Glycoside Hydrolase Family 48

Activities in FamilyChitinase (EC 3.2.1.14);
Reducing end-acting cellobiohydrolase (EC 3.2.1.176);
Endo-β-1,4-glucanase (EC 3.2.1.4);
Cellobiohydrolase (EC 3.2.1.91);
Mechanism Inverting e
ClanGH-M
3D Structure Status( α / α ) 6 barrel
Catalytic Nucleophile/BaseNot known
Catalytic Proton DonorGlu
Noteformerly known as cellulase family L. Some cellobiohydrolases of this family have been reported to act from the reducing ends of cellulose (EC 3.2.1.-), while others have been reported to operate from the non-reducing ends to liberate cellobiose or cellotriose or cellotetraose (EC 3.2.1.-). This family also contains endo-processive cellulases (EC 3.2.1.-), whose activity is hard to distinguish from that of cellobiohydrolases.
External resourcesCAZypedia; HOMSTRAD; PRINTS;
Commercial Enzyme Provider(s)NZYTech;
Statistics GenBank accession (1839); Uniprot accession (24); PDB accession (30); 3D entries (11); cryst (0)
| 1 | ... | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | ... | 17 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 Q7C01_12690   Streptomyces sp. FXY-T5 WMD05207.1    
 KQY30_33065   Streptomyces sp. GMY02 QXE38351.1    
 C1703_33235 (Cbhb1)   Streptomyces sp. Go-475 AXE89902.1    
 C1703_35900 (Cbhb2)   Streptomyces sp. Go-475 AXE90429.1    
 KBP30_08250   Streptomyces sp. Go40/10 Go 40/10 UFR01167.1    
 LUX31_06660   Streptomyces sp. GQFP UIX29743.1    
 LUV23_18285   Streptomyces sp. HNM0561 UHH18089.1    
 MQE23_08265   Streptomyces sp. HP-A2021 UOB09045.1    
 N8I87_33665   Streptomyces sp. HUAS 15-9 UXY31018.1    
 O1G22_07935   Streptomyces sp. HUAS 2-6 WBO62751.1    
 PGH47_35170   Streptomyces sp. HUAS 31 WCE00639.1    
 Q3Y68_05930   Streptomyces sp. HUAS CX7 WKX17585.1    
 DRB96_23025   Streptomyces sp. ICC1 AWZ14656.1    
 DRB89_22835   Streptomyces sp. ICC4 AWZ06986.1    
 RLT58_31245   Streptomyces sp. ITFR-16 WNI27111.1    
 RLT57_26875   Streptomyces sp. ITFR-21 WNI18793.1    
 G7Z13_29185   Streptomyces sp. JB150 QIJ65644.1    
 KJK32_37380   Streptomyces sp. JCM17656 QWA24990.1    
 NOO62_35490   Streptomyces sp. Je 1-369 WAL99314.1    
 HUV60_003590   Streptomyces sp. KMM 9044 WAX76877.1    
 R9806_05785   Streptomyces sp. KN37 WPO70171.1    
 D1J63_05615   Streptomyces sp. KPB2 AZM74485.1    
 F3K22_35830   Streptomyces sp. LBUM 1475 QTU65677.1    
 F3K21_00565   Streptomyces sp. LBUM 1480 QTU51588.1    
 F3K21_35760   Streptomyces sp. LBUM 1480 QTU57490.1    
 F3K20_35715   Streptomyces sp. LBUM 1482 QTU49450.1    
 RKE30_26040   Streptomyces sp. Li-HN-5-11 WNM33604.1    
 RKE30_27130   Streptomyces sp. Li-HN-5-11 WNM33781.1    
 RKE32_24545   Streptomyces sp. Li-HN-5-13 WNW40459.1    
 MUK60_09550   Streptomyces sp. LRE541 UPZ28035.1    
 CFP59_05777 (CbhB)   Streptomyces sp. M56 AUA13611.1    
 M6G08_20175   Streptomyces sp. M92 WCN04237.1    
 K4G22_20020   Streptomyces sp. MA3_2.13 UED86194.1    
 P8A18_02825   Streptomyces sp. Mut1 WLQ38003.1    
 R2B38_35040   Streptomyces sp. N50 WOX13730.1    
 R2B38_00455   Streptomyces sp. N50 WOX07420.1    
 HUT14_29115   Streptomyces sp. NA02536 QKW03642.1    
 HUT15_05395   Streptomyces sp. NA03103 QKW59992.1    
 QFW82_28985   Streptomyces sp. NA07423 WHX20786.1    
 JIW86_02460   Streptomyces sp. NBC00162 UUU37848.1    
 OG428_00785   Streptomyces sp. NBC_01422 WUY01439.1    
 OG290_03750   Streptomyces sp. NBC_01423 WUX94482.1    
 OG627_31995   Streptomyces sp. NBC_01429 WUX71116.1    
 OG522_34340   Streptomyces sp. NBC_01431 WUX63773.1    
 HZZ00_20825   Streptomyces sp. NEAU-sy36 QLJ03181.1    
 C6376_33435   Streptomyces sp. P3 AVV45537.1    
 QTO28_01965   Streptomyces sp. P9-2B-1 WJY29795.1    
 F750_0528   Streptomyces sp. PAMC 26508 AGJ53039.1    
 QR97_13995   Streptomyces sp. PBH53 AKN70776.1    
 V2W30_32940   Streptomyces sp. Q6 WWQ67671.1    
 GPZ77_31475   Streptomyces sp. QHH-9511 QGZ52264.1    
 HYQ63_16240   Streptomyces sp. Rer75 QLH21965.1    
 M4D82_29535   Streptomyces sp. RerS4 UQX04183.1    
 HEP84_41200   Streptomyces sp. RLB1-33 QIY74571.1    
 FNV59_42660   Streptomyces sp. RLB1-8 QDO63925.1    
 FNV58_43675   Streptomyces sp. RLB1-9 QDO01947.1    
 FNV62_41780   Streptomyces sp. RLB3-17 QDO43762.1    
 FNV60_40410   Streptomyces sp. RLB3-5 QDO53680.1    
 FNV61_43415   Streptomyces sp. RLB3-6 QDN91454.1    
 FNV63_42285   Streptomyces sp. S1A1-3 QDO33805.1    
 FNV64_43795   Streptomyces sp. S1A1-7 QDN81556.1    
 FNV65_42260   Streptomyces sp. S1A1-8 QDO23679.1    
 HEP87_42745   Streptomyces sp. S1D4-11 QIZ02071.1    
 FNV66_41930   Streptomyces sp. S1D4-14 QDN71225.1    
 FNV67_43080   Streptomyces sp. S1D4-20 QDN61171.1    
 FNV68_44500   Streptomyces sp. S1D4-23 QDO12279.1    
 N6H00_15045   Streptomyces sp. S465 WAP56177.1    
 D7Y56_02080   Streptomyces sp. S501 QBR04821.1    
 SBE_005229   Streptomyces sp. SBE_14.2 WBO81386.1    
 PS467_16035   Streptomyces sp. SCA4-21 WNE96731.1    
 CAG99_06940   Streptomyces sp. SCSIO 03032 ARQ68626.1    
 CAG99_06955   Streptomyces sp. SCSIO 03032 ARQ68629.1    
 VM636_03580   Streptomyces sp. SCSIO 75703 WVW66633.1    
 C1N79_30295   Streptomyces sp. SGAir0924 QCR50545.1    
 SACTE_0236   Streptomyces sp. SirexAA-E AEN08183.1    
 B9S64_00350   Streptomyces sp. SM18 AWL42562.1    
 HBB06_28290   Streptomyces sp. SNU607 WKV81776.1    
 U5072_09890   Streptomyces sp. SS162 WVS77901.1    
 E5N77_30625   Streptomyces sp. SS52 QCB25684.1    
 U5640_06045   Streptomyces sp. SS7 WYV85262.1    
 A7X85_37640   Streptomyces sp. ST1015 QZZ31198.1    
 GEV49_06485   Streptomyces sp. SYP-A7193 QFX80604.1    
 Itm6   Streptomyces sp. SYP-A7193 QGY73438.1    
 PBV52_40790   Streptomyces sp. T12 WDF42695.1    
 PBV52_05735   Streptomyces sp. T12 WDF36306.1    
 WBG99_04070   Streptomyces sp. TG1A-60 WXC19764.1    
 GLX30_04440   Streptomyces sp. Tu 2975 QIP83440.1    
 KE639_06177 (CbhB)   Streptomyces sp. V17-9 QUW94913.1    
 PYR72_11885   Streptomyces sp. VNUA24 WEH14375.1    
 DLM49_04760   Streptomyces sp. WAC 01438 AZM58968.1    
 DMA15_31900   Streptomyces sp. WAC 01529 AZM56618.1    
 DMB38_06490   Streptomyces sp. WAC 06738 AZM45523.1    
 DMB38_10535   Streptomyces sp. WAC 06738 AZM50693.1    
 IPZ77_07745   Streptomyces sp. XC 2026 QQN77360.1    
 SSPO_063060   Streptomyces sporoclivatus NBRC 100767 BBJ43588.1    
 LDH80_06770   Streptomyces tanashiensis Kala UZX20431.1    
 F3L20_14060   Streptomyces tendae 139 QER86879.1    
 AY578_27635   Streptomyces thermocarboxydus K155 UVT12697.1    
 DEJ45_04235   Streptomyces venezuelae ATCC 10595 QES11696.1    
 SVEN_6599   Streptomyces venezuelae ATCC 10712 CCA59885.1
QES02638.1
   
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