Glycoside Hydrolase Family 5 / Subf 2

Activities in Familyendo-β-1,4-glucanase / cellulase (EC; endo-β-1,4-xylanase (EC; β-glucosidase (EC; β-mannosidase (EC; β-glucosylceramidase (EC; glucan β-1,3-glucosidase (EC; licheninase (EC; exo-β-1,4-glucanase / cellodextrinase (EC; glucan endo-1,6-β-glucosidase (EC; mannan endo-β-1,4-mannosidase (EC; cellulose β-1,4-cellobiosidase (EC; steryl β-glucosidase (EC; endoglycoceramidase (EC; chitosanase (EC; β-primeverosidase (EC; xyloglucan-specific endo-β-1,4-glucanase (EC; endo-β-1,6-galactanase (EC; hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC; β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (1148); Uniprot accession (275); PDB accession (42); 3D entries (14); cryst (0)
All (1031) Bacteria (862) Eukaryota (155) unclassified (14) Structure (14) Characterized (120)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 |
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 DOZ58_15375   Acetobacterium sp. KB-1 AWW27905.1     2
 Awo_c08790   Acetobacterium woodii DSM 1030 AFA47670.1     2
 endo-β-1,4-glucanase Actinomyces sp. 40 AAC06196.1 O66064   2
 SAMN04489716_0268   Actinoplanes derwentensis DSM 43941 SDS21202.1     2
 SAMN04489716_3551   Actinoplanes derwentensis DSM 43941 SDT38399.1     2
 AFR_22970   Actinoplanes friuliensis DSM 7358 AGZ42864.1     2
 AMIS_52810   Actinoplanes missouriensis 431 BAL90501.1     2
 L083_3663 (BglC)   Actinoplanes sp. N902-109 AGL17173.1     2
 ACWT_6045   Actinoplanes sp. SE50 ATO85460.1     2
 ACWT_5047   Actinoplanes sp. SE50 ATO84462.1     2
 ACPL_5177 (BglC)   Actinoplanes sp. SE50/110 AEV86064.1
 ACPL_6177 (BglC)   Actinoplanes sp. SE50/110 AEV87062.1
 ADH66_12235   Acutalibacter muris KB18 ASB41357.1     2
 AEQU_0542   Adlercreutzia equolifaciens DSM 19450 BAN76511.1     2
 Alfi_1589   Alistipes finegoldii DSM 17242 AFL77928.1     2
 SAMN04489726_7657   Allokutzneria albata DSM 44149 SDN66578.1     2
 glycosyl hydrolase family 5_2 domain-containing protein   Alteromonadaceae bacterium Bs08 AIF91547.1     2
 glycosyl hydrolase family 5_2 domain-containing protein   Alteromonadaceae bacterium Bs12 AIF91536.1     2
 A4R43_10805   Amycolatopsis albispora WP1 AXB42975.1     2
 AJAP_19810 (Cele2)   Amycolatopsis japonica MG417-CF17 AIG76823.1     2
 AJAP_11650 (Cele1)   Amycolatopsis japonica MG417-CF17 AIG75215.1     2
 SAMN04489733_0211   Amycolatopsis keratiniphila FH 1893 SDT99530.1     2
 SAMN04489733_1943   Amycolatopsis keratiniphila FH 1893 SDU19440.1     2
 BB31_41955   Amycolatopsis lurida NRRL 2430 AJK59464.1     2
 BB31_05885   Amycolatopsis lurida NRRL 2430 AJK53007.1     2
 B737_4049   Amycolatopsis mediterranei RB AGT84713.1     2
 RAM_20880   Amycolatopsis mediterranei S699 AEK42656.1
 AMED_4097   Amycolatopsis mediterranei U32 ADJ45874.1 D8HQ52   2
 SD37_27170   Amycolatopsis orientalis B-37 ANN18940.1     2
 SD37_19870   Amycolatopsis orientalis B-37 ANN17680.1     2
 AORI_3875   Amycolatopsis orientalis HCCB10007 AGM06460.1     2
 AORI_5568   Amycolatopsis orientalis HCCB10007 AGM08151.1     2
 BKN51_11830   Amycolatopsis sp. BJA-103 AUI58831.1     2
 D1815_03270   Aquimarina sp. AD1 AXT54814.1     2
 D1815_20295   Aquimarina sp. AD1 AXT57978.1     2
 D1815_18535   Aquimarina sp. AD1 AXT57650.1     2
 D1816_00805   Aquimarina sp. AD10 AXT58949.1     2
 D1816_13125   Aquimarina sp. AD10 AXT61247.1     2
 D1816_07620   Aquimarina sp. AD10 AXT60221.1     2
 D1816_23140 (fragment)   Aquimarina sp. AD10 AXT63117.1     2
 D1818_10640   Aquimarina sp. BL5 AXT51262.1     2
 D1818_04315   Aquimarina sp. BL5 AXT50092.1     2
 D1818_12455   Aquimarina sp. BL5 AXT51607.1     2
 A9P82_13735   Arachidicoccus sp. BS20 ANI90259.1     2
 endo-β-1,4-glucanase (Egl-1139) / III-3A (Cel5A) Bacillus akibai / KSM-1139 BAA00045.1
P06564   2
 endoglucanase (EG-I-1)   Bacillus akibai I-1 AFI25187.1     2
 cellulase   Bacillus amyloliquefaciens 157 AVC04903.1     2
 BAALB65_09790   Bacillus amyloliquefaciens ALB65 AWM44312.1     2
 DDT09_09835   Bacillus amyloliquefaciens ALB69 AWM48134.1     2
 DDT10_09310   Bacillus amyloliquefaciens ALB79 AWM51868.1     2
 endoglucanase   Bacillus amyloliquefaciens AMS1 AKS29707.1     2
 A1R12_09055   Bacillus amyloliquefaciens B15 AMR50503.1     2
 endo-β-1,4-glucanase (EgL)   Bacillus amyloliquefaciens BY-5 AMW90767.1     2
 U471_18630   Bacillus amyloliquefaciens CC178 AGZ56565.1     2
 endo-β-1,4-glucanase   Bacillus amyloliquefaciens IARI-SP-2 AGW99978.1     2
 KSO_010315   Bacillus amyloliquefaciens IT-45 AGF27558.1     2
 KHU1_1621   Bacillus amyloliquefaciens KHG19 AJK65578.1     2
 SB45_09085   Bacillus amyloliquefaciens L-H15 AJH24169.1     2
 XM40_09090   Bacillus amyloliquefaciens L-S60 AKD22364.1     2
 U722_09575   Bacillus amyloliquefaciens LFB112 AHC42348.1     2
 BSF20_16750   Bacillus amyloliquefaciens LM2303 APH49957.1     2
 cellulase (fragment)   Bacillus amyloliquefaciens MBAA3 AHJ80840.1     2
 AVM03_03620   Bacillus amyloliquefaciens MBE1283 ALV01512.1     2
 endo-1,4-β-glucanase precursor   Bacillus amyloliquefaciens MN-13 AVI57374.1     2
 endo-1,4-β-glucanase precursor   Bacillus amyloliquefaciens MN-8 AVI57373.1     2
 endoglucanase (EglS)   Bacillus amyloliquefaciens PK1 AUB45039.1     2
 endoglucanase (EglII) Bacillus amyloliquefaciens PSM 3.1 ADC54852.1 D3Y2F0   2
 AS588_06260   Bacillus amyloliquefaciens S499 AMP31635.1     2
 cellulase   Bacillus amyloliquefaciens T3 AWB51882.1     2
 BAMY6614_13370   Bacillus amyloliquefaciens UMAF6614 AMQ74283.1     2
 BAMY6639_00620   Bacillus amyloliquefaciens UMAF6639 AMQ71229.1     2
 endoglucanase A (EngA)   Bacillus amyloliquefaciens UMAS1002 AAL99668.1 Q8RPQ6   2
 BSO20_02700   Bacillus amyloliquefaciens WS-8 APQ49018.1     2
 BAMY_08970   Bacillus amyloliquefaciens Y14 APB82271.1     2
 MUS_2161 (BglC)   Bacillus amyloliquefaciens Y2 AFJ62120.1     2
 BaGK_15910 (fragment)   Bacillus atrophaeus GQJK17 ASS72344.1     2
 D068_cds30840 (fragment)   Bacillus atrophaeus UCMB-5137 AKL85635.1     2
 Bcell_3371   Bacillus cellulosilyticus DSM 2522 ADU31613.1 D2LQZ8   2
 endo-β-1,4-glucanase A (CelA;EgA;Bcell_0438) Bacillus cellulosilyticus DSM 2522 ADU28720.1
 endo-β-1,4-glucanase B (CelB;EgB;Bcell_0437) Bacillus cellulosilyticus DSM 2522 ADU28719.1
D2LVP0   2
 endo-β-1,4-glucanase C (CelC;EgC;Cel2;Bcell_3370) Bacillus cellulosilyticus DSM 2522 ADU31612.1
 endo-β-1,4-glucanase (fragment)   Bacillus cereus IARI-SP-7 AGW99984.1     2
 C1T25_10255   Bacillus cereus MBGJa3 AUZ28685.1     2
 BGM20_03610   Bacillus gibsonii FJAT-10019 AOL29768.1     2
 BGLY_2367 (Bglc2)   Bacillus glycinifermentans SCA86190.1     2
 COP00_03840   Bacillus glycinifermentans KBN06P03352 ATH91857.1     2
 endo-β-1,4-glucanase, partial   Bacillus licheniformis AIY72754.1     2
 endo-β-1,4-glucanase, partial   Bacillus licheniformis AIY72755.1     2
 endo-β-1,4-glucanase, partial   Bacillus licheniformis AIY72756.1     2
 endo-β-1,4-glucanase (Egl01) Bacillus licheniformis AIY72753.1     2
 BLDA23_11255   Bacillus licheniformis 0DA23-1 AXF91061.1     2
 BL14DL4_00305   Bacillus licheniformis 14ADL4 AVI45571.1     2
 CPQ91_10290   Bacillus licheniformis ATCC 9789 ATI78443.1     2
 BL1202_02293   Bacillus licheniformis BL1202 AOP15241.1     2
 CD200_10535   Bacillus licheniformis CBA7132 AWV43010.1     2
 endo-β-1,4-glucanase C (BglC;BLi02088;BL01471) (Cel5A) Bacillus licheniformis DSM 13 = ATCC 14580 AAU23613.2
 endo-β-1,4-glucanase (CelA)   Bacillus licheniformis F11 CAJ70714.1 Q1EM84   2
 endo-β-1,4-glucanase (CelA)   Bacillus licheniformis F5 CAJ70710.1 Q1EM84   2
 endo-β-1,4-glucanase (Cel5A) (Cel5A) Bacillus licheniformis GXN151 / B-41361 AAP51020.1 Q7X3S6   2
 AB684_09875   Bacillus licheniformis HRBL-15TDI7 AMR12722.1     2

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