Glycoside Hydrolase Family 5

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (11393); Uniprot accession (1922); PDB accession (208); 3D entries (73); cryst (0)
All (10017) Archaea (67) Bacteria (7846) Eukaryota (1982) Viruses (5) unclassified (117) Structure (73) Characterized (547)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | ... | 79 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 BRL64_08220   Bacillus safensis BRM1 ARD56165.1     7
 BSL056_08100   Bacillus safensis KCTC 12796BP APJ10920.1     7
 BSA145_16070   Bacillus safensis U14-5 APT47251.1     7
 BSA171_11305   Bacillus safensis U17-1 APT54133.1     7
 BSA41_06410   Bacillus safensis U41 APT49591.1     7
 S101395_02568   Bacillus sonorensis SRCM101395 ASB89075.1     2
 S101395_03069   Bacillus sonorensis SRCM101395 ASB89576.1     7
 S101395_03070   Bacillus sonorensis SRCM101395 ASB89577.1     4
 unnamed protein product   Bacillus sp. CAD67813.1
ABH73763.1
CAH03186.1
    2
 Sequence 16 from patent US 6566114   Bacillus sp. AAQ31841.1     8
 β-mannanase   Bacillus sp. AAQ31834.1     8
 Sequence 22 from patent US 6566114   Bacillus sp. AAQ31844.1     8
 CJO35_09285   Bacillus sp. 1s-1 ASV15340.1     4
 CJO35_10335   Bacillus sp. 1s-1 ASV17692.1     2
 CJO35_09290   Bacillus sp. 1s-1 ASV15341.1     7
 endo-β-1,4-glucanase 3.2.1.4 Bacillus sp. 22-28 BAA12744.1 Q45554   2
 BZ167_00180   Bacillus sp. 275 AQP94520.1     2
 endo-β-1,4-glucanase 3.2.1.4 Bacillus sp. 5H BAA31712.1 O83012   2
 CelS 3.2.1.4 Bacillus sp. 79-23 AAC02536.1 O52731   2
 Sequence 12 from patent US 6566114   Bacillus sp. AAI12 AAQ31839.1     8
 Sequence 20 from patent US 7183093 (fragment)   Bacillus sp. AAI12 ABP12275.1     8
 BAQ53_16135   Bacillus sp. B25(2016b) ANP84232.1     48
 cellulase (CelB) 3.2.1.4 Bacillus sp. BG-CS10 ADD62401.1 D4P8C6 5E09[A]
5E0C[A]
4
 OY17_12185   Bacillus sp. BH072 AJE78821.1     2
 BS34A_20090 (EglS)   Bacillus sp. BS34A CEJ77430.1     2
 unnamed protein product   Bacillus sp. CBS 669.93 AAE86309.1
AAV25062.1
CAD82874.1
    4
 cellulase (BCE103) 3.2.1.4 Bacillus sp. CBS 670.93 CAB59165.1
AAV25061.1
CAB58698.1
CAD82873.1
  1LF1[A] 2
 cellulase (CelC)   Bacillus sp. CY1-3 ABG91147.1 Q0PF31   2
 endo-β-1,4-glucanase (Cel) (fragment) 3.2.1.4 Bacillus sp. D04 AAC43478.1 Q45430   2
 BGM23_12240   Bacillus sp. FJAT-14266 AOL27309.1     2
 BSZ43_10245   Bacillus sp. H15-1 APJ29232.1     2
 BSZ43_09220   Bacillus sp. H15-1 APJ26961.1     7
 BSZ43_09215   Bacillus sp. H15-1 APJ26960.1     4
 endo-β-1,4-glucanase (GluY)   Bacillus sp. HB102 AAU08303.1 Q66NX2   2
 endo-β-1,4-glucanase (GluB) (fragment)   Bacillus sp. HB104 AAX18650.1 Q5D5C5  
 glycosyl hydrolase family 5 mannanase precursor (ManA)   Bacillus sp. HJ14 AHH02586.2
AHH02586.1
    7
 cellulase (Cel1)   Bacillus sp. HY2-3 AAV34758.1 Q5UAZ8   2
 endo-β-1,4-glucanase   Bacillus sp. IARI-SP-4 AGW99980.1     2
 β-mannanase (Amn5) (Man5A) 3.2.1.78 Bacillus sp. JAMB-602 BAD99527.1 Q4W8M3 1WKY[A] 8
 MY9_1980   Bacillus sp. JS AFI28515.1     2
 cellulase, partial (fragment)   Bacillus sp. KP8 AFM99481.1     2
 endo-β-1,4-glucanase K (Egl-K) 3.2.1.4 Bacillus sp. KSM-635 AAA22304.1 P19424 1G01[A]
1G0C[A]
2
 endo-β-1,4-glucanase (Egl-64) 3.2.1.4 Bacillus sp. KSM-64 / Bacillus sp. Z-16 CAJ00039.1
AAA73189.1
ACE14925.1
ACW22976.1
CAJ28077.1
CAT16610.1
Q59241   2
 endoglucanase N252 (Egl252) 3.2.1.4 Bacillus sp. KSM-N252 BAB62295.1 Q93R81   2
 endo-β-1,4-glucanase (Egl-237) 3.2.1.4 Bacillus sp. KSM-S237 CAJ00038.1
ABH71811.1
ACE14923.1
ACW22975.1
BAB19360.1
CAF02232.1
CAJ28076.1
CAT16607.1
Q9F216   2
 BsLM_1923   Bacillus sp. LM 4-2 AKE23721.1     2
 CDO84_08795   Bacillus sp. MD-5 ASB61086.1     2
 β-mannanase (ManA;MAN330) (Man5A) 3.2.1.78 Bacillus sp. N16-5 AAT06599.1
AML27065.1
Q5YEX6 3JUG[A] 8
 endo-β-1,4-glucanase B1 3.2.1.4 Bacillus sp. N186-1 CAA83942.1 Q59232   2
 bifunctional cellulase chitosanase (CelA) 3.2.1.132
3.2.1.4
Bacillus sp. NBL420 AAK73277.1 Q93LI9   2
 endo-β-1,4-glucanase   Bacillus sp. NK-2 ADO85705.1 E3VRS9   2
 endo-β-1,4-glucanase (GluD)   Bacillus sp. NW-2004a AAT97264.1 Q68NH6   2
 endo-β-1,4-glucanase (GluG) (fragment)   Bacillus sp. NW-2004b AAT97263.1 Q68PJ1   2
 SB24_00605   Bacillus sp. Pc3 AJC23751.1     2
 endoglucanase (EgC)   Bacillus sp. RP1 AID18514.1     2
 AUL54_01525   Bacillus sp. SDLI1 AME05095.1     2
 endo-β-1,4-glucanase (fragment)   Bacillus sp. TZT-02 AFR42425.1     2
 endoglucanase   Bacillus sp. VLSH08 AEA30146.1     2
 QR42_07965   Bacillus sp. WP8 AIZ60203.1     7
 cellulase   Bacillus sp. WRD-2 AAX54913.1 Q32T26   2
 QF06_08135   Bacillus sp. YP1 AJO58436.1     2
 endo-1,4-β-glucanase (fragment)   Bacillus subtilis AEK70950.1     2
 endo-1,4-β-glucanase (fragment)   Bacillus subtilis AEK70951.1     2
 endo-1,4-β-glucanase (fragment)   Bacillus subtilis AEK70952.1     2
 endo-β-1,4-glucanase 3.2.1.4 Bacillus subtilis AAA22307.1 Q45532   2
 BKP58_02035   Bacillus subtilis 29R7-12 API94754.1     2
 beta 1,4 endo glucanase, partial (fragment)   Bacillus subtilis a10d AGV05392.1     2
 beta 1,4 endo glucanase, partial (fragment)   Bacillus subtilis a14h AGV05393.1    
 endocellulase   Bacillus subtilis A2 AFA26702.1     2
 β-1,3-1,4-glucanase / cellulase C (CelA;CelC) 3.2.1.4 Bacillus subtilis A8-8 AAO63626.1 Q6Y4Q1   2
 endoglucanase / cellulase (Cel-An5) (fragment)   Bacillus subtilis An5 AHX72143.1     2
 cellulase   Bacillus subtilis ASM6 AKQ62667.1     2
 KS07_08965   Bacillus subtilis ATCC 19217 AIW37597.1     2
 endo-1,4-β-glucanase (GlnC) (partial)   Bacillus subtilis ATTCAU195 AAN07019.1 Q6YK34   2
 endo-β-1,4-glucanase, partial   Bacillus subtilis AuChE413 ALJ10582.1     2
 MA22_12095   Bacillus subtilis B-1 AIU77226.1     2
 β-1,4-endo-glucanase, partial (fragment)   Bacillus subtilis b5b AHD24502.1     2
 endo-β-1,4-glucanase (fragment)   Bacillus subtilis b5d AHC02484.1     2
 beta 1,4 endo glucanase, partial (fragment)   Bacillus subtilis b8a AGV05394.1     2
 endoglucanase (Egl173;Cel;EglS) 3.2.1.4 Bacillus subtilis BEC-1 / Y106 / shu-3 AAK39540.1
ADM12805.1
ADP05286.1
Q93TJ6   2
 BEST7003_1842 (EglS)   Bacillus subtilis BEST7003 BAM58043.1     2
 endo-β-1,4-glucanase (Eg15) (Cel5A) 3.2.1.4 Bacillus subtilis BME-15 ACI15227.1
ACJ12786.1
ACJ12787.1
ACJ12788.1
ACJ12789.1
ACJ12790.1
ACJ12791.1
ACJ12792.1
B6DVJ2   2
 endo-β-1,4-glucanase (Cel5H)   Bacillus subtilis BME12 ACM68436.1 B9W017   2
 B7470_21865   Bacillus subtilis Bs-115 ARI88503.1     2
 β-glucanase   Bacillus subtilis BS-2 ABS70712.1
ABO37787.1
A7LIA1   2
 KO64_09220   Bacillus subtilis Bs-916 AIW30039.1     2
 endo-1,4-β-glucanohydrolase   Bacillus subtilis BS-DX4 AQT39609.1     2
 BS16045_01927   Bacillus subtilis BS16045 AOL97645.1     2
 BSBS38_02055   Bacillus subtilis BS38 AOR98335.1     2
 BS49_20100 (EglS)   Bacillus subtilis BS49 CEI57006.1     2
 endo-β-1,4-glucanase (CMCase;BglC) 3.2.1.4 Bacillus subtilis BSE616 BAA00859.1 P23549   2
 BSn5_00410   Bacillus subtilis BSn5 ADV92718.1     2
 endo-β-1,4-glucanase   Bacillus subtilis BY-2 AGN52749.1     2
 endo-β-1,4-glucanase   Bacillus subtilis BY-4 AHA61366.1     2
 endo-β-1,4-glucanase (EglS;EG) 3.2.1.4 Bacillus subtilis C-36 ABG78039.1 Q0PPV7   2
 cellulase, partial (fragment)   Bacillus subtilis C05-16 AFH66774.1     2
 endo-β-1,4-glucanase (fragment)   Bacillus subtilis C11A ADP76527.1 E5KCL5   2
 endo-β-1,4-glucanase (fragment)   Bacillus subtilis C11B1 ADP76526.1 E5KCL4   2
 endo-β-1,4-glucanase (fragment)   Bacillus subtilis C8K1 ADP76528.1 E5KCL6   2
 endo-β-1,4-glucanase (CelG) 3.2.1.4 Bacillus subtilis CHZ1 AAK94871.1 Q93LD0   2
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