Glycoside Hydrolase Family 48

Activities in Familyreducing end-acting cellobiohydrolase (EC 3.2.1.176); endo-β-1,4-glucanase (EC 3.2.1.4); chitinase (EC 3.2.1.14)
Mechanism Inverting
ClanGH-M
3D Structure Status( α / α ) 6
Catalytic Nucleophile/BaseNot known
Catalytic Proton DonorGlu
Noteformerly known as cellulase family L. Some cellobiohydrolases of this family have been reported to act from the reducing ends of cellulose (EC 3.2.1.-), while others have been reported to operate from the non-reducing ends to liberate cellobiose or cellotriose or cellotetraose (EC 3.2.1.-). This family also contains endo-processive cellulases (EC 3.2.1.-), whose activity is hard to distinguish from that of cellobiohydrolases.
External resourcesCAZypedia; HOMSTRAD; PRINTS;
Commercial Enzyme Provider(s)NZYTech;
Statistics GenBank accession (1143); Uniprot accession (114); PDB accession (26); 3D entries (7); cryst (0)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 cellobiohydrolase (CelS) (Cel48A) 3.2.1.176 Ruminiclostridium thermocellum F7 AAA23226.1 P0C2S5
P38686
1L1Y[A,B,C,D,E,F]
1L2A[A,B,C,D,E,F]
 β-1,4-glucanase (CelY)   Ruminiclostridium thermocellum F7 CAI06105.1 Q5TIQ4  
 Cel48A (fragment)   Ruminococcus albus AJA33590.1    
 Cel48A (fragment)   Ruminococcus albus AJA33593.1    
 Cel48A (fragment)   Ruminococcus albus AJA33594.1    
 Cel48A (fragment)   Ruminococcus albus AJA33597.1    
 Cel48A (fragment)   Ruminococcus albus AJA33598.1    
 Cel48A (fragment)   Ruminococcus albus AJA33599.1    
 Cel48A (fragment)   Ruminococcus albus AJA33600.1    
 Cel48A (fragment)   Ruminococcus albus AJA33603.1    
 Cel48A (fragment)   Ruminococcus albus AJA33604.1    
 Cel48A (fragment)   Ruminococcus albus AJA33605.1    
 Cel48A (fragment)   Ruminococcus albus AJA33606.1    
 Cel48A (fragment)   Ruminococcus albus AJA33591.1    
 Cel48A (fragment)   Ruminococcus albus AJA33592.1    
 Cel48A (fragment)   Ruminococcus albus AJA33595.1    
 Cel48A (fragment)   Ruminococcus albus AJA33596.1    
 Cel48A (fragment)   Ruminococcus albus AJA33601.1    
 Cel48A (fragment)   Ruminococcus albus AJA33602.1    
 Cel48B (CBP2) (Cel48B)   Ruminococcus albus 20 CAS03459.1 B9W4V5  
 Rumal_2606   Ruminococcus albus 7 = DSM 20455 ADU23081.1 E0L8Y3  
 processive endocellulase (Cel48A)   Ruminococcus albus 8 AAR01217.1 Q6TF32  
 Cel48A (fragment)   Ruminococcus albus B199 AJA33607.1    
 cellulase (Cel48A)   Ruminococcus albus F40 BAJ05814.1 D4QGS6  
 cellobiohydrolase (GH48A;RUM_11720) (Cel48A) 3.2.1.- Ruminococcus champanellensis 18P13 = JCM 17042 CBL17316.1 D4LCH1  
 Sare_3180   Salinispora arenicola CNS-205 ABV98987.1 A8LUZ5  
 Strop_2957   Salinispora tropica CNB-440 ABP55395.1 A4X938  
 SAM23877_6250   Streptomyces ambofaciens ATCC 23877 AKZ59295.1    
 SAM40697_5607   Streptomyces ambofaciens DSM 40697 ANB09563.1    
 BV401_17865   Streptomyces autolyticus CGMCC0516 AQA12037.1    
 SAV1855 (GuxA3)   Streptomyces avermitilis MA-4680 = NBRC 14893 BAC69566.1
NP_823031.1
   
 SBI_06901 (Guxa3)   Streptomyces bingchenggensis BCW-1 ADI10021.1 D7C1F6  
 SCO6546 (SC5C7.31c)   Streptomyces coelicolor A3(2) CAA20643.1
NP_630627.1
O86728  
 B446_30095   Streptomyces collinus Tu 365 AGS72823.1    
 TU94_27795   Streptomyces cyaneogriseus subsp. noncyanogenus NMWT 1 AJP04698.1    
 BN159_1887 (CbhB)   Streptomyces davawensis JCM 4913 CCK26266.1    
 SGLAU_27580 (CbhB)   Streptomyces glaucescens GLA.O AIS01454.1    
 SHJG_7498   Streptomyces hygroscopicus subsp. jinggangensis 5008 AEY92765.1    
 SHJGH_7258   Streptomyces hygroscopicus subsp. jinggangensis TL01 AGF66920.1    
 SHL15_6375   Streptomyces hygroscopicus subsp. limoneus KCTC 1717 ALO97411.1    
 SHXM_04452   Streptomyces hygroscopicus XM201 AQW50989.1    
 SIRAN6228   Streptomyces iranensis CDR09622.1    
 SLA_0105   Streptomyces laurentii ATCC 31255 BAU81060.1    
 Sle_12350   Streptomyces leeuwenhoekii C34 (= DSM 42122 = NRRL B-24963) CQR60697.1    
 SLINC_6966   Streptomyces lincolnensis NRRL 2936 ANS69190.1    
 SLIV_05695 (CbhB)   Streptomyces lividans TK24 AIJ12154.1    
 SNOD_27130   Streptomyces nodosus ATCC 14899 AJE43291.1    
 B1H29_06330   Streptomyces pactum ACT12 AQS66594.1    
 Sfla_6038   Streptomyces pratensis ATCC 33331 ADW07424.1    
 SPRI_0883   Streptomyces pristinaespiralis HCCB 10218 ALC19189.1    
 M271_31015   Streptomyces rapamycinicus NRRL 5491 AGP57635.1    
 TUE45_07139 (Cbhb_2)   Streptomyces reticuli CUW32390.1    
 A4G23_01861 (Cbhb_1)   Streptomyces rubrolavendulae MJM4426 AOT59035.1    
 SCAB_17011   Streptomyces scabiei 87.22 CBG68833.1 C9ZEQ0  
 SCAB_90091   Streptomyces scabiei 87.22 CBG75943.1 C9Z9L6  
 CGL27_18770   Streptomyces sp. 11-1-2 ASQ94834.1    
 SAMN05428941_6616   Streptomyces sp. 2114.2 SDT79108.1    
 SAMN05444521_1741   Streptomyces sp. 3124.6 SHH75354.1    
 ASR50_29360   Streptomyces sp. 4F ALV53118.1    
 NI25_05670   Streptomyces sp. CCM_MD2014 AIV33079.1    
 AS200_10475   Streptomyces sp. CdTB01 ALV32416.1    
 AA958_10445   Streptomyces sp. CNQ-509 AKH86669.1    
 AA958_06315   Streptomyces sp. CNQ-509 AKH81883.1    
 F750_0528   Streptomyces sp. PAMC 26508 AGJ53039.1    
 QR97_13995   Streptomyces sp. PBH53 AKN70776.1    
 A4E84_33655   Streptomyces sp. S10(2016) AMW14006.1    
 CAG99_06940   Streptomyces sp. SCSIO 03032 ARQ68626.1    
 CAG99_06955   Streptomyces sp. SCSIO 03032 ARQ68629.1    
 SACTE_0236   Streptomyces sp. SirexAA-E AEN08183.1    
 SVEN_6599   Streptomyces venezuelae ATCC 10712 CCA59885.1    
 BN2537_3227   Streptomyces venezuelae ATCC 15439 CUM37131.1    
 AQF52_6685   Streptomyces venezuelae ATCC 15439 ALO12278.1    
 SVTN_32845   Streptomyces vietnamensis GIM4.0001 AJF68426.1    
 SXIM_39620   Streptomyces xiamenensis 318 AKG45346.1    
 Sros_0936   Streptosporangium roseum DSM 43021 ACZ83940.1 D2B809  
 TJEJU_3614   Tenacibaculum jejuense KCTC 22618 SNR17257.1    
 β-1,4-exocellulase (E6;CelF;TfCel48A;Tfu_1959) (Cel48A) 3.2.1.176 Thermobifida fusca YX AAD39947.1
AAZ55992.1
ACH05304.1
Q47NH7
Q9XCD4
4JJJ[A]
 Tbis_2138   Thermobispora bispora DSM 43833 ADG88849.1 D6Y2K0  
 glycoside hydrolase family 48 protein, partial (Gh48) (fragment)   uncultured actinobacterium ART41344.1    
 glycoside hydrolase family 48 protein, partial (Gh48) (fragment)   uncultured actinobacterium ART41352.1    
 glycoside hydrolase family 48 protein, partial (Gh48) (fragment)   uncultured actinobacterium ART41359.1    
 glycoside hydrolase family 48 protein, partial (Gh48) (fragment)   uncultured actinobacterium ART41335.1    
 glycoside hydrolase family 48 protein, partial (Gh48) (fragment)   uncultured actinobacterium ART41361.1    
 glycoside hydrolase family 48 protein, partial (Gh48) (fragment)   uncultured actinobacterium ART41338.1    
 glycoside hydrolase family 48 protein, partial (Gh48) (fragment)   uncultured actinobacterium ART41347.1    
 glycoside hydrolase family 48 protein, partial (Gh48) (fragment)   uncultured actinobacterium ART41358.1    
 glycoside hydrolase family 48 protein, partial (Gh48) (fragment)   uncultured actinobacterium ART41351.1    
 glycoside hydrolase family 48 protein, partial (Gh48) (fragment)   uncultured actinobacterium ART41350.1    
 glycoside hydrolase family 48 protein, partial (Gh48) (fragment)   uncultured actinobacterium ART41337.1    
 glycoside hydrolase family 48 protein, partial (Gh48) (fragment)   uncultured actinobacterium ART41355.1    
 glycoside hydrolase family 48 protein, partial (Gh48) (fragment)   uncultured actinobacterium ART41334.1    
 glycoside hydrolase family 48 protein, partial (Gh48) (fragment)   uncultured actinobacterium ART41343.1    
 glycoside hydrolase family 48 protein, partial (Gh48) (fragment)   uncultured actinobacterium ART41346.1    
 glycoside hydrolase family 48 protein, partial (Gh48) (fragment)   uncultured actinobacterium ART41333.1    
 glycoside hydrolase family 48 protein, partial (Gh48) (fragment)   uncultured actinobacterium ART41357.1    
 glycoside hydrolase family 48 protein, partial (Gh48) (fragment)   uncultured actinobacterium ART41340.1    
 glycoside hydrolase family 48 protein, partial (Gh48) (fragment)   uncultured actinobacterium ART41342.1    
 glycoside hydrolase family 48 protein, partial (Gh48) (fragment)   uncultured actinobacterium ART41336.1    
 glycoside hydrolase family 48 protein, partial (Gh48) (fragment)   uncultured actinobacterium ART41349.1    
 glycoside hydrolase family 48 protein, partial (Gh48) (fragment)   uncultured actinobacterium ART41363.1    
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