Glycoside Hydrolase Family 48

Activities in Familyreducing end-acting cellobiohydrolase (EC 3.2.1.176); endo-β-1,4-glucanase (EC 3.2.1.4); chitinase (EC 3.2.1.14)
Mechanism Inverting
ClanGH-M
3D Structure Status( α / α ) 6
Catalytic Nucleophile/BaseNot known
Catalytic Proton DonorGlu
Noteformerly known as cellulase family L. Some cellobiohydrolases of this family have been reported to act from the reducing ends of cellulose (EC 3.2.1.-), while others have been reported to operate from the non-reducing ends to liberate cellobiose or cellotriose or cellotetraose (EC 3.2.1.-). This family also contains endo-processive cellulases (EC 3.2.1.-), whose activity is hard to distinguish from that of cellobiohydrolases.
External resourcesCAZypedia; HOMSTRAD; PRINTS;
Commercial Enzyme Provider(s)NZYTech;
Statistics GenBank accession (1146); Uniprot accession (114); PDB accession (26); 3D entries (7); cryst (0)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 exoglucanase (Gux1;Acel_0617)   Acidothermus cellulolyticus 11B ABK52390.1
ACH05295.1
ACH05298.1
ACH05302.1
A0LSI0  
 AHOG_18580 (CbhB)   Actinoalloteichus hoggarensis DSM 45943 ASO21341.1    
 TL08_17650   Actinoalloteichus hymeniacidonis HPA177(T) (=DSM 45092(T)) AOS64330.1    
 UA74_21060   Actinoalloteichus sp. ADI127-7 APU16237.1    
 UA75_21540   Actinoalloteichus sp. GBA129-24 APU22297.1    
 SAMN04489716_3663   Actinoplanes derwentensis DSM 43941 SDT40959.1    
 AFR_18925   Actinoplanes friuliensis DSM 7358 AGZ42059.1    
 AMIS_51220   Actinoplanes missouriensis 431 BAL90342.1    
 L083_4349 (CelY)   Actinoplanes sp. N902-109 AGL17859.1    
 ACPL_2583 (CelY)   Actinoplanes sp. SE50/110 AEV83478.1
SLL99279.1
   
 Amir_2167   Actinosynnema mirum DSM 43827 ACU36112.1 C6WI69  
 CNX65_11065   Actinosynnema pretiosum X47 ATE53767.1    
 B737_5131   Amycolatopsis mediterranei RB AGT85795.1    
 RAM_26455   Amycolatopsis mediterranei S699 AEK43768.1
AFO78667.1
   
 AMED_5193   Amycolatopsis mediterranei U32 ADJ46956.1 D8I1M5  
 SD37_21970   Amycolatopsis orientalis B-37 ANN18052.1    
 CFN77_08480   Bacillus altitudinis SGAir0031 ATH72231.1    
 BGLY_1875 (CelB)   Bacillus glycinifermentans SCA85698.1    
 CPQ91_09255   Bacillus licheniformis ATCC 9789 ATI76020.1    
 BL1202_02033   Bacillus licheniformis BL1202 AOP14981.1    
 BLi01881 / BL01231 (CelB)   Bacillus licheniformis DSM 13 = ATCC 14580 AAU40776.1
AAU23416.1
ACP61485.1
Q65JI8  
 CelC (fragment)   Bacillus licheniformis F11 CAJ70719.1 Q1EM80  
 CelC (fragment)   Bacillus licheniformis F5 CAJ70716.1 Q1EM83  
 AB684_08865   Bacillus licheniformis HRBL-15TDI7 AMR10286.1    
 CelC (fragment)   Bacillus licheniformis MD1 CAH10343.1 Q5K2M1  
 Cel48B (Cel48B)   Bacillus licheniformis MSB03 ACY72381.1 D1L8C6  
 endoglucanase (CelA)   Bacillus licheniformis NCIM 5556 ASE05927.1    
 B37_01400 (CelY)   Bacillus licheniformis SCCB 37 ARC73452.1    
 B14_02582 (CelY)   Bacillus licheniformis SCDB 14 ARC65580.1    
 B34_00220 (CelY)   Bacillus licheniformis SCDB 34 ARC67663.1    
 BaDB11_04387 (CelY)   Bacillus licheniformis SCK B11 ARC62950.1    
 S100141_01267   Bacillus licheniformis SRCM100141 ARW42589.1    
 glycoside hydrolase (Gh48A)   Bacillus licheniformis SVD1 BAL45538.1    
 ORF   Bacillus licheniformis UTM102 AKI30025.1    
 ORF   Bacillus licheniformis UTM104 AKI30030.1    
 ORF   Bacillus licheniformis UTM118 AKI30042.1    
 MUY_001892 (CelB)   Bacillus licheniformis WX-02 AKQ73024.1    
 BaLi_c19150 (CelA)   Bacillus paralicheniformis ATCC 9945a AGN36283.1    
 SC10_B2orf02855   Bacillus paralicheniformis BL-09 AJO18128.1    
 BLMD_09330   Bacillus paralicheniformis MDJK30 ARA85655.1    
 VP59_07435   Bacillus pumilus C4 ANT56638.1    
 BS467_15795   Bacillus pumilus GLB197 APP17116.1    
 ID12_13285   Bacillus pumilus GR-8 AKU32337.1    
 ASM07_07610   Bacillus pumilus ku-bf1 AMB89775.1    
 BW16_08660   Bacillus pumilus MTCC B6033 AHL71450.1    
 SAMEA4076707_01654 (CelB)   Bacillus pumilus NCTC10337 SNV02438.1    
 AKO65_15425   Bacillus pumilus NJ-M2 ALM29340.1    
 AKO66_11750   Bacillus pumilus NJ-V ANY97358.1    
 AMR71_11745   Bacillus pumilus NJ-V2 ALM45877.1    
 BEN31_08000   Bacillus pumilus PDSLzg-1 AOC56745.1    
 BPUM_1559 (CelB)   Bacillus pumilus SAFR-032 ABV62241.1 A8FDC4 5BV9[A]
5CVY[A]
 UP15_08380   Bacillus pumilus SH-B11 AMM88975.1    
 UP12_08095   Bacillus pumilus SH-B9 AMM97308.1    
 CelB   Bacillus pumilus SYBC hb4 AHI58975.1    
 BTUAT1_15750 (CelB)   Bacillus pumilus TUAT1 BAT48709.1    
 VT48_08310   Bacillus pumilus W3 AKC66021.1    
 BRL64_08210   Bacillus safensis BRM1 ARD56163.1    
 BSL056_08090   Bacillus safensis KCTC 12796BP APJ10918.1    
 BSA145_16060   Bacillus safensis U14-5 APT47249.1    
 BSA171_11315   Bacillus safensis U17-1 APT54135.1    
 BSA41_06400   Bacillus safensis U41 APT49589.1    
 S101395_03071   Bacillus sonorensis SRCM101395 ASB89578.1    
 CJO35_09280   Bacillus sp. 1s-1 ASV15339.1    
 BSZ43_09210   Bacillus sp. H15-1 APJ26959.1    
 QR42_07955   Bacillus sp. WP8 AIZ60201.1    
 BK049_00280   Bacillus xiamenensis VV3 AOZ87245.1    
 cellulase (CelA;CbCelA;Athe_1867;Cbes1867;Cbes_1867;CbCBH48A) (Cel9A+Cbh48A) 3.2.1.176
3.2.1.4
Caldicellulosiruptor bescii DSM 6725 ACM60955.1
CAB06786.1
B9MKU7
P96311
4EL8[A]
4L0G[A]
4L0H[A]
4L6X[A]
4TXT[A]
 Athe_1860   Caldicellulosiruptor bescii DSM 6725 ACM60948.1 B9MKU0  
 xylanase / cellobiohydrolase (CelF;Athe_1857;Cbes_1857) (Xyn10C/Cel48B) 3.2.1.- Caldicellulosiruptor bescii DSM 6725 ACM60945.1 B9MKT7  
 Calkro_0850   Caldicellulosiruptor kronotskyensis 2002 ADQ45727.1 E4SDB8  
 Calkro_0853   Caldicellulosiruptor kronotskyensis 2002 ADQ45729.1 E4SDC0  
 Calkro_0861   Caldicellulosiruptor kronotskyensis 2002 ADQ45737.1 E4SDC8  
 Calla_0015   Caldicellulosiruptor lactoaceticus 6A AEM72711.1    
 COB47_1664   Caldicellulosiruptor obsidiansis OB47 ADL42945.1 D9TFH5  
 COB47_1673   Caldicellulosiruptor obsidiansis OB47 ADL42953.1 D9TFI3  
 cellulase (CelA) 3.2.1.4 Caldicellulosiruptor saccharolyticus AAA91086.1
AAA72860.1
P22534  
 Csac_1076 (CelA)   Caldicellulosiruptor saccharolyticus DSM 8903 ABP66690.1 A4XIF5  
 glycosyl hydrolase 4, partial (fragment)   Caldicellulosiruptor sp. Tok7B.1 AAK06397.1    
 glycosyl hydrolase 6, partial (fragment)   Caldicellulosiruptor sp. Tok7B.1 AAK06392.1    
 glycosyl hydrolase 3, partial (fragment)   Caldicellulosiruptor sp. Tok7B.1 AAK06395.1    
 glycosyl hydrolase 6, partial (fragment)   Caldicellulosiruptor sp. Tok7B.1 AAK06393.1    
 Caci_3604   Catenulispora acidiphila DSM 44928 ACU72508.1 C7QAK9  
 cellobiohydrolase B (Cbp120;CbhB;CenE) (Cel48A) 3.2.1.176 Cellulomonas fimi ATCC 484 AAB00822.1
AAA50257.1
ACH05303.1
AEE47513.1
P50899  
 Cfla_3105   Cellulomonas flavigena DSM 20109 ADG75987.1 D5ULA5  
 Celgi_2669   Cellulomonas gilvus ATCC 13127 AEI13168.1    
 CBP52_10455   Cellulomonas sp. PSBB021 ASR55440.1    
 cellobiohydrolase (CGSCsYakCAS_04820) (Cel48A) 3.2.1.- Cellulosilyticum ruminicola CGMCC 1.5065 ACZ98592.1 D2KFJ0  
 CBR64_15945   Cellulosimicrobium cellulans PSBB019 ARU52715.1    
 CAC0911 (CelF) (Cel48A)   Clostridium acetobutylicum ATCC 824 AAK78887.1
NP_347547.1
Q97KK7  
 SMB_G0928 (CelccF)   Clostridium acetobutylicum DSM 1731 AEI33201.1    
 CEA_G0923   Clostridium acetobutylicum EA 2018 ADZ19962.1    
 CM240_3325 (CelA3) (probable fragment)   Clostridium bornimense M2/40 CDM70442.1    
 processive endo-cellulase F (CelF;Ccel_0729) (Cel48F) 3.2.1.176 [Clostridium] cellulolyticum H10 ACL75108.1
AAA73866.1
AAB41452.1
P37698 1F9D[A]
1F9O[A]
1FAE[A]
1FBO[A]
1FBW[A]
1FCE[A]
1G9G[A]
1G9J[A]
2QNO[A]
 CCDG5_1680 (CelY)   [Clostridium] cellulosi CDZ24788.1    
 Clocel_2823 (ExgS)   Clostridium cellulovorans 743B ADL52519.1 D9SS72  
 exoglucanase S (ExgS;P70) 3.2.1.176 Clostridium cellulovorans ATCC 35296 AAC38571.3
AAC38571.2
O65986 4KIH[A]
4KKF[A]
4KKK[A]
4XWL[A]
4XWM[A]
4XWN[A]
 ORF (fragment)   Clostridium clariflavum DSM 19732 ACV92098.1 C9EEU2  
 Clocl_3038   [Clostridium] clariflavum DSM 19732 AEV69573.1    
 exoglucanase (Clocl_4007) 3.2.1.- [Clostridium] clariflavum DSM 19732 AEV70443.1    
 CelD (Cel48A)   Clostridium josui BAA32430.1
BAI52924.1
O82831  
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