Glycoside Hydrolase Family 48

Activities in Familyreducing end-acting cellobiohydrolase (EC 3.2.1.176); endo-β-1,4-glucanase (EC 3.2.1.4); chitinase (EC 3.2.1.14)
Mechanism Inverting
ClanGH-M
3D Structure Status( α / α ) 6
Catalytic Nucleophile/BaseNot known
Catalytic Proton DonorGlu
Noteformerly known as cellulase family L. Some cellobiohydrolases of this family have been reported to act from the reducing ends of cellulose (EC 3.2.1.-), while others have been reported to operate from the non-reducing ends to liberate cellobiose or cellotriose or cellotetraose (EC 3.2.1.-). This family also contains endo-processive cellulases (EC 3.2.1.-), whose activity is hard to distinguish from that of cellobiohydrolases.
External resourcesCAZypedia; HOMSTRAD; PRINTS;
Commercial Enzyme Provider(s)NZYTech;
Statistics GenBank accession (1186); Uniprot accession (114); PDB accession (27); 3D entries (8); cryst (0)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 SMB_G0928 (CelccF)   Clostridium acetobutylicum DSM 1731 AEI33201.1    
 CEA_G0923   Clostridium acetobutylicum EA 2018 ADZ19962.1    
 DK921_10955   Clostridium acetobutylicum LJ4 AWV80606.1    
 CM240_3325 (CelA3) (probable fragment)   Clostridium bornimense M2/40 CDM70442.1    
 processive endo-cellulase F (CelF;Ccel_0729) (Cel48F) 3.2.1.176 [Clostridium] cellulolyticum H10 ACL75108.1
AAA73866.1
AAB41452.1
P37698 1F9D[A]
1F9O[A]
1FAE[A]
1FBO[A]
1FBW[A]
1FCE[A]
1G9G[A]
1G9J[A]
2QNO[A]
 CCDG5_1680 (CelY)   [Clostridium] cellulosi CDZ24788.1    
 Clocel_2823 (ExgS)   Clostridium cellulovorans 743B ADL52519.1 D9SS72  
 exoglucanase S (ExgS;P70) 3.2.1.176 Clostridium cellulovorans ATCC 35296 AAC38571.3
AAC38571.2
O65986 4KIH[A]
4KKF[A]
4KKK[A]
4XWL[A]
4XWM[A]
4XWN[A]
 ORF (fragment)   Clostridium clariflavum DSM 19732 ACV92098.1 C9EEU2  
 Clocl_3038   [Clostridium] clariflavum DSM 19732 AEV69573.1    
 exoglucanase (Clocl_4007) 3.2.1.- [Clostridium] clariflavum DSM 19732 AEV70443.1    
 CelD (Cel48A)   Clostridium josui BAA32430.1
BAI52924.1
O82831  
 Cspa_c18580 (CelA1)   Clostridium saccharoperbutylacetonicum N1-4(HMT) AGF55628.1    
 CLSAP_17890 (CelccF)   Clostridium saccharoperbutylacetonicum N1-504 AQR94480.1    
 Clo1100_1819   Clostridium sp. BNL1100 AEY66029.1    
 ORF (fragment)   Clostridium sp. Iso4-1 ADD83056.1 D4N2U7  
 ORF (fragment)   Clostridium sp. Iso4-2a ADD83057.1 D4N2U8  
 ORF (fragment)   Clostridium sp. Iso5-8 ADD83058.1 D4N2U9  
 glycosyl hydrolase family 48 protein (fragment)   Clostridium sp. Iso5-8 ADM52291.1 E0YVL7  
 ORF (fragment)   Clostridium sp. Iso6-17 ADD83059.1 D4N2V0  
 glycosyl hydrolase family 48 protein (fragment)   Clostridium sp. Iso6-17a ADM52292.1 E0YVL8  
 ORF (fragment)   Clostridium sp. Iso6-24 ADD83060.1 D4N2V1  
 glycosyl hydrolase family 48 protein (fragment)   Clostridium sp. Iso6-24 ADM52293.1 E0YVL9  
 ORF (fragment)   Clostridium sp. Iso6-26 ADD83061.1 D4N2V2  
 glycosyl hydrolase family 48 protein (fragment)   Clostridium sp. Iso6-26 ADM52294.1 E0YVM0  
 ORF (fragment)   Clostridium sp. Iso6-29 ADD83062.1 D4N2V3  
 glycosyl hydrolase family 48 protein (fragment)   Clostridium sp. Iso6-29 ADM52295.1 E0YVM1  
 ORF (fragment)   Clostridium sp. IsoCT1S ADD83065.1 D4N2V6  
 ORF (fragment)   Clostridium sp. IsoCT1Y ADD83063.1 D4N2V4  
 ORF (fragment)   Clostridium sp. IsoCT2S ADD83066.1 D4N2V7  
 ORF (fragment)   Clostridium sp. IsoCT2Y ADD83064.1 D4N2V5  
 cellodextrinohydrolase (avicelase II) (CelY) 3.2.1.176 Clostridium stercorarium CAA93280.1 P50900  
 CSTERLE_09215   [Clostridium] stercorarium subsp. leptospartum DSM 9219 ANX01737.1    
 Cst_c18970 (CelY)   [Clostridium] stercorarium subsp. stercorarium DSM 8532 AGC68874.1
AGI39871.1
P50900  
 CSTERTH_09155   [Clostridium] stercorarium subsp. thermolacticum DSM 2910 ANW99180.1    
 ORF (fragment)   Clostridium straminisolvens CSK1 ACT46161.1 C7ED30  
 ORF (fragment)   Clostridium straminisolvens CSK1 ACV92097.1 C9EEU1  
 CYFUS_007542   Cystobacter fuscus DSM 52655 ATB42066.1    
 MY04_1448 (fragment)   Flammeovirga sp. MY04 ANQ48824.1    
 C1H87_01035   Flavivirga eckloniae ECD14 AUP77377.1    
 cellulase (HCH_02465) 3.2.1.- Hahella chejuensis KCTC 2396 ABC29272.1 Q2SJA2 4FUS[A]
 SD1D_1236 (CelY)   Herbinix luporum SD1D CUH92782.1    
 SD1D_1782 (CelccF)   Herbinix luporum SD1D CUH93327.1    
 HVS_14800 (Cels2)   Herbivorax saccincola GGR1 AUG58811.1    
 Haur_0295   Herpetosiphon aurantiacus DSM 785 ABX02947.1 A9B7H4  
 I598_1166 (CbhB)   Isoptericola dokdonensis DS-3 ANC30733.1    
 BN2497_13421   Janthinobacterium sp. CG23_2 CUI24935.1    
 Jden_1134   Jonesia denitrificans DSM 20603 ACV08790.1 C7R3T3  
 CEP80_12690   Jonesia denitrificans FDAARGOS_301 ASE09888.1    
 NCTC10816_01170 (CbhB)   Jonesia denitrificans NCTC10816 SQH20779.1    
 KSE_56700   Kitasatospora setae KM-6054 BAJ31443.1 E4N0B5  
 CFP65_7267   Kitasatospora sp. MMS16-BH015 AUG81854.1    
 cellobiohydrolase (cphy3368;CpCel48;Cphy_3368) (Cel48) 3.2.1.176 Lachnoclostridium phytofermentans ISDg ABX43721.1 A9KT91  
 BBK82_39465   Lentzea guizhouensis DHS C013 ANZ41157.1    
 Mahau_1111   Mahella australiensis 50-1 BON AEE96308.1    
 AZF01_06870   Martelella sp. AD-3 AMM84110.1    
 CR152_25170   Massilia violaceinigra B2 ATQ77423.1    
 Micau_4167   Micromonospora aurantiaca ATCC 27029 ADL47680.1 D9T3K1  
 DVH21_29825   Micromonospora aurantiaca H14(2018) AXH93755.1    
 GA0070611_2473   Micromonospora auratinigra DSM 44815 SBT43825.1    
 GA0070612_3293   Micromonospora chokoriensis DSM 45160 SCF04716.1    
 GA0070607_4582   Micromonospora coriariae DSM 44875 SCF02628.1    
 GA0070614_1208   Micromonospora coxensis DSM 45161 SCG44390.1    
 GA0070609_1391   Micromonospora echinaurantiaca DSM 43904 SCG43916.1    
 GA0070610_1695   Micromonospora echinofusca DSM 43913 SCG15464.1    
 GA0070618_4227   Micromonospora echinospora DSM 43816 SCF22793.1    
 GA0070620_6490   Micromonospora krabiensis DSM 45344 SBV30884.1    
 GA0070621_2813   Micromonospora narathiwatensis DSM 45248 SBT47120.1    
 GA0074696_2643   Micromonospora purpureochromogenes DSM 43821 SCF08735.1    
 GA0070623_5705   Micromonospora rifamycinica DSM 44983 SCG81331.1    
 GA0074704_4246   Micromonospora siamensis DSM 45097 SCG67004.1    
 ML5_4135   Micromonospora sp. L5 ADU09645.1 D3CKK4  
 CO540_29795   Micromonospora sp. WMMA2032 ATO17510.1    
 GA0070619_3650   Micromonospora zamorensis DSM 45600 SCG57566.1    
 A7982_03338   Minicystis rosea DSM 24000 APR77991.1    
 cellobiohydrolase (Cel48) 3.2.1.176 Myxobacter sp. AL-1 ABD64772.1 Q19VP0  
 CGQ36_15835   Nocardiopsis dassonvillei HZNU_N_1 ASU58944.1    
 A9R04_15640   Nocardiopsis dassonvillei NOCA502F APC36033.1    
 Ndas_2448   Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111 ADH67868.1 D7AWS1  
 BN4615_P346   Nonomuraea gerenzanensis ATCC 39727 SBO90832.1    
 BKM31_47500   Nonomuraea sp. ATCC 55076 AQZ68100.1    
 cellobiohydrolase (Cel48C) 3.2.1.176 Paenibacillus barcinonensis BP-23 CAD32945.1 Q8KKF7  
 PBOR_28070   Paenibacillus borealis DSM 13188 AIQ60376.1    
 B9T62_24600   Paenibacillus donghaensis KCTC 13049 ASA26471.1    
 PGRAT_25310   Paenibacillus graminis DSM 15220 AIQ70582.1    
 B4V02_13295   Paenibacillus kribbensis AM49 ASR47579.1    
 B2K_29550   Paenibacillus mucilaginosus K02 AFH64798.1
AFH64798.2
AFK65316.1
   
 KNP414_06185   Paenibacillus mucilaginosus KNP414 AEI44708.1    
 CD191_23545   Paenibacillus odorifer CBA7130 AWV36864.1    
 PODO_24045   Paenibacillus odorifer DSM 15391 AIQ76079.1    
 ABE82_12090   Paenibacillus peoriae HS311 ALA44829.1    
 VK72_12035   Paenibacillus polymyxa ATCC 15970 APQ62118.1    
 LK13_24205   Paenibacillus polymyxa CF05 AIY11473.1    
 PPE_02302   Paenibacillus polymyxa E681 ADM70135.1
ADM70135.2
E0RLD5  
 C1A50_2435   Paenibacillus polymyxa HY96-2 AUS26605.1    
 AOU00_24560   Paenibacillus polymyxa J AOK93116.1    
 PPM_2277 (Bglc3)   Paenibacillus polymyxa M1 CCC85214.1    
 RE92_00465   Paenibacillus polymyxa Sb3-1 AJE49624.1    
 PPSC2_c2531   Paenibacillus polymyxa SC2 ADO56501.1 E3EJF1  
 PPSQR21_023630   Paenibacillus polymyxa SQR-21 SQR21 AHM66008.1    
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