| Known Activities | reducing end-acting cellobiohydrolase (EC 3.2.1.176); endo-β-1,4-glucanase (EC 3.2.1.4); chitinase (EC 3.2.1.14) |
|---|---|
| Mechanism | Inverting |
| Clan | GH-M |
| 3D Structure Status | ( α / α ) 6 |
| Catalytic Nucleophile/Base | Not known |
| Catalytic Proton Donor | Glu |
| Note | formerly known as cellulase family L. Some cellobiohydrolases of this family have been reported to act from the reducing ends of cellulose (EC 3.2.1.-), while others have been reported to operate from the non-reducing ends to liberate cellobiose or cellotriose or cellotetraose (EC 3.2.1.-). This family also contains endo-processive cellulases (EC 3.2.1.-), whose activity is hard to distinguish from that of cellobiohydrolases. |
| External resources | CAZypedia; HOMSTRAD; InterPro; PFAM; PRINTS; |
| Commercial Enzyme Provider(s) | NZYTech; |
| Statistics | GenBank accession (175); Uniprot accession (113); PDB accession (11); 3D entries (2); cryst (0) |
| Bacteria | ||||||
| Protein Name | EC# | Organism | GenBank | Uniprot | PDB/3D | |
| processive endo-cellulase F (CelF;Ccel_0729) (Cel48F) | 3.2.1.176 | Clostridium cellulolyticum H10 ATCC 35319 | AAA73866.1 AAB41452.1 ACL75108.1 |
P37698 | 1F9D[A] 1F9O[A] 1FAE[A] 1FBO[A] 1FBW[A] 1FCE[A] 1G9G[A] 1G9J[A] 2QNO[A] |
|
| cellobiohydrolase (CelS) (Cel48A) | 3.2.1.176 | Clostridium thermocellum F7 | AAA23226.1 | P0C2S5 P38686 |
1L1Y[A,B,C,D,E,F] 1L2A[A,B,C,D,E,F] |
|