     2
 C0W57_06835   Bacillus velezensis 10075 AUS15916.1     2
 CFN60_09420   Bacillus velezensis 157 ASK58591.1     2
 BK055_10270   Bacillus velezensis 9912D APA02899.1     2
 B7941_11800   Bacillus velezensis 9D-6 ARJ75167.1     2
 RZ52_09125   Bacillus velezensis AP183 AWK46308.1     2
 B938_09365   Bacillus velezensis AS43.3 AFZ90893.1     2
 BMJ37_09290   Bacillus velezensis ATR2 ATU26929.1     2
 BAMMD1_1755 (EglS)   Bacillus velezensis B25 CUX93659.1     2
 D3C60_09205   Bacillus velezensis BIM B-439D AXY37919.1     2
 CMR26_07555   Bacillus velezensis BS-37 AWG38431.1     2
 BACAU_1766 (BglC)   Bacillus velezensis CAU B946 CCF05300.1     2
 BCBMB205_18710   Bacillus velezensis CBMB205 ANF36769.1
ARN87289.1
    2
 A1D33_000185   Bacillus velezensis CC09 ANB45748.1     2
 C3Z10_09765   Bacillus velezensis CGMCC 11640 AVI28645.1     2
 CVD07_09175   Bacillus velezensis CN026 ATY28447.1     2
 A2I97_08780   Bacillus velezensis D2-2 AOU01160.1     2
 DA376_09390   Bacillus velezensis DR-08 AVV94124.1     2
 BVDSYZ_09785   Bacillus velezensis DSYZ AWX72297.1     2
 RBAM_018100   Bacillus velezensis FZB42 CAE11243.1
ABS74173.1
    2
 ABH13_1848   Bacillus velezensis G341 AKL76432.1     2
 B6257_19060   Bacillus velezensis GFP-2 AUJ62547.1     2
 BAGQ_1973   Bacillus velezensis GQJK49 ARZ58207.1     2
 B9C53_00960   Bacillus velezensis GYL4 AWD12147.1     2
 B7L90_08260   Bacillus velezensis Hx05 AWM83213.1     2
 CJP14_07175   Bacillus velezensis J01 ASZ03660.1     2
 AAV29_08940   Bacillus velezensis JJ-D34 AKF30670.1     2
 NG74_01886 (EglS)   Bacillus velezensis JS25R AIU81966.1     2
 BAJT_09240   Bacillus velezensis JTYP2 ARB33457.1     2
 CRH11_14675   Bacillus velezensis L-1 ATO11163.1     2
 CQJ38_09320   Bacillus velezensis LABIM40 ATL39711.1     2
 DDE72_07450   Bacillus velezensis LM23DO2 AWE16031.1     2
 A8142_08875   Bacillus velezensis LS69 ANU30279.1     2
 CXP43_10450   Bacillus velezensis Lzh-a42 AUG36120.1     2
 BBJ33_09410   Bacillus velezensis M75 AOO61741.1     2
 BAPNAU_1934 (BglC)   Bacillus velezensis NAU-B3 CDH95715.1     2
 AW02_018440 (BglC)   Bacillus velezensis NJN-6 AKD29994.1     2
 D0U03_09300   Bacillus velezensis OSY-GA1 AXT12600.1     2
 alkali tolerable endoglucanase, partial (Ega5)   Bacillus velezensis Q5 ALE32753.1     2
 BVQ_09580   Bacillus velezensis QST713 AWD87699.1     2
 endoglucanase (EglS)   Bacillus velezensis RS1 AUB45040.1     2
 BVS141_18850 (EglS)   Bacillus velezensis S141 BBA76409.1     2
 A5891_09010   Bacillus velezensis S3-1 ANS38519.1     2
 CHN56_00337 (EglS)   Bacillus velezensis SCDB 291 ASS60881.1     2
 CLI97_03910 (EglS)   Bacillus velezensis SCGB 1 ATC53134.1     2
 CLI98_03744 (EglS)   Bacillus velezensis SCGB 574 ATD76966.1     2
 C1N92_00760   Bacillus velezensis SGAir0473 AWQ13510.1     2
 V529_17790 (BglC)   Bacillus velezensis SQR9 AHZ15805.1     2
 S100072_01973   Bacillus velezensis SRCM100072 ASB53309.1     2
 S101413_02134   Bacillus velezensis SRCM101413 ASB65581.1     2
 BLL65_09625   Bacillus velezensis sx01604 AQZ73217.1     2
 CEG11_09415   Bacillus velezensis T20E-257 ASF55305.1     2
 CG798_14945   Bacillus velezensis TB1501 ASP26388.1     2
 AJ82_10290   Bacillus velezensis TrigoCor1448 AHK49356.1     2
 RBAU_1784 (EglS)   Bacillus velezensis UCMB5033 CDG29752.1     2
 BAM5036_1746 (EglS)   Bacillus velezensis UCMB5036 CCP21786.1     2
 BASU_1764 (EglS)   Bacillus velezensis UCMB5113 CDG26057.1     2
 C6P48_09830   Bacillus velezensis VCC-2003 AVM08503.1     2
 BANAU_1935 (BglC)   Bacillus velezensis YAU B9601-Y2 CCG49956.1     2
 AAV30_10320   Bacillus velezensis YJ11-1-4 AKF76524.1     2
 D3N19_09300   Bacillus velezensis ZF2 AXY70422.1     2
 BK049_00270   Bacillus xiamenensis VV3 AOZ87243.1     7
 cellulase   bacterium enrichment culture AJO67866.1     4
 cellulase (CelA10) 3.2.1.4 bacterium enrichment culture clone CelA10 ACR23656.1 C5HG53   2
 cellulase (CelA24) 3.2.1.4 bacterium enrichment culture clone CelA24 ACR23659.1 C5HG56   26
 endoglucanase (Cel5) (Cel5A) 3.2.1.4 bacterium enrichment culture clone FV-Cel5A AEL31246.1     2
 endoglucanase (Cel17) (Cel5B) 3.2.1.4 bacterium enrichment culture clone FXVII-Cel5B AEL31247.1     1
 BRDCF_09535   Bacteroidales bacterium CF AGX08895.1
AGY54507.1
    7
 BACCELL_03415   Bacteroides cellulosilyticus DSM 14838 EEF88964.1     21
 BcellWH2_02030 (EglS)   Bacteroides cellulosilyticus WH2 ALJ59275.1     2
 BcellWH2_02825 (Xynb_4)   Bacteroides cellulosilyticus WH2 ALJ60064.1     21
 BcellWH2_04303   Bacteroides cellulosilyticus WH2 ALJ61520.1     21
 BcellWH2_02558   Bacteroides cellulosilyticus WH2 ALJ59797.1     46
 BcellWH2_03343 (Cela_1)   Bacteroides cellulosilyticus WH2 ALJ60576.1     4
 BcellWH2_02031   Bacteroides cellulosilyticus WH2 ALJ59276.1     7
 BcellWH2_03344 (Cela_2)   Bacteroides cellulosilyticus WH2 ALJ60577.1     4
 EL88_18305   Bacteroides dorei isolate HS1_L1_B_010 AII64978.1     7
 endoxylanase (ORF1299;BACEGG_01299) (BeXyn5A) 3.2.1.8 Bacteroides eggerthii DSM 20697 EEC54456.1 B7AFX5   21
 BF638R_0823   Bacteroides fragilis 638R CBW21396.1 E1WLN2   7
 MB0529_00763   Bacteroides fragilis BE1 CUA17419.1     7
 VU15_03540   Bacteroides fragilis BOB25 AKA54083.1     7
 BUN20_01115   Bacteroides fragilis Q1F2 AUI45335.1     7
 AE940_01030   Bacteroides fragilis S14 ANQ62842.1     7
 BF0840   Bacteroides fragilis YCH46 BAD47591.1 Q64Y35   7
 Bache_0234   Bacteroides helcogenes P 36-108 ADV42264.1     7
 Bache_0610   Bacteroides helcogenes P 36-108 ADV42635.1     46
 C3V43_14535   Bacteroides heparinolyticus F0111 AVM59109.1     7
 C3V43_09000   Bacteroides heparinolyticus F0111 AVM57877.1     21
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