Glycoside Hydrolase Family 5

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (13513); Uniprot accession (1922); PDB accession (214); 3D entries (76); cryst (0)
All (12129) Archaea (93) Bacteria (9771) Eukaryota (2138) Viruses (7) unclassified (120) Structure (76) Characterized (549)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | ... | 98 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 glycosyl hydrolase family 5_8 domain-containing protein   Alteromonadaceae bacterium Bs12 AIF91534.1     8
 glycosyl hydrolase family 5_53 domain-containing protein   Alteromonadaceae bacterium Bsc2 AIF91521.1     53
 AV939_12175   Alteromonas sp. Mac1 AMJ87257.1     41
 AV940_11940   Alteromonas sp. Mac2 AMJ91120.1     41
 A6F57_02120   Alteromonas stellipolaris PQQ-44 ANB24109.1     41
 AA2016_1400   Aminobacter aminovorans KCTC 2477 AMS40334.1    
 AA2016_1944   Aminobacter aminovorans KCTC 2477 AMS40874.1     48
 CO731_02078   Aminobacter sp. MSH1 AWC22614.1     48
 CO731_01363 (CelC)   Aminobacter sp. MSH1 AWC21909.1    
 AXY_08250   Amphibacillus xylanus NBRC 15112 BAM46957.1     8
 A4R43_02425   Amycolatopsis albispora WP1 AXB48222.1     25
 A4R43_06505   Amycolatopsis albispora WP1 AXB42227.1     1
 A4R43_10805   Amycolatopsis albispora WP1 AXB42975.1     2
 A4R43_06415   Amycolatopsis albispora WP1 AXB42212.1     8
 AJAP_23210   Amycolatopsis japonica MG417-CF17 AIG77495.1     51
 AJAP_19810 (Cele2)   Amycolatopsis japonica MG417-CF17 AIG76823.1     2
 AJAP_11650 (Cele1)   Amycolatopsis japonica MG417-CF17 AIG75215.1     2
 SAMN04489733_2631   Amycolatopsis keratiniphila FH 1893 SDU27618.1     51
 SAMN04489733_0211   Amycolatopsis keratiniphila FH 1893 SDT99530.1     2
 SAMN04489733_1943   Amycolatopsis keratiniphila FH 1893 SDU19440.1     2
 BB31_41955   Amycolatopsis lurida NRRL 2430 AJK59464.1     2
 BB31_05885   Amycolatopsis lurida NRRL 2430 AJK53007.1     2
 B737_4049   Amycolatopsis mediterranei RB AGT84713.1     2
 B737_7271   Amycolatopsis mediterranei RB AGT87932.1     4
 B737_5130   Amycolatopsis mediterranei RB AGT85794.1     1
 B737_8016   Amycolatopsis mediterranei RB AGT88677.1     40
 B737_2653   Amycolatopsis mediterranei RB AGT83317.1     18
 B737_7302   Amycolatopsis mediterranei RB AGT87963.1     8
 B737_2348   Amycolatopsis mediterranei RB AGT83012.1     43
 RAM_38105   Amycolatopsis mediterranei S699 AEK46088.1
AFO80835.1
    8
 RAM_20880   Amycolatopsis mediterranei S699 AEK42656.1
AFO77585.1
    2
 RAM_13630   Amycolatopsis mediterranei S699 AEK41214.1
AFO76188.1
    18
 RAM_37950   Amycolatopsis mediterranei S699 AEK46057.1
AFO80804.1
    4
 RAM_41810   Amycolatopsis mediterranei S699 AEK46829.1
AFO81548.1
    40
 RAM_26450   Amycolatopsis mediterranei S699 AEK43767.1
AFO78666.1
    1
 RAM_12075   Amycolatopsis mediterranei S699 AEK40905.1
AFO75883.1
    43
 AMED_2374   Amycolatopsis mediterranei U32 ADJ44170.1 D8HUX2   43
 AMED_2681   Amycolatopsis mediterranei U32 ADJ44476.1 D8HY34   18
 AMED_4097   Amycolatopsis mediterranei U32 ADJ45874.1 D8HQ52   2
 AMED_5192   Amycolatopsis mediterranei U32 ADJ46955.1 D8I1M4   1
 AMED_7382   Amycolatopsis mediterranei U32 ADJ49096.1 D8I9C9   4
 AMED_7413   Amycolatopsis mediterranei U32 ADJ49127.1 D8I9G0   8
 AMED_8139   Amycolatopsis mediterranei U32 ADJ49840.1 D8HLV8   40
 SD37_27170   Amycolatopsis orientalis B-37 ANN18940.1     2
 SD37_17825   Amycolatopsis orientalis B-37 ANN17321.1     4
 SD37_19870   Amycolatopsis orientalis B-37 ANN17680.1     2
 SD37_21965   Amycolatopsis orientalis B-37 ANN21935.1     1
 SD37_23615   Amycolatopsis orientalis B-37 ANN18328.1     43
 SD37_16955   Amycolatopsis orientalis B-37 ANN17163.1     8
 SD37_26450   Amycolatopsis orientalis B-37 ANN22051.1     40
 AORI_3215   Amycolatopsis orientalis HCCB10007 AGM05800.1     51
 AORI_3875   Amycolatopsis orientalis HCCB10007 AGM06460.1     2
 AORI_5568   Amycolatopsis orientalis HCCB10007 AGM08151.1     2
 BKN51_11830   Amycolatopsis sp. BJA-103 AUI58831.1     2
 endo-β-1,4-glucanase (End2)   Anabaena laxa RPAN8 / CCC 381 ADE22239.1 D5KTA0  
 ANA_C11786   Anabaena sp. 90 AFW94547.1     55
 ANT_03660   Anaerolinea thermophila UNI-1 BAJ62400.1     37
 ANT_22130   Anaerolinea thermophila UNI-1 BAJ64239.1     12
 ANT_18750   Anaerolinea thermophila UNI-1 BAJ63901.1     25
 BEQ56_08495   Anaerolineaceae bacterium oral taxon 439 W11661 AOH43511.1     4
 Anae109_4201   Anaeromyxobacter sp. Fw109-5 ABS28379.1 A7HI33  
 Anae109_3225   Anaeromyxobacter sp. Fw109-5 ABS27420.1 A7HFC4  
 GFC28_925   Anoxybacillus sp. B2M1 ANB56319.1     22
 GFC29_701   Anoxybacillus sp. B7M1 ANB65284.1     22
 SAMN00777080_1515   Aquiflexum balticum DSM 16537 SMD42944.1     25
 SAMN00777080_2486   Aquiflexum balticum DSM 16537 SMD43874.1     38
 SAMN00777080_1055   Aquiflexum balticum DSM 16537 SMD42501.1     36
 A9P82_12630   Arachidicoccus sp. BS20 ANI90055.1     13
 A9P82_13735   Arachidicoccus sp. BS20 ANI90259.1     2
 Arch_0033   Arcanobacterium haemolyticum DSM 20595 ADH91800.1 D7BLK1   18
 NCTC8452_00154   Arcanobacterium haemolyticum NCTC8452 SQH27378.1     18
 SAMN04489737_0425   Arcanobacterium phocae DSM 10002 SDU78319.1     18
 SAMN04489737_0244   Arcanobacterium phocae DSM 10002 SDU77936.1     28
 AA314_01832   Archangium gephyra DSM 2261 AKJ00206.1     7
 DJ013_04540   Arcticibacterium luteifluviistationis SM1504 AWV97476.1     36
 DJ013_13375   Arcticibacterium luteifluviistationis SM1504 AWV99104.1     42
 DJ013_21585   Arcticibacterium luteifluviistationis SM1504 AWW00634.1     25
 AREALGSMS7_03094   Arenibacter algicola SMS7 ASO06525.1     13
 CCB80_07970   Armatimonadetes bacterium Uphvl-Ar1 ARU41080.1     47
 AOC05_14730   Arthrobacter alpinus R3.8 ALE93292.1     18
 CGQ24_15805   Arthrobacter sp. 7749 ASN40324.1     18
 MB46_17100   Arthrobacter sp. A3 ALV46941.1     18
 UM93_09880   Arthrobacter sp. IHBB 11108 AJT41747.1     18
 ART_2884   Arthrobacter sp. PAMC 25486 AIY02483.1     18
 ART_1927   Arthrobacter sp. PAMC 25486 AIY01526.1    
 CFN17_10160 (fragment)   Arthrobacter sp. PM3 AXJ11793.1     1
 CGK93_22015   Arthrobacter sp. YN ASN22040.1     18
 CGK93_22205   Arthrobacter sp. YN ASN22069.1     18
 Astex_2349   Asticcacaulis excentricus CB 48 ADU14002.1 C5SHS4   48
 Astex_2497   Asticcacaulis excentricus CB 48 ADU14148.1 C5SQ05   25
 Astex_2880   Asticcacaulis excentricus CB 48 ADU14517.1 C5SNP2   7
 Astex_3212   Asticcacaulis excentricus CB 48 ADU14847.1 C5SP55   4
 EM6_2485   Asticcacaulis excentricus M6 BBF81876.1     25
 EM6_2592   Asticcacaulis excentricus M6 BBF81973.1     4
 EM6_2786   Asticcacaulis excentricus M6 BBF82157.1     7
 Apar_1088   Atopobium parvulum DSM 20469 ACV51516.1 C8W7S5  
 M673_19220   Aureimonas sp. AU20 ALN74859.1    
 CEW87_07940   Azoarcus communis TSNA42 AWI79302.1     45
 dqs_2441   Azoarcus olearius DQS4 ANQ85471.1     45
 dqs_2369   Azoarcus olearius DQS4 ANQ85400.1     5
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