Glycoside Hydrolase Family 48

Activities in Familyreducing end-acting cellobiohydrolase (EC 3.2.1.176); endo-β-1,4-glucanase (EC 3.2.1.4); chitinase (EC 3.2.1.14)
Mechanism Inverting
ClanGH-M
3D Structure Status( α / α ) 6
Catalytic Nucleophile/BaseNot known
Catalytic Proton DonorGlu
Noteformerly known as cellulase family L. Some cellobiohydrolases of this family have been reported to act from the reducing ends of cellulose (EC 3.2.1.-), while others have been reported to operate from the non-reducing ends to liberate cellobiose or cellotriose or cellotetraose (EC 3.2.1.-). This family also contains endo-processive cellulases (EC 3.2.1.-), whose activity is hard to distinguish from that of cellobiohydrolases.
External resourcesCAZypedia; HOMSTRAD; PRINTS;
Commercial Enzyme Provider(s)NZYTech;
Statistics GenBank accession (1146); Uniprot accession (114); PDB accession (26); 3D entries (7); cryst (0)
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 cellulase (CelA;CbCelA;Athe_1867;Cbes1867;Cbes_1867;CbCBH48A) (Cel9A+Cbh48A) 3.2.1.176
3.2.1.4
Caldicellulosiruptor bescii DSM 6725 ACM60955.1
CAB06786.1
B9MKU7
P96311
4EL8[A]
4L0G[A]
4L0H[A]
4L6X[A]
4TXT[A]
 xylanase / cellobiohydrolase (CelF;Athe_1857;Cbes_1857) (Xyn10C/Cel48B) 3.2.1.- Caldicellulosiruptor bescii DSM 6725 ACM60945.1 B9MKT7  
 cellulase (CelA) 3.2.1.4 Caldicellulosiruptor saccharolyticus AAA91086.1
AAA72860.1
P22534  
 cellobiohydrolase B (Cbp120;CbhB;CenE) (Cel48A) 3.2.1.176 Cellulomonas fimi ATCC 484 AAB00822.1
AAA50257.1
ACH05303.1
AEE47513.1
P50899  
 cellobiohydrolase (CGSCsYakCAS_04820) (Cel48A) 3.2.1.- Cellulosilyticum ruminicola CGMCC 1.5065 ACZ98592.1 D2KFJ0  
 processive endo-cellulase F (CelF;Ccel_0729) (Cel48F) 3.2.1.176 [Clostridium] cellulolyticum H10 ACL75108.1
AAA73866.1
AAB41452.1
P37698 1F9D[A]
1F9O[A]
1FAE[A]
1FBO[A]
1FBW[A]
1FCE[A]
1G9G[A]
1G9J[A]
2QNO[A]
 exoglucanase S (ExgS;P70) 3.2.1.176 Clostridium cellulovorans ATCC 35296 AAC38571.3
AAC38571.2
O65986 4KIH[A]
4KKF[A]
4KKK[A]
4XWL[A]
4XWM[A]
4XWN[A]
 exoglucanase (Clocl_4007) 3.2.1.- [Clostridium] clariflavum DSM 19732 AEV70443.1    
 cellodextrinohydrolase (avicelase II) (CelY) 3.2.1.176 Clostridium stercorarium CAA93280.1 P50900  
 cellulase (HCH_02465) 3.2.1.- Hahella chejuensis KCTC 2396 ABC29272.1 Q2SJA2 4FUS[A]
 cellobiohydrolase (cphy3368;CpCel48;Cphy_3368) (Cel48) 3.2.1.176 Lachnoclostridium phytofermentans ISDg ABX43721.1 A9KT91  
 cellobiohydrolase (Cel48) 3.2.1.176 Myxobacter sp. AL-1 ABD64772.1 Q19VP0  
 cellobiohydrolase (Cel48C) 3.2.1.176 Paenibacillus barcinonensis BP-23 CAD32945.1 Q8KKF7  
 endo-β-1,4-glucanase Y (CelY;Cthe_0071) (Cel48B=Cel48Y) 3.2.1.4 Ruminiclostridium thermocellum ATCC 27405 ABN51312.1 A3DBI3  
 exo-cellulase S (CelS;Cthe_2089) (Cel48A=Cel48S) 3.2.1.176 Ruminiclostridium thermocellum ATCC 27405 ABN53296.1 A3DH67  
 cellobiohydrolase (CelS) (Cel48A) 3.2.1.176 Ruminiclostridium thermocellum F7 AAA23226.1 P0C2S5
P38686
1L1Y[A,B,C,D,E,F]
1L2A[A,B,C,D,E,F]
 cellobiohydrolase (GH48A;RUM_11720) (Cel48A) 3.2.1.- Ruminococcus champanellensis 18P13 = JCM 17042 CBL17316.1 D4LCH1  
 β-1,4-exocellulase (E6;CelF;TfCel48A;Tfu_1959) (Cel48A) 3.2.1.176 Thermobifida fusca YX AAD39947.1
AAZ55992.1
ACH05304.1
Q47NH7
Q9XCD4
4JJJ[A]
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 chitinase (active phase-associated protein I) (Apap1) 3.2.1.14 Gastrophysa atrocyanea BAE94320.1 Q1JUL1  
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