Glycoside Hydrolase Family 48

Activities in FamilyChitinase (EC 3.2.1.14);
Reducing end-acting cellobiohydrolase (EC 3.2.1.176);
Endo-β-1,4-glucanase (EC 3.2.1.4);
Cellobiohydrolase (EC 3.2.1.91);
Mechanism Inverting e
ClanGH-M
3D Structure Status( α / α ) 6 barrel
Catalytic Nucleophile/BaseNot known
Catalytic Proton DonorGlu
Noteformerly known as cellulase family L. Some cellobiohydrolases of this family have been reported to act from the reducing ends of cellulose (EC 3.2.1.-), while others have been reported to operate from the non-reducing ends to liberate cellobiose or cellotriose or cellotetraose (EC 3.2.1.-). This family also contains endo-processive cellulases (EC 3.2.1.-), whose activity is hard to distinguish from that of cellobiohydrolases.
External resourcesCAZypedia; HOMSTRAD; PRINTS;
Commercial Enzyme Provider(s)NZYTech;
Statistics GenBank accession (1903); Uniprot accession (25); PDB accession (30); 3D entries (11); cryst (0)


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