Glycoside Hydrolase Family 5 / Subf 2

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (1020); Uniprot accession (275); PDB accession (40); 3D entries (13); cryst (0)
All (905) Bacteria (737) Eukaryota (154) unclassified (14) Structure (13) Characterized (119)
Bacteria
Protein Name EC# OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
Subf
 cellulase (BCE103) 3.2.1.4 Bacillus sp. CBS 670.93 CAB59165.1
AAV25061.1
CAB58698.1
CAD82873.1
 
1LF1[A] 1.70
2
 endo-β-1,4-glucanase K (Egl-K) 3.2.1.4 Bacillus sp. KSM-635 AAA22304.1 P19424
1G01[A] 1.90
1G0C[A] β-D-Glcp-(1-4)-α-D-Glcp
1.90
2
 endo-β-1,4-glucanase (EglS;BglC;Gld;BSU18130;BsCel5;BsCel5A) (Cel5A) 3.2.1.4 Bacillus subtilis subsp. subtilis str. 168 CAA82317.1
AEJ76923.1
AIY93123.1
AQR81804.1
AQR86018.1
CAA97610.1
CAB13696.2
NP_389695.1
P10475
3PZT[A,B] 1.97
3PZU[A,B] 2.10
3PZV[A,B,C,D] 2.87
2
 endoglucanase (Csac_0678) 3.2.1.4 Caldicellulosiruptor saccharolyticus DSM 8903 ABP66297.1 A4XHB2
5ECU[A] 1.50
2
 periplasmic endoglucanase 5B (CHU_2103) (Cel5B) 3.2.1.4 Cytophaga hutchinsonii ATCC 33406 ABG59366.1 Q11T98
5IHS[A] 1.10
2
 endo-β-1,4-glucanase Z (CelZ;EgZ;Dda3937_02793) (Cel5A=Cel5Z) 3.2.1.4 Dickeya dadantii 3937 ADM99099.1
CAA68604.1
P07103
1EGZ[A,B,C] 2.30
2
 endo-β-1,4-glucanase (CelA;GsCelA) 3.2.1.4 Geobacillus sp. 70PC53 ACJ60856.1 C5H6X3
4XZB[A] 1.62
4XZW[A] 1.50
2
 endoglucanase (CelG) (Cel5G) 3.2.1.4 Pseudoalteromonas haloplanktis A23 CAA76775.1 O86099
1TVN[A,B] 1.41
1TVP[A,B] β-D-Glcp-(1-4)-β-D-Glcp
1.60
2
 endo-β-1,4-glucanase 5A (Cel5A) 3.2.1.4 Salipaludibacillus agaradhaerens AAC19169.1 O85465
1A3H[A] 1.57
1E5J[A] β-D-Glcp-(1-4)-α-D-Glcp4S-(1-4)-β-D-Glcp4S-(1-4)-β-D-Glcp-(1-1)-methyl
1.85
1H11[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-α-D-Glcp2F-(1-4)-GLU
1.08
1H2J[A] β-D-Glcp-(1-4)-α-D-Glcp2F-(1-4)-GLU
1.15
1H5V[A] β-D-Glcp-(1-4)-β-D-Glcp4S-(1-4)-β-D-Glcp4S-(1-4)-β-D-Glcp4S-(1-4)-α-D-Glcp4S-(1-1)-methyl
1.1
1HF5[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-α-D-Glcp2F-(1-4)-GLU
1.10
1HF6[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-1)-<non_carb>
1.15
1HF7[A] β-D-Glcp-(1-4)-α-D-Glcp2F-(1-4)-GLU
β-D-Glcp-(1-4)-β-D-Glcp2F-(1-1)-<non_carb>
1.10
1OCQ[A] β-D-Glcp-(1-4)-<carb_like_IFM>
<carb_like_IFM>
1.08
1QHZ[A] 1.95
1QI0[A] β-D-Glcp-(1-4)-β-D-Glcp
2.10
1QI2[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-α-D-Glcp2F-(1-4)-GLU
1.75
1W3K[A] β-D-Glcp-(1-1)-<non_carb>
<carb_like_OXZ>
1.2
1W3L[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-1)-<non_carb>
<carb_like_OXZ>
1.04
2A3H[A] β-D-Glcp-(1-4)-β-D-Glcp
2.00
2V38[A] β-D-Glcp-(1-1)-<non_carb>
<carb_like_IFL>
1.50
3A3H[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-α-D-Glcp
1.64
4A3H[A] β-D-Glcp-(1-4)-β-D-Glcp2F-(1-1)-<non_carb>
1.65
5A3H[A] β-D-Glcp-(1-4)-α-D-Glcp2F-(1-4)-GLU
1.82
6A3H[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-α-D-Glcp2F-(1-4)-GLU
1.68
7A3H[A] 0.95
8A3H[A] β-D-Glcp-(1-1)-<non_carb>
0.97
2
 endo-β-1,4-glucanase / celulase (CelDZ1a) 3.2.1.4 Thermoanaerobacterium sp. A57Txylan ALX38276.1  
5FIP[A,B,C,D] 1.88
2
 endo-β-1,4-glucanase 5A (E5;CelE;TfCel5A;Tfu_0901) (Cel5A) 3.2.1.4 Thermobifida fusca YX AAZ54939.1
AAC09379.1
Q01786
Q47RH8
2CKR[A,B] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
1.77
2CKS[A,B] 1.6
2
 cellulase 5R (Cel5R;Cel5R_FS) 3.2.1.4 uncultured bacterium AND74761.1  
5I2U[A,B] 2.20
2
 cellulase (CelE1) 3.2.1.4 uncultured bacterium AHA42547.2
AHA42547.1
 
4M1R[A,B] 1.80
2
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