Activities in Family	β-glucosidase (EC 3.2.1.21); xylan 1,4-β-xylosidase (EC 3.2.1.37); β-glucosylceramidase (EC 3.2.1.45); β-N-acetylhexosaminidase (EC 3.2.1.52); α-L-arabinofuranosidase (EC 3.2.1.55); glucan 1,4-β-glucosidase (EC 3.2.1.74); isoprimeverose-producing oligoxyloglucan hydrolase (EC 3.2.1.120); coniferin β-glucosidase (EC 3.2.1.126); exo-1,3-1,4-glucanase (EC 3.2.1.-); β-N-acetylglucosaminide phosphorylases (EC 2.4.1.-); β-1,2-glucosidase (EC 3.2.1.-); β-1,3-glucosidase (EC 3.2.1.-); xyloglucan-specific exo-β-1,4-glucanase / exo-xyloglucanase (EC 3.2.1.155)
Mechanism	Retaining
Catalytic Nucleophile/Base	Asp (experimental);
Catalytic Proton Donor	Glu for hydrolases (experimental); histidine for phosphorylases (experimental)
Note	A recent paper by Macdonald et al. (PMID=25533455) has shown that some enzymes that cleave b-hexosaminides are in fact retaining b-glycoside phosphorylases.
External resources	CAZypedia; HOMSTRAD; PRINTS; PROSITE;
Commercial Enzyme Provider(s)	MEGAZYME; PROZOMIX ;
Statistics	GenBank accession (32553); Uniprot accession (2560); PDB accession (148); 3D entries (53); cryst (4)

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Archaea
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
HFX_5029 (Amy6;GlyAHme)	3.2.1.-	Haloferax mediterranei ATCC 33500 CGMCC 1.2087	AFK20866.1 QCQ77294.1
β-xylosidase / α-L-arabinosidase (XarS;SSO3032)	3.2.1.37 3.2.1.55	Saccharolobus solfataricus P2	AAK43134.1 NP_344344.1	Q97UI4
β-glucosidase (Bgl;TpBgl;Tpen_1494)	3.2.1.21	Thermofilum pendens Hrk 5	ABL78891.1	A1S0B1
Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
β-glucosidase (BglAm;Amir_2978)	3.2.1.21	Actinosynnema mirum DSM 43827	ACU36898.1	C6WRQ6
β-glucosidase (EryBI)	3.2.1.21	Aeromicrobium erythreum	AAU93797.1	Q5Y9H4
coniferin β-glucosidase (Cbg1;Cbg-1)	3.2.1.21 3.2.1.126	Agrobacterium tumefaciens	AAA22082.1	P27034
β-xylosidase (BglX;TC41_2927)	3.2.1.37	Alicyclobacillus acidocaldarius subsp. acidocaldarius Tc-4-1	AEJ44817.1
β-glucosidase B	3.2.1.21	Bacillus sp. GL1	BAA36161.1	Q9ZNN6
β-N-acetylglucosaminidase (NagZ;YbbD;YzbA;BSU01660)	3.2.1.52	Bacillus subtilis subsp. subtilis str. 168	AAA64351.1 AIY91451.1 AQR80107.1 AQR84320.1 BAA19499.1 CAB11942.1 NP_388047.1	P40406	3BMX[A,B] 3CQM[A,B] 3LK6[A,B,C,D] 3NVD[A,B] 4GYJ[A,B] 4GYK[A,B]
β-xylosidase (BACINT_00926) (Xyl3A)	3.2.1.37	Bacteroides intestinalis DSM 17393	EDV05842.1
β-glucosidase (BACOVA_02738; Bovatus_03146; Bglx_6)	3.2.1.21	Bacteroides ovatus ATCC 8483	ALJ47754.1 EDO11529.1
β-glucosidase (Bovatus_01321; Bglx_1;BACOVA_00625 ZP_02063674.1)	3.2.1.21	Bacteroides ovatus ATCC 8483	ALJ45967.1
Bovatus_03424 (Bglb_4; revised model of BACOVA_00946 ZP_02063987.1)	3.2.1.21	Bacteroides ovatus ATCC 8483	ALJ48031.1
β-glucosidase (BACOVA_02745; Bovatus_03153)	3.2.1.21	Bacteroides ovatus ATCC 8483	ALJ47761.1 EDO11536.1
β-glucosidase (Bglb_3;BoGH3A;BACOVA_02644;Bovatus_03064)	3.2.1.21	Bacteroides ovatus ATCC 8483	ALJ47672.1
β-glucosidase (Bglx_5;BoGH3B;BACOVA_02659;Bovatus_03075)	3.2.1.21	Bacteroides ovatus ATCC 8483	ALJ47683.1		5JP0[A,B]
β-1,2-glucosidase (BT_3567)	3.2.1.-	Bacteroides thetaiotaomicron HB-13	AOP17662.1
β-1,2-glucosidase (BT3567)	3.2.1.-	Bacteroides thetaiotaomicron VPI-5482	AAO78673.1 NP_812479.1	Q8A1U1	5XXL[A,B] 5XXM[A,B] 5XXN[A,B] 5XXO[A,B]
β-glucosidase (BT3314;BT_3314)	3.2.1.21	Bacteroides thetaiotaomicron VPI-5482	AAO78420.1 NP_812226.1	Q8A2J1
exo-β-1,3-glucanase (BuGH3;BACUNI_01484)	3.2.1.-	Bacteroides uniformis ATCC 8492	ZP_02070067.1
β-glucosidase (Bgl8;BuBGL8) (partial)	3.2.1.21	Bacteroides uniformis ZL1	AGU13704.1
BAD_1194	3.2.1.21	Bifidobacterium adolescentis ATCC 15703	BAF39975.1	A1A2P2	5WAB[A,B,C,D]
α-L-arabinopyranosidase / β-galactosidase (Apy;Apy-H1)	3.2.1.23 3.2.1.-	Bifidobacterium longum H-1	ADT80794.1	E7CY69
β-glucosidase (BglX)	3.2.1.21	Bifidobacterium longum H-1	ADY62498.1
β-glucosidase / β-xylosidase / multi-functional glycoside hydrolase (BGL;XYL;Blon_0625)	3.2.1.21 3.2.1.37	Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088	ACJ51732.1	B7GPK2
β-glucosidase (BLNIAS_00597; Bglx2)	3.2.1.21	Bifidobacterium longum subsp. longum KACC 91563	AEI96973.1		5Z9S[A,B]
BCN122_I0864 (NagZ)	3.2.1.52	Burkholderia cenocepacia GIMC4560:Bcn122	ARF84251.1		6DTE[A,B]
β-glucosidase A (BglA)	3.2.1.21	Butyrivibrio fibrisolvens H17C	AAA23008.1	P16084
β-xylosidase (ORF0541) (Xyl3A)	3.2.1.37	Caldanaerobius polysaccharolyticus KMCJ	AFM44649.1
β-xylosidase (Cb2487;Cb1172;CbXyl3A;Athe_2354) (Xyl3A)	3.2.1.37	Caldicellulosiruptor bescii DSM 6725	ACM61424.1	B9MN93
β-glucosidase (Cba)	3.2.1.21	Cellulomonas biazotea	AAC38196.1	O51843
bifunctional N-acetyl-β-glucosaminidase/β-glucosidase (Nag3) (acts as a phosphorylase in presence of phosphate) (Nag3A)	3.2.1.21 3.2.1.52 2.4.1.-	Cellulomonas fimi ATCC 484	AAQ05801.1	Q7WUL3
β-xylosidase (CfXyl3A;Celf_2726) (Xyl3A)	3.2.1.37	Cellulomonas fimi ATCC 484	AEE46850.1
β-glucosidase (CfBgl3A;Celf_0140) (Bgl3A)	3.2.1.21	Cellulomonas fimi ATCC 484	AEE44289.1
β-glycosidase (CfBgl3C;Celf_3372) (Bgl3C)	3.2.1.-	Cellulomonas fimi ATCC 484	AEE47485.1
β-glucosidase (CfBgl3B;Celf_0468) (Bgl3B)	3.2.1.21	Cellulomonas fimi ATCC 484	AEE44608.1
β-glucosidase (BglA) (fragment)	3.2.1.21	Cellulomonas flavigena CDBB531 / PN-120	AFP89333.1
β-glucosidase (CgB)	3.2.1.21	Cellulomonas gilvus ATCC13127	BAA03152.1	P96316
β-glucosidase (Bgl3A;CJA_0204) (Cel3A)	3.2.1.- 3.2.1.74	Cellvibrio japonicus Ueda107	ACE84847.1	B3PGE9
exo-xyloglucanase (Blg3D;CJA_1140) (Cel3D)	3.2.1.155	Cellvibrio japonicus Ueda107	ACE82897.1	B3PBS6
β-glucosidase (Bgl3B;CJA_1497) (Cel3B)	3.2.1.- 3.2.1.21 3.2.1.-	Cellvibrio japonicus Ueda107	ACE83024.1	B3PDN7
β-glucosidase (Bgl3C;CJA_0223) (Cel3C)	3.2.1.-	Cellvibrio japonicus Ueda107	ACE85841.1	B3PGG8
β-glucosidase (CMM_0947)	3.2.1.21	Clavibacter michiganensis subsp. michiganensis NCPPB 382	CAN00986.1	A5CPI7
β-N-acetylglucosaminidase (Nag) (Nag3A)	3.2.1.52	Clostridium paraputrificum M-21	BAC56177.1	Q84IZ5
β-xylosidase (XylD)	3.2.1.37	Corynebacterium alkanolyticum Nakao et al.	AJY53618.1
β-glucosidase / β-xylosidase (BgxA)	3.2.1.21 3.2.1.37	Dickeya chrysanthemi D1	AAA80156.1	Q46684
β-xylosidase (Dtur_0852)	3.2.1.37	Dictyoglomus turgidum DSM 6724	ACK42133.1	B8E050
β-glucosidase / β-glycosidase (Dtur_0219)	3.2.1.21	Dictyoglomus turgidum DSM 6724	ACK41548.1 YP_002352162.1	B8E1M3
β-glucosidase (Bgl;Fbgl;FmBGL)	3.2.1.21	Elizabethkingia meningoseptica	AAB66561.1	O30713
NagZ	3.2.1.52	Escherichia coli CFT073	AAN79850.1 NP_753290.1	Q8FIN2
β-glucosidase (BglX)	3.2.1.21	Escherichia coli str. K-12 substr. MG1655	AAA60495.1 AAB38487.1 AAC75193.1 AIZ90796.1 ALI40123.1 AMC95086.1 APC52371.1 AUG16880.1 AVI56630.1 AYG18842.1 NP_416636.1	P33363
β-N-acetylglucosaminidase (NagZ;YcfO)	3.2.1.52	Escherichia coli str. K-12 substr. MG1655	AAC74191.1 ACX49759.1 AIZ91775.1 ALI41114.1 AMC98318.1 AUG15890.1 AVI55625.1 AYG19803.1 BAA35922.1 NP_415625.1	P75949
β-glucosidase (FgBgl3A) (Bgl3A)	3.2.1.21	Fervidobacterium gondwanense AB39	AFY97405.1
β-xylosidase (FgXyl3A) (Xyl3A)	3.2.1.37	Fervidobacterium gondwanense AB39	AFY97406.1
Fisuc_2065 / FSU_2592	3.2.1.-	Fibrobacter succinogenes subsp. succinogenes S85	ACX75652.1 ADL25584.1	C9RJD5
β-glucosidase (BglF3;Fjoh_0775)	3.2.1.21	Flavobacterium johnsoniae UW101	ABQ03809.1	A5FLV3
β-glucosidase (BglBX10;Fjoh_3392)	3.2.1.21	Flavobacterium johnsoniae UW101	ABQ06406.1	A5FEF5
β-xylosidase (BN863_22130)	3.2.1.37	Formosa agariphila KMM 3901	CDF79925.1
β-glucosidase (GOTRE_010_00060) (possible fragment)	3.2.1.21	Gordonia terrae NBRC 100016	GAB42172.1
β-glycosidase (HaGH03;Haur_1431)	3.2.1.-	Herpetosiphon aurantiacus DSM 785	ABX04075.1	A9B3B2
β-glucosidase B (BglB;Cthe_1256)	3.2.1.21	Hungateiclostridium thermocellum ATCC 27405	ABN52488.1	P14002
β-glucosidase B (BglB)	3.2.1.21	Hungateiclostridium thermocellum DSM 1237	CAA33665.1	P14002
β-xylosidase (BxyL)	3.2.1.37	Klebsiella sp. T4-1	AMK07469.1
β-xylosidase (XylB)	3.2.1.37	Klebsiella sp. T5-5	AMK07510.1
exo-β-1,4-glucosidase / β-glucosidase (β-Glu;G3ase)	3.2.1.21 3.2.1.74	Komagataeibacter sucrofermentans BPR2001	AAQ38005.1 BAA23595.1 BAA31467.1	O24749
β-glucosidase (LVIS_1961)	3.2.1.21	Lactobacillus brevis ATCC 367	ABJ65020.1	Q03P52
β-1,2-glucosidase / β-1,3-glucosidase (Lin1840)	3.2.1.- 3.2.1.-	Listeria innocua Clip11262	CAC97071.1 NP_471175.1	Q92AS9	4ZO6[A,B] 4ZO7[A,B] 4ZO8[A,B] 4ZO9[A,B] 4ZOA[A,B] 4ZOB[A,B] 4ZOC[A,B] 4ZOD[A,B] 4ZOE[A,B]
β-glucosidase (Gluc3M)	3.2.1.21	Martelella mediterranea gluc3m	ADC53302.1	D3Y125
ginsenoside β-glucosidase (Bgp3)	3.2.1.21	Microbacterium esteraromaticum GS514 / KACC16318	AEX88467.1
ginsenoside β-glucosidase (Bgp1)	3.2.1.21	Microbacterium esteraromaticum KACC16318	AEX88466.1
ginsenoside β-glucosidase (BglQM;Bgl-QM49-1)	3.2.1.21	Mucilaginibacter sp. QM49	AFS34656.1
β-glucosidase (Bgl-QM49-2)	3.2.1.-	Mucilaginibacter sp. QM49	AFS34657.1
β-N-acetylglucosaminidase (Rv0237;LpqI)	3.2.1.52	Mycobacterium tuberculosis H37Rv	CAA17329.1 AFN48090.1 CAE55256.1 CCP42966.1 NP_214751.1		6GFV[A,B]
β-glucosidase (SalB)	3.2.1.21	Niveispirillum irakense KBC1	AAF21799.1	Q9RH02
β-glucosidase (SalA)	3.2.1.21	Niveispirillum irakense KBC1	AAF21798.1	Q9RH03
cellobiase (CelA)	3.2.1.21	Niveispirillum irakense KBC1	AAG43575.1	Q9F0N9
β-glucosidase (SBGL)	3.2.1.21	Novosphingobium sp. GX9	AGS08637.1
β-glucosidase (OENOO_34001)	3.2.1.21	Oenococcus oeni ATCC BAA-1163	EAV39986.1 ZP_01543735.1	A0NHN3
isoprimeverose-producing oligoxyloglucan hydrolase (IPase)	3.2.1.120	Oerskovia sp. Y1	BAM08953.1
β-N-acetyl-D-glucosaminidase	3.2.1.52	Paenibacillaceae			6K5J[A]
β-glucosidase (PstG;PSTG)	3.2.1.21	Paenibacillus relictisesami	BAJ09393.1	D6RVX0
β-glucosidase (BglY)	3.2.1.21	Paenibacillus sp. C7	AAX35883.1	Q58PF3
glucocerebrosidase	3.2.1.45	Paenibacillus sp. TS12	BAC16750.1	Q8GAT9
β-glucosidase (BglA)	3.2.1.21	Paenibacillus xylanilyticus KJ-03	AFC68969.1
exo-1,4-β-glucosidase	3.2.1.21	Prevotella albensis M384	CAC07184.1	Q9F3Y0
exo-β-1,4-glucosidase (CdxA;Orf0348;00348-GPBOY)	3.2.1.21 3.2.1.74	Prevotella bryantii B14	AAA86753.2 AAA86753.1	Q59716
β-xylosidase (Orf00398;00398-GPBOY) (Xyl3A)	3.2.1.37	Prevotella bryantii B14	ADD92014.1
β-xylosidase (Orf0911;00911-GPBOY) (Xyl3B)	3.2.1.37	Prevotella bryantii B14	ADD92015.1
β-xylosidase (Orf0975;00975-GPBOY) (Xyl3C)	3.2.1.37	Prevotella bryantii B14	ADD92016.1
β-xylosidase / α-L-arabinofuranosidase (Xyl3A; PRU_2730) (Xyl3A)	3.2.1.37 3.2.1.55	Prevotella ruminicola 23	ACN78955.1 ADE82109.1	D5EY15
β-N-acetylglucosaminidase A (Cht60)	3.2.1.52	Pseudoalteromonas piscicida O-7	BAA04223.1 I39596	P48823
exo-1,3/1,4-β-glucanase (GluA;ExoP)	3.2.1.-	Pseudoalteromonas sp. BB1	ABC88234.1	Q0QJA3	3F93[A,B,C,D] 3F94[A] 3RRX[A] 3USZ[A] 3UT0[A,B,C,D]
β-N-acetylglucosaminidase (NagZ;PA3005)	3.2.1.52	Pseudomonas aeruginosa PAO1	AAG06393.1 NP_251695.1	Q9HZK0	5G1M[A,B] 5G2M[A,B] 5G3R[A,B] 5G5K[A,B] 5G5U[A,B] 5G6T[A,B] 5LY7[A,B]
PA1726 (BglX)	3.2.1.- 3.2.1.-	Pseudomonas aeruginosa PAO1	AAG05115.1 NP_250417.1	Q9I311	6R5I[A,B] 6R5N[A,B] 6R5O[A,B] 6R5P[A,B] 6R5R[A,B] 6R5T[A,B] 6R5U[A,B] 6R5V[A,B]
β-glucosidase (BglPC28;BglG1537b)	3.2.1.21	Pseudonocardia sp. Gsoil1536	AGA60134.1
β-xylosidase (XynB3;Theth_0138)	3.2.1.37	Pseudothermotoga thermarum DSM 5069	AEH50242.1
β-glucosidase (possible fragment)	3.2.1.21	Rhizobium leguminosarum bv. trifolii	AAM93475.1	Q7X201
β-N-acetylhexosaminidase (RRR_05655)	3.2.1.52	Rickettsia rickettsii str. R	AJG33435.1
xylan β-1,4-xylosidase (RiXyl3A;ROSINTL182_08202) (Xyl3A)	3.2.1.37	Roseburia intestinalis L1-82	EEU99897.1
β-galactosidase (RIL182_00213;ROSINTL182_07684;Bglb_2)	3.2.1.-	Roseburia intestinalis L1-82	VCV20358.1 EEV00398.1
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