Glycoside Hydrolase Family 48

Activities in Familyreducing end-acting cellobiohydrolase (EC 3.2.1.176); endo-β-1,4-glucanase (EC 3.2.1.4); chitinase (EC 3.2.1.14)
Mechanism Inverting
ClanGH-M
3D Structure Status( α / α ) 6
Catalytic Nucleophile/BaseNot known
Catalytic Proton DonorGlu
Noteformerly known as cellulase family L. Some cellobiohydrolases of this family have been reported to act from the reducing ends of cellulose (EC 3.2.1.-), while others have been reported to operate from the non-reducing ends to liberate cellobiose or cellotriose or cellotetraose (EC 3.2.1.-). This family also contains endo-processive cellulases (EC 3.2.1.-), whose activity is hard to distinguish from that of cellobiohydrolases.
External resourcesCAZypedia; HOMSTRAD; PRINTS;
Commercial Enzyme Provider(s)NZYTech;
Statistics GenBank accession (1250); Uniprot accession (114); PDB accession (29); 3D entries (10); cryst (0)
All (1091) Bacteria (1049) Eukaryota (34) Viruses (2) unclassified (6) Structure (10) Characterized (20)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | ... | 11 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 exoglucanase (Gux1;Acel_0617)   Acidothermus cellulolyticus 11B ABK52390.1
ACH05295.1
ACH05298.1
ACH05302.1
A0LSI0  
 AHOG_18580 (CbhB)   Actinoalloteichus hoggarensis DSM 45943 ASO21341.1    
 TL08_17650   Actinoalloteichus hymeniacidonis HPA177(T) (=DSM 45092(T)) AOS64330.1    
 UA74_21060   Actinoalloteichus sp. ADI127-7 APU16237.1    
 C1701_17920   Actinoalloteichus sp. AHMU CJ021 AUS79894.1    
 UA75_21540   Actinoalloteichus sp. GBA129-24 APU22297.1    
 EF847_01335   Actinobacteria bacterium YIM 96077 AYY11565.1    
 SAMN04489716_3663   Actinoplanes derwentensis DSM 43941 SDT40959.1    
 AFR_18925   Actinoplanes friuliensis DSM 7358 AGZ42059.1    
 AMIS_51220   Actinoplanes missouriensis 431 BAL90342.1    
 L083_4349 (CelY)   Actinoplanes sp. N902-109 AGL17859.1    
 ACTI_76160   Actinoplanes sp. OR16 BBH70931.1    
 ACWT_2456   Actinoplanes sp. SE50 ATO81871.1    
 ACPL_2583 (CelY)   Actinoplanes sp. SE50/110 AEV83478.1
SLL99279.1
   
 Amir_2167   Actinosynnema mirum DSM 43827 ACU36112.1 C6WI69  
 APASM_2200   Actinosynnema pretiosum subsp. pretiosum ATCC 31280 AXX29565.1    
 CNX65_11065   Actinosynnema pretiosum X47 ATE53767.1    
 A4R43_06420   Amycolatopsis albispora WP1 AXB42213.1    
 B737_5131   Amycolatopsis mediterranei RB AGT85795.1    
 RAM_26455   Amycolatopsis mediterranei S699 AEK43768.1
AFO78667.1
   
 AMED_5193   Amycolatopsis mediterranei U32 ADJ46956.1 D8I1M5  
 SD37_21970   Amycolatopsis orientalis B-37 ANN18052.1    
 D1815_10495   Aquimarina sp. AD1 AXT56161.1    
 D1816_19575   Aquimarina sp. AD10 AXT63719.1    
 D1818_21415   Aquimarina sp. BL5 AXT54148.1    
 BAE_15690   Bacillus aerophilus 232 QAR54174.1    
 BPGQ101_08700   Bacillus altitudinis GQYP101 QCU18937.1    
 CFN77_08480   Bacillus altitudinis SGAir0031 ATH72231.1    
 BGLY_1875 (CelB)   Bacillus glycinifermentans SCA85698.1    
 EQZ20_09640   Bacillus glycinifermentans SRCM103574 QAT65155.1    
 BLDA23_10210   Bacillus licheniformis 0DA23-1 AXF88641.1    
 BL14DL4_04367   Bacillus licheniformis 14ADL4 AVI49504.1    
 CPQ91_09255   Bacillus licheniformis ATCC 9789 ATI76020.1    
 BL1202_02033   Bacillus licheniformis BL1202 AOP14981.1    
 CD200_09495   Bacillus licheniformis CBA7132 AWV40655.1    
 BLi01881 / BL01231 (CelB)   Bacillus licheniformis DSM 13 = ATCC 14580 AAU40776.1
AAU23416.1
ACP61485.1
Q65JI8  
 CelC (fragment)   Bacillus licheniformis F11 CAJ70719.1 Q1EM80  
 CelC (fragment)   Bacillus licheniformis F5 CAJ70716.1 Q1EM83  
 AB684_08865   Bacillus licheniformis HRBL-15TDI7 AMR10286.1    
 C1T27_09535   Bacillus licheniformis MBGJa67 AUZ30576.1    
 EYQ98_10190   Bacillus licheniformis MCC 2514 QBR20042.1    
 CelC (fragment)   Bacillus licheniformis MD1 CAH10343.1 Q5K2M1  
 Cel48B (Cel48B)   Bacillus licheniformis MSB03 ACY72381.1 D1L8C6  
 endoglucanase (CelA)   Bacillus licheniformis NCIM 5556 ASE05927.1    
 NCTC10341_02010 (CelB)   Bacillus licheniformis NCTC10341 VEH78114.1    
 NCTC8721_01957 (CelB)   Bacillus licheniformis NCTC8721 VEB18927.1    
 CXG95_10810   Bacillus licheniformis PB3 AZN79548.1    
 B37_01400 (CelY)   Bacillus licheniformis SCCB 37 ARC73452.1    
 B14_02582 (CelY)   Bacillus licheniformis SCDB 14 ARC65580.1    
 B34_00220 (CelY)   Bacillus licheniformis SCDB 34 ARC67663.1    
 BaDB11_04387 (CelY)   Bacillus licheniformis SCK B11 ARC62950.1    
 S100141_01267   Bacillus licheniformis SRCM100141 ARW42589.1    
 EQY74_09940   Bacillus licheniformis SRCM103529 QAT53196.1    
 ETA57_09960   Bacillus licheniformis SRCM103583 QAW28882.1    
 ETK49_09645   Bacillus licheniformis SRCM103608 QAW37506.1    
 EQJ69_09620   Bacillus licheniformis SRCM103914 QAS16155.1    
 glycoside hydrolase (Gh48A)   Bacillus licheniformis SVD1 BAL45538.1    
 C7M53_09505   Bacillus licheniformis TAB7 AYC51496.1    
 ORF   Bacillus licheniformis UTM102 AKI30025.1    
 ORF   Bacillus licheniformis UTM104 AKI30030.1    
 ORF   Bacillus licheniformis UTM118 AKI30042.1    
 MUY_001892 (CelB)   Bacillus licheniformis WX-02 AKQ73024.1    
 BaLi_c19150 (CelA)   Bacillus paralicheniformis ATCC 9945a AGN36283.1    
 SC10_B2orf02855   Bacillus paralicheniformis BL-09 AJO18128.1    
 D5285_09565   Bacillus paralicheniformis CBMAI 1303 AYQ16313.1    
 BLMD_09330   Bacillus paralicheniformis MDJK30 ARA85655.1    
 C5695_08380   Bacillus pumilus 145 AVM23852.1    
 C5Y82_07935   Bacillus pumilus 150a AVI40949.1    
 VP59_07435   Bacillus pumilus C4 ANT56638.1    
 BS467_15795   Bacillus pumilus GLB197 APP17116.1    
 ID12_13285   Bacillus pumilus GR-8 AKU32337.1    
 ASM07_07610   Bacillus pumilus ku-bf1 AMB89775.1    
 cellobiohydrolase   Bacillus pumilus LAF-A8 AVG70970.1    
 BW16_08660   Bacillus pumilus MTCC B6033 AHL71450.1    
 SAMEA4076707_01654 (CelB)   Bacillus pumilus NCTC10337 SNV02438.1    
 AKO65_15425   Bacillus pumilus NJ-M2 ALM29340.1    
 AKO66_11750   Bacillus pumilus NJ-V ANY97358.1    
 AMR71_11745   Bacillus pumilus NJ-V2 ALM45877.1    
 BEN31_08000   Bacillus pumilus PDSLzg-1 AOC56745.1    
 BPUM_1559 (CelB)   Bacillus pumilus SAFR-032 ABV62241.1 A8FDC4 5BV9[A]
5CVY[A]
 UP15_08380   Bacillus pumilus SH-B11 AMM88975.1    
 UP12_08095   Bacillus pumilus SH-B9 AMM97308.1   5VMA[A]
 CelB   Bacillus pumilus SYBC hb4 AHI58975.1    
 BTUAT1_15750 (CelB)   Bacillus pumilus TUAT1 BAT48709.1    
 VT48_08310   Bacillus pumilus W3 AKC66021.1    
 DKE43_04275   Bacillus pumilus ZB201701 AZV52367.1    
 BRL64_08210   Bacillus safensis BRM1 ARD56163.1    
 RS87_08140   Bacillus safensis FO-36b AWI36697.1    
 BSL056_08090   Bacillus safensis KCTC 12796BP APJ10918.1    
 CS953_10695   Bacillus safensis sami AYJ90159.1    
 BSA145_16060   Bacillus safensis U14-5 APT47249.1    
 BSA171_11315   Bacillus safensis U17-1 APT54135.1    
 BSA41_06400   Bacillus safensis U41 APT49589.1    
 S101395_03071   Bacillus sonorensis SRCM101395 ASB89578.1    
 CJO35_09280   Bacillus sp. 1s-1 ASV15339.1    
 BSZ43_09210   Bacillus sp. H15-1 APJ26959.1    
 QR42_07955   Bacillus sp. WP8 AIZ60201.1    
 BK049_00280   Bacillus xiamenensis VV3 AOZ87245.1    
 cellulase (CelA;CbCelA;Athe_1867;Cbes1867;Cbes_1867;CbCBH48A) (Cel9A+Cbh48A) 3.2.1.176
3.2.1.4
Caldicellulosiruptor bescii DSM 6725 ACM60955.1
CAB06786.1
B9MKU7
P96311
4EL8[A]
4L0G[A]
4L0H[A]
4L6X[A]
4TXT[A]
 Athe_1860   Caldicellulosiruptor bescii DSM 6725 ACM60948.1 B9MKU0  
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