Activities in Family	Chitinase (EC 3.2.1.14); Reducing end-acting cellobiohydrolase (EC 3.2.1.176); Endo-β-1,4-glucanase (EC 3.2.1.4); Cellobiohydrolase (EC 3.2.1.91);
Mechanism	Inverting e
Clan	GH-M
3D Structure Status	( α / α ) 6 barrel
Catalytic Nucleophile/Base	Not known
Catalytic Proton Donor	Glu
Note	formerly known as cellulase family L. Some cellobiohydrolases of this family have been reported to act from the reducing ends of cellulose (EC 3.2.1.-), while others have been reported to operate from the non-reducing ends to liberate cellobiose or cellotriose or cellotetraose (EC 3.2.1.-). This family also contains endo-processive cellulases (EC 3.2.1.-), whose activity is hard to distinguish from that of cellobiohydrolases.
External resources	CAZypedia; HOMSTRAD; PRINTS;
Commercial Enzyme Provider(s)	NZYTech;
Statistics	GenBank accession (1841); Uniprot accession (24); PDB accession (30); 3D entries (11); cryst (0)

Bacteria
Protein Name	EC#	Reference	Organism	GenBank	Uniprot	PDB/3D
endo-β-1,4-glucanase (Clocl_4007)	3.2.1.4	pubmed	Acetivibrio clariflavus DSM 19732	AEV70443.1	G8M3C3
endo-β-1,4-glucanase Y (CelY;Cthe_0071) (Cel48B=Cel48Y)	3.2.1.4	pubmed	Acetivibrio thermocellus ATCC 27405	ABN51312.1	A3DBI3
exo-cellulase S (CelS;Cthe_2089) (Cel48A=Cel48S)	3.2.1.176	pubmed	Acetivibrio thermocellus ATCC 27405	ABN53296.1	A3DH67
exo-β-1,4-glucanase (Clo1313_2747; CelS)	3.2.1.176	pubmed	Acetivibrio thermocellus DSM 1313	ADU75731.1 ACT46162.1	C7ED31	5YJ6[A]
cellobiohydrolase (CelS) (Cel48A)	3.2.1.176	pubmed	Acetivibrio thermocellus F7	AAA23226.1	A3DH67 P0C2S5 P38686	1L1Y[A,B,C,D,E,F] 1L2A[A,B,C,D,E,F]
cellulase (BLi01881 / BL01231;CelB)	3.2.1.4	pubmed	Bacillus licheniformis DSM 13 = ATCC 14580	AAU40776.1 AAU23416.1 ACP61485.1	Q65JI8	7KW6[A]
cellulase (CelA;CbCelA;Athe_1867;Cbes1867;Cbes_1867;CbCBH48A) (Cel9A+Cbh48A)	3.2.1.176	pubmed	Caldicellulosiruptor bescii DSM 6725	ACM60955.1 CAB06786.1	B9MKU7 P96311	4EL8[A] 4L0G[A] 4L0H[A] 4L6X[A] 4TXT[A]
cellobiohydrolase B (Cbp120;CbhB;CenE) (Cel48A)	3.2.1.176	pubmed	Cellulomonas fimi ATCC 484	AAB00822.1 AAA50257.1 ACH05303.1 AEE47513.1	P50899
cellobiohydrolase (CGSCsYakCAS_04820) (Cel48A)	3.2.1.91	pubmed	Cellulosilyticum ruminicola CGMCC 1.5065	ACZ98592.1	D2KFJ0
exoglucanase S (ExgS;P70)	3.2.1.176	pubmed	Clostridium cellulovorans ATCC 35296	AAC38571.3 AAC38571.2	O65986	4KIH[A] 4KKF[A] 4KKK[A] 4XWL[A] 4XWM[A] 4XWN[A]
cellulase (HCH_02465)	3.2.1.4	pubmed	Hahella chejuensis KCTC 2396	ABC29272.1	Q2SJA2	4FUS[A]
cellobiohydrolase (cphy3368;CpCel48;Cphy_3368) (Cel48)	3.2.1.176	pubmed	Lachnoclostridium phytofermentans ISDg	ABX43721.1	A9KT91
cellobiohydrolase (Cel48)	3.2.1.176	pubmed	Myxobacter sp. AL-1	ABD64772.1	Q19VP0
cellobiohydrolase (Cel48C)	3.2.1.176	pubmed	Paenibacillus barcinonensis BP-23	CAD32945.1	Q8KKF7
processive endo-cellulase F (CelF;Ccel_0729) (Cel48F)	3.2.1.176	pubmed	Ruminiclostridium cellulolyticum H10	ACL75108.1 AAA73866.1 AAB41452.1	P37698	1F9D[A] 1F9O[A] 1FAE[A] 1FBO[A] 1FBW[A] 1FCE[A] 1G9G[A] 1G9J[A] 2QNO[A]
β-1,4-exocellulase (E6;CelF;TfCel48A;Tfu_1959) (Cel48A)	3.2.1.176	pubmed	Thermobifida fusca YX	AAD39947.1 AAZ55992.1 ACH05304.1	Q47NH7 Q9XCD4	4JJJ[A]
cellodextrinohydrolase (avicelase II) (CelY)	3.2.1.176	pubmed	Thermoclostridium stercorarium	CAA93280.1	P50900
Eukaryota
Protein Name	EC#	Reference	Organism	GenBank	Uniprot	PDB/3D
chitinase (active phase-associated protein I) (Apap1)	3.2.1.14	pubmed	Gastrophysa atrocyanea	BAE94320.1	Q1JUL1
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