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Glycoside Hydrolase Family 5

Activities in Family[retaining] arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-);
β-1,3-mannanase (EC 3.2.1.-);
β-rutinosidase /α-L-rhamnose-(1,6)-β-D-glucosidase (EC 3.2.1.-);
Glucomannan-specific endo-β-1,4-glucanase (EC 3.2.1.-);
Mannan exo-β-1,4-mannosidase (EC 3.2.1.-);
Steryl β-glucosidase (EC 3.2.1.104);
Endoglycosylceramidase (EC 3.2.1.123);
Chitosanase (EC 3.2.1.132);
β-D-galactofuranosidase (EC 3.2.1.146);
β-primeverosidase (EC 3.2.1.149);
Oligoxyloglucan reducing-end-specific cellobiohydrolase (EC 3.2.1.150);
Xyloglucan-specific endo-β-1,4-glucanase / endo-xyloglucanase (EC 3.2.1.151);
Endo-β-1,6-galactanase (EC 3.2.1.164);
Hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168);
β-glucosidase (EC 3.2.1.21);
β-galactosidase (EC 3.2.1.23);
β-mannosidase (EC 3.2.1.25);
Xylan β-1,4-xylosidase (EC 3.2.1.37);
Endo-β-1,3-glucanase / laminarinase (EC 3.2.1.39);
Endo-β-1,4-glucanase (EC 3.2.1.4);
β-glucosylceramidase (EC 3.2.1.45);
β-galactosylceramidase (EC 3.2.1.46);
β-N-acetylhexosaminidase (EC 3.2.1.52);
α-L-arabinofuranosidase (EC 3.2.1.55);
Exo-β-1,3-glucanase (EC 3.2.1.58);
Endo-β-1,3(4)-glucanase / lichenase-laminarinase (EC 3.2.1.6);
Lichenase / endo-β-1,3-1,4-glucanase (EC 3.2.1.73);
Exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74);
Endo-β-1,6-glucanase (EC 3.2.1.75);
Endo-β-1,4-mannanase (EC 3.2.1.78);
Endo-β-1,4-xylanase (EC 3.2.1.8);
Cellobiohydrolase (EC 3.2.1.91);
Mechanism Retaining e
ClanGH-A
3D Structure Status( β / α ) 8 barrel
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (30664); Uniprot accession (670); PDB accession (295); 3D entries (109); cryst (0)
Summary
Download GH5 (43911) Taxonomic display Structure (109) Characterized (622)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | ... | 242 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 IAD21_01083   Abditibacteriota bacterium IAD-21 BCM89238.1    
 IAD21_05857   Abditibacteriota bacterium IAD-21 BCM93962.1     13
 IAD21_01123   Abditibacteriota bacterium IAD-21 BCM89278.1    
 IAD21_04620 (EgL)   Abditibacteriota bacterium IAD-21 BCM92738.1     5
 IAD21_06358   Abditibacteriota bacterium IAD-21 BCM94451.1     13
 MQE35_00650   Abyssalbus ytuae MT3330 UOB17822.1    
 MQE35_05445   Abyssalbus ytuae MT3330 UOB18735.1     4
 MQE35_14540   Abyssalbus ytuae MT3330 UOB16944.1     26
 MQE35_05845   Abyssalbus ytuae MT3330 UOB18814.1     7
 MQE35_07135   Abyssalbus ytuae MT3330 UOB19063.1     42
 MQE35_12920   Abyssalbus ytuae MT3330 UOB16635.1     46
 endoglucanase Cel5   Acetivibrio cellulolyticus WP_010249057.1     1
 glucomannanase (AceceDRAFT_0142) 3.2.1.- Acetivibrio cellulolyticus WP_010248927.1 A0A5S8WF61 6MQ4[A] 4
 AcGH5 / AceceDRAFT_1592 3.2.1.- Acetivibrio cellulolyticus CD2 EFL62381.1 E1KC96   34
 Clocl_0350   Acetivibrio clariflavus DSM 19732 AEV67086.1     4
 Clocl_1981   Acetivibrio clariflavus DSM 19732 AEV68583.1     1
 Clocl_3932   Acetivibrio clariflavus DSM 19732 AEV70372.1     1
 Clocl_1122   Acetivibrio clariflavus DSM 19732 AEV67797.1     1
 HVS_14300 (fragment)   Acetivibrio saccincola GGR1 AUG58721.1     2
 HVS_09600 (Cele5)   Acetivibrio saccincola GGR1 AUG57819.1     4
 HVS_03380   Acetivibrio saccincola GGR1 AUG56624.1     1
 HVS_07025   Acetivibrio saccincola GGR1 AUG57322.1     1
 HVS_12420 (Cel5A)   Acetivibrio saccincola GGR1 AUG58357.1     2
 HVS_16090 (Mana3)   Acetivibrio saccincola GGR1 AUG59057.1     55
 endo-β-1,4-glucanase E (CelE;EgE) (Cel5C) 3.2.1.4
3.2.1.8
3.2.1.-		 Acetivibrio thermocellus AAA23224.1 P10477 4IM4[A,B,C,D,E,F] 4
 AD2_02839   Acetivibrio thermocellus AD2 ALX09817.1     1
 AD2_01411   Acetivibrio thermocellus AD2 ALX08404.1     55
 AD2_01719   Acetivibrio thermocellus AD2 ALX08709.1     1
 AD2_02267   Acetivibrio thermocellus AD2 ALX09255.1     25
 AD2_02266   Acetivibrio thermocellus AD2 ALX09254.1    
 AD2_02890   Acetivibrio thermocellus AD2 ALX09868.1     34
 AD2_00416   Acetivibrio thermocellus AD2 ALX07424.1     1
 AD2_00399   Acetivibrio thermocellus AD2 ALX07407.1     37
 AD2_01837   Acetivibrio thermocellus AD2 ALX08827.1     1
 AD2_01437   Acetivibrio thermocellus AD2 ALX08430.1     4
 cellulose-specific sensor (Rsi24C;Cthe_1471)   Acetivibrio thermocellus ATCC 27405 ABN52700.1
CCF82161.1		    
 Cthe_0405 (CelL) 3.2.1.4 Acetivibrio thermocellus ATCC 27405 ABN51643.1 A3DCG4   1
 endo-β-1,4-glucanase B (CelB;EgB;Cthe_0536) (Cel5A) 3.2.1.4 Acetivibrio thermocellus ATCC 27405 ABN51772.1 P04956   1
 acetylxylan esterase / 6-O-glycoside deacetylase (CelE;CtCE2;Cthe_0797) (Cel5C)   Acetivibrio thermocellus ATCC 27405 ABN52032.1 A3DDK3
P10477		   4
 β-mannanase (CtMan5A;Cthe_0821) (Man5A) 3.2.1.78 Acetivibrio thermocellus ATCC 27405 ABN52056.1 A3DDM7   55
 bifunctional endo-β-1,4-glucanase / β-1,4-xylanase H (CelH;EgH;CtCelH;CtCel5E;Cthe_1472) (Lic26A;Cel5E) 3.2.1.4
3.2.1.8		 Acetivibrio thermocellus ATCC 27405 ABN52701.1
CCF82162.1		 H6SHY4
P16218		 4U3A[A,B]
4U5I[A,B]
4U5K[A,B]
5BYW[A,B,C,D,E] 		25
 Cthe_2147 (CelO) (Cel5F)   Acetivibrio thermocellus ATCC 27405 ABN53350.1     1
 xylanase (M6;CtM6;CtXyl5A;Cthe_2193) (arabinoxylan-specific) (Xyl5A) 3.2.1.- Acetivibrio thermocellus ATCC 27405 ABN53395.1 A3DHG6 2Y8K[A]
5AK1[A]
5G56[A]
5LA0[A]
5LA1[A]
5LA2[A,B] 		34
 Cthe_2807 (CelC)   Acetivibrio thermocellus ATCC 27405 ABN54006.1     37
 endo-β-1,4-glucanase G (CelG;Cthe_2872) (Cel5D) 3.2.1.4 Acetivibrio thermocellus ATCC 27405 ABN54070.1 Q05332   1
 Clo1313_1701   Acetivibrio thermocellus DSM 1313 ADU74758.1     1
 Clo1313_1425   Acetivibrio thermocellus DSM 1313 ADU74487.1     4
 Clo1313_1398   Acetivibrio thermocellus DSM 1313 ADU74461.1     55
 Clo1313_2233   Acetivibrio thermocellus DSM 1313 ADU75266.1    
 Clo1313_2856   Acetivibrio thermocellus DSM 1313 ADU75836.1     34
 Clo1313_0395   Acetivibrio thermocellus DSM 1313 ADU73485.1     37
 Clo1313_2234   Acetivibrio thermocellus DSM 1313 ADU75267.1     25
 Clo1313_1816   Acetivibrio thermocellus DSM 1313 ADU74872.1     1
 Clo1313_2805   Acetivibrio thermocellus DSM 1313 ADU75785.1     1
 Clo1313_0413   Acetivibrio thermocellus DSM 1313 ADU73502.1     1
 LQRI_2265   Acetivibrio thermocellus DSM 2360 LQRI ANV77006.1    
 LQRI_1836   Acetivibrio thermocellus DSM 2360 LQRI ANV76577.1     1
 LQRI_1412   Acetivibrio thermocellus DSM 2360 LQRI ANV76153.1     55
 LQRI_1720   Acetivibrio thermocellus DSM 2360 LQRI ANV76461.1     1
 LQRI_1438   Acetivibrio thermocellus DSM 2360 LQRI ANV76179.1     4
 LQRI_0399   Acetivibrio thermocellus DSM 2360 LQRI ANV75146.1     37
 LQRI_2901   Acetivibrio thermocellus DSM 2360 LQRI ANV77642.1     34
 LQRI_2266   Acetivibrio thermocellus DSM 2360 LQRI ANV77007.1     25
 LQRI_2850   Acetivibrio thermocellus DSM 2360 LQRI ANV77591.1     1
 LQRI_0416   Acetivibrio thermocellus DSM 2360 LQRI ANV75163.1     1
 endo-1,4-β-glucanase (CelL)   Acetivibrio thermocellus F7 CAK18680.1     1
 cellobiohydrolase (CelO) (Cel5F) 3.2.1.74 Acetivibrio thermocellus F7 CAB76938.1 Q9L3J2   1
 endo-β-1,4-glucanase C (CelC) 3.2.1.4 Acetivibrio thermocellus F7 CAC27410.1 Q9AL36   37
 Cther_1146   Acetivibrio thermocellus JW20 EFB38194.1     34
 N1236_11700   Acetivibrio thermocellus M3 UWV46228.1    
 N1236_02010   Acetivibrio thermocellus M3 UWV47316.1     37
 N1236_14670   Acetivibrio thermocellus M3 UWV46765.1     34
 N1236_07620   Acetivibrio thermocellus M3 UWV48370.1     4
 N1236_11705   Acetivibrio thermocellus M3 UWV46229.1     25
 N1236_14420   Acetivibrio thermocellus M3 UWV46719.1     1
 N1236_07485   Acetivibrio thermocellus M3 UWV48345.1     55
 N1236_09000   Acetivibrio thermocellus M3 UWV45720.1     1
 N1236_09580   Acetivibrio thermocellus M3 UWV45830.1     1
 N1236_02105   Acetivibrio thermocellus M3 UWV47335.1     1
 endo-β-1,4-glucanase B (CelB;EgB) (Cel5A) 3.2.1.4 Acetivibrio thermocellus NCIB 10682 CAA27266.1 P04956   1
 endo-β-1,4-glucanase G (CelG) (Cel5D) 3.2.1.4 Acetivibrio thermocellus NCIB 10682 CAA49187.1 Q05332   1
 endo-β-1,4-glucanase / β-1,3:1,4-glucanase H (CelH) (Lic26A;Cel5E) 3.2.1.4 Acetivibrio thermocellus NCIB 10682 AAA23225.1 H6SHY4
P16218		   25
 endo-β-1,4-glucanase C (LC2;CelC;EgC) (Cel5B) 3.2.1.4 Acetivibrio thermocellus NCIB 10682EL AAA23220.1 P07985
P0C2S3		 1CEC[A]
1CEN[A]
1CEO[A] 		37
 AAJCM20276_12050 (EgL) (fragment)   Acetobacter aceti JCM20276 BCI66581.1     5
 EMQ_1124 (EgL)   Acetobacter aceti NBRC 14818 BCK75518.1     5
 A0U92_11525   Acetobacter aceti TMW2.1153 AQS85316.1     5
 HN018_01005   Acetobacteraceae bacterium PAMC 26569 QKE88818.1     5
 HN018_26200 (fragment)   Acetobacteraceae bacterium PAMC 26569 QKE93646.1    
 HN018_18315   Acetobacteraceae bacterium PAMC 26569 QKE91726.1     39
 HN018_13605   Acetobacteraceae bacterium PAMC 26569 QKE90937.1     5
 HN018_26165   Acetobacteraceae bacterium PAMC 26569 QKE93796.1     13
 HN018_06990   Acetobacteraceae bacterium PAMC 26569 QKE89820.1    
 HN018_13630   Acetobacteraceae bacterium PAMC 26569 QKE90941.1     5
 HN018_13595   Acetobacteraceae bacterium PAMC 26569 QKE90936.1     5
 DOZ58_15375   Acetobacterium sp. KB-1 AWW27905.1     2
 Awo_c08790   Acetobacterium woodii DSM 1030 AFA47670.1     2
 NCTC10172_01384   Acholeplasma hippikon NCTC10172 VEU83309.1     7
 Aocu_05710   Acholeplasma oculi CDR30644.1    
 Afer_0065   Acidimicrobium ferrooxidans DSM 10331 ACU53036.1    
 Afer_2006   Acidimicrobium ferrooxidans DSM 10331 ACU54908.1    
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