Glycoside Hydrolase Family 48

Activities in FamilyChitinase (EC 3.2.1.14);
Reducing end-acting cellobiohydrolase (EC 3.2.1.176);
Endo-β-1,4-glucanase (EC 3.2.1.4);
Cellobiohydrolase (EC 3.2.1.91);
Mechanism Inverting e
ClanGH-M
3D Structure Status( α / α ) 6 barrel
Catalytic Nucleophile/BaseNot known
Catalytic Proton DonorGlu
Noteformerly known as cellulase family L. Some cellobiohydrolases of this family have been reported to act from the reducing ends of cellulose (EC 3.2.1.-), while others have been reported to operate from the non-reducing ends to liberate cellobiose or cellotriose or cellotetraose (EC 3.2.1.-). This family also contains endo-processive cellulases (EC 3.2.1.-), whose activity is hard to distinguish from that of cellobiohydrolases.
External resourcesCAZypedia; HOMSTRAD; PRINTS;
Commercial Enzyme Provider(s)NZYTech;
Statistics GenBank accession (1820); Uniprot accession (24); PDB accession (30); 3D entries (11); cryst (0)
| 1 | ... | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | ... | 16 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 KJK29_05195   Streptomyces koelreuteriae MG62 QWB22018.1    
 P8A22_34260   Streptomyces laculatispora Mut2 WLQ45533.1    
 SLA_0105   Streptomyces laurentii ATCC 31255 BAU81060.1    
 J3S85_17830   Streptomyces lavenduligriseus Tu901 WDM13231.1    
 Sle_12350   Streptomyces leeuwenhoekii C34 (= DSM 42122 = NRRL B-24963) CQR60697.1    
 JEQ17_10185   Streptomyces liliifuscus ZYC-3 QQM39800.1    
 GJU35_37270   Streptomyces lincolnensis B48 QMV10772.1    
 SLCG_6954   Streptomyces lincolnensis LC-G AXG58109.1    
 SLINC_6966   Streptomyces lincolnensis NRRL 2936 ANS69190.1    
 SLITK23_64210   Streptomyces lividans TK23 BDE43176.1    
 SLIV_05695 (CbhB)   Streptomyces lividans TK24 AIJ12154.1    
 SMALA_2844   Streptomyces malaysiensis DSM 4137 ATL83078.1
QDL72733.1
   
 R8789_29745   Streptomyces malaysiensis NA3722 WPB93056.1    
 LC193_21525   Streptomyces marincola SCSIO 64649 UCM90302.1    
 SMIR_03295   Streptomyces mirabilis P16B-1 QUW78288.1    
 POD33_25990   Streptomyces moderatus DT446 WCH95403.1    
 GO605_16715   Streptomyces murinus CR-43 UWW92298.1    
 ME763_00835   Streptomyces murinus JS029 WDO04315.1    
 CP967_32720   Streptomyces nitrosporeus ATCC 12769 QEU76106.1    
 CP978_27415   Streptomyces nodosus ATCC 14899 QEV41786.1    
 SNOD_27130   Streptomyces nodosus ATCC 14899 AJE43291.1    
 B1H29_06330   Streptomyces pactum ACT12 AQS66594.1    
 DVK44_00895   Streptomyces paludis GSSD-12 AXG76469.1    
 OGH68_33140   Streptomyces peucetius NA0869 UYQ65824.1    
 OHB35_10605   Streptomyces phaeochromogenes NBC 01752 WSD13655.1    
 OG931_10340   Streptomyces phaeochromogenes NBC_00186 WRZ28116.1    
 F9278_39780   Streptomyces phaeolivaceus GY16 QFR01308.1    
 NFX46_11435   Streptomyces phaeoluteigriseus Qhu-M197 USQ84354.1    
 CP972_29985   Streptomyces prasinus ATCC 13879 QEV09279.1    
 V3O62_28960   Streptomyces prasinus WY33 WVU01582.1    
 Sfla_6038   Streptomyces pratensis ATCC 33331 ADW07424.1    
 SPRI_0883   Streptomyces pristinaespiralis HCCB 10218 ALC19189.1    
 H3L99_32545   Streptomyces pristinaespiralis PR11 QMU17732.1    
 A4E84_33655   Streptomyces qaidamensis S10(2016) AMW14006.1    
 LIV37_31495   Streptomyces rapamycinicus NRRL 5491 UTP33455.1    
 M271_31015   Streptomyces rapamycinicus NRRL 5491 AGP57635.1    
 LJB45_26365   Streptomyces rapamycinicus SRMK07 UTO65497.1    
 TUE45_07139 (Cbhb_2)   Streptomyces reticuli CUW32390.1    
 TR631_30920   Streptomyces rochei D21E05 WQC15998.1    
 P7W03_29705   Streptomyces rochei JK1 WMC89526.1    
 RBH85_05830   Streptomyces rochei S32 WMI56351.1    
 IAG44_07175   Streptomyces roseirectus CRXT-G-22 QNP69241.1    
 A4G23_01861 (Cbhb_1)   Streptomyces rubrolavendulae MJM4426 AOT59035.1    
 SCAB_17011   Streptomyces scabiei 87.22 CBG68833.1    
 SCAB_90091   Streptomyces scabiei 87.22 CBG75943.1    
 HUT11_31955   Streptomyces seoulensis A01 QKW30225.1    
 I1A49_18135   Streptomyces solisilvae HNM0141 QPI56588.1    
 CGL27_18770   Streptomyces sp. 11-1-2 ASQ94834.1    
 P8T65_08025   Streptomyces sp. 11x1 WNZ07532.1    
 SAMN05428941_6616   Streptomyces sp. 2114.2 SDT79108.1    
 SAMN05444521_1741   Streptomyces sp. 3214.6 SHH75354.1    
 ASR50_29360   Streptomyces sp. 4F ALV53118.1    
 K5X85_29615   Streptomyces sp. A144 UAX56885.1    
 IOD14_22300   Streptomyces sp. A2-16 QUC59270.1    
 IOD14_13270   Streptomyces sp. A2-16 QUC57691.1    
 N7U49_38125   Streptomyces sp. AD2-2 UXX96170.1    
 AS97_33550   Streptomyces sp. AgN23 AJZ85736.2    
 P8A21_04640   Streptomyces sp. Alt1 WLQ53230.1    
 P8A19_36460   Streptomyces sp. Alt2 WLQ61925.1    
 P8A20_35180   Streptomyces sp. Alt3 WLQ68488.1    
 PZB77_27135   Streptomyces sp. AM 2-1-1 WEH43882.1    
 PZB77_30030   Streptomyces sp. AM 2-1-1 WEH43395.1    
 RPQ02_12485   Streptomyces sp. AM8-1-1 WNO69761.1    
 CVT30_06290   Streptomyces sp. AMCC400023 UJV39526.1    
 RI578_05985   Streptomyces sp. BB1-1-1 WND33864.1    
 JIX56_06775   Streptomyces sp. CA-210063 UUU29610.1    
 C4J65_29745   Streptomyces sp. CB09001 AXL92009.1    
 NI25_05670   Streptomyces sp. CCM_MD2014 AIV33079.1    
 AS200_10475   Streptomyces sp. CdTB01 ALV32416.1    
 RJD14_27950   Streptomyces sp. CGMCC 4.1456 WNF66186.1    
 VJ737_06815   Streptomyces sp. CGMCC 4.1772 WRT97408.1    
 Q2K21_13180   Streptomyces sp. CGMCC 4.7035 WNB98951.1    
 SJH97_28775   Streptomyces sp. CL7 WPP33084.1    
 CXR04_28285   Streptomyces sp. CMB-StM0423 AUH43552.1    
 CXR04_24195   Streptomyces sp. CMB-StM0423 AUH45101.1    
 AA958_10445   Streptomyces sp. CNQ-509 AKH86669.1    
 AA958_06315   Streptomyces sp. CNQ-509 AKH81883.1    
 NNW99_05225   Streptomyces sp. CRCS-T-1 UUA12573.1    
 NNW98_05225   Streptomyces sp. CRLD-Y-1 UUA04950.1    
 JIX55_41055   Streptomyces sp. DSM 40750 UUU26107.1    
 HB370_32435   Streptomyces sp. DSM 40868 QIS74117.1    
 EASAB2608_06033 (GuxA)   Streptomyces sp. EAS-AB2608 NBRC 114648 BCM70699.1    
 SAM9427_31300   Streptomyces sp. ETH9427 AXI89739.1    
 A6P39_010170   Streptomyces sp. FXJ1.172 WEO94339.1    
 Q7C01_12690   Streptomyces sp. FXY-T5 WMD05207.1    
 KQY30_33065   Streptomyces sp. GMY02 QXE38351.1    
 C1703_33235 (Cbhb1)   Streptomyces sp. Go-475 AXE89902.1    
 C1703_35900 (Cbhb2)   Streptomyces sp. Go-475 AXE90429.1    
 KBP30_08250   Streptomyces sp. Go40/10 Go 40/10 UFR01167.1    
 LUX31_06660   Streptomyces sp. GQFP UIX29743.1    
 LUV23_18285   Streptomyces sp. HNM0561 UHH18089.1    
 MQE23_08265   Streptomyces sp. HP-A2021 UOB09045.1    
 N8I87_33665   Streptomyces sp. HUAS 15-9 UXY31018.1    
 O1G22_07935   Streptomyces sp. HUAS 2-6 WBO62751.1    
 PGH47_35170   Streptomyces sp. HUAS 31 WCE00639.1    
 PYS65_05120   Streptomyces sp. HUAS 5 WGD39569.1    
 Q3Y68_05930   Streptomyces sp. HUAS CX7 WKX17585.1    
 DRB96_23025   Streptomyces sp. ICC1 AWZ14656.1    
 DRB89_22835   Streptomyces sp. ICC4 AWZ06986.1    
 RLT58_31245   Streptomyces sp. ITFR-16 WNI27111.1    
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