Glycoside Hydrolase Family 5

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (11921); Uniprot accession (1922); PDB accession (209); 3D entries (74); cryst (0)
All (10543) Archaea (67) Bacteria (8307) Eukaryota (2044) Viruses (5) unclassified (120) Structure (74) Characterized (547)
| 1 | ... | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | ... | 84 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 S100072_01973   Bacillus velezensis SRCM100072 ASB53309.1     2
 S101413_02134   Bacillus velezensis SRCM101413 ASB65581.1     2
 BLL65_09625   Bacillus velezensis sx01604 AQZ73217.1     2
 CEG11_09415   Bacillus velezensis T20E-257 ASF55305.1     2
 CG798_14945   Bacillus velezensis TB1501 ASP26388.1     2
 AJ82_10290   Bacillus velezensis TrigoCor1448 AHK49356.1     2
 RBAU_1784 (EglS)   Bacillus velezensis UCMB5033 CDG29752.1     2
 BAM5036_1746 (EglS)   Bacillus velezensis UCMB5036 CCP21786.1     2
 BASU_1764 (EglS)   Bacillus velezensis UCMB5113 CDG26057.1     2
 BANAU_1935 (BglC)   Bacillus velezensis YAU B9601-Y2 CCG49956.1     2
 AAV30_10320   Bacillus velezensis YJ11-1-4 AKF76524.1     2
 BK049_00270   Bacillus xiamenensis VV3 AOZ87243.1     7
 cellulase   bacterium enrichment culture AJO67866.1     4
 cellulase (CelA10) 3.2.1.4 bacterium enrichment culture clone CelA10 ACR23656.1 C5HG53   2
 cellulase (CelA24) 3.2.1.4 bacterium enrichment culture clone CelA24 ACR23659.1 C5HG56   26
 endoglucanase (Cel5) (Cel5A) 3.2.1.4 bacterium enrichment culture clone FV-Cel5A AEL31246.1     2
 endoglucanase (Cel17) (Cel5B) 3.2.1.4 bacterium enrichment culture clone FXVII-Cel5B AEL31247.1     1
 BRDCF_09535   Bacteroidales bacterium CF AGX08895.1
AGY54507.1
    7
 BACCELL_03415   Bacteroides cellulosilyticus DSM 14838 EEF88964.1     21
 BcellWH2_02030 (EglS)   Bacteroides cellulosilyticus WH2 ALJ59275.1     2
 BcellWH2_02825 (Xynb_4)   Bacteroides cellulosilyticus WH2 ALJ60064.1     21
 BcellWH2_04303   Bacteroides cellulosilyticus WH2 ALJ61520.1     21
 BcellWH2_02558   Bacteroides cellulosilyticus WH2 ALJ59797.1     46
 BcellWH2_03343 (Cela_1)   Bacteroides cellulosilyticus WH2 ALJ60576.1     4
 BcellWH2_02031   Bacteroides cellulosilyticus WH2 ALJ59276.1     7
 BcellWH2_03344 (Cela_2)   Bacteroides cellulosilyticus WH2 ALJ60577.1     4
 EL88_18305   Bacteroides dorei isolate HS1_L1_B_010 AII64978.1     7
 endoxylanase (ORF1299;BACEGG_01299) (BeXyn5A) 3.2.1.8 Bacteroides eggerthii DSM 20697 EEC54456.1 B7AFX5   21
 BF638R_0823   Bacteroides fragilis 638R CBW21396.1 E1WLN2   7
 MB0529_00763   Bacteroides fragilis BE1 CUA17419.1     7
 VU15_03540   Bacteroides fragilis BOB25 AKA54083.1     7
 AE940_01030   Bacteroides fragilis S14 ANQ62842.1     7
 BF0840   Bacteroides fragilis YCH46 BAD47591.1 Q64Y35   7
 Bache_0234   Bacteroides helcogenes P 36-108 ADV42264.1     7
 Bache_0610   Bacteroides helcogenes P 36-108 ADV42635.1     46
 BACINT_01125 (ORF1125)   Bacteroides intestinalis DSM 17393 EDV06040.1 B3C9G1   21
 endo-β-1,4-xylanase (BiXyn5A;ORF4213;BACINT_04213) (Xyn5A) 3.2.1.8 Bacteroides intestinalis DSM 17393 EDV05070.1 B3CET2   21
 Bovatus_03051 (Egl_1)   Bacteroides ovatus ATCC 8483 ALJ47659.1     5
 endo-xyloglucanase (CelA;BoGH5A;BACOVA_02653;Bovatus_03072) 3.2.1.151 Bacteroides ovatus ATCC 8483 ALJ47680.1   3ZMR[A,B] 4
 Bovatus_03047 (EglS)   Bacteroides ovatus ATCC 8483 ALJ47655.1     2
 Bovatus_03053 (Egl_2)   Bacteroides ovatus ATCC 8483 ALJ47661.1     5
 Bovatus_02440   Bacteroides ovatus ATCC 8483 ALJ47066.1     13
 BACOV975_00834   Bacteroides ovatus V975 SCV07078.1     4
 BACOV975_00809   Bacteroides ovatus V975 SCV07053.1     2
 BACOV975_00219   Bacteroides ovatus V975 SCV06471.1     13
 BACOV975_00815   Bacteroides ovatus V975 SCV07059.1     5
 BACOV975_00813   Bacteroides ovatus V975 SCV07057.1     5
 Bacsa_1708   Bacteroides salanitronis DSM 18170 ADY36271.1     7
 Bacsa_1914   Bacteroides salanitronis DSM 18170 ADY36470.1     38
 Bacsa_0886   Bacteroides salanitronis DSM 18170 ADY35478.1     4
 BXY_17850   Bacteroides xylanisolvens XB1A CBK66886.1 D6CXI4   13
 BXY_18020   Bacteroides xylanisolvens XB1A CBK66901.1 D6CXJ9   13
 BXY_21090   Bacteroides xylanisolvens XB1A CBK67187.1 D6CYD5   2
 BXY_21130   Bacteroides xylanisolvens XB1A CBK67191.1 D6CYD9   5
 BXY_21150   Bacteroides xylanisolvens XB1A CBK67193.1 D6CYE1   5
 BXY_29320   Bacteroides xylanisolvens XB1A CBK67955.1 D6D0K3   21
 endo-cellulase (AC2aCel5A) (Cel5A) 3.2.1.4 Bacteroidetes bacterium AC2a AIJ19564.1   4YHE[A,B] 4
 BDW_10700   Bdellovibrio bacteriovorus W AHI06640.1    
 Belba_3292   Belliella baltica DSM 15883 AFL85800.1     13
 Belba_2165   Belliella baltica DSM 15883 AFL84732.1     21
 Bcav_2260   Beutenbergia cavernae DSM 12333 ACQ80511.1 C5BVC4  
 Bcav_4045   Beutenbergia cavernae DSM 12333 ACQ82286.1 C5C5E6   46
 BADO_1350   Bifidobacterium adolescentis 22L AII76760.1     44
 BADO_1348   Bifidobacterium adolescentis 22L AII76759.1     44
 BAD_1202   Bifidobacterium adolescentis ATCC 15703 BAF39983.1 A1A2Q0   44
 BAD_1204   Bifidobacterium adolescentis ATCC 15703 BAF39985.1 A1A2Q2   44
 BBMN23_1378   Bifidobacterium adolescentis BBMN23 AJE06350.1     44
 BBMN23_1380   Bifidobacterium adolescentis BBMN23 AJE06352.1     44
 BAA6_1442   Bifidobacterium animalis A6 AJD34555.1     8
 BGL50_07200   Bifidobacterium animalis BL3 ASL78238.1     8
 EN10_07335   Bifidobacterium animalis RH AIA33432.1     8
 BANAN_06350   Bifidobacterium animalis subsp. animalis ATCC 25527 AFI63478.1     2
 A4U98_07950   Bifidobacterium animalis subsp. animalis YL2 ARE60173.1     2
 BLA_0648   Bifidobacterium animalis subsp. lactis AD011 ACL28941.1 B8DWU0   8
 BLAC_06500 (fragment)   Bifidobacterium animalis subsp. lactis ATCC 27673 AGW85477.1     2
 BLAC_07295   Bifidobacterium animalis subsp. lactis ATCC 27673 AGW85630.1     8
 W7Y_1448   Bifidobacterium animalis subsp. lactis B420 AFJ17159.1     8
 BIF_00941   Bifidobacterium animalis subsp. lactis BB-12 ADC84837.1 D3R6V5   8
 GU89_07345   Bifidobacterium animalis subsp. lactis BF052 AJD89158.1     8
 W91_1479   Bifidobacterium animalis subsp. lactis Bi-07 AFJ18748.1     8
 ManN   Bifidobacterium animalis subsp. lactis BI07 BAH23806.1 B9X294   8
 Balac_1450 3.2.1.78 Bifidobacterium animalis subsp. lactis Bl-04 ACS46797.1 C6A9J9   8
 Bl12_1362   Bifidobacterium animalis subsp. lactis Bl12 AGO52880.1     8
 BLC1_1405   Bifidobacterium animalis subsp. lactis BLC1 AEN77175.1     8
 BALAC2494_01288   Bifidobacterium animalis subsp. lactis CNCM I-2494 AEK30917.1     8
 Balat_1450   Bifidobacterium animalis subsp. lactis DSM 10140 ACS48364.1 C6AFP1   8
 U723_07350   Bifidobacterium animalis subsp. lactis KLDS2.0603 AJC77114.1     8
 BalV_1405   Bifidobacterium animalis subsp. lactis V9 ADG33993.1 D5TIR7   8
 BA20089_02115   Bifidobacterium asteroides DSM 20089 ATO41093.1     18
 BAST_0565   Bifidobacterium asteroides PRL2011 AFU71154.1     18
 BB017W439_1229   Bifidobacterium breve 017W439 AUD95530.1     18
 BB017W439_1522   Bifidobacterium breve 017W439 AUD95818.1     44
 BB082W48_1492   Bifidobacterium breve 082W48 AUD97712.1     44
 BB082W48_1222   Bifidobacterium breve 082W48 AUD97447.1     18
 B12L_1041   Bifidobacterium breve 12L AHJ15788.1     18
 B12L_1363   Bifidobacterium breve 12L AHJ16099.1     44
 BB139W423_1576   Bifidobacterium breve 139W423 AUD99682.1     44
 BB139W423_1304   Bifidobacterium breve 139W423 AUD99416.1     18
 BB180W83_1202   Bifidobacterium breve 180W83 AUE01327.1     18
 BB180W83_1480   Bifidobacterium breve 180W83 AUE01600.1     44
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