Glycoside Hydrolase Family 5 / Subf 2

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
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Statistics GenBank accession (1020); Uniprot accession (275); PDB accession (40); 3D entries (13); cryst (0)
All (905) Bacteria (737) Eukaryota (154) unclassified (14) Structure (13) Characterized (119)
| 1 | 2 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3DSubf
 endo-β-1,4-glucanase 3.2.1.4 Actinomyces sp. 40 AAC06196.1 O66064   2
 endo-β-1,4-glucanase (Egl-1139) / III-3A (Cel5A) 3.2.1.4 Bacillus akibai / KSM-1139 BAA00045.1
AAA22305.1
ACE14924.1
P06564   2
 endoglucanase (EglII) 3.2.1.4 Bacillus amyloliquefaciens PSM 3.1 ADC54852.1 D3Y2F0   2
 endo-β-1,4-glucanase A (CelA;EgA;Bcell_0438) 3.2.1.4 Bacillus cellulosilyticus DSM 2522 ADU28720.1
AAA22301.1
D2LVP1
P06566
  2
 endo-β-1,4-glucanase B (CelB;EgB;Bcell_0437) 3.2.1.4 Bacillus cellulosilyticus DSM 2522 ADU28719.1
AAA22299.1
D2LVP0   2
 endo-β-1,4-glucanase C (CelC;EgC;Cel2;Bcell_3370) 3.2.1.4 Bacillus cellulosilyticus DSM 2522 ADU31612.1
AAA22306.1
D2LQZ9
P19570
  2
 endo-β-1,4-glucanase (Egl01) 3.2.1.4 Bacillus licheniformis AIY72753.1     2
 endo-β-1,4-glucanase C (BglC;BLi02088;BL01471) (Cel5A) 3.2.1.4 Bacillus licheniformis DSM 13 = ATCC 14580 AAU23613.2
AAU23613.1
AAU40977.1
ACR87895.1
CAF05574.1
CAV28462.1
A5A671
Q65IY7
  2
 endo-β-1,4-glucanase (Cel5A) (Cel5A) 3.2.1.4 Bacillus licheniformis GXN151 / B-41361 AAP51020.1 Q7X3S6   2
 endoglucanase (CelA) 3.2.1.4 Bacillus licheniformis MD1 CAE82178.1 Q5QSM2   2
 glucanase (BglC) (fragment) 3.2.1.4 Bacillus megaterium L103 AGG91154.1     2
 endo-β-1,4-glucanase 3.2.1.4 Bacillus sp. 22-28 BAA12744.1 Q45554   2
 endo-β-1,4-glucanase 3.2.1.4 Bacillus sp. 5H BAA31712.1 O83012   2
 CelS 3.2.1.4 Bacillus sp. 79-23 AAC02536.1 O52731   2
 cellulase (BCE103) 3.2.1.4 Bacillus sp. CBS 670.93 CAB59165.1
AAV25061.1
CAB58698.1
CAD82873.1
  1LF1[A] 2
 endo-β-1,4-glucanase (Cel) (fragment) 3.2.1.4 Bacillus sp. D04 AAC43478.1 Q45430   2
 endo-β-1,4-glucanase K (Egl-K) 3.2.1.4 Bacillus sp. KSM-635 AAA22304.1 P19424 1G01[A]
1G0C[A]
2
 endo-β-1,4-glucanase (Egl-64) 3.2.1.4 Bacillus sp. KSM-64 / Bacillus sp. Z-16 CAJ00039.1
AAA73189.1
ACE14925.1
ACW22976.1
CAJ28077.1
CAT16610.1
Q59241   2
 endoglucanase N252 (Egl252) 3.2.1.4 Bacillus sp. KSM-N252 BAB62295.1 Q93R81   2
 endo-β-1,4-glucanase (Egl-237) 3.2.1.4 Bacillus sp. KSM-S237 CAJ00038.1
ABH71811.1
ACE14923.1
ACW22975.1
BAB19360.1
CAF02232.1
CAJ28076.1
CAT16607.1
Q9F216   2
 endo-β-1,4-glucanase B1 3.2.1.4 Bacillus sp. N186-1 CAA83942.1 Q59232   2
 bifunctional cellulase chitosanase (CelA) 3.2.1.132
3.2.1.4
Bacillus sp. NBL420 AAK73277.1 Q93LI9   2
 endo-β-1,4-glucanase 3.2.1.4 Bacillus subtilis AAA22307.1 Q45532   2
 β-1,3-1,4-glucanase / cellulase C (CelA;CelC) 3.2.1.4 Bacillus subtilis A8-8 AAO63626.1 Q6Y4Q1   2
 endoglucanase (Egl173;Cel;EglS) 3.2.1.4 Bacillus subtilis BEC-1 / Y106 / shu-3 AAK39540.1
ADM12805.1
ADP05286.1
Q93TJ6   2
 endo-β-1,4-glucanase (Eg15) (Cel5A) 3.2.1.4 Bacillus subtilis BME-15 ACI15227.1
ACJ12786.1
ACJ12787.1
ACJ12788.1
ACJ12789.1
ACJ12790.1
ACJ12791.1
ACJ12792.1
B6DVJ2   2
 endo-β-1,4-glucanase (CMCase;BglC) 3.2.1.4 Bacillus subtilis BSE616 BAA00859.1 P23549   2
 endo-β-1,4-glucanase (EglS;EG) 3.2.1.4 Bacillus subtilis C-36 ABG78039.1 Q0PPV7   2
 endo-β-1,4-glucanase (CelG) 3.2.1.4 Bacillus subtilis CHZ1 AAK94871.1 Q93LD0   2
 endo-β-1,4-glucanase (EglS) 3.2.1.4 Bacillus subtilis CK-2 CAA47429.1 G1DE47
P10475
  2
 endo-β-1,4-glucanase (BglC;Gld) 3.2.1.4 Bacillus subtilis DLG AAA22496.1 P07983   2
 cellulase (CelDR) 3.2.1.4 Bacillus subtilis DR ABV45393.1
ACI63223.1
A8D0T0   2
 endo-β-1,4-glucanase (CelI15) 3.2.1.4 Bacillus subtilis I15 ACK38261.1 B7UAM4   2
 endo-β-1,4-glucanase (Egl499;Egl330) 3.2.1.4 Bacillus subtilis JA18 AAZ22322.1 Q45T78   2
 cellulase (Cel15;Cell15) 3.2.1.4 Bacillus subtilis LN ACR59602.1 C5I946   2
 endo-β-1,4-glucanase (EglS;BglC;Gld;BSU18130;BsCel5;BsCel5A) (Cel5A) 3.2.1.4 Bacillus subtilis subsp. subtilis str. 168 CAA82317.1
AEJ76923.1
AIY93123.1
AQR81804.1
AQR86018.1
CAA97610.1
CAB13696.2
NP_389695.1
P10475 3PZT[A,B]
3PZU[A,B]
3PZV[A,B,C,D]
2
 endo-β-1,4-glucanase 3.2.1.4 Bacillus subtilis subsp. subtilis UMC7 AGG11030.1     2
 cellulase (CelA10) 3.2.1.4 bacterium enrichment culture clone CelA10 ACR23656.1 C5HG53   2
 endoglucanase (Cel5) (Cel5A) 3.2.1.4 bacterium enrichment culture clone FV-Cel5A AEL31246.1     2
 endo-1,4-glucanase A 3.2.1.4 Butyrivibrio fibrisolvens A46 AAA20893.1 P22541   2
 endo-β-1,4-glucanase (TTE0359) (Cel5A) 3.2.1.4 Caldanaerobacter subterraneus subsp. tengcongensis MB4 AAM23649.1
NP_622045.1
Q8RCQ7   2
 endo-β-1,4-glucanase D (CelD; Athe_0594) 3.2.1.4 Caldicellulosiruptor bescii DSM 6725 CAB01405.2
ACM59720.1
CAB01405.1
CAB01405.2
Q59154   2
 endoglucanase (Csac_0678) 3.2.1.4 Caldicellulosiruptor saccharolyticus DSM 8903 ABP66297.1 A4XHB2 5ECU[A] 2
 endo-β-1,4-glucanase (CelB) 3.2.1.4 Caldicellulosiruptor sp. F32 AFO70071.1     2
 endoglucanase (Celal_2753) 3.2.1.4 Cellulophaga algicola DSM 14237 ADV50035.1     2
 endoglucanase (CelA) 3.2.1.4 Cellulophaga sp. QY3 ADB80152.1     2
 endo-β-1,4-glucanase E / 5B (CelE;CJA_2983) (Cel5B) 3.2.1.4 Cellvibrio japonicus Ueda107 ACE84076.1
CAA60493.1
B3PCS3
Q59665
  2
 endo-β-1,4-glucanase B (CelB) (Cel5A;Cel5B) 3.2.1.4 Cellvibrio mixtus ATCC 12120 AAB61462.2 O07653   2
 endo-β-1,4-glucanase 5A (EngF) (Cel5A) 3.2.1.4 Clostridium cellulovorans AAB40891.1 P94622   2
 endo-β-1,4-glucanase 5A (CelA) (Cel5A) 3.2.1.4 Clostridium josui BAA12826.1
BAA12826.2
Q59290   2
 endo-β-1,4-glucanase (EglA) 3.2.1.4 Clostridium saccharobutylicum P262 AAA23230.1 P15704   2
 endoglucanase 5A (ChCel5A;CHU_1107) (Cel5A) 3.2.1.4 Cytophaga hutchinsonii ATCC 33406 ABG58383.1 Q11W33   2
 periplasmic endoglucanase 5B (CHU_2103) (Cel5B) 3.2.1.4 Cytophaga hutchinsonii ATCC 33406 ABG59366.1 Q11T98 5IHS[A] 2
 endo-β-1,4-glucanase (Cel5Z) 3.2.1.4 Dickeya chrysanthemi PY35 AAF18152.1 Q9REW0   2
 endo-β-1,4-glucanase Z (CelZ;EgZ;Dda3937_02793) (Cel5A=Cel5Z) 3.2.1.4 Dickeya dadantii 3937 ADM99099.1
CAA68604.1
P07103 1EGZ[A,B,C] 2
 Fisuc_1224 / FSU_1685 3.2.1.4 Fibrobacter succinogenes subsp. succinogenes S85 ACX74827.1
ADL26286.1
C9RQJ1   2
 endoglucanase (partial) 3.2.1.4 Fibrobacter succinogenes subsp. succinogenes S85 AAC06197.1 O66065   2
 cellulase (Fisuc_2364;FSU_2914) (Cel5H) 3.2.1.4 Fibrobacter succinogenes subsp. succinogenes S85 ABU45500.1
ACX75950.1
ADL27061.1
A7UG69   2
 endo-β-1,4-glucanase (CelA;GsCelA) 3.2.1.4 Geobacillus sp. 70PC53 ACJ60856.1 C5H6X3 4XZB[A]
4XZW[A]
2
 endoglucanase (Cel5;HCH_03914) 3.2.1.4 Hahella chejuensis KCTC 2396 ABC30636.1 Q2SFD8   2
 cellulase 5A (Cel5A) 3.2.1.4 Paenibacillus polymyxa GS01 ABV08875.1 A9Q741   2
 endo-β-1,4-glucanase N (CelN) (fragment) 3.2.1.4 Pectobacterium carotovorum ATROSEPTICA AAC37033.1 Q59394   2
 endo-β-1,4-glucanase V1 3.2.1.4 Pectobacterium carotovorum SCC3193 CAA55823.1 Q59395   2
 endo-β-1,4-glucanase V 3.2.1.4 Pectobacterium carotovorum SCRI193 CAA53592.1 Q47096   2
 endo-β-1,4-glucanase (CelA) 3.2.1.4 Pectobacterium carotovorum subsp. carotovorum LY34 AAC02964.2
AAC02964.1
O31029   2
 endoglucanase (CelG) (Cel5G) 3.2.1.4 Pseudoalteromonas haloplanktis A23 CAA76775.1 O86099 1TVN[A,B]
1TVP[A,B]
2
 endoglucanase (CelA) 3.2.1.4 Pseudoalteromonas sp. MB-1 AAS58467.1 Q6QA02   2
 cellulase (CelY) 3.2.1.4 Pseudoalteromonas sp. NO3 ACN62172.1 C0KZC4   2
 endo-β-1,4-glucanase (CelX) 3.2.1.4 psychrophilic marine bacterium DY3 AAP04424.1 Q841J5   2
 endo-1,4-glucanase 4 (EGIV) 3.2.1.4 Ruminococcus albus BAA32286.1 Q07940   2
 endo-β-1,4-glucanase 5J (Sde_2494) (processive) (Cel5J) 3.2.1.4 Saccharophagus degradans 2-40 ABD81754.1 Q21HS5   2
 endo-β-1,4-glucanase 5H (Sde_3237) (processive) (Cel5H) 3.2.1.4 Saccharophagus degradans 2-40 ABD82494.1 Q21FN5   2
 endo-β-1,4-glucanase 5G (Sde_3239) (processive) (Cel5G) 3.2.1.4 Saccharophagus degradans 2-40 ABD82496.1 Q21FN3   2
 cellulase (CelMytB) 3.2.1.4 Saccharophagus sp. Myt-1 BAM21527.1     2
 endo-β-1,4-glucanase 5A (Cel5A) 3.2.1.4 Salipaludibacillus agaradhaerens AAC19169.1 O85465 1A3H[A]
1E5J[A]
1H11[A]
1H2J[A]
1H5V[A]
1HF5[A]
1HF6[A]
1HF7[A]
1OCQ[A]
1QHZ[A]
1QI0[A]
1QI2[A]
1W3K[A]
1W3L[A]
2A3H[A]
2V38[A]
3A3H[A]
4A3H[A]
5A3H[A]
6A3H[A]
7A3H[A]
8A3H[A]
2
 STHERM_c14520 3.2.1.4 Spirochaeta thermophila DSM 6192 ADN02392.1 E0RT96   2
 chitosanase II (ChoII) 3.2.1.132 Streptomyces griseus HUT 6037 BAC65342.1 Q83VL5   2
 endo-β-1,4-glucanase A (CelA) 3.2.1.4 Streptomyces lividans 1326   P27035   2
 bifunctional β-1,4-endoglucanase / cellobiohydrolase (CelAB) 3.2.1.4
3.2.1.91
Teredinibacter turnerae T7901 ABS72374.1 A9Q634   2
 endo-β-1,4-glucanase / celulase (CelDZ1a) 3.2.1.4 Thermoanaerobacterium sp. A57Txylan ALX38276.1   5FIP[A,B,C,D] 2
 endo-β-1,4-glucanase 5A (E5;CelE;TfCel5A;Tfu_0901) (Cel5A) 3.2.1.4 Thermobifida fusca YX AAZ54939.1
AAC09379.1
Q01786
Q47RH8
2CKR[A,B]
2CKS[A,B]
2
 cellulase 5R (Cel5R;Cel5R_FS) 3.2.1.4 uncultured bacterium AND74761.1   5I2U[A,B] 2
 β-glucanase (UmCel5G;RC1) 3.2.1.4 uncultured bacterium ABA42184.1 Q3HXC4   2
 β-glucanase (UmCel5H;RC2) 3.2.1.4 uncultured bacterium ABA42185.1 Q3HXC3   2
 endo-β-1,4-glucanase (CRS200) (Cel5B) 3.2.1.4 uncultured bacterium AFJ44728.1     2
 endo-β-1,4-glucanase (CelWS3) 3.2.1.4 uncultured bacterium AFX88673.1     2
 endo-β-1,4-glucanase (CelWS14) 3.2.1.4 uncultured bacterium AFX88668.1     2
 endo-β-1,4-glucanase (CelWS6) 3.2.1.4 uncultured bacterium AFX88666.1     2
 endo-β-1,4-glucanase (CelWS30) (fragment) 3.2.1.4 uncultured bacterium AFX88671.1     2
 cellulase (CS10;CelCS10) 3.2.1.4 uncultured bacterium AGL50932.1     2
 endo-β-1,4-glucanase (RC3) 3.2.1.4 uncultured bacterium ABI94085.1 Q06B38   2
 endo-β-1,4-glucanase (RC5) 3.2.1.4 uncultured bacterium ABI94086.1 Q06B37   2
 cellulase (CelE1) 3.2.1.4 uncultured bacterium AHA42547.2
AHA42547.1
  4M1R[A,B] 2
 endo-β-1,4-glucanase (Cel5A) (Cel5A) 3.2.1.4 Vibrio xiamenensis G21 ADJ93836.1 D8V609   2
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3DSubf
 cellulase / exo-β-glucanase 5B (AmCel-5B) 3.2.1.4 Anoplophora chinensis AFN89566.1     2
 endoglucanase III (Ag-EGaseIII) 3.2.1.4 Apriona germari AAX18655.1 Q5DIE3   2
 glycoside hydrolase family 5 subfamily 2 (Gh5-6) 3.2.1.4 Apriona japonica AHI15751.1     2
 endoglucanase (Eng1;Dα-Eng1) 3.2.1.4 Ditylenchus africanus ABY52965.1 B6CI25   2
 β-1,4-endoglucanase (Eng-3) 3.2.1.4 Globodera rostochiensis RO-1 AAN03645.1
AAN03646.1
Q8MM42   2
 β-1,4-endoglucanase (Eng-4) 3.2.1.4 Globodera rostochiensis RO-1 AAN03647.1
AAN03648.1
Q8MM50   2
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