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Glycoside Hydrolase Family 48

Activities in FamilyChitinase (EC 3.2.1.14);
Reducing end-acting cellobiohydrolase (EC 3.2.1.176);
Endo-β-1,4-glucanase (EC 3.2.1.4);
Cellobiohydrolase (EC 3.2.1.91);
Mechanism Inverting e
ClanGH-M
3D Structure Status( α / α ) 6 barrel
Catalytic Nucleophile/BaseNot known
Catalytic Proton DonorGlu
Noteformerly known as cellulase family L. Some cellobiohydrolases of this family have been reported to act from the reducing ends of cellulose (EC 3.2.1.-), while others have been reported to operate from the non-reducing ends to liberate cellobiose or cellotriose or cellotetraose (EC 3.2.1.-). This family also contains endo-processive cellulases (EC 3.2.1.-), whose activity is hard to distinguish from that of cellobiohydrolases.
External resourcesCAZypedia; HOMSTRAD; PRINTS;
Commercial Enzyme Provider(s)NZYTech;
Statistics GenBank accession (1820); Uniprot accession (24); PDB accession (30); 3D entries (11); cryst (0)
Summary
Download GH48 (1755) Taxonomic display Structure (11) Characterized (18)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | ... | 16 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 ORF (fragment)   Acetivibrio clariflavus DSM 19732 ACV92098.1    
 Clocl_3038   Acetivibrio clariflavus DSM 19732 AEV69573.1    
  endo-β-1,4-glucanase (Clocl_4007) 3.2.1.4 Acetivibrio clariflavus DSM 19732 AEV70443.1 G8M3C3  
 HVS_14800 (Cels2)   Acetivibrio saccincola GGR1 AUG58811.1    
 ORF (fragment)   Acetivibrio straminisolvens CSK1 ACT46161.1    
 ORF (fragment)   Acetivibrio straminisolvens CSK1 ACV92097.1    
 AD2_02783   Acetivibrio thermocellus AD2 ALX09761.1    
 AD2_02188   Acetivibrio thermocellus AD2 ALX09176.1    
 endo-β-1,4-glucanase Y (CelY;Cthe_0071) (Cel48B=Cel48Y) 3.2.1.4 Acetivibrio thermocellus ATCC 27405 ABN51312.1 A3DBI3  
 exo-cellulase S (CelS;Cthe_2089) (Cel48A=Cel48S) 3.2.1.176 Acetivibrio thermocellus ATCC 27405 ABN53296.1 A3DH67  
 exo-β-1,4-glucanase (Clo1313_2747; CelS) 3.2.1.176 Acetivibrio thermocellus DSM 1313 ADU75731.1
ACT46162.1		 C7ED31 5YJ6[A]
 Clo1313_2161 (CelY)   Acetivibrio thermocellus DSM 1313 ADU75201.1
ACT46163.1		    
 LQRI_2794   Acetivibrio thermocellus DSM 2360 LQRI ANV77535.1    
 LQRI_2187   Acetivibrio thermocellus DSM 2360 LQRI ANV76928.1    
 cellobiohydrolase (CelS) (Cel48A) 3.2.1.176 Acetivibrio thermocellus F7 AAA23226.1 A3DH67
P0C2S5
P38686		 1L1Y[A,B,C,D,E,F]
1L2A[A,B,C,D,E,F]
 β-1,4-glucanase (CelY)   Acetivibrio thermocellus F7 CAI06105.1    
 N1236_14105   Acetivibrio thermocellus M3 UWV46662.1    
 N1236_11310   Acetivibrio thermocellus M3 UWV46153.1    
 exoglucanase (Gux1;Acel_0617)   Acidothermus cellulolyticus 11B ABK52390.1
ACH05295.1
ACH05298.1
ACH05302.1		    
 NYE86_05985   Actinacidiphila bryophytorum DS3 UWE08316.1    
 UA74_21060   Actinoalloteichus fjordicus ADI127-7 APU16237.1    
 AHOG_18580 (CbhB)   Actinoalloteichus hoggarensis DSM 45943 ASO21341.1    
 TL08_17650   Actinoalloteichus hymeniacidonis HPA177(T) (=DSM 45092(T)) AOS64330.1    
 C1701_17920   Actinoalloteichus sp. AHMU CJ021 AUS79894.1    
 UA75_21540   Actinoalloteichus sp. GBA129-24 APU22297.1    
 EF847_01335   Actinobacteria bacterium YIM 96077 AYY11565.1    
 Actkin_03808 (Cbhb_1)   Actinokineospora sp. UTMC 2448 UVS80058.1    
 LUW74_10075   Actinomadura madurae MRC005 URN03639.1    
 LUW76_00315   Actinomadura madurae MRC008 URM92911.1    
 BKM31_47500   [Actinomadura] parvosata subsp. kistnae ATCC 55076 AQZ68100.1    
 HUT06_19465   Actinomadura sp. NAK00032 QKW35945.1    
 SAMN04489716_3663   Actinoplanes derwentensis DSM 43941 SDT40959.1    
 GCM10020092_058960 (fragment)   Actinoplanes digitatis JCM 3060 BFE72595.1    
 GCM10020092_058950 (fragment)   Actinoplanes digitatis JCM 3060 BFE72594.1    
 AFR_18925   Actinoplanes friuliensis DSM 7358 AGZ42059.1    
 Aiant_71720   Actinoplanes ianthinogenes NBRC 13996 BCJ46515.1    
 AMIS_51220   Actinoplanes missouriensis 431 BAL90342.1    
 ACTOB_002574   Actinoplanes oblitus NRRL 3884 WIM98950.1    
 Q0Z83_057360   Actinoplanes sichuanensis 03-723 BEL07545.1    
 L3i22_028160   Actinoplanes sp. L3-i22 BCY07728.1    
 L083_4349 (CelY)   Actinoplanes sp. N902-109 AGL17859.1    
 Asp14428_03510   Actinoplanes sp. NBRC 14428 BCJ48876.1    
 ACTI_76160   Actinoplanes sp. OR16 BBH70931.1    
 ACWT_2456   Actinoplanes sp. SE50 ATO81871.1    
 ACPL_2583 (CelY)   Actinoplanes sp. SE50/110 AEV83478.1
SLL99279.1		    
 TPMA0078_27450   Actinoplanes sp. TPMA0078 BFD51341.1    
 KCV87_09170   Actinosynnema mirum ATCC 31280 QUF06203.1    
 Amir_2167   Actinosynnema mirum DSM 43827 ACU36112.1    
 APASM_2200   Actinosynnema pretiosum subsp. pretiosum ATCC 31280 AXX29565.1    
 CNX65_11065   Actinosynnema pretiosum X47 ATE53767.1    
 LQZ07_17760   Agarivorans sp. B2Z047 UQN41597.1    
 LQZ07_17765   Agarivorans sp. B2Z047 UQN41598.1    
 OAG1_12420   Agarivorans sp. OAG1 BEU02442.1    
 OAG1_12430   Agarivorans sp. OAG1 BEU02443.1    
 A4R43_06420   Amycolatopsis albispora WP1 AXB42213.1    
 ISP_005396   Amycolatopsis mediterranei ISP5501 UZF72083.1    
 B737_5131   Amycolatopsis mediterranei RB AGT85795.1    
 RAM_26455   Amycolatopsis mediterranei S699 AEK43768.1
AFO78667.1		    
 AMED_5193   Amycolatopsis mediterranei U32 ADJ46956.1    
 QRX60_40175   Amycolatopsis mongoliensis 4-36 WIY00219.1    
 SD37_21970   Amycolatopsis orientalis B-37 ANN18052.1    
 MUY14_11610   Amycolatopsis pretoriensis FBCC-B4732 UOX91229.1    
 NQK81_39375   Amycolatopsis roodepoortensis ZEL-1 UUV30763.1    
 QP939_37930   Amycolatopsis sp. 2-2 WIV54586.1    
 QRY02_16200   Amycolatopsis sp. DG1A-15b WIX91891.1    
 MJQ72_12455   Amycolatopsis sp. EV170708-02-1 UMP05583.1    
 HUT10_49410   Amycolatopsis sp. Hca4 QKV80912.1    
 MUY22_38835   Amycolatopsis sp. WQ 127309 UOZ04744.1    
 YIM_19775 (CbhB)   Amycolatopsis sp. YIM 10 QFU89134.1    
 acsn021_13350   Anaerocolumna cellulosilytica SN021 BCJ93766.1    
 R2R35_03690   Anaerocolumna sp. AGMB13020 WOO39145.1    
 bsdtb5_18070   Anaeromicropila herbilytica TB5 BCN30512.1    
 D1815_10495   Aquimarina sp. AD1 AXT56161.1    
 D1816_19575   Aquimarina sp. AD10 AXT63719.1    
 D1818_21415   Aquimarina sp. BL5 AXT54148.1    
 F0U60_32780   Archangium minus Cbm 6 WNG48370.1    
 F0U61_32880   Archangium violaceum Cbvi 34 WNG37942.1    
 JQX13_46660   Archangium violaceum SDU34 QRK07425.1    
 JRI60_30180   Archangium violaceum SDU8 QRN93446.1    
 RE735_11540   Bacillus aerius NEB1378 WMT27767.1    
 BAE_15690   Bacillus aerophilus 232 QAR54174.1    
 L2D31_08100   Bacillus aerophilus KJ82 UJM29222.1    
 HRJ37_08500   Bacillus altitudinis 11-1-1 QKJ40205.1    
 I4W80_08130   Bacillus altitudinis 1817 QSI46051.1    
 NIZ93_08125   Bacillus altitudinis 1943r2a1 USY52784.1    
 Q6357_17015   Bacillus altitudinis 28M1-1 WLF30073.1    
 NMH04_08355   Bacillus altitudinis 47 UTX10447.1    
 JNE42_08525   Bacillus altitudinis 63-2-2 QRF85095.1    
 J9319_08425   Bacillus altitudinis 6ww6 QTV14110.1    
 LOS13_13000   Bacillus altitudinis ABT_AC37 WBL50449.1    
 NM966_08135   Bacillus altitudinis B12 UTV34400.1    
 RI02_08015   Bacillus altitudinis BA06 QKL21611.1    
 NP445_08230   Bacillus altitudinis BDGP7 UUH75811.1    
 INQ56_08200   Bacillus altitudinis BIM B-263 QOV51207.1    
 QNH40_08265   Bacillus altitudinis CES-OCA-19 WHX73193.1    
 EVS87_008165   Bacillus altitudinis CHB19 QEO62176.1    
 LIS79_08500   Bacillus altitudinis CMF5 USK25993.1    
 D0438_04050   Bacillus altitudinis Cr2-1 QDZ94127.1    
 QRD87_08805   Bacillus altitudinis D9_B_49 WJE31963.1    
 P5623_06640   Bacillus altitudinis DSM 103869 WEZ72461.1    
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