Glycoside Hydrolase Family 5

Activities in Familyendo-β-1,4-glucanase / cellulase (EC; endo-β-1,4-xylanase (EC; β-glucosidase (EC; β-mannosidase (EC; β-glucosylceramidase (EC; glucan β-1,3-glucosidase (EC; licheninase (EC; exo-β-1,4-glucanase / cellodextrinase (EC; glucan endo-1,6-β-glucosidase (EC; mannan endo-β-1,4-mannosidase (EC; cellulose β-1,4-cellobiosidase (EC; steryl β-glucosidase (EC; endoglycoceramidase (EC; chitosanase (EC; β-primeverosidase (EC; xyloglucan-specific endo-β-1,4-glucanase (EC; endo-β-1,6-galactanase (EC; hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC; β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Mechanism Retaining
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (11393); Uniprot accession (1922); PDB accession (208); 3D entries (73); cryst (0)
All (10017) Archaea (67) Bacteria (7846) Eukaryota (1982) Viruses (5) unclassified (117) Structure (73) Characterized (547)
| 1 | ... | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | ... | 79 |
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 xylanase (Xyl141)   Bacillus subtilis Xyl14-KBRB ADP09027.1 E3UQM6   2
 β-1,4-endo-glucanase, partial (fragment)   Bacillus subtilis Y AHD24507.1     2
 endoglucanase (CeL)   Bacillus tequilensis S17I28 AIJ27554.1     2
 CAB88_17695   Bacillus thuringiensis ATCC 10792 ARP61015.1     48
 BtBc_18320   Bacillus thuringiensis Bc601 AMX80339.1     48
 BMB171_C3198   Bacillus thuringiensis BMB171 ADH08008.1 D5TT95   48
 BTI247_37720   Bacillus thuringiensis Bt18247 AOM12154.1     48
 AXW78_16645   Bacillus thuringiensis Bt185 AMR05601.1     48
 BTB_c35880   Bacillus thuringiensis Bt407 AFV19270.1     48
 β-glucosidase   Bacillus thuringiensis G13 ALJ10949.1     48
 BTG_01865   Bacillus thuringiensis HD-771 AFQ13876.1     48
 BTF1_15010   Bacillus thuringiensis HD-789 AFQ27177.1     48
 AS86_507   Bacillus thuringiensis HD1002 AJH08483.1     48
 A3L20_18535   Bacillus thuringiensis HD12 AMR88058.1     48
 A3L20_18535   Bacillus thuringiensis HD12 AMR88058.1     48
 AC241_17265   Bacillus thuringiensis HS18-1 AKR12420.1     48
 endo-β-1,4-glucanase (fragment)   Bacillus thuringiensis IARI-SP-6 AGW99983.1     2
 BCM43_11585   Bacillus thuringiensis KNU-07 ANV74005.1     48
 B4918_19610   Bacillus thuringiensis L-7601 AQY42210.1     48
 MC28_G027   Bacillus thuringiensis MC28 AFU17760.1     48
 BT246_38300 (fragment)   Bacillus thuringiensis MYBT18246 ANS49178.1     48
 BT246_63680 (fragment)   Bacillus thuringiensis MYBT18246 ANS51660.1     48
 BT246_66980 (fragment)   Bacillus thuringiensis MYBT18246 ANS51990.1     48
 Bt4C1_17180   Bacillus thuringiensis serovar alesti BGSC 4C1 AND10926.1     48
 CT43_CH3456   Bacillus thuringiensis serovar chinensis CT-43 AEA17123.1     48
 A9498_18185   Bacillus thuringiensis serovar coreanensis ST7 ANN35388.1     48
 BT4G5_29985 (fragment)   Bacillus thuringiensis serovar galleriae HD-29 AJA23074.1     48
 BT4G5_18355   Bacillus thuringiensis serovar galleriae HD-29 AJA22935.1     48
 NF53_3388   Bacillus thuringiensis serovar indiana HD521 AKR36466.1     48
 ATN07_17345   Bacillus thuringiensis serovar israelensis AM65-52 AND27454.1     48
 BG08_2313   Bacillus thuringiensis serovar kurstaki HD 1 AJK42767.1     48
 BTK_18640   Bacillus thuringiensis serovar kurstaki str. HD-1 AIE34780.1     48
 HD73_3790   Bacillus thuringiensis serovar kurstaki str. HD73 AGE79368.1     48
 DF16_orf02442 (BglC)   Bacillus thuringiensis serovar kurstaki str. YBT-1520 AIM30857.1     48
 YBT1520_18690   Bacillus thuringiensis serovar kurstaki str. YBT-1520 AHZ52363.1     48
 SD98_18215   Bacillus thuringiensis serovar morrisoni BGSC 4AA1 AJQ62320.1     48
 H175_ch3513   Bacillus thuringiensis serovar thuringiensis str. IS5056 AGG02225.1     48
 BG07_1333   Bacillus thuringiensis str. Al Hakam AJI15237.1     48
 BG07_59 (fragment)   Bacillus thuringiensis str. Al Hakam AJI17850.1     48
 YBT1518_19285   Bacillus thuringiensis YBT-1518 AHA72997.1     48
 XI92_25155   Bacillus thuringiensis YC-10 AKJ62307.1     48
 BVH75_15275   Bacillus thuringiensis YGD22-03 ARX69947.1     48
 BVH75_30260   Bacillus thuringiensis YGD22-03 ARX70213.1     28
 AQ980_12375   Bacillus thuringiensis YWC2-8 ALL61887.1     48
 B9C48_09240   Bacillus vallismortis NBIF-001 ARM28000.1     2
 CFN60_09420   Bacillus velezensis 157 ASK58591.1     2
 BK055_10270   Bacillus velezensis 9912D APA02899.1     2
 B7941_11800   Bacillus velezensis 9D-6 ARJ75167.1     2
 B938_09365   Bacillus velezensis AS43.3 AFZ90893.1     2
 BAMMD1_1755 (EglS)   Bacillus velezensis B25 CUX93659.1     2
 BACAU_1766 (BglC)   Bacillus velezensis CAU B946 CCF05300.1     2
 BCBMB205_18710   Bacillus velezensis CBMB205 ANF36769.1
 A1D33_000185   Bacillus velezensis CC09 ANB45748.1     2
 A2I97_08780   Bacillus velezensis D2-2 AOU01160.1     2
 RBAM_018100   Bacillus velezensis FZB42 CAE11243.1
 ABH13_1848   Bacillus velezensis G341 AKL76432.1     2
 BAGQ_1973   Bacillus velezensis GQJK49 ARZ58207.1     2
 CJP14_07175   Bacillus velezensis J01 ASZ03660.1     2
 AAV29_08940   Bacillus velezensis JJ-D34 AKF30670.1     2
 NG74_01886 (EglS)   Bacillus velezensis JS25R AIU81966.1     2
 BAJT_09240   Bacillus velezensis JTYP2 ARB33457.1     2
 A8142_08875   Bacillus velezensis LS69 ANU30279.1     2
 BBJ33_09410   Bacillus velezensis M75 AOO61741.1     2
 BAPNAU_1934 (BglC)   Bacillus velezensis NAU-B3 CDH95715.1     2
 AW02_018440 (BglC)   Bacillus velezensis NJN-6 AKD29994.1     2
 alkali tolerable endoglucanase, partial (Ega5)   Bacillus velezensis Q5 ALE32753.1     2
 A5891_09010   Bacillus velezensis S3-1 ANS38519.1     2
 CHN56_00337 (EglS)   Bacillus velezensis SCDB 291 ASS60881.1     2
 CLI97_03910 (EglS)   Bacillus velezensis SCGB 1 ATC53134.1     2
 CLI98_03744 (EglS)   Bacillus velezensis SCGB 574 ATD76966.1     2
 V529_17790 (BglC)   Bacillus velezensis SQR9 AHZ15805.1     2
 S100072_01973   Bacillus velezensis SRCM100072 ASB53309.1     2
 S101413_02134   Bacillus velezensis SRCM101413 ASB65581.1     2
 BLL65_09625   Bacillus velezensis sx01604 AQZ73217.1     2
 CEG11_09415   Bacillus velezensis T20E-257 ASF55305.1     2
 CG798_14945   Bacillus velezensis TB1501 ASP26388.1     2
 AJ82_10290   Bacillus velezensis TrigoCor1448 AHK49356.1     2
 RBAU_1784 (EglS)   Bacillus velezensis UCMB5033 CDG29752.1     2
 BAM5036_1746 (EglS)   Bacillus velezensis UCMB5036 CCP21786.1     2
 BASU_1764 (EglS)   Bacillus velezensis UCMB5113 CDG26057.1     2
 BANAU_1935 (BglC)   Bacillus velezensis YAU B9601-Y2 CCG49956.1     2
 AAV30_10320   Bacillus velezensis YJ11-1-4 AKF76524.1     2
 BK049_00270   Bacillus xiamenensis VV3 AOZ87243.1     7
 cellulase   bacterium enrichment culture AJO67866.1     4
 cellulase (CelA10) bacterium enrichment culture clone CelA10 ACR23656.1 C5HG53   2
 cellulase (CelA24) bacterium enrichment culture clone CelA24 ACR23659.1 C5HG56   26
 endoglucanase (Cel5) (Cel5A) bacterium enrichment culture clone FV-Cel5A AEL31246.1     2
 endoglucanase (Cel17) (Cel5B) bacterium enrichment culture clone FXVII-Cel5B AEL31247.1     1
 BRDCF_09535   Bacteroidales bacterium CF AGX08895.1
 BACCELL_03415   Bacteroides cellulosilyticus DSM 14838 EEF88964.1     21
 BcellWH2_02030 (EglS)   Bacteroides cellulosilyticus WH2 ALJ59275.1     2
 BcellWH2_02825 (Xynb_4)   Bacteroides cellulosilyticus WH2 ALJ60064.1     21
 BcellWH2_04303   Bacteroides cellulosilyticus WH2 ALJ61520.1     21
 BcellWH2_02558   Bacteroides cellulosilyticus WH2 ALJ59797.1     46
 BcellWH2_03343 (Cela_1)   Bacteroides cellulosilyticus WH2 ALJ60576.1     4
 BcellWH2_02031   Bacteroides cellulosilyticus WH2 ALJ59276.1     7
 BcellWH2_03344 (Cela_2)   Bacteroides cellulosilyticus WH2 ALJ60577.1     4
 EL88_18305   Bacteroides dorei isolate HS1_L1_B_010 AII64978.1     7
 endoxylanase (ORF1299;BACEGG_01299) (BeXyn5A) Bacteroides eggerthii DSM 20697 EEC54456.1 B7AFX5   21
 BF638R_0823   Bacteroides fragilis 638R CBW21396.1 E1WLN2   7

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