Glycoside Hydrolase Family 5 / Subf 2

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (1020); Uniprot accession (275); PDB accession (40); 3D entries (13); cryst (0)
All (905) Bacteria (737) Eukaryota (154) unclassified (14) Structure (13) Characterized (119)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 |
Bacteria
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 AJ82_10290   Bacillus velezensis TrigoCor1448 AHK49356.1     2
 RBAU_1784 (EglS)   Bacillus velezensis UCMB5033 CDG29752.1     2
 BAM5036_1746 (EglS)   Bacillus velezensis UCMB5036 CCP21786.1     2
 BASU_1764 (EglS)   Bacillus velezensis UCMB5113 CDG26057.1     2
 BANAU_1935 (BglC)   Bacillus velezensis YAU B9601-Y2 CCG49956.1     2
 AAV30_10320   Bacillus velezensis YJ11-1-4 AKF76524.1     2
 cellulase (CelA10) 3.2.1.4 bacterium enrichment culture clone CelA10 ACR23656.1 C5HG53   2
 endoglucanase (Cel5) (Cel5A) 3.2.1.4 bacterium enrichment culture clone FV-Cel5A AEL31246.1     2
 BcellWH2_02030 (EglS)   Bacteroides cellulosilyticus WH2 ALJ59275.1     2
 Bovatus_03047 (EglS)   Bacteroides ovatus ATCC 8483 ALJ47655.1     2
 BACOV975_00809   Bacteroides ovatus V975 SCV07053.1     2
 BXY_21090   Bacteroides xylanisolvens XB1A CBK67187.1 D6CYD5   2
 BANAN_06350   Bifidobacterium animalis subsp. animalis ATCC 25527 AFI63478.1     2
 A4U98_07950   Bifidobacterium animalis subsp. animalis YL2 ARE60173.1     2
 BLAC_06500 (fragment)   Bifidobacterium animalis subsp. lactis ATCC 27673 AGW85477.1     2
 D805_1196   Bifidobacterium thermophilum RBL67 AGH41463.1     2
 D805_0646   Bifidobacterium thermophilum RBL67 AGH40913.1     2
 AWC36_06835   Brenneria goodwinii FRB141 ATA23843.1     2
 CIY_33540   Butyrivibrio fibrisolvens 16/4 CBK75816.1 D4IYH3   2
 CIY_23350   Butyrivibrio fibrisolvens 16/4 CBK74991.1 D4IW48   2
 endo-1,4-glucanase A 3.2.1.4 Butyrivibrio fibrisolvens A46 AAA20893.1 P22541   2
 endo-β-1,4-glucanase (TTE0359) (Cel5A) 3.2.1.4 Caldanaerobacter subterraneus subsp. tengcongensis MB4 AAM23649.1
NP_622045.1
Q8RCQ7   2
 endo-β-1,4-glucanase D (CelD; Athe_0594) 3.2.1.4 Caldicellulosiruptor bescii DSM 6725 CAB01405.2
ACM59720.1
CAB01405.1
CAB01405.2
Q59154   2
 Calhy_2064   Caldicellulosiruptor hydrothermalis 108 ADQ07774.1 E4QEF5   2
 Calkr_2007   Caldicellulosiruptor kristjanssonii I77R1B ADQ41479.1 E4S4X9   2
 Calkro_2036   Caldicellulosiruptor kronotskyensis 2002 ADQ46879.1 E4SGK4   2
 Calla_0352   Caldicellulosiruptor lactoaceticus 6A AEM73020.1     2
 COB47_0546   Caldicellulosiruptor obsidiansis OB47 ADL41864.1 D9TIN2   2
 Calow_0459   Caldicellulosiruptor owensensis OL ADQ04043.1 E4Q408   2
 endoglucanase (Csac_0678) 3.2.1.4 Caldicellulosiruptor saccharolyticus DSM 8903 ABP66297.1 A4XHB2 5ECU[A] 2
 endo-β-1,4-glucanase (CelB) 3.2.1.4 Caldicellulosiruptor sp. F32 AFO70071.1     2
 LH89_20630   Cedecea neteri ND14b AIR71493.1     2
 CBP52_12625   Cellulomonas sp. PSBB021 ASR55800.1     2
 endoglucanase (Celal_2753) 3.2.1.4 Cellulophaga algicola DSM 14237 ADV50035.1     2
 Celal_3912   Cellulophaga algicola DSM 14237 ADV51156.1     2
 M666_10995   Cellulophaga baltica 18 AIZ42064.1     2
 M667_10975   Cellulophaga baltica NN016038 AIY13691.1     2
 A5M85_05245   Cellulophaga lytica DAU203 APU09708.1     2
 A5M85_01365   Cellulophaga lytica DAU203 APU08986.1     2
 Celly_0269   Cellulophaga lytica DSM 7489 ADY28104.1     2
 Celly_0965   Cellulophaga lytica DSM 7489 ADY28795.1     2
 IX49_01015   Cellulophaga lytica HI1 AIM59179.1     2
 endoglucanase (CelA) 3.2.1.4 Cellulophaga sp. QY3 ADB80152.1     2
 endo-β-1,4-glucanase E / 5B (CelE;CJA_2983) (Cel5B) 3.2.1.4 Cellvibrio japonicus Ueda107 ACE84076.1
CAA60493.1
B3PCS3
Q59665
  2
 endo-β-1,4-glucanase B (CelB) (Cel5A;Cel5B) 3.2.1.4 Cellvibrio mixtus ATCC 12120 AAB61462.2 O07653   2
 CBR65_07670   Cellvibrio sp. PSBB006 ARU27326.1     2
 CBR65_04985   Cellvibrio sp. PSBB006 ARU26834.1     2
 B0D95_09905   Cellvibrio sp. PSBB023 AQT60375.1     2
 Cpin_2009   Chitinophaga pinensis DSM 2588 ACU59504.1 C7PCC1   2
 CK934_17930   Chitinophaga sp. MD30 ASZ12701.1     2
 CMC5_057090   Chondromyces crocatus Cm c5 AKT41501.1     2
 CMC5_059560   Chondromyces crocatus Cm c5 AKT41745.1     2
 CAC0706   Clostridium acetobutylicum ATCC 824 AAK78683.1
NP_347343.1
Q97L56   2
 SMB_G0720 (EglA)   Clostridium acetobutylicum DSM 1731 AEI34191.1     2
 CEA_G0717   Clostridium acetobutylicum EA 2018 ADZ19756.1     2
 β-1,4-glucanase (Cel5I;Ccel_0428) (Cel5I)   [Clostridium] cellulolyticum H10 ACL74811.1
AAL79562.1
B8I5Z4
Q8RLT7
  2
 CCDG5_0576   [Clostridium] cellulosi CDZ23707.1     2
 endoglucanase (Eng5F)   Clostridium cellulovorans BAV13064.1     2
 endo-β-1,4-glucanase 5A (EngF) (Cel5A) 3.2.1.4 Clostridium cellulovorans AAB40891.1 P94622   2
 Clocel_0905   Clostridium cellulovorans 743B ADL50675.1 D9ST59   2
 Clocel_3662   Clostridium cellulovorans 743B ADL53332.1 D9SWQ0   2
 A7L45_18475   Clostridium estertheticum subsp. estertheticum DSM 8809 APC41907.1     2
 endo-β-1,4-glucanase 5A (CelA) (Cel5A) 3.2.1.4 Clostridium josui BAA12826.1
BAA12826.2
Q59290   2
 Clole_1921   Clostridium lentocellum DSM 5427 ADZ83641.1     2
 Clole_3976   Clostridium lentocellum DSM 5427 ADZ85654.1     2
 CSACC_09830 (Cel5A)   Clostridium saccharobutylicum BAS/B3/SW/136 AQR99180.1     2
 CLSA_c09900 (EglA)   Clostridium saccharobutylicum DSM 13864 AGX42001.1     2
 CLOSACC_09830 (Cel5A)   Clostridium saccharobutylicum NCP 195 AQS13168.1     2
 CLOSC_09760 (Cel5A)   Clostridium saccharobutylicum NCP 200 AQR89279.1     2
 CLOBY_10270 (Cel5A)   Clostridium saccharobutylicum NCP 258 AQS08912.1     2
 endo-β-1,4-glucanase (EglA) 3.2.1.4 Clostridium saccharobutylicum P262 AAA23230.1 P15704   2
 Clo1100_1353   Clostridium sp. BNL1100 AEY65590.1     2
 CCU_20020   Coprococcus sp. ART55/1 CBK83458.1 D5HEX5   2
 CCU_25500   Coprococcus sp. ART55/1 CBK83877.1 D5HG44   2
 CYFUS_008414   Cystobacter fuscus DSM 52655 ATB42935.1     2
 CYFUS_001603   Cystobacter fuscus DSM 52655 ATB36189.1     2
 endoglucanase 5A (ChCel5A;CHU_1107) (Cel5A) 3.2.1.4 Cytophaga hutchinsonii ATCC 33406 ABG58383.1 Q11W33   2
 periplasmic endoglucanase 5B (CHU_2103) (Cel5B) 3.2.1.4 Cytophaga hutchinsonii ATCC 33406 ABG59366.1 Q11T98 5IHS[A] 2
 SAMN06298216_2068   Cytophagales bacterium TFI 002 SOE21610.1     2
 DTL3_1188   Defluviitoga tunisiensis CEP78490.1     2
 endocellulase (Cel5)   Deinococcus cellulosilyticus 5516J-15 AKN19928.1     2
 Dd1591_1529   Dickeya chrysanthemi Ech1591 ACT06384.1 C6CF34   2
 endo-β-1,4-glucanase (Cel5Z) 3.2.1.4 Dickeya chrysanthemi PY35 AAF18152.1 Q9REW0   2
 endo-β-1,4-glucanase Z (CelZ;EgZ;Dda3937_02793) (Cel5A=Cel5Z) 3.2.1.4 Dickeya dadantii 3937 ADM99099.1
CAA68604.1
P07103 1EGZ[A,B,C] 2
 Dd703_1886   Dickeya paradisiaca Ech703 ACS85678.1 C6C568   2
 A4U42_01465   Dickeya solani IPO 2222 ANE74123.1     2
 W909_12595   Dickeya zeae EC1 AJC66868.1     2
 Dd586_1489   Dickeya zeae Ech586 ACZ76357.1 D2BWX3   2
 Echvi_1632   Echinicola vietnamensis DSM 17526 AGA77897.1     2
 EUBELI_20587   [Eubacterium] eligens ATCC 27750 ACR73731.1 C4Z6Y9   2
 EUBREC_0616   [Eubacterium rectale] ATCC 33656 ACR74405.1 C4ZCQ0   2
 EUR_02280   [Eubacterium] rectale DSM 17629 CBK89462.1 D6E222   2
 ERE_23730   [Eubacterium] rectale M104/1 CBK94241.1 D4JKU4   2
 EUS_00270   [Eubacterium] siraeum 70/3 CBK95395.1 D4JQM6   2
 ES1_04480   [Eubacterium] siraeum V10Sc8a CBL33590.1 D4MIK7   2
 AALO17_05750 (fragment)   Faecalibaculum rodentium Alo17 AMK53709.1     2
 AALO17_05740 (fragment)   Faecalibaculum rodentium Alo17 AMK53708.1     2
 Fisuc_1224 / FSU_1685 3.2.1.4 Fibrobacter succinogenes subsp. succinogenes S85 ACX74827.1
ADL26286.1
C9RQJ1   2
 Fisuc_1661 / FSU_2150   Fibrobacter succinogenes subsp. succinogenes S85 ACX75256.1
ADL25349.1
C9RRS0   2
 Fisuc_2011 / FSU_2534   Fibrobacter succinogenes subsp. succinogenes S85 ACX75598.1
ADL25634.1
C9RJ81   2
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