Glycoside Hydrolase Family 48

Activities in Familyreducing end-acting cellobiohydrolase (EC 3.2.1.176); endo-β-1,4-glucanase (EC 3.2.1.4); chitinase (EC 3.2.1.14)
Mechanism Inverting
ClanGH-M
3D Structure Status( α / α ) 6
Catalytic Nucleophile/BaseNot known
Catalytic Proton DonorGlu
Noteformerly known as cellulase family L. Some cellobiohydrolases of this family have been reported to act from the reducing ends of cellulose (EC 3.2.1.-), while others have been reported to operate from the non-reducing ends to liberate cellobiose or cellotriose or cellotetraose (EC 3.2.1.-). This family also contains endo-processive cellulases (EC 3.2.1.-), whose activity is hard to distinguish from that of cellobiohydrolases.
External resourcesCAZypedia; HOMSTRAD; PRINTS;
Commercial Enzyme Provider(s)NZYTech;
Statistics GenBank accession (1149); Uniprot accession (114); PDB accession (26); 3D entries (7); cryst (0)
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 BPUM_1559 (CelB)   Bacillus pumilus SAFR-032 ABV62241.1 A8FDC4
5BV9[A] β-D-Glcp-(1-4)-β-D-Glcp
1.93
5CVY[A] L-2,3,4-deoxy-Xylp
β-D-Glcp-(1-4)-β-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
2.00
 cellulase (CelA;CbCelA;Athe_1867;Cbes1867;Cbes_1867;CbCBH48A) (Cel9A+Cbh48A) 3.2.1.176
3.2.1.4
Caldicellulosiruptor bescii DSM 6725 ACM60955.1
CAB06786.1
B9MKU7
P96311
4EL8[A] 2.45
4L0G[A] β-D-Glcp-(1-4)-β-D-Glcp
2.00
4L0H[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-α-D-Glcp
2.00
4L6X[A] 1.70
4TXT[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
2.00
 processive endo-cellulase F (CelF;Ccel_0729) (Cel48F) 3.2.1.176 [Clostridium] cellulolyticum H10 ACL75108.1
AAA73866.1
AAB41452.1
P37698
1F9D[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
2.30
1F9O[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp1SH
2.50
1FAE[A] β-D-Glcp-(1-4)-β-D-Glcp
2.00
1FBO[A] β-D-Glcp-(1-1)-<non_carb>
2.30
1FBW[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
2.00
1FCE[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp4S-(1-4)-β-D-Glcp-(1-1)-methyl
2.00
1G9G[A] 1.90
1G9J[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
1.90
2QNO[A] β-D-Glcp4S-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp4S-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp4S-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp4S-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp4S
2.00
 exoglucanase S (ExgS;P70) 3.2.1.176 Clostridium cellulovorans ATCC 35296 AAC38571.3
AAC38571.2
O65986
4KIH[A] 2.05
4KKF[A] β-D-Glcp-(1-4)-α-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp
1.70
4KKK[A] β-D-Glcp-(1-4)-β-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
2.88
4XWL[A] 2.05
4XWM[A] β-D-Glcp-(1-4)-α-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp
1.70
4XWN[A] β-D-Glcp-(1-4)-β-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
2.88
 cellulase (HCH_02465) 3.2.1.- Hahella chejuensis KCTC 2396 ABC29272.1 Q2SJA2
4FUS[A] β-D-Glcp-(1-4)-β-D-Glcp
1.75
 cellobiohydrolase (CelS) (Cel48A) 3.2.1.176 Ruminiclostridium thermocellum F7 AAA23226.1 P0C2S5
P38686
1L1Y[A,B,C,D,E,F] β-D-Glcp-(1-4)-D-1-deoxy-Glcp
2.40
1L2A[A,B,C,D,E,F] β-D-Glcp-(1-4)-D-1-deoxy-Glcp
β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
2.50
 β-1,4-exocellulase (E6;CelF;TfCel48A;Tfu_1959) (Cel48A) 3.2.1.176 Thermobifida fusca YX AAD39947.1
AAZ55992.1
ACH05304.1
Q47NH7
Q9XCD4
4JJJ[A] β-D-Glcp-(1-4)-β-D-Glcp
β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
1.60
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