Glycoside Hydrolase Family 5 / Subf 2

Activities in Familyendo-β-1,4-glucanase / cellulase (EC; endo-β-1,4-xylanase (EC; β-glucosidase (EC; β-mannosidase (EC; β-glucosylceramidase (EC; glucan β-1,3-glucosidase (EC; licheninase (EC; exo-β-1,4-glucanase / cellodextrinase (EC; glucan endo-1,6-β-glucosidase (EC; mannan endo-β-1,4-mannosidase (EC; cellulose β-1,4-cellobiosidase (EC; steryl β-glucosidase (EC; endoglycoceramidase (EC; chitosanase (EC; β-primeverosidase (EC; xyloglucan-specific endo-β-1,4-glucanase (EC; endo-β-1,6-galactanase (EC; hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC; β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (1020); Uniprot accession (275); PDB accession (40); 3D entries (13); cryst (0)
All (905) Bacteria (737) Eukaryota (154) unclassified (14) Structure (13) Characterized (119)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 |
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 Awo_c08790   Acetobacterium woodii DSM 1030 AFA47670.1     2
 endo-β-1,4-glucanase Actinomyces sp. 40 AAC06196.1 O66064   2
 SAMN04489716_0268   Actinoplanes derwentensis DSM 43941 SDS21202.1     2
 SAMN04489716_3551   Actinoplanes derwentensis DSM 43941 SDT38399.1     2
 AFR_22970   Actinoplanes friuliensis DSM 7358 AGZ42864.1     2
 AMIS_52810   Actinoplanes missouriensis 431 BAL90501.1     2
 L083_3663 (BglC)   Actinoplanes sp. N902-109 AGL17173.1     2
 ACPL_5177 (BglC)   Actinoplanes sp. SE50/110 AEV86064.1
 ACPL_6177 (BglC)   Actinoplanes sp. SE50/110 AEV87062.1
 ADH66_12235   Acutalibacter muris KB18 ASB41357.1     2
 AEQU_0542   Adlercreutzia equolifaciens DSM 19450 BAN76511.1     2
 Alfi_1589   Alistipes finegoldii DSM 17242 AFL77928.1     2
 SAMN04489726_7657   Allokutzneria albata DSM 44149 SDN66578.1     2
 glycosyl hydrolase family 5_2 domain-containing protein   Alteromonadaceae bacterium Bs08 AIF91547.1     2
 glycosyl hydrolase family 5_2 domain-containing protein   Alteromonadaceae bacterium Bs12 AIF91536.1     2
 AJAP_19810 (Cele2)   Amycolatopsis japonica MG417-CF17 AIG76823.1     2
 AJAP_11650 (Cele1)   Amycolatopsis japonica MG417-CF17 AIG75215.1     2
 SAMN04489733_0211   Amycolatopsis keratiniphila FH 1893 SDT99530.1     2
 SAMN04489733_1943   Amycolatopsis keratiniphila FH 1893 SDU19440.1     2
 BB31_41955   Amycolatopsis lurida NRRL 2430 AJK59464.1     2
 BB31_05885   Amycolatopsis lurida NRRL 2430 AJK53007.1     2
 B737_4049   Amycolatopsis mediterranei RB AGT84713.1     2
 RAM_20880   Amycolatopsis mediterranei S699 AEK42656.1
 AMED_4097   Amycolatopsis mediterranei U32 ADJ45874.1 D8HQ52   2
 SD37_27170   Amycolatopsis orientalis B-37 ANN18940.1     2
 SD37_19870   Amycolatopsis orientalis B-37 ANN17680.1     2
 AORI_3875   Amycolatopsis orientalis HCCB10007 AGM06460.1     2
 AORI_5568   Amycolatopsis orientalis HCCB10007 AGM08151.1     2
 A9P82_13735   Arachidicoccus sp. BS20 ANI90259.1     2
 endo-β-1,4-glucanase (Egl-1139) / III-3A (Cel5A) Bacillus akibai / KSM-1139 BAA00045.1
P06564   2
 endoglucanase (EG-I-1)   Bacillus akibai I-1 AFI25187.1     2
 endoglucanase   Bacillus amyloliquefaciens AMS1 AKS29707.1     2
 A1R12_09055   Bacillus amyloliquefaciens B15 AMR50503.1     2
 endo-β-1,4-glucanase (EgL)   Bacillus amyloliquefaciens BY-5 AMW90767.1     2
 U471_18630   Bacillus amyloliquefaciens CC178 AGZ56565.1     2
 endo-β-1,4-glucanase   Bacillus amyloliquefaciens IARI-SP-2 AGW99978.1     2
 KSO_010315   Bacillus amyloliquefaciens IT-45 AGF27558.1     2
 KHU1_1621   Bacillus amyloliquefaciens KHG19 AJK65578.1     2
 SB45_09085   Bacillus amyloliquefaciens L-H15 AJH24169.1     2
 XM40_09090   Bacillus amyloliquefaciens L-S60 AKD22364.1     2
 U722_09575   Bacillus amyloliquefaciens LFB112 AHC42348.1     2
 BSF20_16750   Bacillus amyloliquefaciens LM2303 APH49957.1     2
 cellulase (fragment)   Bacillus amyloliquefaciens MBAA3 AHJ80840.1     2
 AVM03_03620   Bacillus amyloliquefaciens MBE1283 ALV01512.1     2
 endoglucanase (EglII) Bacillus amyloliquefaciens PSM 3.1 ADC54852.1 D3Y2F0   2
 AS588_06260   Bacillus amyloliquefaciens S499 AMP31635.1     2
 BAMY6614_13370   Bacillus amyloliquefaciens UMAF6614 AMQ74283.1     2
 BAMY6639_00620   Bacillus amyloliquefaciens UMAF6639 AMQ71229.1     2
 endoglucanase A (EngA)   Bacillus amyloliquefaciens UMAS1002 AAL99668.1 Q8RPQ6   2
 BSO20_02700   Bacillus amyloliquefaciens WS-8 APQ49018.1     2
 BAMY_08970   Bacillus amyloliquefaciens Y14 APB82271.1     2
 MUS_2161 (BglC)   Bacillus amyloliquefaciens Y2 AFJ62120.1     2
 BaGK_15910 (fragment)   Bacillus atrophaeus GQJK17 ASS72344.1     2
 D068_cds30840 (fragment)   Bacillus atrophaeus UCMB-5137 AKL85635.1     2
 Bcell_3371   Bacillus cellulosilyticus DSM 2522 ADU31613.1 D2LQZ8   2
 endo-β-1,4-glucanase A (CelA;EgA;Bcell_0438) Bacillus cellulosilyticus DSM 2522 ADU28720.1
 endo-β-1,4-glucanase B (CelB;EgB;Bcell_0437) Bacillus cellulosilyticus DSM 2522 ADU28719.1
D2LVP0   2
 endo-β-1,4-glucanase C (CelC;EgC;Cel2;Bcell_3370) Bacillus cellulosilyticus DSM 2522 ADU31612.1
 endo-β-1,4-glucanase (fragment)   Bacillus cereus IARI-SP-7 AGW99984.1     2
 BGM20_03610   Bacillus gibsonii FJAT-10019 AOL29768.1     2
 BGLY_2367 (Bglc2)   Bacillus glycinifermentans SCA86190.1     2
 endo-β-1,4-glucanase, partial   Bacillus licheniformis AIY72754.1     2
 endo-β-1,4-glucanase, partial   Bacillus licheniformis AIY72755.1     2
 endo-β-1,4-glucanase, partial   Bacillus licheniformis AIY72756.1     2
 endo-β-1,4-glucanase (Egl01) Bacillus licheniformis AIY72753.1     2
 BL1202_02293   Bacillus licheniformis BL1202 AOP15241.1     2
 endo-β-1,4-glucanase C (BglC;BLi02088;BL01471) (Cel5A) Bacillus licheniformis DSM 13 = ATCC 14580 AAU23613.2
 endo-β-1,4-glucanase (CelA)   Bacillus licheniformis F11 CAJ70714.1 Q1EM84   2
 endo-β-1,4-glucanase (CelA)   Bacillus licheniformis F5 CAJ70710.1 Q1EM84   2
 endo-β-1,4-glucanase (Cel5A) (Cel5A) Bacillus licheniformis GXN151 / B-41361 AAP51020.1 Q7X3S6   2
 AB684_09875   Bacillus licheniformis HRBL-15TDI7 AMR12722.1     2
 endo-β-1,4-glucanase   Bacillus licheniformis IARI-SP-3 AGW99979.1     2
 cellulase   Bacillus licheniformis K11 ABK63476.1 A0T1G5   2
 endoglucanase (CelA) Bacillus licheniformis MD1 CAE82178.1 Q5QSM2   2
 cellulose hydrolase (Cel5H)   Bacillus licheniformis MSB03 ACY72379.1 D1L8C4   2
 B37_01607 (EglS)   Bacillus licheniformis SCCB 37 ARC73659.1     2
 B14_02377 (EglS)   Bacillus licheniformis SCDB 14 ARC65375.1     2
 B34_00630 (EglS)   Bacillus licheniformis SCDB 34 ARC68073.1     2
 BaDB11_00288 (EglS)   Bacillus licheniformis SCK B11 ARC58957.1     2
 S100141_01476   Bacillus licheniformis SRCM100141 ARW42798.1     2
 S101441_02103   Bacillus licheniformis SRCM101441 ARW31652.1     2
 endoglucanase (Gh5A)   Bacillus licheniformis SVD1 BAL45504.1     2
 MUY_002122 (BglC)   Bacillus licheniformis WX-02 AKQ73254.1     2
 endo-glucanase   Bacillus megaterium AP25 ADI82821.1 D9IA39   2
 endo-β-1,4-glucanase   Bacillus megaterium IARI-SP-9 AGW99981.1     2
 glucanase (BglC) (fragment) Bacillus megaterium L103 AGG91154.1     2
 endo-β-1,4-glucanase (fragment)   Bacillus mycoides IARI-SP-8 AGW99985.1     2
 endo-β-1,4-glucanase (fragment)   Bacillus oceanisediminis IARI-SP-10 AGW99986.1     2
 BaLi_c21530 (EglS)   Bacillus paralicheniformis ATCC 9945a AGN36513.1     2
 SC10_B2orf03183   Bacillus paralicheniformis BL-09 AJO18373.1     2
 BLMD_10500   Bacillus paralicheniformis MDJK30 ARA88014.1     2
 Cel5S   Bacillus pumilus HY1 ACY72384.1 D1L8C9   2
 endo-β-1,4-glucanase (fragment)   Bacillus pumilus IARI-SP-5 AGW99982.1     2
 S101395_02568   Bacillus sonorensis SRCM101395 ASB89075.1     2
 unnamed protein product   Bacillus sp. CAD67813.1
 CJO35_10335   Bacillus sp. 1s-1 ASV17692.1     2
 endo-β-1,4-glucanase Bacillus sp. 22-28 BAA12744.1 Q45554   2
 BZ167_00180   Bacillus sp. 275 AQP94520.1     2
 endo-β-1,4-glucanase Bacillus sp. 5H BAA31712.1 O83012   2
 CelS Bacillus sp. 79-23 AAC02536.1 O52731   2

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