Glycoside Hydrolase Family 5 / Subf 2

Activities in Familyendo-β-1,4-glucanase / cellulase (EC; endo-β-1,4-xylanase (EC; β-glucosidase (EC; β-mannosidase (EC; β-glucosylceramidase (EC; glucan β-1,3-glucosidase (EC; licheninase (EC; exo-β-1,4-glucanase / cellodextrinase (EC; glucan endo-1,6-β-glucosidase (EC; mannan endo-β-1,4-mannosidase (EC; cellulose β-1,4-cellobiosidase (EC; steryl β-glucosidase (EC; endoglycoceramidase (EC; chitosanase (EC; β-primeverosidase (EC; xyloglucan-specific endo-β-1,4-glucanase (EC; endo-β-1,6-galactanase (EC; hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC; β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (1073); Uniprot accession (275); PDB accession (41); 3D entries (14); cryst (0)
All (956) Bacteria (788) Eukaryota (154) unclassified (14) Structure (14) Characterized (119)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 |
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 endo-β-1,4-glucanase (fragment)   Bacillus pumilus IARI-SP-5 AGW99982.1     2
 CWD84_11935   Bacillus siamensis SCSIO 05746 AUJ77469.1     2
 S101395_02568   Bacillus sonorensis SRCM101395 ASB89075.1     2
 unnamed protein product   Bacillus sp. (in: Bacteria) CAD67813.1
 endo-β-1,4-glucanase Bacillus sp. (in: Bacteria) 22-28 BAA12744.1 Q45554   2
 endo-β-1,4-glucanase Bacillus sp. (in: Bacteria) 5H BAA31712.1 O83012   2
 BS34A_20090 (EglS)   Bacillus sp. (in: Bacteria) BS34A CEJ77430.1     2
 cellulase (BCE103) Bacillus sp. (in: Bacteria) CBS 670.93 CAB59165.1
  1LF1[A] 2
 endo-β-1,4-glucanase (Cel) (fragment) Bacillus sp. (in: Bacteria) D04 AAC43478.1 Q45430   2
 endo-β-1,4-glucanase B1 Bacillus sp. (in: Bacteria) N186-1 CAA83942.1 Q59232   2
 CJO35_10335   Bacillus sp. 1s-1 ASV17692.1     2
 BZ167_00180   Bacillus sp. 275 AQP94520.1     2
 CelS Bacillus sp. 79-23 AAC02536.1 O52731   2
 OY17_12185   Bacillus sp. BH072 AJE78821.1     2
 cellulase (CelC)   Bacillus sp. CY1-3 ABG91147.1 Q0PF31   2
 BGM23_12240   Bacillus sp. FJAT-14266 AOL27309.1     2
 BSZ43_10245   Bacillus sp. H15-1 APJ29232.1     2
 endo-β-1,4-glucanase (GluY)   Bacillus sp. HB102 AAU08303.1 Q66NX2   2
 cellulase (Cel1)   Bacillus sp. HY2-3 AAV34758.1 Q5UAZ8   2
 endo-β-1,4-glucanase   Bacillus sp. IARI-SP-4 AGW99980.1     2
 MY9_1980   Bacillus sp. JS AFI28515.1     2
 cellulase, partial (fragment)   Bacillus sp. KP8 AFM99481.1     2
 endo-β-1,4-glucanase K (Egl-K) Bacillus sp. KSM-635 AAA22304.1 P19424 1G01[A]
 endo-β-1,4-glucanase (Egl-64) Bacillus sp. KSM-64 / Bacillus sp. Z-16 CAJ00039.1
Q59241   2
 endoglucanase N252 (Egl252) Bacillus sp. KSM-N252 BAB62295.1 Q93R81   2
 endo-β-1,4-glucanase (Egl-237) Bacillus sp. KSM-S237 CAJ00038.1
Q9F216   2
 BsLM_1923   Bacillus sp. LM 4-2 AKE23721.1     2
 CS547_09465   Bacillus sp. Lzh-5 ATV22947.1     2
 C1T29_11520   Bacillus sp. MBGLi79 AUZ38888.1     2
 CDO84_08795   Bacillus sp. MD-5 ASB61086.1     2
 bifunctional cellulase chitosanase (CelA)
Bacillus sp. NBL420 AAK73277.1 Q93LI9   2
 endo-β-1,4-glucanase   Bacillus sp. NK-2 ADO85705.1 E3VRS9   2
 endo-β-1,4-glucanase (GluD)   Bacillus sp. NW-2004a AAT97264.1 Q68NH6   2
 endo-β-1,4-glucanase (GluG) (fragment)   Bacillus sp. NW-2004b AAT97263.1 Q68PJ1   2
 SB24_00605   Bacillus sp. Pc3 AJC23751.1     2
 endoglucanase (EgC)   Bacillus sp. RP1 AID18514.1     2
 AUL54_01525   Bacillus sp. SDLI1 AME05095.1     2
 endo-β-1,4-glucanase (fragment)   Bacillus sp. TZT-02 AFR42425.1     2
 endoglucanase   Bacillus sp. VLSH08 AEA30146.1     2
 cellulase   Bacillus sp. WRD-2 AAX54913.1 Q32T26   2
 QF06_08135   Bacillus sp. YP1 AJO58436.1     2
 endo-1,4-β-glucanase (fragment)   Bacillus subtilis AEK70950.1     2
 endo-1,4-β-glucanase (fragment)   Bacillus subtilis AEK70951.1     2
 endo-1,4-β-glucanase (fragment)   Bacillus subtilis AEK70952.1     2
 endo-β-1,4-glucanase Bacillus subtilis AAA22307.1 Q45532   2
 BKP58_02035   Bacillus subtilis 29R7-12 API94754.1     2
 beta 1,4 endo glucanase, partial (fragment)   Bacillus subtilis a10d AGV05392.1     2
 endocellulase   Bacillus subtilis A2 AFA26702.1     2
 β-1,3-1,4-glucanase / cellulase C (CelA;CelC) Bacillus subtilis A8-8 AAO63626.1 Q6Y4Q1   2
 endoglucanase / cellulase (Cel-An5) (fragment)   Bacillus subtilis An5 AHX72143.1     2
 cellulase   Bacillus subtilis ASM6 AKQ62667.1     2
 KS07_08965   Bacillus subtilis ATCC 19217 AIW37597.1     2
 endo-1,4-β-glucanase (GlnC) (partial)   Bacillus subtilis ATTCAU195 AAN07019.1 Q6YK34   2
 endo-β-1,4-glucanase, partial   Bacillus subtilis AuChE413 ALJ10582.1     2
 MA22_12095   Bacillus subtilis B-1 AIU77226.1     2
 β-1,4-endo-glucanase, partial (fragment)   Bacillus subtilis b5b AHD24502.1     2
 endo-β-1,4-glucanase (fragment)   Bacillus subtilis b5d AHC02484.1     2
 beta 1,4 endo glucanase, partial (fragment)   Bacillus subtilis b8a AGV05394.1     2
 endoglucanase (Egl173;Cel;EglS) Bacillus subtilis BEC-1 / Y106 / shu-3 AAK39540.1
Q93TJ6   2
 BEST7003_1842 (EglS)   Bacillus subtilis BEST7003 BAM58043.1     2
 C0W65_19480   Bacillus subtilis BJ3-2 AUS14012.1     2
 endo-β-1,4-glucanase (Eg15) (Cel5A) Bacillus subtilis BME-15 ACI15227.1
B6DVJ2   2
 endo-β-1,4-glucanase (Cel5H)   Bacillus subtilis BME12 ACM68436.1 B9W017   2
 B7470_21865   Bacillus subtilis Bs-115 ARI88503.1     2
 β-glucanase   Bacillus subtilis BS-2 ABS70712.1
A7LIA1   2
 KO64_09220   Bacillus subtilis Bs-916 AIW30039.1     2
 endo-1,4-β-glucanohydrolase   Bacillus subtilis BS-DX4 AQT39609.1     2
 BS16045_01927   Bacillus subtilis BS16045 AOL97645.1     2
 BSBS38_02055   Bacillus subtilis BS38 AOR98335.1     2
 BS49_20100 (EglS)   Bacillus subtilis BS49 CEI57006.1     2
 endo-β-1,4-glucanase (CMCase;BglC) Bacillus subtilis BSE616 BAA00859.1 P23549   2
 BSn5_00410   Bacillus subtilis BSn5 ADV92718.1     2
 endo-β-1,4-glucanase   Bacillus subtilis BY-2 AGN52749.1     2
 endo-β-1,4-glucanase   Bacillus subtilis BY-4 AHA61366.1     2
 endo-β-1,4-glucanase (EglS;EG) Bacillus subtilis C-36 ABG78039.1 Q0PPV7   2
 cellulase, partial (fragment)   Bacillus subtilis C05-16 AFH66774.1     2
 endo-β-1,4-glucanase (fragment)   Bacillus subtilis C11A ADP76527.1 E5KCL5   2
 endo-β-1,4-glucanase (fragment)   Bacillus subtilis C11B1 ADP76526.1 E5KCL4   2
 endo-β-1,4-glucanase (fragment)   Bacillus subtilis C8K1 ADP76528.1 E5KCL6   2
 endo-β-1,4-glucanase (CelG) Bacillus subtilis CHZ1 AAK94871.1 Q93LD0   2
 endo-β-1,4-glucanase (EglS) Bacillus subtilis CK-2 CAA47429.1 G1DE47
 BCV50_02950   Bacillus subtilis CW14 ARV44015.1     2
 endo-β-1,4-glucanase (Egl)   Bacillus subtilis dcy-1 ADH93702.1 D7R4Z8   2
 CJZ70_10320   Bacillus subtilis DKU_NT_02 ASU98698.1     2
 CJZ71_00325   Bacillus subtilis DKU_NT_03 ASV00768.1     2
 endo-β-1,4-glucanase (BglC;Gld) Bacillus subtilis DLG AAA22496.1 P07983   2
 cellulase (CelDR) Bacillus subtilis DR ABV45393.1
A8D0T0   2
 endo-β-1,4-glucanase (fragment)   Bacillus subtilis DR-8806 AGT14428.1     2
 cellulase   Bacillus subtilis DR8806 AJS13457.1     2
 BSK2_09725   Bacillus subtilis GQJK2 ARB37208.1     2
 β-1,4-endo-glucanase, partial (fragment)   Bacillus subtilis h13f AHD24515.1     2
 β-1,4-endo-glucanase, partial (fragment)   Bacillus subtilis h13h AHD24509.1     2
 β-1,4-endo-glucanase, partial (fragment)   Bacillus subtilis h14h AHD24511.1     2
 BSHJ0_02123   Bacillus subtilis HJ0-6 AOA54695.1     2
 AW03_018510 (BglC)   Bacillus subtilis HJ5 AKD35233.1     2
 cellulase   Bacillus subtilis Ho27 AIV00153.1     2
 A4A60_10410   Bacillus subtilis HRBS-10TDI13 AOS68054.1     2
 endo-β-1,4-glucanase (CelI15) Bacillus subtilis I15 ACK38261.1 B7UAM4   2
 endo-β-1,4-glucanase   Bacillus subtilis IARI-SP-1 AGW99977.1     2
 BHE96_09500   Bacillus subtilis J-5 APH35804.1     2

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