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Glycoside Hydrolase Family 5

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (14935); Uniprot accession (1921); PDB accession (224); 3D entries (78); cryst (0)
Summary
All (13534) Archaea (95) Bacteria (11085) Eukaryota (2219) Viruses (8) unclassified (127) Structure (78) Characterized (563)
| 1 | ... | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | ... | 111 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 ES968_09975   Bacillus subtilis SRCM103697 QAW04318.1     2
 ETA10_09875   Bacillus subtilis SRCM103773 QAW12463.1     2
 ETA18_09865   Bacillus subtilis SRCM103835 QAW20823.1     2
 ETA19_09865   Bacillus subtilis SRCM103837 QAW16732.1     2
 EQH88_10175   Bacillus subtilis SRCM103862 QAR96979.1     2
 EQI56_09700   Bacillus subtilis SRCM103881 QAR83559.1     2
 EQH95_10430   Bacillus subtilis SRCM103886 QAR79504.1     2
 EQI27_10020   Bacillus subtilis SRCM103923 QAS12184.1     2
 EQI87_10175   Bacillus subtilis SRCM103971 QAR92862.1     2
 EQI48_09930   Bacillus subtilis SRCM104005 QAS08050.1     2
 EQJ08_09725   Bacillus subtilis SRCM104008 QAS20594.1     2
 EQJ84_09725   Bacillus subtilis SRCM104011 QAS03980.1     2
 endo-β-1,4-glucanase   Bacillus subtilis SSA2 ALL27206.1     2
 AN935_09445   Bacillus subtilis subsp. inaquosorum DE111 AMA52498.1     2
 DKG76_10225   Bacillus subtilis subsp. inaquosorum KCTC 13429 AWM17127.1     2
 BSNT_02999 (BglC;EglS)   Bacillus subtilis subsp. natto BEST195 BAI85501.1 D4FXC0   2
 AWV81_10300   Bacillus subtilis subsp. natto CGMCC 2108 AMK72491.1     2
 SD85_09595   Bacillus subtilis subsp. spizizenii NRS 231 AJD36478.1     2
 BSUW23_09325 (EglS)   Bacillus subtilis subsp. spizizenii str. W23 ADM37911.1 E0TWG4   2
 DQ231_09570   Bacillus subtilis subsp. spizizenii SW83 AXC53088.1     2
 GYO_2183   Bacillus subtilis subsp. spizizenii TU-B-10 AEP86815.1     2
 BFI33_09960   Bacillus subtilis subsp. subtilis 168G AOA11130.1     2
 D9C08_13840   Bacillus subtilis subsp. subtilis 2KL1 AYL01429.1     2
 D9C12_11780   Bacillus subtilis subsp. subtilis 2RL2-3 AYK74463.1     2
 RP72_09860   Bacillus subtilis subsp. subtilis 3NA AJE94503.1     2
 BSU6051_18130 (EglS)   Bacillus subtilis subsp. subtilis 6051-HGW AGG61188.1     2
 AT706_08820   Bacillus subtilis subsp. subtilis BSD-2 ALS82012.1     2
 endo-1,4-β-glucanase (EglS)   Bacillus subtilis subsp. subtilis BTN7A AIO08301.1     2
 AWM80_09840   Bacillus subtilis subsp. subtilis CU1050 AMB24249.1     2
 A8O17_09375   Bacillus subtilis subsp. subtilis delta6 ANJ30819.1     2
 DL538_10180   Bacillus subtilis subsp. subtilis G7 QBJ82393.1     2
 D9C09_13990   Bacillus subtilis subsp. subtilis GFR-12 AYK70778.1     2
 BEN36_07350   Bacillus subtilis subsp. subtilis IIG-Bs27-47-24 ANY32358.1     2
 DYS67_09720   Bacillus subtilis subsp. subtilis IITK SM1 AXP48504.1     2
 AS891_14270   Bacillus subtilis subsp. subtilis KCTC 3135 ANX08323.1     2
 endo-β-1,4-glucanase (EglS)   Bacillus subtilis subsp. subtilis M 015 AKC00620.1     2
 D9C10_08065   Bacillus subtilis subsp. subtilis MH-1 AYK57135.1     2
 D9C16_03445   Bacillus subtilis subsp. subtilis N1-1 AYK85581.1     2
 D9C17_00520   Bacillus subtilis subsp. subtilis N2-2 AYK89166.1     2
 D9C18_21995   Bacillus subtilis subsp. subtilis N3-1 AYK84702.1     2
 D9C20_20175   Bacillus subtilis subsp. subtilis N4-2 AYK80242.1     2
 BEP06_07030   Bacillus subtilis subsp. subtilis PG10 ANY35199.1     2
 D9C11_22230   Bacillus subtilis subsp. subtilis PJ-7 AYK67880.1     2
 BEP07_07080   Bacillus subtilis subsp. subtilis PS38 ANY37961.1     2
 BHY07_09960   Bacillus subtilis subsp. subtilis QB5412 AOT48097.1     2
 S100333_02083   Bacillus subtilis subsp. subtilis SRCM100333 ASB69976.1     2
 S100757_02006   Bacillus subtilis subsp. subtilis SRCM100757 ARW02937.1     2
 S100761_02016   Bacillus subtilis subsp. subtilis SRCM100761 ASB57345.1     2
 S101392_02048   Bacillus subtilis subsp. subtilis SRCM101392 ASB93521.1     2
 S101444_02015   Bacillus subtilis subsp. subtilis SRCM101444 ARV98863.1     2
 D9C14_18840   Bacillus subtilis subsp. subtilis SSJ-1 AYK63269.1     2
 endo-β-1,4-glucanase (EglS;BglC;Gld;BSU18130;BsCel5;BsCel5A) (Cel5A) 3.2.1.4 Bacillus subtilis subsp. subtilis str. 168 CAA82317.1
AEJ76923.1
AIY93123.1
AQR81804.1
AQR86018.1
CAA97610.1
CAB13696.2
NP_389695.1		 P10475 3PZT[A,B]
3PZU[A,B]
3PZV[A,B,C,D] 		2
 BSUB_01951 (EglS)   Bacillus subtilis subsp. subtilis str. AG1839 AIC44469.1     2
 I653_09410   Bacillus subtilis subsp. subtilis str. BAB-1 AGI29134.1     2
 A7A1_0701   Bacillus subtilis subsp. subtilis str. BSP1 AGA21319.1     2
 BSUA_01951 (EglS)   Bacillus subtilis subsp. subtilis str. JH642 substr. AG174 AIC40237.1     2
 Q433_10715   Bacillus subtilis subsp. subtilis str. OH 131.1 AIC98399.1     2
 I33_2031   Bacillus subtilis subsp. subtilis str. RO-NN-1 AEP90990.1     2
 endo-β-1,4-glucanase 3.2.1.4 Bacillus subtilis subsp. subtilis UMC7 AGG11030.1     2
 BSSX_2016   Bacillus subtilis SX01705 ASK23911.1     2
 endo-β-1,4-glucanase (fragment)   Bacillus subtilis SYYS AFV95351.1     2
 A3772_09840   Bacillus subtilis SZMC 6179J AMS47376.1     2
 β-1,4-endo-glucanase, partial (fragment)   Bacillus subtilis T28d AHD24514.1     2
 BIS30_19935   Bacillus subtilis T30 AJW87252.1     2
 β-1,4-endo-glucanase, partial (fragment)   Bacillus subtilis t37a AHD24506.1     2
 ORF (fragment)   Bacillus subtilis T41a AIT71752.1     2
 cellulase   Bacillus subtilis TB-2 ABS70711.1     2
 CLD04_10445   Bacillus subtilis TLO3 ASZ61563.1     2
 M036_09535   Bacillus subtilis TO-A AII35811.1     2
 ABU16_2893   Bacillus subtilis TO-A JPC AKN13969.1     2
 ABA10_09875   Bacillus subtilis UD1022 AKI92270.1     2
 BKN48_19800   Bacillus subtilis VV2 AOY07432.1     2
 β-1,4-endo-glucanase, partial (fragment)   Bacillus subtilis w AHD24516.1     2
 D3Z87_09910   Bacillus subtilis WB800N AYE64410.1     2
 cellulase (Egls3)   Bacillus subtilis WL001 AOY41715.1     2
 endoglucanase (CelW)   Bacillus subtilis WL001 AHZ62779.1     2
 C663_1868 (EglS)   Bacillus subtilis XF-1 AGE63656.1     2
 xylanase (Xyl141)   Bacillus subtilis Xyl14-KBRB ADP09027.1 E3UQM6   2
 β-1,4-endo-glucanase, partial (fragment)   Bacillus subtilis Y AHD24507.1     2
 endoglucanase (CeL)   Bacillus tequilensis S17I28 AIJ27554.1     2
 CAB88_17695   Bacillus thuringiensis ATCC 10792 ARP61015.1     48
 BtBc_18320   Bacillus thuringiensis Bc601 AMX80339.1     48
 BMB171_C3198   Bacillus thuringiensis BMB171 ADH08008.1 D5TT95   48
 BTI247_37720   Bacillus thuringiensis Bt18247 AOM12154.1     48
 AXW78_16645   Bacillus thuringiensis Bt185 AMR05601.1     48
 BTB_c35880   Bacillus thuringiensis Bt407 AFV19270.1     48
 EWV32_21185   Bacillus thuringiensis Bti QBM63051.1     48
 BtSCAC15_19180   Bacillus thuringiensis C15 AZR78328.1     48
 β-glucosidase   Bacillus thuringiensis G13 ALJ10949.1     48
 BTG_01865   Bacillus thuringiensis HD-771 AFQ13876.1     48
 BTF1_15010   Bacillus thuringiensis HD-789 AFQ27177.1     48
 AS86_507   Bacillus thuringiensis HD1002 AJH08483.1     48
 A3L20_18535   Bacillus thuringiensis HD12 AMR88058.1     48
 A3L20_18535   Bacillus thuringiensis HD12 AMR88058.1     48
 AC241_17265   Bacillus thuringiensis HS18-1 AKR12420.1     48
 endo-β-1,4-glucanase (fragment)   Bacillus thuringiensis IARI-SP-6 AGW99983.1     2
 BCM43_11585   Bacillus thuringiensis KNU-07 ANV74005.1     48
 B4918_19610   Bacillus thuringiensis L-7601 AQY42210.1     48
 CUC43_32110   Bacillus thuringiensis LM1212 AXY11283.1     28
 MC28_G027   Bacillus thuringiensis MC28 AFU17760.1     48
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