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Glycoside Hydrolase Family 48

Known Activitiesreducing end-acting cellobiohydrolase (EC 3.2.1.176); endo-β-1,4-glucanase (EC 3.2.1.4); chitinase (EC 3.2.1.14)
Mechanism Inverting
ClanGH-M
3D Structure Status( α / α ) 6
Catalytic Nucleophile/BaseNot known
Catalytic Proton DonorGlu
Noteformerly known as cellulase family L. Some cellobiohydrolases of this family have been reported to act from the reducing ends of cellulose (EC 3.2.1.-), while others have been reported to operate from the non-reducing ends to liberate cellobiose or cellotriose or cellotetraose (EC 3.2.1.-). This family also contains endo-processive cellulases (EC 3.2.1.-), whose activity is hard to distinguish from that of cellobiohydrolases.
External resourcesCAZypedia; HOMSTRAD; InterPro; PFAM; PRINTS;
Commercial Enzyme Provider(s)NZYTech;
Statistics GenBank accession (175); Uniprot accession (113); PDB accession (11); 3D entries (2); cryst (0)
Summary
All (152) Bacteria (128) Eukaryota (22) Viruses (1) unclassified (1) Structure (2 ) Characterized (14)
Bacteria
Protein Name EC#OrganismGenBankUniprotPDB/3D
 exoglucanase (Gux1;Acel_0617)   Acidothermus cellulolyticus 11B ATCC 43068 ABK52390.1
ACH05295.1
ACH05298.1
ACH05302.1		 A0LSI0  
 ACPL_2583 (CelY)   Actinoplanes sp. SE50/110 AEV83478.1    
 Amir_2167   Actinosynnema mirum DSM 43827 ACU36112.1 C6WI69  
 RAM_26455   Amycolatopsis mediterranei S699 AEK43768.1    
 AMED_5193   Amycolatopsis mediterranei U32 ADJ46956.1 D8I1M5  
 cellulase (CelA;Athe_1867) 3.2.1.4 Anaerocellum thermophilum DSM 6725 ACM60955.1
CAB06786.1		 B9MKU7
P96311		  
 Athe_1860   Anaerocellum thermophilum DSM 6725 ACM60948.1 B9MKU0  
 Athe_1857   Anaerocellum thermophilum DSM 6725 ACM60945.1 B9MKT7  
 BLi01881 / BL01231 (CelB)   Bacillus licheniformis ATCC 14580 / DSM13 AAU23416.1
AAU40776.1
ACP61485.1		 Q65JI8  
 CelC (fragment)   Bacillus licheniformis F11 CAJ70719.1 Q1EM80  
 CelC (fragment)   Bacillus licheniformis F5 CAJ70716.1 Q1EM83  
 CelC (fragment)   Bacillus licheniformis MD1 CAH10343.1 Q5K2M1  
 Cel48B (Cel48B)   Bacillus licheniformis MSB03 ACY72381.1 D1L8C6  
 glycoside hydrolase (Gh48A)   Bacillus licheniformis SVD1 BAL45538.1    
 BPUM_1559   Bacillus pumilus SAFR-032 ABV62241.1 A8FDC4  
 processive glycoside hydrolase Cel48A (Cel48A)   Bacteroides cellulosolvens ATCC 35603 AAR23324.1 Q6UB36  
 Calkro_0850   Caldicellulosiruptor kronotskyensis 2002 ADQ45727.1 E4SDB8  
 Calkro_0853   Caldicellulosiruptor kronotskyensis 2002 ADQ45729.1 E4SDC0  
 Calkro_0861   Caldicellulosiruptor kronotskyensis 2002 ADQ45737.1 E4SDC8  
 Calla_0015   Caldicellulosiruptor lactoaceticus 6A AEM72711.1    
 COB47_1664   Caldicellulosiruptor obsidiansis OB47 ADL42945.1 D9TFH5  
 COB47_1673   Caldicellulosiruptor obsidiansis OB47 ADL42953.1 D9TFI3  
 cellulase (CelA)   Caldicellulosiruptor saccharolyticus AAA72860.1
AAA91086.1		 P22534.2  
 Csac_1076 (CelA)   Caldicellulosiruptor saccharolyticus DSM 8903 ABP66690.1 A4XIF5  
 Caci_3604   Catenulispora acidiphila DSM 44928 ACU72508.1 C7QAK9  
 cellobiohydrolase B (Cbp120;CbhB;CenE) (Cel48A) 3.2.1.176 Cellulomonas fimi ATCC 484 AAA50257.1
AAB00822.1
ACH05303.1		 P50899  
 Celf_3400   Cellulomonas fimi ATCC 484 AEE47513.1    
 Cfla_3105   Cellulomonas flavigena DSM 20109 ADG75987.1 D5ULA5  
 cellobiohydrolase (CGSCsYakCAS_04820) (Cel48A)   Cellulosilyticum ruminicola CGMCC 1.5065 ACZ98592.1 D2KFJ0  
 Celgi_2669   Cellvibrio gilvus ATCC 13127 AEI13168.1    
 CelF (CAC0911) (Cel48A)   Clostridium acetobutylicum ATCC 824 AAK78887.1
NP_347547.1		 Q97KK7  
 SMB_G0928 (CelccF)   Clostridium acetobutylicum DSM 1731 AEI33201.1    
 CEA_G0923   Clostridium acetobutylicum EA 2018 ADZ19962.1    
 processive endo-cellulase F (CelF;Ccel_0729) (Cel48F) 3.2.1.176 Clostridium cellulolyticum H10 ATCC 35319 AAA73866.1
AAB41452.1
ACL75108.1		 P37698 1F9D[A]
1F9O[A]
1FAE[A]
1FBO[A]
1FBW[A]
1FCE[A]
1G9G[A]
1G9J[A]
2QNO[A]
 exoglucanase S (ExgS;P70) 3.2.1.176 Clostridium cellulovorans AAC38571.2
AAC38571.3		 O65986  
 Clocel_2823   Clostridium cellulovorans 743B ADL52519.1 D9SS72  
 ORF (fragment)   Clostridium clariflavum DSM 19732 ACV92098.1 C9EEU2  
 Clocl_3038   Clostridium clariflavum DSM 19732 AEV69573.1    
 Clocl_4007   Clostridium clariflavum DSM 19732 AEV70443.1    
 CelD (Cel48A)   Clostridium josui BAA32430.1
BAI52924.1		 O82831  
 Clole_3668   Clostridium lentocellum DSM 5427 ADZ85351.1    
 cellobiohydrolase (CpCel48;Cphy_3368) (Cel48) 3.2.1.176 Clostridium phytofermentans ISDg ABX43721.1 A9KT91  
 Clo1100_1819   Clostridium sp. BNL1100 AEY66029.1    
 ORF (fragment)   Clostridium sp. Iso4-1 ADD83056.1 D4N2U7  
 ORF (fragment)   Clostridium sp. Iso4-2a ADD83057.1 D4N2U8  
 ORF (fragment)   Clostridium sp. Iso5-8 ADD83058.1 D4N2U9  
 glycosyl hydrolase family 48 protein (fragment)   Clostridium sp. Iso5-8 ADM52291.1 E0YVL7  
 ORF (fragment)   Clostridium sp. Iso6-17 ADD83059.1 D4N2V0  
 glycosyl hydrolase family 48 protein (fragment)   Clostridium sp. Iso6-17a ADM52292.1 E0YVL8  
 ORF (fragment)   Clostridium sp. Iso6-24 ADD83060.1 D4N2V1  
 glycosyl hydrolase family 48 protein (fragment)   Clostridium sp. Iso6-24 ADM52293.1 E0YVL9  
 ORF (fragment)   Clostridium sp. Iso6-26 ADD83061.1 D4N2V2  
 glycosyl hydrolase family 48 protein (fragment)   Clostridium sp. Iso6-26 ADM52294.1 E0YVM0  
 ORF (fragment)   Clostridium sp. Iso6-29 ADD83062.1 D4N2V3  
 glycosyl hydrolase family 48 protein (fragment)   Clostridium sp. Iso6-29 ADM52295.1 E0YVM1  
 ORF (fragment)   Clostridium sp. IsoCT1S ADD83065.1 D4N2V6  
 ORF (fragment)   Clostridium sp. IsoCT1Y ADD83063.1 D4N2V4  
 ORF (fragment)   Clostridium sp. IsoCT2S ADD83066.1 D4N2V7  
 ORF (fragment)   Clostridium sp. IsoCT2Y ADD83064.1 D4N2V5  
 cellodextrinohydrolase (avicelase II) (CelY) 3.2.1.176 Clostridium stercorarium CAA93280.1 P50900  
 ORF (fragment)   Clostridium straminisolvens CSK1 ACT46161.1 C7ED30  
 ORF (fragment)   Clostridium straminisolvens CSK1 ACV92097.1 C9EEU1  
 endo-β-1,4-glucanase Y (CelY;Cthe_0071) (Cel48B=Cel48Y) 3.2.1.4 Clostridium thermocellum ATCC 27405 ABN51312.1 A3DBI3  
 exo-cellulase S (CelS;Cthe_2089) (Cel48A=Cel48S) 3.2.1.176 Clostridium thermocellum ATCC 27405 ABN53296.1 A3DH67  
 Clo1313_2747 (CelS)   Clostridium thermocellum DSM 1313 ACT46162.1
ADU75731.1		 C7ED31  
 Clo1313_2161 (CelY)   Clostridium thermocellum DSM 1313 ACT46163.1
ADU75201.1		 C7ED32  
 cellobiohydrolase (CelS) (Cel48A) 3.2.1.176 Clostridium thermocellum F7 AAA23226.1 P0C2S5
P38686		 1L1Y[A,B,C,D,E,F]
1L2A[A,B,C,D,E,F]
 β-1,4-glucanase (CelY)   Clostridium thermocellum F7 CAI06105.1 Q5TIQ4  
 HCH_02465   Hahella chejuensis KCTC 2396 ABC29272.1 Q2SJA2  
 Haur_0295   Herpetosiphon aurantiacus ATCC 23779 ABX02947.1 A9B7H4  
 Jden_1134   Jonesia denitrificans DSM 20603 ACV08790.1 C7R3T3  
 Mahau_1111   Mahella australiensis 50-1 BON AEE96308.1    
 Micau_4167   Micromonospora aurantiaca ATCC 27029 ADL47680.1 D9T3K1  
 ML5_4135   Micromonospora sp. L5 ADU09645.1 D3CKK4  
 cellobiohydrolase (Cel48) 3.2.1.176 Myxobacter sp. AL-1 ABD64772.1 Q19VP0  
 Ndas_2448   Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111 ADH67868.1 D7AWS1  
 cellobiohydrolase (Cel48C) 3.2.1.176 Paenibacillus barcinonensis BP-23 CAD32945.1 Q8KKF7  
 KNP414_06185   Paenibacillus mucilaginosus KNP414 AEI44708.1    
 PPE_02302   Paenibacillus polymyxa E681 ADM70135.1 E0RLD5  
 PPM_2277 (Bglc3)   Paenibacillus polymyxa M1 CCC85214.1    
 PPSC2_c2531   Paenibacillus polymyxa SC2 ADO56501.1 E3EJF1  
 HPL003_22355   Paenibacillus terrae HPL-003 AET61195.1    
 Cel48B (CBP2) (Cel48B)   Ruminococcus albus 20 CAS03459.1 B9W4V5  
 Rumal_2606   Ruminococcus albus 7 ADU23081.1 E0L8Y3  
 cellulase (Cel48A) 3.2.1.4 Ruminococcus albus 8 AAR01217.1 Q6TF32  
 cellulase (Cel48A)   Ruminococcus albus F40 BAJ05814.1 D4QGS6  
 RUM_11720   Ruminococcus sp. 18P13 CBL17316.1 D4LCH1  
 Sare_3180   Salinispora arenicola CNS-205 ABV98987.1 A8LUZ5  
 Strop_2957   Salinispora tropica CNB-440 ABP55395.1 A4X938  
 SAV1855 (GuxA3)   Streptomyces avermitilis MA-4680 BAC69566.1
NP_823031.1		    
 SBI_06901 (Guxa3)   Streptomyces bingchenggensis BCW-1 ADI10021.1 D7C1F6  
 SCO6546 (SC5C7.31c)   Streptomyces coelicolor A3(2) CAA20643.1
NP_630627.1		 O86728  
 Sfla_6038   Streptomyces flavogriseus ATCC 33331 ADW07424.1    
 SHJG_7498   Streptomyces hygroscopicus subsp. jinggangensis 5008 AEY92765.1    
 SCAB_17011   Streptomyces scabiei 87.22 CBG68833.1 C9ZEQ0  
 SCAB_90091   Streptomyces scabiei 87.22 CBG75943.1 C9Z9L6  
 SACTE_0236   Streptomyces sp. SirexAA-E AEN08183.1    
 SVEN_6599   Streptomyces venezuelae ATCC 10712 CCA59885.1    
 Sros_0936   Streptosporangium roseum DSM 43021 ACZ83940.1 D2B809  
 β-1,4-exocellulase (E6;CelF;Tfu_1959) (Cel48A) 3.2.1.176 Thermobifida fusca YX AAD39947.1
AAZ55992.1
ACH05304.1		 Q47NH7
Q9XCD4		  
 Tbis_2138   Thermobispora bispora DSM 43833 ADG88849.1 D6Y2K0  
 CO4-G1 (fragment)   uncultured bacterium ACT46150.1 C7ED19  
 CO4-G3 (fragment)   uncultured bacterium ACT46151.1 C7ED20  
 CO4-G12 (fragment)   uncultured bacterium ACT46152.1 C7ED21  
 CO4-G19 (fragment)   uncultured bacterium ACT46153.1 C7ED22  
 CO4-G20 (fragment)   uncultured bacterium ACT46154.1 C7ED23  
 CO4-G22 (fragment)   uncultured bacterium ACT46155.1 C7ED24  
 CO5-G09 (fragment)   uncultured bacterium ACT46156.1 C7ED25  
 CO5-G10 (fragment)   uncultured bacterium ACT46157.1 C7ED26  
 CO6-G1 (fragment)   uncultured bacterium ACT46158.1 C7ED27  
 CO6-G35 (fragment)   uncultured bacterium ACT46159.1 C7ED28  
 Cel48_C5-01 (fragment)   uncultured bacterium ACV50347.1 C9D772  
 Cel48_C5-12 (fragment)   uncultured bacterium ACV50348.1 C9D773  
 Cel48_C5-13 (fragment)   uncultured bacterium ACV50349.1 C9D774  
 Cel48_C5-11 (fragment)   uncultured bacterium ACV50350.1 C9D775  
 Cel48_C5-02 (fragment)   uncultured bacterium ACV50351.1 C9D776  
 Cel48_C5-15 (fragment)   uncultured bacterium ACV50352.1 C9D777  
 Cel48_C5-16 (fragment)   uncultured bacterium ACV50353.1 C9D778  
 Cel48_5 (fragment)   uncultured bacterium ADD73515.1 D4P3I5  
 Cel48_27 (fragment)   uncultured bacterium ADD73516.1 D4P3I6  
 Cel48_71 (fragment)   uncultured bacterium ADD73517.1 D4P3I7  
 Cel48_82 (fragment)   uncultured bacterium ADD73518.1 D4P3I8  
 Cel48_87 (fragment)   uncultured bacterium ADD73519.1 D4P3I9  
 Cel48_94 (fragment)   uncultured bacterium ADD73520.1 D4P3J0  
 Cel48_99 (fragment)   uncultured bacterium ADD73522.1 D4P3J2  
 Orf5   uncultured bacterium AEM44250.1    
 VAB18032_25085   Verrucosispora maris AB-18-032 AEB46115.1    
 Xcel_1153   Xylanimonas cellulosilytica DSM 15894 ACZ30184.1 D1BZN0  




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