Glycoside Hydrolase Family 3

Activities in Familyβ-glucosidase (EC; xylan 1,4-β-xylosidase (EC; β-glucosylceramidase (EC; β-N-acetylhexosaminidase (EC; α-L-arabinofuranosidase (EC; glucan 1,3-β-glucosidase (EC; glucan 1,4-β-glucosidase (EC; isoprimeverose-producing oligoxyloglucan hydrolase (EC; coniferin β-glucosidase (EC; exo-1,3-1,4-glucanase (EC 3.2.1.-); β-N-acetylglucosaminide phosphorylases (EC 2.4.1.-)
Mechanism Retaining
Catalytic Nucleophile/BaseAsp (experimental);
Catalytic Proton DonorGlu for hydrolases (experimental); histidine for phosphorylases (experimental)
NoteA recent paper by Macdonald et al. (PMID=25533455) has shown that the enzymes that cleave b-hexosaminides are in fact retaining b-glycoside phosphorylases.
External resourcesCAZypedia; HOMSTRAD; PRINTS; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; PROZOMIX ;
Statistics GenBank accession (20620); Uniprot accession (2560); PDB accession (117); 3D entries (40); cryst (4)
All (19731) Archaea (102) Bacteria (18469) Eukaryota (1058) Viruses (1) unclassified (101) Structure (40 - 4 cryst) Characterized (300)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | ... | 185 |
Protein Name EC#OrganismGenBank UniprotPDB/3D
 CHY23_00120 (NagZ)   Actinobacillus pleuropneumoniae KL 16 ASU14937.1    
 NCTC11384_01202 (NagZ)   Actinobacillus pleuropneumoniae NCTC11384 SQF64890.1    
 APPSER1_06075   Actinobacillus pleuropneumoniae serovar 1 str. 4074 AWG95546.1    
 APJL_1130   Actinobacillus pleuropneumoniae serovar 3 str. JL03 ABY69686.1 B0BQ51  
 APL_1111   Actinobacillus pleuropneumoniae serovar 5b str. L20 ABN74203.1 A3N1B7  
 APP7_1168   Actinobacillus pleuropneumoniae serovar 7 str. AP76 ACE61820.1 B3GXZ7  
 MIDG2331_01151 (NagZ)   Actinobacillus pleuropneumoniae serovar 8 CUU52434.1    
 DDU33_06415   Actinobacillus porcitonsillarum 9953L55 AWI51133.1    
 Asuc_0211   Actinobacillus succinogenes 130Z ABR73591.1 A6VKU4  
 ASU1_05970   Actinobacillus suis ATCC 33415 AIJ31457.1    
 ASU2_05900   Actinobacillus suis H91-0380 AFU19318.1    
 SAMEA4504061_01242 (NagZ)   Actinobacillus suis NCTC12996 SNV33018.1    
 IMCC26256_111541   Actinobacteria bacterium IMCC26256 AKL73815.1    
 BH719_04590   Actinomyces hongkongensis HKU8 AOS47226.1    
 AN27039_0168   Actinomyces naeslundii ATCC 27039 BAV83238.1    
 AN27039_0521 (fragment)   Actinomyces naeslundii ATCC 27039 BAV83591.1    
 AXE84_01570   Actinomyces oris T14V AMD98273.1    
 AXE84_02985   Actinomyces oris T14V AMD98510.1    
 AXF14_09230   Actinomyces radicidentis CCUG 36733 AMD88535.1    
 AXF14_01020   Actinomyces radicidentis CCUG 36733 AMD86440.1    
 AXF14_06400   Actinomyces radicidentis CCUG 36733 AMD88471.1    
 AXF14_07555   Actinomyces radicidentis CCUG 36733 AMD88498.1    
 SAMN04489714_0046   Actinomyces radingae DSM 9169 SDT85434.1    
 SAMN04489714_0364   Actinomyces radingae DSM 9169 SDT86876.1    
 SAMN04489714_2092   Actinomyces radingae DSM 9169 SDU08918.1    
 CHIBA101_0394   Actinomyces sp. Chiba101 BAW92265.1    
 CHIBA101_0960   Actinomyces sp. Chiba101 BAW92825.1    
 AM609_12070   Actinomyces sp. oral taxon 414 F0588 ALD00005.1    
 AM609_12760   Actinomyces sp. oral taxon 414 F0588 ALD00100.1    
 B6G06_05780   Actinomyces sp. pika_114 ARD41909.1    
 B6G06_08275   Actinomyces sp. pika_114 ARD42333.1    
 BK816_04130   Actinomyces sp. VUL4_3 AOZ72582.1    
 SAMN04489716_9137   Actinoplanes derwentensis DSM 43941 SDT80280.1    
 SAMN04489716_8925   Actinoplanes derwentensis DSM 43941 SDT79772.1    
 SAMN04489716_3817   Actinoplanes derwentensis DSM 43941 SDT44383.1    
 SAMN04489716_2323   Actinoplanes derwentensis DSM 43941 SDT03721.1    
 SAMN04489716_3760   Actinoplanes derwentensis DSM 43941 SDT43079.1    
 SAMN04489716_5293   Actinoplanes derwentensis DSM 43941 SDT65907.1    
 SAMN04489716_0422   Actinoplanes derwentensis DSM 43941 SDS27730.1    
 SAMN04489716_5707   Actinoplanes derwentensis DSM 43941 SDT69010.1    
 SAMN04489716_2968   Actinoplanes derwentensis DSM 43941 SDT24042.1    
 SAMN04489716_4816   Actinoplanes derwentensis DSM 43941 SDT60590.1    
 SAMN04489716_3767   Actinoplanes derwentensis DSM 43941 SDT43237.1    
 SAMN04489716_2455   Actinoplanes derwentensis DSM 43941 SDT08265.1    
 SAMN04489716_8777   Actinoplanes derwentensis DSM 43941 SDT79414.1    
 SAMN04489716_5494   Actinoplanes derwentensis DSM 43941 SDT67573.1    
 SAMN04489716_7925   Actinoplanes derwentensis DSM 43941 SDT77356.1    
 SAMN04489716_5122   Actinoplanes derwentensis DSM 43941 SDT64244.1    
 AFR_07935   Actinoplanes friuliensis DSM 7358 AGZ39876.1    
 AFR_08445   Actinoplanes friuliensis DSM 7358 AGZ39978.1    
 AFR_08670   Actinoplanes friuliensis DSM 7358 AGZ40023.1    
 AFR_11225   Actinoplanes friuliensis DSM 7358 AGZ40534.1    
 AFR_17980   Actinoplanes friuliensis DSM 7358 AGZ41874.1    
 AFR_25375   Actinoplanes friuliensis DSM 7358 AGZ43339.1    
 AFR_27495   Actinoplanes friuliensis DSM 7358 AGZ43760.1    
 AFR_31255 (fragment)   Actinoplanes friuliensis DSM 7358 AGZ44511.1    
 AFR_37100   Actinoplanes friuliensis DSM 7358 AGZ45674.1    
 AFR_17600   Actinoplanes friuliensis DSM 7358 AGZ41798.1    
 AFR_30325   Actinoplanes friuliensis DSM 7358 AGZ44325.1    
 AMIS_61630   Actinoplanes missouriensis 431 BAL91383.1    
 AMIS_63140   Actinoplanes missouriensis 431 BAL91534.1    
 AMIS_71580   Actinoplanes missouriensis 431 BAL92378.1    
 AMIS_11780   Actinoplanes missouriensis 431 BAL86398.1    
 AMIS_13050   Actinoplanes missouriensis 431 BAL86525.1    
 AMIS_14540   Actinoplanes missouriensis 431 BAL86674.1    
 AMIS_29470   Actinoplanes missouriensis 431 BAL88167.1    
 AMIS_35960   Actinoplanes missouriensis 431 BAL88816.1    
 AMIS_37740   Actinoplanes missouriensis 431 BAL88994.1    
 AMIS_9980   Actinoplanes missouriensis 431 BAL86218.1    
 AMIS_17150   Actinoplanes missouriensis 431 BAL86935.1    
 AMIS_37250   Actinoplanes missouriensis 431 BAL88945.1    
 L083_0732 (BglK)   Actinoplanes sp. N902-109 AGL14242.1    
 L083_1586   Actinoplanes sp. N902-109 AGL15096.1    
 L083_1755 (NagA)   Actinoplanes sp. N902-109 AGL15265.1    
 L083_2146 (BglX)   Actinoplanes sp. N902-109 AGL15656.1    
 L083_2625   Actinoplanes sp. N902-109 AGL16135.1    
 L083_2754   Actinoplanes sp. N902-109 AGL16264.1    
 L083_3243   Actinoplanes sp. N902-109 AGL16753.1    
 L083_4236   Actinoplanes sp. N902-109 AGL17746.1    
 L083_4654   Actinoplanes sp. N902-109 AGL18164.1    
 L083_6099   Actinoplanes sp. N902-109 AGL19609.1    
 L083_6554   Actinoplanes sp. N902-109 AGL20064.1    
 L083_7020   Actinoplanes sp. N902-109 AGL20530.1    
 L083_4111   Actinoplanes sp. N902-109 AGL17621.1    
 L083_5876   Actinoplanes sp. N902-109 AGL19386.1    
 ACWT_6438   Actinoplanes sp. SE50 ATO85853.1    
 ACWT_2301   Actinoplanes sp. SE50 ATO81716.1    
 ACWT_2606 (fragment)   Actinoplanes sp. SE50 ATO82021.1    
 ACWT_7279   Actinoplanes sp. SE50 ATO86694.1    
 ACWT_2353   Actinoplanes sp. SE50 ATO81768.1    
 ACWT_1289   Actinoplanes sp. SE50 ATO80704.1    
 ACWT_1399   Actinoplanes sp. SE50 ATO80814.1    
 ACWT_6295   Actinoplanes sp. SE50 ATO85710.1    
 ACPL_1410 (BglK)   Actinoplanes sp. SE50/110 AEV82307.1
 ACPL_1520 (NagA)   Actinoplanes sp. SE50/110 AEV82417.1
 ACPL_2940 (possible fragment)   Actinoplanes sp. SE50/110 AEV83835.1
 ACPL_6428 (BglX)   Actinoplanes sp. SE50/110 AEV87310.1
 ACPL_6569   Actinoplanes sp. SE50/110 AEV87451.1
 ACPL_2428   Actinoplanes sp. SE50/110 AEV83323.1
 ACPL_2480   Actinoplanes sp. SE50/110 AEV83375.1

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