Glycoside Hydrolase Family 5

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (11450); Uniprot accession (1922); PDB accession (208); 3D entries (73); cryst (0)
All (10074) Archaea (67) Bacteria (7903) Eukaryota (1982) Viruses (5) unclassified (117) Structure (73) Characterized (547)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | ... | 80 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 AcGH5 / AceceDRAFT_1592 3.2.1.- Acetivibrio cellulolyticus CD2 EFL62381.1 E1KC96   34
 A0U92_11525   Acetobacter aceti TMW2.1153 AQS85316.1     5
 Awo_c08790   Acetobacterium woodii DSM 1030 AFA47670.1     2
 Aocu_05710   Acholeplasma oculi CDR30644.1    
 Afer_0065   Acidimicrobium ferrooxidans DSM 10331 ACU53036.1 C7M1I7  
 Afer_2006   Acidimicrobium ferrooxidans DSM 10331 ACU54908.1 C7M2B9  
 PACID_31000   Acidipropionibacterium acidipropionici ATCC 4875 AFV90860.1     19
 PACID_31160   Acidipropionibacterium acidipropionici ATCC 4875 AFV90876.1     18
 AXH35_08510   Acidipropionibacterium acidipropionici ATCC 55737 AMS05481.1     19
 AXH35_08595   Acidipropionibacterium acidipropionici ATCC 55737 AMS07131.1     18
 ASQ49_06605   Acidipropionibacterium acidipropionici CGMCC 1.2230 ALN16772.1     18
 A8L58_09955   Acidipropionibacterium acidipropionici F3E8 AOZ46953.1     19
 A8L58_10040   Acidipropionibacterium acidipropionici F3E8 AOZ48331.1     18
 BWX38_08325   Acidipropionibacterium acidipropionici WSH1105 APZ09244.1     18
 LuPra_04602   Acidobacteria bacterium DSM 100886 AMY11352.1    
 LuPra_01176   Acidobacteria bacterium DSM 100886 AMY07988.1     13
 ACP_0988   Acidobacterium capsulatum ATCC 51196 ACO32108.1 C1F3J6   46
 β-mannanase (ManA) 3.2.1.78 Acidothermus cellulolyticus ABJ41262.1
ABJ41263.1
ABJ41266.1
    7
 endo-β-1,4-glucanase E1 (EGAc;EGI;TcE1;Acel_0614) (Cel5A) 3.2.1.4 Acidothermus cellulolyticus 11B AAA75477.1
ABH84883.1
ABK52387.1
ACW33392.1
CAD42489.1
CAR96693.1
P54583 1C0D[A,B]
1ECE[A,B]
1VRX[A,B]
1
 mannanase (Acel_0616)   Acidothermus cellulolyticus 11B ABK52389.1 A0LSH9   7
 Acav_2361   Acidovorax avenae subsp. avenae ATCC 19860 ADX46273.1    
 Acav_3053   Acidovorax avenae subsp. avenae ATCC 19860 ADX46955.1     1
 Aave_2102   Acidovorax citrulli AAC00-1 ABM32683.1 A1TNZ5   1
 Aave_2924   Acidovorax citrulli AAC00-1 ABM33492.1 A1TRA4  
 CQB05_08805   Acidovorax citrulli KACC17005 ATG94120.1    
 CQB05_04045   Acidovorax citrulli KACC17005 ATG93317.1     1
 endoglucanase, partial   Acidovorax citrulli xjgb-wy6 AKT09126.1     1
 Gly (fragment)   Acinetobacter baumannii 7037 ABL75132.1 A5Y0S2   48
 Gly (fragment)   Acinetobacter baumannii 7037 ABL75136.1 A5Y0S6   48
 AHOG_12310 (Mana1)   Actinoalloteichus hoggarensis DSM 45943 ASO20105.1     8
 AHOG_06610   Actinoalloteichus hoggarensis DSM 45943 ASO18971.1    
 TL08_12195   Actinoalloteichus hymeniacidonis HPA177(T) (=DSM 45092(T)) AOS63253.1     8
 UA74_13020   Actinoalloteichus sp. ADI127-7 APU14662.1     8
 UA74_06880   Actinoalloteichus sp. ADI127-7 APU13446.1    
 UA75_13100   Actinoalloteichus sp. GBA129-24 APU20630.1     8
 UA75_06875   Actinoalloteichus sp. GBA129-24 APU19395.1    
 IMCC26256_11575   Actinobacteria bacterium IMCC26256 AKL72871.1     13
 SAMN04489714_2031   Actinomyces radingae DSM 9169 SDU07880.1     18
 endo-β-1,4-glucanase 3.2.1.4 Actinomyces sp. 40 AAC06196.1 O66064   2
 SAMN04489716_4311   Actinoplanes derwentensis DSM 43941 SDT52805.1     8
 SAMN04489716_1143   Actinoplanes derwentensis DSM 43941 SDS59746.1     1
 SAMN04489716_0268   Actinoplanes derwentensis DSM 43941 SDS21202.1     2
 SAMN04489716_8416   Actinoplanes derwentensis DSM 43941 SDT78544.1    
 SAMN04489716_5330   Actinoplanes derwentensis DSM 43941 SDT66250.1    
 SAMN04489716_1697   Actinoplanes derwentensis DSM 43941 SDS81858.1     4
 SAMN04489716_1987   Actinoplanes derwentensis DSM 43941 SDS92153.1     51
 SAMN04489716_0859   Actinoplanes derwentensis DSM 43941 SDS47321.1    
 SAMN04489716_3551   Actinoplanes derwentensis DSM 43941 SDT38399.1     2
 SAMN04489716_1035   Actinoplanes derwentensis DSM 43941 SDS55170.1    
 SAMN04489716_4612   Actinoplanes derwentensis DSM 43941 SDT57550.1     43
 SAMN04489716_3740   Actinoplanes derwentensis DSM 43941 SDT42643.1     8
 SAMN04489716_5708   Actinoplanes derwentensis DSM 43941 SDT69013.1     4
 AFR_12400   Actinoplanes friuliensis DSM 7358 AGZ40766.1     4
 AFR_18915   Actinoplanes friuliensis DSM 7358 AGZ42057.1     8
 AFR_22970   Actinoplanes friuliensis DSM 7358 AGZ42864.1     2
 AFR_24740   Actinoplanes friuliensis DSM 7358 AGZ43214.1     1
 AFR_13800   Actinoplanes friuliensis DSM 7358 AGZ41046.1    
 AMIS_52810   Actinoplanes missouriensis 431 BAL90501.1     2
 AMIS_66390   Actinoplanes missouriensis 431 BAL91859.1    
 AMIS_9970   Actinoplanes missouriensis 431 BAL86217.1     4
 AMIS_23050   Actinoplanes missouriensis 431 BAL87525.1     8
 AMIS_23960   Actinoplanes missouriensis 431 BAL87616.1    
 AMIS_49860   Actinoplanes missouriensis 431 BAL90206.1     4
 AMIS_38990   Actinoplanes missouriensis 431 BAL89119.1     1
 AMIS_40420   Actinoplanes missouriensis 431 BAL89262.1     8
 L083_0808   Actinoplanes sp. N902-109 AGL14318.1     18
 L083_3363 (CelA)   Actinoplanes sp. N902-109 AGL16873.1     40
 L083_3484   Actinoplanes sp. N902-109 AGL16994.1     1
 L083_3663 (BglC)   Actinoplanes sp. N902-109 AGL17173.1     2
 L083_4706   Actinoplanes sp. N902-109 AGL18216.1     4
 L083_5388   Actinoplanes sp. N902-109 AGL18898.1     8
 ACPL_4099   Actinoplanes sp. SE50/110 AEV84994.1
SLM00792.1
    1
 ACPL_5001   Actinoplanes sp. SE50/110 AEV85890.1
SLM01696.1
   
 ACPL_5177 (BglC)   Actinoplanes sp. SE50/110 AEV86064.1
SLM01872.1
    2
 ACPL_6130   Actinoplanes sp. SE50/110 AEV87015.1
SLM02825.1
    4
 ACPL_6177 (BglC)   Actinoplanes sp. SE50/110 AEV87062.1
SLM02872.1
    2
 ACPL_6337 (CelA)   Actinoplanes sp. SE50/110 AEV87219.1
SLM03033.1
    40
 ACPL_2275   Actinoplanes sp. SE50/110 AEV83172.1
SLL98973.1
   
 ACPL_2761   Actinoplanes sp. SE50/110 AEV83656.1
SLL99607.1
   
 ACPL_3874   Actinoplanes sp. SE50/110 AEV84769.1
SLM00568.1
   
 ACPL_6902   Actinoplanes sp. SE50/110 AEV87784.1
SLM03600.1
   
 SAMN04489717_0883   Actinopolymorpha singaporensis DSM 22024 SDR87823.1     7
 SAMN04489717_1670   Actinopolymorpha singaporensis DSM 22024 SDS11517.1     4
 SAMN04489717_2988   Actinopolymorpha singaporensis DSM 22024 SDS53076.1     1
 CDG81_12880   Actinopolyspora erythraea YIM 90600 ASU79031.1     19
 CDG81_11150   Actinopolyspora erythraea YIM 90600 ASU78741.1    
 CDG81_11260   Actinopolyspora erythraea YIM 90600 ASU78759.1     19
 Amir_1830   Actinosynnema mirum DSM 43827 ACU35778.1 C6WE35   8
 Amir_4131   Actinosynnema mirum DSM 43827 ACU37986.1 C6WH67   19
 Amir_4152   Actinosynnema mirum DSM 43827 ACU38007.1 C6WH88   8
 Amir_4607   Actinosynnema mirum DSM 43827 ACU38440.1 C6WLP7   18
 Amir_2781   Actinosynnema mirum DSM 43827 ACU36714.1 C6WP45   4
 Amir_3216   Actinosynnema mirum DSM 43827 ACU37124.1 C6W8M5   1
 Amir_3335   Actinosynnema mirum DSM 43827 ACU37240.1 C6W9M3   4
 Amir_4225   Actinosynnema mirum DSM 43827 ACU38080.1 C6WHG1   51
 Amir_6164   Actinosynnema mirum DSM 43827 ACU39971.1 C6WHM2   43
 asmnew07   Actinosynnema pretiosum subsp. auranticum ATCC 31565 AEC53450.1     1
 CNX65_14080   Actinosynnema pretiosum X47 ATE54282.1     4
 CNX65_22910   Actinosynnema pretiosum X47 ATE55778.1     18
 CNX65_20775   Actinosynnema pretiosum X47 ATE55417.1     8
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