Glycoside Hydrolase Family 5 / Subf 2

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (1112); Uniprot accession (275); PDB accession (42); 3D entries (14); cryst (0)
All (995) Bacteria (826) Eukaryota (155) unclassified (14) Structure (14) Characterized (119)
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Bacteria
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 BK055_10270   Bacillus velezensis 9912D APA02899.1     2
 B7941_11800   Bacillus velezensis 9D-6 ARJ75167.1     2
 RZ52_09125   Bacillus velezensis AP183 AWK46308.1     2
 B938_09365   Bacillus velezensis AS43.3 AFZ90893.1     2
 BMJ37_09290   Bacillus velezensis ATR2 ATU26929.1     2
 BAMMD1_1755 (EglS)   Bacillus velezensis B25 CUX93659.1     2
 CMR26_07555   Bacillus velezensis BS-37 AWG38431.1     2
 BACAU_1766 (BglC)   Bacillus velezensis CAU B946 CCF05300.1     2
 BCBMB205_18710   Bacillus velezensis CBMB205 ANF36769.1
ARN87289.1
    2
 A1D33_000185   Bacillus velezensis CC09 ANB45748.1     2
 C3Z10_09765   Bacillus velezensis CGMCC 11640 AVI28645.1     2
 CVD07_09175   Bacillus velezensis CN026 ATY28447.1     2
 A2I97_08780   Bacillus velezensis D2-2 AOU01160.1     2
 DA376_09390   Bacillus velezensis DR-08 AVV94124.1     2
 RBAM_018100   Bacillus velezensis FZB42 CAE11243.1
ABS74173.1
    2
 ABH13_1848   Bacillus velezensis G341 AKL76432.1     2
 B6257_19060   Bacillus velezensis GFP-2 AUJ62547.1     2
 BAGQ_1973   Bacillus velezensis GQJK49 ARZ58207.1     2
 B9C53_00960   Bacillus velezensis GYL4 AWD12147.1     2
 CJP14_07175   Bacillus velezensis J01 ASZ03660.1     2
 AAV29_08940   Bacillus velezensis JJ-D34 AKF30670.1     2
 NG74_01886 (EglS)   Bacillus velezensis JS25R AIU81966.1     2
 BAJT_09240   Bacillus velezensis JTYP2 ARB33457.1     2
 CRH11_14675   Bacillus velezensis L-1 ATO11163.1     2
 CQJ38_09320   Bacillus velezensis LABIM40 ATL39711.1     2
 DDE72_07450   Bacillus velezensis LM23DO2 AWE16031.1     2
 A8142_08875   Bacillus velezensis LS69 ANU30279.1     2
 CXP43_10450   Bacillus velezensis Lzh-a42 AUG36120.1     2
 BBJ33_09410   Bacillus velezensis M75 AOO61741.1     2
 BAPNAU_1934 (BglC)   Bacillus velezensis NAU-B3 CDH95715.1     2
 AW02_018440 (BglC)   Bacillus velezensis NJN-6 AKD29994.1     2
 alkali tolerable endoglucanase, partial (Ega5)   Bacillus velezensis Q5 ALE32753.1     2
 BVQ_09580   Bacillus velezensis QST713 AWD87699.1     2
 endoglucanase (EglS)   Bacillus velezensis RS1 AUB45040.1     2
 BVS141_18850 (EglS)   Bacillus velezensis S141 BBA76409.1     2
 A5891_09010   Bacillus velezensis S3-1 ANS38519.1     2
 CHN56_00337 (EglS)   Bacillus velezensis SCDB 291 ASS60881.1     2
 CLI97_03910 (EglS)   Bacillus velezensis SCGB 1 ATC53134.1     2
 CLI98_03744 (EglS)   Bacillus velezensis SCGB 574 ATD76966.1     2
 C1N92_00760   Bacillus velezensis SGAir0473 AWQ13510.1     2
 V529_17790 (BglC)   Bacillus velezensis SQR9 AHZ15805.1     2
 S100072_01973   Bacillus velezensis SRCM100072 ASB53309.1     2
 S101413_02134   Bacillus velezensis SRCM101413 ASB65581.1     2
 BLL65_09625   Bacillus velezensis sx01604 AQZ73217.1     2
 CEG11_09415   Bacillus velezensis T20E-257 ASF55305.1     2
 CG798_14945   Bacillus velezensis TB1501 ASP26388.1     2
 AJ82_10290   Bacillus velezensis TrigoCor1448 AHK49356.1     2
 RBAU_1784 (EglS)   Bacillus velezensis UCMB5033 CDG29752.1     2
 BAM5036_1746 (EglS)   Bacillus velezensis UCMB5036 CCP21786.1     2
 BASU_1764 (EglS)   Bacillus velezensis UCMB5113 CDG26057.1     2
 C6P48_09830   Bacillus velezensis VCC-2003 AVM08503.1     2
 BANAU_1935 (BglC)   Bacillus velezensis YAU B9601-Y2 CCG49956.1     2
 AAV30_10320   Bacillus velezensis YJ11-1-4 AKF76524.1     2
 cellulase (CelA10) 3.2.1.4 bacterium enrichment culture clone CelA10 ACR23656.1 C5HG53   2
 endoglucanase (Cel5) (Cel5A) 3.2.1.4 bacterium enrichment culture clone FV-Cel5A AEL31246.1     2
 BcellWH2_02030 (EglS)   Bacteroides cellulosilyticus WH2 ALJ59275.1     2
 Bovatus_03047 (EglS)   Bacteroides ovatus ATCC 8483 ALJ47655.1     2
 BACOV975_00809   Bacteroides ovatus V975 SCV07053.1     2
 BXY_21090   Bacteroides xylanisolvens XB1A CBK67187.1 D6CYD5   2
 BANAN_06350   Bifidobacterium animalis subsp. animalis ATCC 25527 AFI63478.1     2
 A4U98_07950   Bifidobacterium animalis subsp. animalis YL2 ARE60173.1     2
 BLAC_06500 (fragment)   Bifidobacterium animalis subsp. lactis ATCC 27673 AGW85477.1     2
 BcFMB_00600   Bifidobacterium choerinum FMB-1 ATU19681.1     2
 D805_1196   Bifidobacterium thermophilum RBL67 AGH41463.1     2
 D805_0646   Bifidobacterium thermophilum RBL67 AGH40913.1     2
 AWC36_06835   Brenneria goodwinii FRB141 ATA23843.1     2
 CIY_33540   Butyrivibrio fibrisolvens 16/4 CBK75816.1 D4IYH3   2
 CIY_23350   Butyrivibrio fibrisolvens 16/4 CBK74991.1 D4IW48   2
 endo-1,4-glucanase A 3.2.1.4 Butyrivibrio fibrisolvens A46 AAA20893.1 P22541   2
 endo-β-1,4-glucanase (TTE0359) (Cel5A) 3.2.1.4 Caldanaerobacter subterraneus subsp. tengcongensis MB4 AAM23649.1
NP_622045.1
Q8RCQ7   2
 endo-β-1,4-glucanase D (CelD; Athe_0594) 3.2.1.4 Caldicellulosiruptor bescii DSM 6725 CAB01405.2
ACM59720.1
CAB01405.1
CAB01405.2
Q59154   2
 Calhy_2064   Caldicellulosiruptor hydrothermalis 108 ADQ07774.1 E4QEF5   2
 Calkr_2007   Caldicellulosiruptor kristjanssonii I77R1B ADQ41479.1 E4S4X9   2
 Calkro_2036   Caldicellulosiruptor kronotskyensis 2002 ADQ46879.1 E4SGK4   2
 Calla_0352   Caldicellulosiruptor lactoaceticus 6A AEM73020.1     2
 COB47_0546   Caldicellulosiruptor obsidiansis OB47 ADL41864.1 D9TIN2   2
 Calow_0459   Caldicellulosiruptor owensensis OL ADQ04043.1 E4Q408   2
 endoglucanase (Csac_0678) 3.2.1.4 Caldicellulosiruptor saccharolyticus DSM 8903 ABP66297.1 A4XHB2 5ECU[A] 2
 endo-β-1,4-glucanase (CelB) 3.2.1.4 Caldicellulosiruptor sp. F32 AFO70071.1     2
 LH89_20630   Cedecea neteri ND14b AIR71493.1     2
 CBP52_12625   Cellulomonas sp. PSBB021 ASR55800.1     2
 endoglucanase (Celal_2753) 3.2.1.4 Cellulophaga algicola DSM 14237 ADV50035.1     2
 Celal_3912   Cellulophaga algicola DSM 14237 ADV51156.1     2
 M666_10995   Cellulophaga baltica 18 AIZ42064.1     2
 M667_10975   Cellulophaga baltica NN016038 AIY13691.1     2
 A5M85_05245   Cellulophaga lytica DAU203 APU09708.1     2
 A5M85_01365   Cellulophaga lytica DAU203 APU08986.1     2
 Celly_0269   Cellulophaga lytica DSM 7489 ADY28104.1     2
 Celly_0965   Cellulophaga lytica DSM 7489 ADY28795.1     2
 IX49_01015   Cellulophaga lytica HI1 AIM59179.1     2
 endoglucanase (CelA) 3.2.1.4 Cellulophaga sp. QY3 ADB80152.1     2
 endo-β-1,4-glucanase E / 5B (CelE;CJA_2983) (Cel5B) 3.2.1.4 Cellvibrio japonicus Ueda107 ACE84076.1
CAA60493.1
B3PCS3
Q59665
  2
 endo-β-1,4-glucanase B (CelB) (Cel5A;Cel5B) 3.2.1.4 Cellvibrio mixtus ATCC 12120 AAB61462.2 O07653   2
 CBR65_07670   Cellvibrio sp. PSBB006 ARU27326.1     2
 CBR65_04985   Cellvibrio sp. PSBB006 ARU26834.1     2
 B0D95_09905   Cellvibrio sp. PSBB023 AQT60375.1     2
 Cpin_2009   Chitinophaga pinensis DSM 2588 ACU59504.1 C7PCC1   2
 CK934_17930   Chitinophaga sp. MD30 ASZ12701.1     2
 CMC5_057090   Chondromyces crocatus Cm c5 AKT41501.1     2
 CMC5_059560   Chondromyces crocatus Cm c5 AKT41745.1     2
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