Glycoside Hydrolase Family 5

Activities in Familyendo-β-1,4-glucanase / cellulase (EC; endo-β-1,4-xylanase (EC; β-glucosidase (EC; β-mannosidase (EC; β-glucosylceramidase (EC; glucan β-1,3-glucosidase (EC; exo-β-1,4-glucanase / cellodextrinase (EC; glucan endo-1,6-β-glucosidase (EC; mannan endo-β-1,4-mannosidase (EC; cellulose β-1,4-cellobiosidase (EC; steryl β-glucosidase (EC; endoglycoceramidase (EC; chitosanase (EC; β-primeverosidase (EC; xyloglucan-specific endo-β-1,4-glucanase (EC; endo-β-1,6-galactanase (EC; β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-); lichenase / endo-β-1,3-1,4-glucanase (EC; β-glycosidase (EC 3.2.1.-); endo-β-1,3-glucanase / laminarinase (EC; β-N-acetylhexosaminidase (EC; chitosanase (EC; β-D-galactofuranosidase (EC; β-galactosylceramidase (EC; ; β-rutinosidase /α-L-rhamnose-(1,6)-β-D-glucosidase (EC 3.2.1.-); α-L-arabinofuranosidase (EC; glucomannan-specific endo-β-1,4-glucanase (EC 3.2.1.-)
Mechanism Retaining
3D Structure Status( β / α ) 8 barrel
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (20190); Uniprot accession (1919); PDB accession (251); 3D entries (95); cryst (0)
All (18714) Archaea (124) Bacteria (15439) Eukaryota (3012) Viruses (13) unclassified (126) Structure (95) Characterized (576)
| 1 | ... | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | ... | 155 |
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 glycoside hydrolase (Gh5C)   Bacillus licheniformis SVD1 BAL45506.1     7
 glycoside hydrolase (Gh5B)   Bacillus licheniformis SVD1 BAL45505.1     4
 endoglucanase (Gh5A)   Bacillus licheniformis SVD1 BAL45504.1     2
 C7M53_10540   Bacillus licheniformis TAB7 AYC51697.1     2
 C7M53_09515   Bacillus licheniformis TAB7 AYC51498.1     7
 C7M53_09510   Bacillus licheniformis TAB7 AYC51497.1     4
 D9Y32_16055   Bacillus licheniformis TCCC 11148 QDL78813.1     4
 D9Y32_15025   Bacillus licheniformis TCCC 11148 QDL80169.1     2
 MUY_001893 (CelC)   Bacillus licheniformis WX-02 AKQ73025.1     4
 MUY_002122 (BglC)   Bacillus licheniformis WX-02 AKQ73254.1     2
 MUY_001894 (CelD)   Bacillus licheniformis WX-02 AKQ73026.1     7
 I9X38_18955   Bacillus mojavensis PS17 QQF62462.1     2
 HC660_18660 (EglS)   Bacillus mojavensis UCMB5075 QJC96342.1     2
 DJ92_3612   Bacillus mycoides 219298 AIK39363.1     48
 DJ92_4888 (fragment)   Bacillus mycoides 219298 AIK39908.1     48
 BG05_5473   Bacillus mycoides ATCC 6462 AJH17041.1     48
 DN409_29205   Bacillus mycoides BPN401 QEL88355.1     19
 I6G81_01365   Bacillus mycoides FDAARGOS_924 QQA13562.1     48
 endo-β-1,4-glucanase (fragment)   Bacillus mycoides IARI-SP-8 AGW99985.1     2
 β-mannanase (MANPN11) (fragment) Bacillus nealsonii PN-11 AGU71466.2
 FLQ07_16450   Bacillus paralicheniformis A4-3 QEO07050.1     7
 FLQ07_16445   Bacillus paralicheniformis A4-3 QEO07049.1     4
 FLQ07_17600   Bacillus paralicheniformis A4-3 QEO08445.1     2
 BaLi_c21530 (EglS)   Bacillus paralicheniformis ATCC 9945a AGN36513.1     2
 BaLi_c19160 (CelB)   Bacillus paralicheniformis ATCC 9945a AGN36284.1     4
 BaLi_c19170 (CelD)   Bacillus paralicheniformis ATCC 9945a AGN36285.1     7
 SC10_B2orf03183   Bacillus paralicheniformis BL-09 AJO18373.1     2
 SC10_B2orf02856   Bacillus paralicheniformis BL-09 AJO18129.1     4
 SC10_B2orf02858 (fragment)   Bacillus paralicheniformis BL-09 AJO18131.1     7
 D5285_10710   Bacillus paralicheniformis CBMAI 1303 AYQ18800.1     2
 D5285_09575   Bacillus paralicheniformis CBMAI 1303 AYQ16315.1     7
 D5285_09570   Bacillus paralicheniformis CBMAI 1303 AYQ16314.1     4
 D2B33_10050   Bacillus paralicheniformis FA6 QFY41066.1     2
 D2B33_11190   Bacillus paralicheniformis FA6 QFY38926.1     4
 D2B33_11185   Bacillus paralicheniformis FA6 QFY38925.1     7
 BLMD_10500   Bacillus paralicheniformis MDJK30 ARA88014.1     2
 BLMD_09335   Bacillus paralicheniformis MDJK30 ARA85656.1     4
 BLMD_09340   Bacillus paralicheniformis MDJK30 ARA85657.1     7
 G3M81_10740   Bacillus paralicheniformis ZAP17 QII51600.1     2
 G3M81_09630   Bacillus paralicheniformis ZAP17 QII48993.1     7
 C5Y82_07945   Bacillus pumilus 150a AVI40951.1     7
 GZ55_13460   Bacillus pumilus 3-19 QKN78740.1     7
 DJ67_013510   Bacillus pumilus 7P QLI45299.1     7
 VP59_07445   Bacillus pumilus C4 ANT56640.1     7
 β-mannanase   Bacillus pumilus GBSW 19 AHF81566.1     7
 BS467_15785   Bacillus pumilus GLB197 APP17114.1     7
 ID12_13295   Bacillus pumilus GR-8 AKU32339.1     7
 Cel5S   Bacillus pumilus HY1 ACY72384.1 D1L8C9   2
 endo-β-1,4-glucanase (fragment)   Bacillus pumilus IARI-SP-5 AGW99982.1     2
 ASM07_07620   Bacillus pumilus ku-bf1 AMB89777.1     7
 BW16_08670   Bacillus pumilus MTCC B6033 AHL71452.1     7
 SAMEA4076707_01656   Bacillus pumilus NCTC10337 SNV02448.1     7
 AKO65_15415   Bacillus pumilus NJ-M2 ALM29338.1     7
 AKO66_11740   Bacillus pumilus NJ-V ANY97356.1     7
 AMR71_11735   Bacillus pumilus NJ-V2 ALM45875.1     7
 H9S87_07710   Bacillus pumilus ONU 554 QNP17861.1     7
 BEN31_07990   Bacillus pumilus PDSLzg-1 AOC56743.1     7
 BPUM_1561   Bacillus pumilus SAFR-032 ABV62243.1 A8FDC6   7
 GPS65_08550   Bacillus pumilus SF-4 QHQ76169.1     7
 UP15_08390   Bacillus pumilus SH-B11 AMM88977.1     7
 UP12_08105   Bacillus pumilus SH-B9 AMM97310.1     7
 BTUAT1_15770   Bacillus pumilus TUAT1 BAT48711.1     7
 HZ310_11005   Bacillus pumilus UAMX QLI78307.1     7
 VT48_08320   Bacillus pumilus W3 AKC66023.1     7
 DKE43_04285   Bacillus pumilus ZB201701 AZV52369.1     7
 BRL64_08220   Bacillus safensis BRM1 ARD56165.1     7
 JNE45_08115   Bacillus safensis F6 QRF33821.1     7
 RS87_08150   Bacillus safensis FO-36b AWI36699.1     7
 BsIDN1_30480 (fragment)   Bacillus safensis IDN1 BBP89430.1     7
 BSL056_08100   Bacillus safensis KCTC 12796BP APJ10920.1     7
 FX981_03751   Bacillus safensis PgKB20 QEK65481.1     7
 CS953_10685   Bacillus safensis sami AYJ90157.1     7
 BSA145_16070   Bacillus safensis U14-5 APT47251.1     7
 BSA171_11305   Bacillus safensis U17-1 APT54133.1     7
 BSA41_06410   Bacillus safensis U41 APT49591.1     7
 JD965_09670   Bacillus siamensis B28 QQD83826.1     2
 IXY25_03525   Bacillus siamensis BZR 86 QPG18760.1     2
 CWD84_11935   Bacillus siamensis SCSIO 05746 AUJ77469.1     2
 endo-glucanase   Bacillus sonorensis BD92 QGW63294.1     2
 S101395_02568   Bacillus sonorensis SRCM101395 ASB89075.1     2
 S101395_03069   Bacillus sonorensis SRCM101395 ASB89576.1     7
 S101395_03070   Bacillus sonorensis SRCM101395 ASB89577.1     4
 unnamed protein product   Bacillus sp. (in: Bacteria) CAD67813.1
 Sequence 16 from patent US 6566114   Bacillus sp. (in: Bacteria) AAQ31841.1     8
 β-mannanase   Bacillus sp. (in: Bacteria) AAQ31834.1     8
 Sequence 22 from patent US 6566114   Bacillus sp. (in: Bacteria) AAQ31844.1     8
 endo-β-1,4-glucanase Bacillus sp. (in: Bacteria) 22-28 BAA12744.1 Q45554   2
 endo-β-1,4-glucanase Bacillus sp. (in: Bacteria) 5H BAA31712.1 O83012   2
 Sequence 12 from patent US 6566114   Bacillus sp. (in: Bacteria) AAI12 AAQ31839.1     8
 Sequence 20 from patent US 7183093 (fragment)   Bacillus sp. (in: Bacteria) AAI12 ABP12275.1     8
 endo-1,4-β-glucanase, partial   Bacillus sp. (in: Bacteria) AGh1 QLI42581.1     2
 BS34A_20090 (EglS)   Bacillus sp. (in: Bacteria) BS34A CEJ77430.1     2
 unnamed protein product   Bacillus sp. (in: Bacteria) CBS 669.93 AAE86309.1
 cellulase (BCE103) Bacillus sp. (in: Bacteria) CBS 670.93 CAB59165.1
  1LF1[A] 2
 endo-β-1,4-glucanase (Cel5L)   Bacillus sp. (in: Bacteria) KD1014 AYV97589.1     2
 ba103 (Man5A)   Bacillus sp. (in: Bacteria) KW1 QGN03632.1     7
 endo-β-1,4-glucanase B1 Bacillus sp. (in: Bacteria) N186-1 CAA83942.1 Q59232   2
 endo-β-1,4-glucanase, partial (CelD) (fragment)   Bacillus sp. (in: Bacteria) NZ-3 QEQ43012.1     2
 endo-β-1,4-glucanase, partial (CelD) (fragment)   Bacillus sp. (in: Bacteria) NZ-3 QEQ43012.1     2
 CJO35_09285   Bacillus sp. 1s-1 ASV15340.1     4

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