Glycoside Hydrolase Family 5

Activities in Familyendo-β-1,4-glucanase / cellulase (EC; endo-β-1,4-xylanase (EC; β-glucosidase (EC; β-mannosidase (EC; β-glucosylceramidase (EC; glucan β-1,3-glucosidase (EC; licheninase (EC; exo-β-1,4-glucanase / cellodextrinase (EC; glucan endo-1,6-β-glucosidase (EC; mannan endo-β-1,4-mannosidase (EC; cellulose β-1,4-cellobiosidase (EC; steryl β-glucosidase (EC; endoglycoceramidase (EC; chitosanase (EC; β-primeverosidase (EC; xyloglucan-specific endo-β-1,4-glucanase (EC; endo-β-1,6-galactanase (EC; hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC; β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Mechanism Retaining
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (12681); Uniprot accession (1922); PDB accession (213); 3D entries (75); cryst (0)
All (11302) Archaea (67) Bacteria (9025) Eukaryota (2084) Viruses (6) unclassified (120) Structure (75) Characterized (547)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | ... | 91 |
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 ABE28_010285   Bacillus muralis G25-68 AOH54738.1     48
 DJ92_3612   Bacillus mycoides 219298 AIK39363.1     48
 DJ92_4888 (fragment)   Bacillus mycoides 219298 AIK39908.1     48
 BG05_5473   Bacillus mycoides ATCC 6462 AJH17041.1     48
 endo-β-1,4-glucanase (fragment)   Bacillus mycoides IARI-SP-8 AGW99985.1     2
 β-mannanase (MANPN11) (fragment) Bacillus nealsonii PN-11 AGU71466.2
 endo-β-1,4-glucanase (fragment)   Bacillus oceanisediminis IARI-SP-10 AGW99986.1     2
 BaLi_c21530 (EglS)   Bacillus paralicheniformis ATCC 9945a AGN36513.1     2
 BaLi_c19160 (CelB)   Bacillus paralicheniformis ATCC 9945a AGN36284.1     4
 BaLi_c19170 (CelD)   Bacillus paralicheniformis ATCC 9945a AGN36285.1     7
 SC10_B2orf03183   Bacillus paralicheniformis BL-09 AJO18373.1     2
 SC10_B2orf02856   Bacillus paralicheniformis BL-09 AJO18129.1     4
 SC10_B2orf02858 (fragment)   Bacillus paralicheniformis BL-09 AJO18131.1     7
 BLMD_10500   Bacillus paralicheniformis MDJK30 ARA88014.1     2
 BLMD_09335   Bacillus paralicheniformis MDJK30 ARA85656.1     4
 BLMD_09340   Bacillus paralicheniformis MDJK30 ARA85657.1     7
 C5Y82_07945   Bacillus pumilus 150a AVI40951.1     7
 VP59_07445   Bacillus pumilus C4 ANT56640.1     7
 β-mannanase   Bacillus pumilus GBSW 19 AHF81566.1     7
 BS467_15785   Bacillus pumilus GLB197 APP17114.1     7
 ID12_13295   Bacillus pumilus GR-8 AKU32339.1     7
 Cel5S   Bacillus pumilus HY1 ACY72384.1 D1L8C9   2
 endo-β-1,4-glucanase (fragment)   Bacillus pumilus IARI-SP-5 AGW99982.1     2
 ASM07_07620   Bacillus pumilus ku-bf1 AMB89777.1     7
 BW16_08670   Bacillus pumilus MTCC B6033 AHL71452.1     7
 SAMEA4076707_01656   Bacillus pumilus NCTC10337 SNV02448.1     7
 AKO65_15415   Bacillus pumilus NJ-M2 ALM29338.1     7
 AKO66_11740   Bacillus pumilus NJ-V ANY97356.1     7
 AMR71_11735   Bacillus pumilus NJ-V2 ALM45875.1     7
 BEN31_07990   Bacillus pumilus PDSLzg-1 AOC56743.1     7
 BPUM_1561   Bacillus pumilus SAFR-032 ABV62243.1 A8FDC6   7
 UP15_08390   Bacillus pumilus SH-B11 AMM88977.1     7
 UP12_08105   Bacillus pumilus SH-B9 AMM97310.1     7
 BTUAT1_15770   Bacillus pumilus TUAT1 BAT48711.1     7
 VT48_08320   Bacillus pumilus W3 AKC66023.1     7
 BRL64_08220   Bacillus safensis BRM1 ARD56165.1     7
 BSL056_08100   Bacillus safensis KCTC 12796BP APJ10920.1     7
 BSA145_16070   Bacillus safensis U14-5 APT47251.1     7
 BSA171_11305   Bacillus safensis U17-1 APT54133.1     7
 BSA41_06410   Bacillus safensis U41 APT49591.1     7
 CWD84_11935   Bacillus siamensis SCSIO 05746 AUJ77469.1     2
 S101395_02568   Bacillus sonorensis SRCM101395 ASB89075.1     2
 S101395_03069   Bacillus sonorensis SRCM101395 ASB89576.1     7
 S101395_03070   Bacillus sonorensis SRCM101395 ASB89577.1     4
 unnamed protein product   Bacillus sp. (in: Bacteria) CAD67813.1
 Sequence 16 from patent US 6566114   Bacillus sp. (in: Bacteria) AAQ31841.1     8
 β-mannanase   Bacillus sp. (in: Bacteria) AAQ31834.1     8
 Sequence 22 from patent US 6566114   Bacillus sp. (in: Bacteria) AAQ31844.1     8
 endo-β-1,4-glucanase Bacillus sp. (in: Bacteria) 22-28 BAA12744.1 Q45554   2
 endo-β-1,4-glucanase Bacillus sp. (in: Bacteria) 5H BAA31712.1 O83012   2
 Sequence 12 from patent US 6566114   Bacillus sp. (in: Bacteria) AAI12 AAQ31839.1     8
 Sequence 20 from patent US 7183093 (fragment)   Bacillus sp. (in: Bacteria) AAI12 ABP12275.1     8
 BS34A_20090 (EglS)   Bacillus sp. (in: Bacteria) BS34A CEJ77430.1     2
 unnamed protein product   Bacillus sp. (in: Bacteria) CBS 669.93 AAE86309.1
 cellulase (BCE103) Bacillus sp. (in: Bacteria) CBS 670.93 CAB59165.1
  1LF1[A] 2
 endo-β-1,4-glucanase (Cel) (fragment) Bacillus sp. (in: Bacteria) D04 AAC43478.1 Q45430   2
 endo-β-1,4-glucanase B1 Bacillus sp. (in: Bacteria) N186-1 CAA83942.1 Q59232   2
 CJO35_09285   Bacillus sp. 1s-1 ASV15340.1     4
 CJO35_10335   Bacillus sp. 1s-1 ASV17692.1     2
 CJO35_09290   Bacillus sp. 1s-1 ASV15341.1     7
 BZ167_00180   Bacillus sp. 275 AQP94520.1     2
 CelS Bacillus sp. 79-23 AAC02536.1 O52731   2
 BAQ53_16135   Bacillus sp. B25(2016b) ANP84232.1     48
 cellulase (CelB) Bacillus sp. BG-CS10 ADD62401.1 D4P8C6 5E09[A]
 OY17_12185   Bacillus sp. BH072 AJE78821.1     2
 cellulase (CelC)   Bacillus sp. CY1-3 ABG91147.1 Q0PF31   2
 BGM23_12240   Bacillus sp. FJAT-14266 AOL27309.1     2
 BSZ43_10245   Bacillus sp. H15-1 APJ29232.1     2
 BSZ43_09220   Bacillus sp. H15-1 APJ26961.1     7
 BSZ43_09215   Bacillus sp. H15-1 APJ26960.1     4
 endo-β-1,4-glucanase (GluY)   Bacillus sp. HB102 AAU08303.1 Q66NX2   2
 endo-β-1,4-glucanase (GluB) (fragment)   Bacillus sp. HB104 AAX18650.1 Q5D5C5  
 glycosyl hydrolase family 5 mannanase precursor (ManA)   Bacillus sp. HJ14 AHH02586.2
 cellulase (Cel1)   Bacillus sp. HY2-3 AAV34758.1 Q5UAZ8   2
 endo-β-1,4-glucanase   Bacillus sp. IARI-SP-4 AGW99980.1     2
 β-mannanase (Amn5) (Man5A) Bacillus sp. JAMB-602 BAD99527.1 Q4W8M3 1WKY[A] 8
 MY9_1980   Bacillus sp. JS AFI28515.1     2
 cellulase, partial (fragment)   Bacillus sp. KP8 AFM99481.1     2
 endo-β-1,4-glucanase K (Egl-K) Bacillus sp. KSM-635 AAA22304.1 P19424 1G01[A]
 endo-β-1,4-glucanase (Egl-64) Bacillus sp. KSM-64 / Bacillus sp. Z-16 CAJ00039.1
Q59241   2
 endoglucanase N252 (Egl252) Bacillus sp. KSM-N252 BAB62295.1 Q93R81   2
 endo-β-1,4-glucanase (Egl-237) Bacillus sp. KSM-S237 CAJ00038.1
Q9F216   2
 BsLM_1923   Bacillus sp. LM 4-2 AKE23721.1     2
 CS547_09465   Bacillus sp. Lzh-5 ATV22947.1     2
 C1T29_11520   Bacillus sp. MBGLi79 AUZ38888.1     2
 C1T29_10825 (fragment)   Bacillus sp. MBGLi79 AUZ38770.1     7
 CDO84_08795   Bacillus sp. MD-5 ASB61086.1     2
 β-mannanase (ManA;MAN330) (Man5A) Bacillus sp. N16-5 AAT06599.1
Q5YEX6 3JUG[A] 8
 bifunctional cellulase chitosanase (CelA)
Bacillus sp. NBL420 AAK73277.1 Q93LI9   2
 endo-β-1,4-glucanase   Bacillus sp. NK-2 ADO85705.1 E3VRS9   2
 endo-β-1,4-glucanase (GluD)   Bacillus sp. NW-2004a AAT97264.1 Q68NH6   2
 endo-β-1,4-glucanase (GluG) (fragment)   Bacillus sp. NW-2004b AAT97263.1 Q68PJ1   2
 SB24_00605   Bacillus sp. Pc3 AJC23751.1     2
 endoglucanase (EgC)   Bacillus sp. RP1 AID18514.1     2
 AUL54_01525   Bacillus sp. SDLI1 AME05095.1     2
 endo-β-1,4-glucanase (fragment)   Bacillus sp. TZT-02 AFR42425.1     2
 endoglucanase   Bacillus sp. VLSH08 AEA30146.1     2
 QR42_07965   Bacillus sp. WP8 AIZ60203.1     7
 cellulase   Bacillus sp. WRD-2 AAX54913.1 Q32T26   2
 QF06_08135   Bacillus sp. YP1 AJO58436.1     2

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