Glycoside Hydrolase Family 5 / Subf 2

Activities in Familyendo-β-1,4-glucanase / cellulase (EC; endo-β-1,4-xylanase (EC; β-glucosidase (EC; β-mannosidase (EC; β-glucosylceramidase (EC; glucan β-1,3-glucosidase (EC; licheninase (EC; exo-β-1,4-glucanase / cellodextrinase (EC; glucan endo-1,6-β-glucosidase (EC; mannan endo-β-1,4-mannosidase (EC; cellulose β-1,4-cellobiosidase (EC; steryl β-glucosidase (EC; endoglycoceramidase (EC; chitosanase (EC; β-primeverosidase (EC; xyloglucan-specific endo-β-1,4-glucanase (EC; endo-β-1,6-galactanase (EC; hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC; β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (1148); Uniprot accession (275); PDB accession (42); 3D entries (14); cryst (0)
All (1031) Bacteria (862) Eukaryota (155) unclassified (14) Structure (14) Characterized (120)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 |
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 endo-β-1,4-glucanase   Bacillus licheniformis IARI-SP-3 AGW99979.1     2
 cellulase   Bacillus licheniformis K11 ABK63476.1 A0T1G5   2
 C1T27_10580   Bacillus licheniformis MBGJa67 AUZ32937.1     2
 endoglucanase (CelA) Bacillus licheniformis MD1 CAE82178.1 Q5QSM2   2
 cellulose hydrolase (Cel5H)   Bacillus licheniformis MSB03 ACY72379.1 D1L8C4   2
 B37_01607 (EglS)   Bacillus licheniformis SCCB 37 ARC73659.1     2
 B14_02377 (EglS)   Bacillus licheniformis SCDB 14 ARC65375.1     2
 B34_00630 (EglS)   Bacillus licheniformis SCDB 34 ARC68073.1     2
 BaDB11_00288 (EglS)   Bacillus licheniformis SCK B11 ARC58957.1     2
 S100141_01476   Bacillus licheniformis SRCM100141 ARW42798.1     2
 S101441_02103   Bacillus licheniformis SRCM101441 ARW31652.1     2
 endoglucanase (Gh5A)   Bacillus licheniformis SVD1 BAL45504.1     2
 MUY_002122 (BglC)   Bacillus licheniformis WX-02 AKQ73254.1     2
 endo-glucanase   Bacillus megaterium AP25 ADI82821.1 D9IA39   2
 endo-β-1,4-glucanase   Bacillus megaterium IARI-SP-9 AGW99981.1     2
 glucanase (BglC) (fragment) Bacillus megaterium L103 AGG91154.1     2
 endo-β-1,4-glucanase (fragment)   Bacillus mycoides IARI-SP-8 AGW99985.1     2
 endo-β-1,4-glucanase (fragment)   Bacillus oceanisediminis IARI-SP-10 AGW99986.1     2
 BaLi_c21530 (EglS)   Bacillus paralicheniformis ATCC 9945a AGN36513.1     2
 SC10_B2orf03183   Bacillus paralicheniformis BL-09 AJO18373.1     2
 BLMD_10500   Bacillus paralicheniformis MDJK30 ARA88014.1     2
 Cel5S   Bacillus pumilus HY1 ACY72384.1 D1L8C9   2
 endo-β-1,4-glucanase (fragment)   Bacillus pumilus IARI-SP-5 AGW99982.1     2
 CWD84_11935   Bacillus siamensis SCSIO 05746 AUJ77469.1     2
 S101395_02568   Bacillus sonorensis SRCM101395 ASB89075.1     2
 unnamed protein product   Bacillus sp. (in: Bacteria) CAD67813.1
 endo-β-1,4-glucanase Bacillus sp. (in: Bacteria) 22-28 BAA12744.1 Q45554   2
 endo-β-1,4-glucanase Bacillus sp. (in: Bacteria) 5H BAA31712.1 O83012   2
 BS34A_20090 (EglS)   Bacillus sp. (in: Bacteria) BS34A CEJ77430.1     2
 cellulase (BCE103) Bacillus sp. (in: Bacteria) CBS 670.93 CAB59165.1
  1LF1[A] 2
 endo-β-1,4-glucanase (Cel) (fragment) Bacillus sp. (in: Bacteria) D04 AAC43478.1 Q45430   2
 endo-β-1,4-glucanase B1 Bacillus sp. (in: Bacteria) N186-1 CAA83942.1 Q59232   2
 CJO35_10335   Bacillus sp. 1s-1 ASV17692.1     2
 BZ167_00180   Bacillus sp. 275 AQP94520.1     2
 CelS Bacillus sp. 79-23 AAC02536.1 O52731   2
 OY17_12185   Bacillus sp. BH072 AJE78821.1     2
 cellulase (CelC)   Bacillus sp. CY1-3 ABG91147.1 Q0PF31   2
 DS740_10005   Bacillus sp. DM2 AXF33155.1     2
 BGM23_12240   Bacillus sp. FJAT-14266 AOL27309.1     2
 BSZ43_10245   Bacillus sp. H15-1 APJ29232.1     2
 endo-β-1,4-glucanase (GluY)   Bacillus sp. HB102 AAU08303.1 Q66NX2   2
 cellulase (Cel1)   Bacillus sp. HY2-3 AAV34758.1 Q5UAZ8   2
 endo-β-1,4-glucanase   Bacillus sp. IARI-SP-4 AGW99980.1     2
 MY9_1980   Bacillus sp. JS AFI28515.1     2
 cellulase, partial (fragment)   Bacillus sp. KP8 AFM99481.1     2
 endo-β-1,4-glucanase K (Egl-K) Bacillus sp. KSM-635 AAA22304.1 P19424 1G01[A]
 endo-β-1,4-glucanase (Egl-64) Bacillus sp. KSM-64 / Bacillus sp. Z-16 CAJ00039.1
Q59241   2
 endoglucanase N252 (Egl252) Bacillus sp. KSM-N252 BAB62295.1 Q93R81   2
 endo-β-1,4-glucanase (Egl-237) Bacillus sp. KSM-S237 CAJ00038.1
Q9F216   2
 BsLM_1923   Bacillus sp. LM 4-2 AKE23721.1     2
 CS547_09465   Bacillus sp. Lzh-5 ATV22947.1     2
 C1T29_11520   Bacillus sp. MBGLi79 AUZ38888.1     2
 CDO84_08795   Bacillus sp. MD-5 ASB61086.1     2
 bifunctional cellulase chitosanase (CelA)
Bacillus sp. NBL420 AAK73277.1 Q93LI9   2
 endo-β-1,4-glucanase   Bacillus sp. NK-2 ADO85705.1 E3VRS9   2
 endo-β-1,4-glucanase (GluD)   Bacillus sp. NW-2004a AAT97264.1 Q68NH6   2
 endo-β-1,4-glucanase (GluG) (fragment)   Bacillus sp. NW-2004b AAT97263.1 Q68PJ1   2
 SB24_00605   Bacillus sp. Pc3 AJC23751.1     2
 endoglucanase (EgC)   Bacillus sp. RP1 AID18514.1     2
 AUL54_01525   Bacillus sp. SDLI1 AME05095.1     2
 endo-β-1,4-glucanase (fragment)   Bacillus sp. TZT-02 AFR42425.1     2
 endoglucanase   Bacillus sp. VLSH08 AEA30146.1     2
 cellulase   Bacillus sp. WRD-2 AAX54913.1 Q32T26   2
 QF06_08135   Bacillus sp. YP1 AJO58436.1     2
 C5I45_10330   Bacillus sp. ZY-1-1 AVX17239.1     2
 endo-1,4-β-glucanase (fragment)   Bacillus subtilis AEK70950.1     2
 endo-1,4-β-glucanase (fragment)   Bacillus subtilis AEK70951.1     2
 endo-1,4-β-glucanase (fragment)   Bacillus subtilis AEK70952.1     2
 endo-β-1,4-glucanase Bacillus subtilis AAA22307.1 Q45532   2
 BKP58_02035   Bacillus subtilis 29R7-12 API94754.1     2
 beta 1,4 endo glucanase, partial (fragment)   Bacillus subtilis a10d AGV05392.1     2
 endocellulase   Bacillus subtilis A2 AFA26702.1     2
 β-1,3-1,4-glucanase / cellulase C (CelA;CelC) Bacillus subtilis A8-8 AAO63626.1 Q6Y4Q1   2
 endoglucanase / cellulase (Cel-An5) (fragment)   Bacillus subtilis An5 AHX72143.1     2
 cellulase   Bacillus subtilis ASM6 AKQ62667.1     2
 KS07_08965   Bacillus subtilis ATCC 19217 AIW37597.1     2
 BS21228_00510   Bacillus subtilis ATCC 21228 AVL03010.1     2
 endo-1,4-β-glucanase (GlnC) (partial)   Bacillus subtilis ATTCAU195 AAN07019.1 Q6YK34   2
 endo-β-1,4-glucanase, partial   Bacillus subtilis AuChE413 ALJ10582.1     2
 MA22_12095   Bacillus subtilis B-1 AIU77226.1     2
 β-1,4-endo-glucanase, partial (fragment)   Bacillus subtilis b5b AHD24502.1     2
 endo-β-1,4-glucanase (fragment)   Bacillus subtilis b5d AHC02484.1     2
 beta 1,4 endo glucanase, partial (fragment)   Bacillus subtilis b8a AGV05394.1     2
 endoglucanase (Egl173;Cel;EglS) Bacillus subtilis BEC-1 / Y106 / shu-3 AAK39540.1
Q93TJ6   2
 BEST7003_1842 (EglS)   Bacillus subtilis BEST7003 BAM58043.1     2
 C0W65_19480   Bacillus subtilis BJ3-2 AUS14012.1     2
 endo-β-1,4-glucanase (Eg15) (Cel5A) Bacillus subtilis BME-15 ACI15227.1
B6DVJ2   2
 endo-β-1,4-glucanase (Cel5H)   Bacillus subtilis BME12 ACM68436.1 B9W017   2
 B7470_21865   Bacillus subtilis Bs-115 ARI88503.1     2
 β-glucanase   Bacillus subtilis BS-2 ABS70712.1
A7LIA1   2
 EG5C   Bacillus subtilis BS-5 AVD69633.1     2
 EG5C-1, partial   Bacillus subtilis BS-5 AVD69632.1     2
 KO64_09220   Bacillus subtilis Bs-916 AIW30039.1     2
 endo-1,4-β-glucanohydrolase   Bacillus subtilis BS-DX4 AQT39609.1     2
 BS16045_01927   Bacillus subtilis BS16045 AOL97645.1     2
 β-1,4-endo glucanase, partial (fragment)   Bacillus subtilis BS3-2J AVV48623.1     2
 BSBS38_02055   Bacillus subtilis BS38 AOR98335.1     2
 BS49_20100 (EglS)   Bacillus subtilis BS49 CEI57006.1     2
 endo-β-1,4-glucanase (CMCase;BglC) Bacillus subtilis BSE616 BAA00859.1 P23549   2
 BSn5_00410   Bacillus subtilis BSn5 ADV92718.1     2

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