Glycoside Hydrolase Family 5 / Subf 2

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (1020); Uniprot accession (275); PDB accession (40); 3D entries (13); cryst (0)
All (905) Bacteria (737) Eukaryota (154) unclassified (14) Structure (13) Characterized (119)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 |
Bacteria
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 QX56_09975   Bacillus subtilis PS832 AIY97432.1     2
 U712_09550   Bacillus subtilis PY79 AHA77853.1     2
 B657_18130 (EglS)   Bacillus subtilis QB928 AFQ57748.1     2
 β-1,4-endo-glucanase, partial (fragment)   Bacillus subtilis S2f AHD24512.1     2
 cellulase   Bacillus subtilis S52-2 AFH66776.1     2
 β-1,4-endo-glucanase, partial (fragment)   Bacillus subtilis s5d AHD24510.1     2
 endo-β-1,4-glucanase   Bacillus subtilis S6 ADR57074.1 E5Q9G6   2
 β-1,4-endo-glucanase, partial (fragment)   Bacillus subtilis s6a AHD24513.1     2
 beta 1,4 endo glucanase, partial (fragment)   Bacillus subtilis s7e AGV05395.1     2
 endoglucanase   Bacillus subtilis SB13 ARO50177.1     2
 endo-β-1,4-glucanase   Bacillus subtilis sdau9506 ADJ94890.1 D9IP74   2
 OB04_01939 (EglS)   Bacillus subtilis SG6 AIX07599.1     2
 cellulase, partial (fragment)   Bacillus subtilis SL9-9 AFH66775.1     2
 CDA59_00395   Bacillus subtilis SR1 ASC81030.1     2
 endo-β-1,4-glucanase   Bacillus subtilis SSA2 ALL27206.1     2
 AN935_09445   Bacillus subtilis subsp. inaquosorum DE111 AMA52498.1     2
 BSNT_02999 (BglC;EglS)   Bacillus subtilis subsp. natto BEST195 BAI85501.1 D4FXC0   2
 AWV81_10300   Bacillus subtilis subsp. natto CGMCC 2108 AMK72491.1     2
 SD85_09595   Bacillus subtilis subsp. spizizenii NRS 231 AJD36478.1     2
 BSUW23_09325 (EglS)   Bacillus subtilis subsp. spizizenii str. W23 ADM37911.1 E0TWG4   2
 GYO_2183   Bacillus subtilis subsp. spizizenii TU-B-10 AEP86815.1     2
 BFI33_09960   Bacillus subtilis subsp. subtilis 168G AOA11130.1     2
 RP72_09860   Bacillus subtilis subsp. subtilis 3NA AJE94503.1     2
 BSU6051_18130 (EglS)   Bacillus subtilis subsp. subtilis 6051-HGW AGG61188.1     2
 AT706_08820   Bacillus subtilis subsp. subtilis BSD-2 ALS82012.1     2
 endo-1,4-β-glucanase (EglS)   Bacillus subtilis subsp. subtilis BTN7A AIO08301.1     2
 AWM80_09840   Bacillus subtilis subsp. subtilis CU1050 AMB24249.1     2
 A8O17_09375   Bacillus subtilis subsp. subtilis delta6 ANJ30819.1     2
 BEN36_07350   Bacillus subtilis subsp. subtilis IIG-Bs27-47-24 ANY32358.1     2
 AS891_14270   Bacillus subtilis subsp. subtilis KCTC 3135 ANX08323.1     2
 endo-β-1,4-glucanase (EglS)   Bacillus subtilis subsp. subtilis M 015 AKC00620.1     2
 BEP06_07030   Bacillus subtilis subsp. subtilis PG10 ANY35199.1     2
 BEP07_07080   Bacillus subtilis subsp. subtilis PS38 ANY37961.1     2
 BHY07_09960   Bacillus subtilis subsp. subtilis QB5412 AOT48097.1     2
 S100333_02083   Bacillus subtilis subsp. subtilis SRCM100333 ASB69976.1     2
 S100757_02006   Bacillus subtilis subsp. subtilis SRCM100757 ARW02937.1     2
 S100761_02016   Bacillus subtilis subsp. subtilis SRCM100761 ASB57345.1     2
 S101392_02048   Bacillus subtilis subsp. subtilis SRCM101392 ASB93521.1     2
 S101444_02015   Bacillus subtilis subsp. subtilis SRCM101444 ARV98863.1     2
 endo-β-1,4-glucanase (EglS;BglC;Gld;BSU18130;BsCel5;BsCel5A) (Cel5A) 3.2.1.4 Bacillus subtilis subsp. subtilis str. 168 CAA82317.1
AEJ76923.1
AIY93123.1
AQR81804.1
AQR86018.1
CAA97610.1
CAB13696.2
NP_389695.1
P10475 3PZT[A,B]
3PZU[A,B]
3PZV[A,B,C,D]
2
 BSUB_01951 (EglS)   Bacillus subtilis subsp. subtilis str. AG1839 AIC44469.1     2
 I653_09410   Bacillus subtilis subsp. subtilis str. BAB-1 AGI29134.1     2
 A7A1_0701   Bacillus subtilis subsp. subtilis str. BSP1 AGA21319.1     2
 BSUA_01951 (EglS)   Bacillus subtilis subsp. subtilis str. JH642 substr. AG174 AIC40237.1     2
 Q433_10715   Bacillus subtilis subsp. subtilis str. OH 131.1 AIC98399.1     2
 I33_2031   Bacillus subtilis subsp. subtilis str. RO-NN-1 AEP90990.1     2
 endo-β-1,4-glucanase 3.2.1.4 Bacillus subtilis subsp. subtilis UMC7 AGG11030.1     2
 BSSX_2016   Bacillus subtilis SX01705 ASK23911.1     2
 endo-β-1,4-glucanase (fragment)   Bacillus subtilis SYYS AFV95351.1     2
 A3772_09840   Bacillus subtilis SZMC 6179J AMS47376.1     2
 β-1,4-endo-glucanase, partial (fragment)   Bacillus subtilis T28d AHD24514.1     2
 BIS30_19935   Bacillus subtilis T30 AJW87252.1     2
 β-1,4-endo-glucanase, partial (fragment)   Bacillus subtilis t37a AHD24506.1     2
 ORF (fragment)   Bacillus subtilis T41a AIT71752.1     2
 cellulase   Bacillus subtilis TB-2 ABS70711.1     2
 CLD04_10445   Bacillus subtilis TLO3 ASZ61563.1     2
 M036_09535   Bacillus subtilis TO-A AII35811.1     2
 ABU16_2893   Bacillus subtilis TO-A JPC AKN13969.1     2
 ABA10_09875   Bacillus subtilis UD1022 AKI92270.1     2
 BKN48_19800   Bacillus subtilis VV2 AOY07432.1     2
 β-1,4-endo-glucanase, partial (fragment)   Bacillus subtilis w AHD24516.1     2
 cellulase (Egls3)   Bacillus subtilis WL001 AOY41715.1     2
 endoglucanase (CelW)   Bacillus subtilis WL001 AHZ62779.1     2
 C663_1868 (EglS)   Bacillus subtilis XF-1 AGE63656.1     2
 xylanase (Xyl141)   Bacillus subtilis Xyl14-KBRB ADP09027.1 E3UQM6   2
 β-1,4-endo-glucanase, partial (fragment)   Bacillus subtilis Y AHD24507.1     2
 endoglucanase (CeL)   Bacillus tequilensis S17I28 AIJ27554.1     2
 endo-β-1,4-glucanase (fragment)   Bacillus thuringiensis IARI-SP-6 AGW99983.1     2
 B9C48_09240   Bacillus vallismortis NBIF-001 ARM28000.1     2
 CFN60_09420   Bacillus velezensis 157 ASK58591.1     2
 BK055_10270   Bacillus velezensis 9912D APA02899.1     2
 B7941_11800   Bacillus velezensis 9D-6 ARJ75167.1     2
 B938_09365   Bacillus velezensis AS43.3 AFZ90893.1     2
 BAMMD1_1755 (EglS)   Bacillus velezensis B25 CUX93659.1     2
 BACAU_1766 (BglC)   Bacillus velezensis CAU B946 CCF05300.1     2
 BCBMB205_18710   Bacillus velezensis CBMB205 ANF36769.1
ARN87289.1
    2
 A1D33_000185   Bacillus velezensis CC09 ANB45748.1     2
 A2I97_08780   Bacillus velezensis D2-2 AOU01160.1     2
 RBAM_018100   Bacillus velezensis FZB42 CAE11243.1
ABS74173.1
    2
 ABH13_1848   Bacillus velezensis G341 AKL76432.1     2
 BAGQ_1973   Bacillus velezensis GQJK49 ARZ58207.1     2
 CJP14_07175   Bacillus velezensis J01 ASZ03660.1     2
 AAV29_08940   Bacillus velezensis JJ-D34 AKF30670.1     2
 NG74_01886 (EglS)   Bacillus velezensis JS25R AIU81966.1     2
 BAJT_09240   Bacillus velezensis JTYP2 ARB33457.1     2
 A8142_08875   Bacillus velezensis LS69 ANU30279.1     2
 BBJ33_09410   Bacillus velezensis M75 AOO61741.1     2
 BAPNAU_1934 (BglC)   Bacillus velezensis NAU-B3 CDH95715.1     2
 AW02_018440 (BglC)   Bacillus velezensis NJN-6 AKD29994.1     2
 alkali tolerable endoglucanase, partial (Ega5)   Bacillus velezensis Q5 ALE32753.1     2
 A5891_09010   Bacillus velezensis S3-1 ANS38519.1     2
 CHN56_00337 (EglS)   Bacillus velezensis SCDB 291 ASS60881.1     2
 CLI97_03910 (EglS)   Bacillus velezensis SCGB 1 ATC53134.1     2
 CLI98_03744 (EglS)   Bacillus velezensis SCGB 574 ATD76966.1     2
 V529_17790 (BglC)   Bacillus velezensis SQR9 AHZ15805.1     2
 S100072_01973   Bacillus velezensis SRCM100072 ASB53309.1     2
 S101413_02134   Bacillus velezensis SRCM101413 ASB65581.1     2
 BLL65_09625   Bacillus velezensis sx01604 AQZ73217.1     2
 CEG11_09415   Bacillus velezensis T20E-257 ASF55305.1     2
 CG798_14945   Bacillus velezensis TB1501 ASP26388.1     2
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