Glycoside Hydrolase Family 5 / Subf 2

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (1112); Uniprot accession (275); PDB accession (42); 3D entries (14); cryst (0)
All (995) Bacteria (826) Eukaryota (155) unclassified (14) Structure (14) Characterized (119)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 |
Bacteria
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 C6W10_11910   Plantactinospora sp. BB1 AVT37049.1     2
 C6361_13510   Plantactinospora sp. BC1 AVT30345.1     2
 CIK06_15180   Plantactinospora sp. KBS50 ASW55230.1     2
 BTO07_06690   Polaribacter sp. SA4-12 ARV14855.1     2
 AAW51_2818   [Polyangium] brachysporum DSM 7029 AKJ29509.1     2
 AAW51_2817   [Polyangium] brachysporum DSM 7029 AKJ29508.1     2
 PARC_b0695   Pseudoalteromonas arctica A 37-1-2 ATC88864.1     2
 Patl_1404   Pseudoalteromonas atlantica T6c ABG39929.1 Q15W09   2
 PCAR9_B0611 (fragment)   Pseudoalteromonas carrageenovora IAM 12662 ATCC 43555 SOU43078.1     2
 PCAR9_B0610 (fragment)   Pseudoalteromonas carrageenovora IAM 12662 ATCC 43555 SOU43077.1     2
 CelA8   Pseudoalteromonas haloplanktis ADI47126.1 D9I3V0   2
 endoglucanase (CelG) (Cel5G) 3.2.1.4 Pseudoalteromonas haloplanktis A23 CAA76775.1 O86099 1TVN[A,B]
1TVP[A,B]
2
 endoglucanase (Cel5A)   Pseudoalteromonas haloplanktis A5 ADD17064.1 D3YHF1   2
 S4054_20400   Pseudoalteromonas luteoviolacea S4054 AOT19860.1     2
 S40542_20395   Pseudoalteromonas luteoviolacea S40542 AOT14944.1     2
 S4054249_20425   Pseudoalteromonas luteoviolacea S4054249 AOT10033.1     2
 AT705_23635   Pseudoalteromonas rubra SCSIO 6842 ALU45920.1     2
 AOR04_20710   Pseudoalteromonas sp. 1_2015MBL_MicDiv ATG79951.1     2
 D172_019580   Pseudoalteromonas sp. Bsw20308 ALQ10273.1
AEK35325.1
    2
 endoglucanase (CelA) 3.2.1.4 Pseudoalteromonas sp. MB-1 AAS58467.1 Q6QA02   2
 cellulase (CelY) 3.2.1.4 Pseudoalteromonas sp. NO3 ACN62172.1 C0KZC4   2
 cellulase (AclA)   Pseudomonas sp. ND137 BAB79288.1 Q8VUT3   2
 endo-β-1,4-glucanase (CelX) 3.2.1.4 psychrophilic marine bacterium DY3 AAP04424.1 Q841J5   2
 RD2015_3542   Roseateles depolymerans KCTC 42856 ALV07998.1     2
 DC20_12305   Rufibacter tibetensis strain 1351 ALJ01419.1     2
 DC20_05235   Rufibacter tibetensis strain 1351 ALJ01230.1     2
 DC20_16535   Rufibacter tibetensis strain 1351 ALJ01521.1     2
 A4V00_16090   Ruminiclostridium sp. KB18 ANU55408.1     2
 endo-1,4-glucanase 4 (EGIV) 3.2.1.4 Ruminococcus albus BAA32286.1 Q07940   2
 Rumal_1845   Ruminococcus albus 7 = DSM 20455 ADU22343.1 E0L4M7   2
 RBI_I00026   Ruminococcus bicirculans 80/3 CCO03766.1     2
 endo-β-1,4-glucanase 5J (Sde_2494) (processive) (Cel5J) 3.2.1.4 Saccharophagus degradans 2-40 ABD81754.1 Q21HS5   2
 endoglucanase 5A (Sde_3003) (Cel5A)   Saccharophagus degradans 2-40 ABD82260.1 Q21GB9   2
 endoglucanase 5A (Sde_3003) (Cel5A)   Saccharophagus degradans 2-40 ABD82260.1 Q21GB9   2
 endo-β-1,4-glucanase 5H (Sde_3237) (processive) (Cel5H) 3.2.1.4 Saccharophagus degradans 2-40 ABD82494.1 Q21FN5   2
 endo-β-1,4-glucanase 5G (Sde_3239) (processive) (Cel5G) 3.2.1.4 Saccharophagus degradans 2-40 ABD82496.1 Q21FN3   2
 endoglucanase (Egl-R1)   Saccharophagus sp. JAM-R001 BAI50016.1 D0VYQ8   2
 cellulase (CelMytA)   Saccharophagus sp. Myt-1 BAL42331.1     2
 cellulase (CelMytA)   Saccharophagus sp. Myt-1 BAL42331.1     2
 cellulase (CelMytB) 3.2.1.4 Saccharophagus sp. Myt-1 BAM21527.1     2
 SACE_4004   Saccharopolyspora erythraea NRRL 2338 CAM03275.1 A4FGV0   2
 BN6_31760 (CelE)   Saccharothrix espanaensis DSM 44229 type strain: DSM 44229 CCH30481.1     2
 Sare_2410   Salinispora arenicola CNS-205 ABV98267.1 A8M2F1   2
 Strop_2285   Salinispora tropica CNB-440 ABP54735.1 A4X785   2
 Strop_4424   Salinispora tropica CNB-440 ABP56852.1 A4XD45   2
 endo-β-1,4-glucanase 5A (Cel5A) 3.2.1.4 Salipaludibacillus agaradhaerens AAC19169.1 O85465 1A3H[A]
1E5J[A]
1H11[A]
1H2J[A]
1H5V[A]
1HF5[A]
1HF6[A]
1HF7[A]
1OCQ[A]
1QHZ[A]
1QI0[A]
1QI2[A]
1W3K[A]
1W3L[A]
2A3H[A]
2V38[A]
3A3H[A]
4A3H[A]
5A3H[A]
6A3H[A]
7A3H[A]
8A3H[A]
2
 BWZ22_15220   Seonamhaeicola sp. S2-3 APY12487.1     2
 Ser39006_2780   Serratia sp. ATCC 39006 AGU87995.1
AUH00725.1
AUH05046.1
    2
 cellulase (Cel5tm2)   Simiduia sp. TM-2 BAX64261.1     2
 Solca_2501   Solitalea canadensis DSM 3403 AFD07536.1     2
 SOCE26_059880   Sorangium cellulosum So ce26 AUX44524.1     2
 SOCE26_082810   Sorangium cellulosum So ce26 AUX46772.1     2
 SOCE26_020140   Sorangium cellulosum So ce26 AUX40613.1     2
 sce1468   Sorangium cellulosum So ce56 CAN91626.1 A9FC50   2
 sce4910 (fragment)   Sorangium cellulosum So ce56 CAN95073.1 A9FK25   2
 SCE1572_09655   Sorangium cellulosum So0157-2 AGP34753.1     2
 SCE1572_28110   Sorangium cellulosum So0157-2 AGP37996.1     2
 SCE1572_29465   Sorangium cellulosum So0157-2 AGP38247.1     2
 STHERM_c14520 3.2.1.4 Spirochaeta thermophila DSM 6192 ADN02392.1 E0RT96   2
 Spith_0779   Spirochaeta thermophila DSM 6578 AEJ61055.1     2
 AWR27_01240   Spirosoma montaniterrae DY10 AQG78093.1     2
 Snas_1941   Stackebrandtia nassauensis DSM 44728 ADD41637.1 D3PZG3   2
 SMD44_00718   Streptomyces alboflavus MDJK44 ARX81320.1     2
 cellulase (Cel5A)   Streptomyces argenteolus M178 BAP19001.1     2
 BB341_00650   Streptomyces clavuligerus F613-1 ANW21741.1     2
 SCO7637 or SC10F4.10c   Streptomyces coelicolor A3(2) CAC16970.1
NP_631677.1
Q9F3Q0   2
 TU94_26220   Streptomyces cyaneogriseus subsp. noncyanogenus NMWT 1 AJP04440.1     2
 BN159_1272   Streptomyces davaonensis JCM 4913 CCK25651.1     2
 SFUL_6132   Streptomyces fulvissimus DSM 40593 AGK81015.1     2
 SGLAU_30920 (CelA)   Streptomyces glaucescens GLA.O AIS02118.1     2
 WQO_28580   Streptomyces globisporus C-1027 ALU96942.1     2
 DIJ69_04765   Streptomyces globisporus TFH56 AWL85329.1     2
 chitosanase II (ChoII) 3.2.1.132 Streptomyces griseus HUT 6037 BAC65342.1 Q83VL5   2
 SGR_1341 (ChoII)   Streptomyces griseus subsp. griseus NBRC 13350 BAG18170.1 B1VVI6   2
 Sle_15630   Streptomyces leeuwenhoekii C34 (= DSM 42122 = NRRL B-24963) CQR61025.1     2
 endo-β-1,4-glucanase A (CelA) 3.2.1.4 Streptomyces lividans 1326   P27035   2
 SLIV_01130   Streptomyces lividans TK24 AIJ11255.1     2
 SLUN_35790   Streptomyces lunaelactis MM109 AVZ76762.1     2
 BBN63_26235   Streptomyces niveus SCSIO 3406 AQU69157.1     2
 Spa2297_02775   Streptomyces parvulus 2297 ANJ06000.1     2
 CGZ69_33165   Streptomyces peucetius subsp. caesius ATCC 27952 ATW51918.1     2
 Sfla_1774   Streptomyces pratensis ATCC 33331 ADW03209.1 C9NJR0   2
 SPRI_0488   Streptomyces pristinaespiralis HCCB 10218 ALC18794.1     2
 TUE45_03304 (CelA)   Streptomyces reticuli CUW28565.1     2
 A4G23_05286 (CelE)   Streptomyces rubrolavendulae MJM4426 AOT62390.1     2
 SCAB_86311   Streptomyces scabiei 87.22 CBG75572.1 C9Z351   2
 SAMN05428941_7586   Streptomyces sp. 2114.2 SDT81869.1     2
 ASR50_33260   Streptomyces sp. 4F ALV54720.1     2
 NI25_36320   Streptomyces sp. CCM_MD2014 AIV38329.1     2
 ABE83_05735   Streptomyces sp. CFMR 7 ALC26638.1     2
 CAC01_21465   Streptomyces sp. CLI2509 CLI2905 ASY34930.1     2
 CXR04_03425   Streptomyces sp. CMB-StM0423 AUH39430.1     2
 AA958_30920   Streptomyces sp. CNQ-509 AKH85894.1     2
 F750_5063 (CelA)   Streptomyces sp. PAMC 26508 AGJ57501.1     2
 QR97_13405   Streptomyces sp. PBH53 AKN70681.1     2
 A6E92_04910   Streptomyces sp. S8 ARI51563.1     2
 CAG99_24650   Streptomyces sp. SCSIO 03032 ARQ71592.1     2
 SACTE_0482   Streptomyces sp. SirexAA-E AEN08423.1     2
 TK78_05020   Streptomyces sp. Tue 6075 Tue6075 APS18384.1     2
 C5L38_02755   Streptomyces sp. WAC00288 AVH94115.1     2
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