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Glycoside Hydrolase Family 3

Activities in Familyβ-glucosidase (EC 3.2.1.21); xylan 1,4-β-xylosidase (EC 3.2.1.37); β-glucosylceramidase (EC 3.2.1.45); β-N-acetylhexosaminidase (EC 3.2.1.52); α-L-arabinofuranosidase (EC 3.2.1.55); glucan 1,3-β-glucosidase (EC 3.2.1.58); glucan 1,4-β-glucosidase (EC 3.2.1.74); isoprimeverose-producing oligoxyloglucan hydrolase (EC 3.2.1.120); coniferin β-glucosidase (EC 3.2.1.126); exo-1,3-1,4-glucanase (EC 3.2.1.-); β-N-acetylglucosaminide phosphorylases (EC 2.4.1.-)
Mechanism Retaining
Catalytic Nucleophile/BaseAsp (experimental);
Catalytic Proton DonorGlu for hydrolases (experimental); histidine for phosphorylases (experimental)
NoteA recent paper by Macdonald et al. (PMID=25533455) has shown that the enzymes that cleave b-hexosaminides are in fact retaining b-glycoside phosphorylases.
External resourcesCAZypedia; HOMSTRAD; PRINTS; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; PROZOMIX ;
Statistics GenBank accession (25796); Uniprot accession (2560); PDB accession (127); 3D entries (45); cryst (4)
Summary
All (24866) Archaea (111) Bacteria (23265) Eukaryota (1179) Viruses (1) unclassified (310) Structure (45 - 4 cryst) Characterized (307)
| 1 | 2 | 3 | 4 |
Archaea
Protein Name EC#OrganismGenBank UniprotPDB/3D
 HFX_5029 (Amy6;GlyAHme) 3.2.1.- Haloferax mediterranei ATCC 33500 CGMCC 1.2087 AFK20866.1
QCQ77294.1		    
 β-xylosidase / α-L-arabinosidase (XarS;SSO3032) 3.2.1.37
3.2.1.55		 Saccharolobus solfataricus P2 AAK43134.1
NP_344344.1		 Q97UI4  
 β-glucosidase (Bgl;TpBgl;Tpen_1494) 3.2.1.21 Thermofilum pendens Hrk 5 ABL78891.1 A1S0B1  
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 β-glucosidase (BglAm;Amir_2978) 3.2.1.21 Actinosynnema mirum DSM 43827 ACU36898.1 C6WRQ6  
 β-glucosidase (EryBI) 3.2.1.21 Aeromicrobium erythreum AAU93797.1 Q5Y9H4  
 coniferin β-glucosidase (Cbg1;Cbg-1) 3.2.1.21
3.2.1.126		 Agrobacterium tumefaciens AAA22082.1 P27034  
 β-xylosidase (BglX;TC41_2927) 3.2.1.37 Alicyclobacillus acidocaldarius subsp. acidocaldarius Tc-4-1 AEJ44817.1    
 β-glucosidase B 3.2.1.21 Bacillus sp. GL1 BAA36161.1 Q9ZNN6  
 β-N-acetylglucosaminidase (NagZ;YbbD;YzbA;BSU01660) 3.2.1.52 Bacillus subtilis subsp. subtilis str. 168 AAA64351.1
AIY91451.1
AQR80107.1
AQR84320.1
BAA19499.1
CAB11942.1
NP_388047.1		 P40406 3BMX[A,B]
3CQM[A,B]
3LK6[A,B,C,D]
3NVD[A,B]
4GYJ[A,B]
4GYK[A,B]
 β-xylosidase (BACINT_00926) (Xyl3A) 3.2.1.37 Bacteroides intestinalis DSM 17393 EDV05842.1    
 β-glucosidase (BACOVA_02738; Bovatus_03146; Bglx_6) 3.2.1.21 Bacteroides ovatus ATCC 8483 ALJ47754.1
EDO11529.1		    
 β-glucosidase (Bovatus_01321; Bglx_1;BACOVA_00625 ZP_02063674.1) 3.2.1.21 Bacteroides ovatus ATCC 8483 ALJ45967.1    
 Bovatus_03424 (Bglb_4; revised model of BACOVA_00946 ZP_02063987.1) 3.2.1.21 Bacteroides ovatus ATCC 8483 ALJ48031.1    
 β-glucosidase (BACOVA_02745; Bovatus_03153) 3.2.1.21 Bacteroides ovatus ATCC 8483 ALJ47761.1
EDO11536.1		    
 β-glucosidase (Bglb_3;BoGH3A;BACOVA_02644;Bovatus_03064) 3.2.1.21 Bacteroides ovatus ATCC 8483 ALJ47672.1    
 β-glucosidase (Bglx_5;BoGH3B;BACOVA_02659;Bovatus_03075) 3.2.1.21 Bacteroides ovatus ATCC 8483 ALJ47683.1   5JP0[A,B]
 β-1,2-glucosidase (BT_3567) 3.2.1.- Bacteroides thetaiotaomicron HB-13 AOP17662.1    
 β-1,2-glucosidase (BT3567) 3.2.1.- Bacteroides thetaiotaomicron VPI-5482 AAO78673.1
NP_812479.1		 Q8A1U1 5XXL[A,B]
5XXM[A,B]
5XXN[A,B]
5XXO[A,B]
 β-glucosidase (BT3314;BT_3314) 3.2.1.21 Bacteroides thetaiotaomicron VPI-5482 AAO78420.1
NP_812226.1		 Q8A2J1  
 β-glucosidase (Bgl8;BuBGL8) (partial) 3.2.1.21 Bacteroides uniformis ZL1 AGU13704.1    
 BAD_1194 3.2.1.21 Bifidobacterium adolescentis ATCC 15703 BAF39975.1 A1A2P2 5WAB[A,B,C,D]
 α-L-arabinopyranosidase / β-galactosidase (Apy;Apy-H1) 3.2.1.23
3.2.1.-		 Bifidobacterium longum H-1 ADT80794.1 E7CY69  
 β-glucosidase (BglX) 3.2.1.21 Bifidobacterium longum H-1 ADY62498.1    
 β-glucosidase / β-xylosidase / multi-functional glycoside hydrolase (BGL;XYL;Blon_0625) 3.2.1.21
3.2.1.37		 Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088 ACJ51732.1 B7GPK2  
 β-glucosidase (BLNIAS_00597; Bglx2) 3.2.1.21 Bifidobacterium longum subsp. longum KACC 91563 AEI96973.1   5Z9S[A,B]
 BCN122_I0864 (NagZ) 3.2.1.52 Burkholderia cenocepacia GIMC4560:Bcn122 ARF84251.1   6DTE[A,B]
 β-glucosidase A (BglA) 3.2.1.21 Butyrivibrio fibrisolvens H17C AAA23008.1 P16084  
 β-xylosidase (ORF0541) (Xyl3A) 3.2.1.37 Caldanaerobius polysaccharolyticus KMCJ AFM44649.1    
 β-xylosidase (Cb2487;Cb1172;CbXyl3A;Athe_2354) (Xyl3A) 3.2.1.37 Caldicellulosiruptor bescii DSM 6725 ACM61424.1 B9MN93  
 β-glucosidase (Cba) 3.2.1.21 Cellulomonas biazotea AAC38196.1 O51843  
 bifunctional N-acetyl-β-glucosaminidase/β-glucosidase (Nag3) (acts as a phosphorylase in presence of phosphate) (Nag3A) 3.2.1.21
3.2.1.52
2.4.1.-		 Cellulomonas fimi ATCC 484 AAQ05801.1 Q7WUL3  
 β-xylosidase (CfXyl3A;Celf_2726) (Xyl3A) 3.2.1.37 Cellulomonas fimi ATCC 484 AEE46850.1    
 β-glucosidase (CfBgl3A;Celf_0140) (Bgl3A) 3.2.1.21 Cellulomonas fimi ATCC 484 AEE44289.1    
 β-glycosidase (CfBgl3C;Celf_3372) (Bgl3C) 3.2.1.- Cellulomonas fimi ATCC 484 AEE47485.1    
 β-glucosidase (CfBgl3B;Celf_0468) (Bgl3B) 3.2.1.21 Cellulomonas fimi ATCC 484 AEE44608.1    
 β-glucosidase (BglA) (fragment) 3.2.1.21 Cellulomonas flavigena CDBB531 / PN-120 AFP89333.1    
 β-glucosidase (CgB) 3.2.1.21 Cellulomonas gilvus ATCC13127 BAA03152.1 P96316  
 β-glucosidase / cellodextrinase D (CelD;CJA_0204) (Cel3A) 3.2.1.74 Cellvibrio japonicus Ueda107 ACE84847.1
CAA46499.1		 B3PGE9
Q47912		  
 β-glucosidase (CJA_1497) (Cel3B) 3.2.1.21 Cellvibrio japonicus Ueda107 ACE83024.1 B3PDN7  
 β-glucosidase (CMM_0947) 3.2.1.21 Clavibacter michiganensis subsp. michiganensis NCPPB 382 CAN00986.1 A5CPI7  
 β-N-acetylglucosaminidase (Nag) (Nag3A) 3.2.1.52 Clostridium paraputrificum M-21 BAC56177.1 Q84IZ5  
 β-xylosidase (XylD) 3.2.1.37 Corynebacterium alkanolyticum Nakao et al. AJY53618.1    
 β-glucosidase / β-xylosidase (BgxA) 3.2.1.21
3.2.1.37		 Dickeya chrysanthemi D1 AAA80156.1 Q46684  
 β-xylosidase (Dtur_0852) 3.2.1.37 Dictyoglomus turgidum DSM 6724 ACK42133.1 B8E050  
 β-glucosidase / β-glycosidase (Dtur_0219) 3.2.1.21 Dictyoglomus turgidum DSM 6724 ACK41548.1
YP_002352162.1		 B8E1M3  
 β-glucosidase (Bgl;Fbgl;FmBGL) 3.2.1.21 Elizabethkingia meningoseptica AAB66561.1 O30713  
 NagZ 3.2.1.52 Escherichia coli CFT073 AAN79850.1
NP_753290.1		 Q8FIN2  
 β-glucosidase (BglX) 3.2.1.21 Escherichia coli str. K-12 substr. MG1655 AAA60495.1
AAB38487.1
AAC75193.1
AIZ90796.1
ALI40123.1
AMC95086.1
APC52371.1
AUG16880.1
AVI56630.1
AYG18842.1
NP_416636.1		 P33363  
 β-N-acetylglucosaminidase (NagZ;YcfO) 3.2.1.52 Escherichia coli str. K-12 substr. MG1655 AAC74191.1
ACX49759.1
AIZ91775.1
ALI41114.1
AMC98318.1
AUG15890.1
AVI55625.1
AYG19803.1
BAA35922.1
NP_415625.1		 P75949  
 β-glucosidase (FgBgl3A) (Bgl3A) 3.2.1.21 Fervidobacterium gondwanense AB39 AFY97405.1    
 β-xylosidase (FgXyl3A) (Xyl3A) 3.2.1.37 Fervidobacterium gondwanense AB39 AFY97406.1    
 Fisuc_2065 / FSU_2592 3.2.1.- Fibrobacter succinogenes subsp. succinogenes S85 ACX75652.1
ADL25584.1		 C9RJD5  
 β-glucosidase (BglF3;Fjoh_0775) 3.2.1.21 Flavobacterium johnsoniae UW101 ABQ03809.1 A5FLV3  
 β-glucosidase (BglBX10;Fjoh_3392) 3.2.1.21 Flavobacterium johnsoniae UW101 ABQ06406.1 A5FEF5  
 β-xylosidase (BN863_22130) 3.2.1.37 Formosa agariphila KMM 3901 CDF79925.1    
 β-glucosidase (GOTRE_010_00060) (possible fragment) 3.2.1.21 Gordonia terrae NBRC 100016 GAB42172.1    
 β-glycosidase (HaGH03;Haur_1431) 3.2.1.- Herpetosiphon aurantiacus DSM 785 ABX04075.1 A9B3B2  
 β-glucosidase B (BglB;Cthe_1256) 3.2.1.21 Hungateiclostridium thermocellum ATCC 27405 ABN52488.1 P14002  
 β-glucosidase B (BglB) 3.2.1.21 Hungateiclostridium thermocellum DSM 1237 CAA33665.1 P14002  
 β-xylosidase (BxyL) 3.2.1.37 Klebsiella sp. T4-1 AMK07469.1    
 β-xylosidase (XylB) 3.2.1.37 Klebsiella sp. T5-5 AMK07510.1    
 exo-β-1,4-glucosidase / β-glucosidase (β-Glu;G3ase) 3.2.1.21
3.2.1.74		 Komagataeibacter sucrofermentans BPR2001 AAQ38005.1
BAA23595.1
BAA31467.1		 O24749  
 β-glucosidase (LVIS_1961) 3.2.1.21 Lactobacillus brevis ATCC 367 ABJ65020.1 Q03P52  
 β-1,2-glucosidase / β-1,3-glucosidase (Lin1840) 3.2.1.-
3.2.1.-		 Listeria innocua Clip11262 CAC97071.1
NP_471175.1		 Q92AS9 4ZO6[A,B]
4ZO7[A,B]
4ZO8[A,B]
4ZO9[A,B]
4ZOA[A,B]
4ZOB[A,B]
4ZOC[A,B]
4ZOD[A,B]
4ZOE[A,B]
 β-glucosidase (Gluc3M) 3.2.1.21 Martelella mediterranea gluc3m ADC53302.1 D3Y125  
 ginsenoside β-glucosidase (Bgp3) 3.2.1.21 Microbacterium esteraromaticum GS514 / KACC16318 AEX88467.1    
 ginsenoside β-glucosidase (Bgp1) 3.2.1.21 Microbacterium esteraromaticum KACC16318 AEX88466.1    
 ginsenoside β-glucosidase (BglQM;Bgl-QM49-1) 3.2.1.21 Mucilaginibacter sp. QM49 AFS34656.1    
 β-glucosidase (Bgl-QM49-2) 3.2.1.- Mucilaginibacter sp. QM49 AFS34657.1    
 β-glucosidase (SalB) 3.2.1.21 Niveispirillum irakense KBC1 AAF21799.1 Q9RH02  
 β-glucosidase (SalA) 3.2.1.21 Niveispirillum irakense KBC1 AAF21798.1 Q9RH03  
 cellobiase (CelA) 3.2.1.21 Niveispirillum irakense KBC1 AAG43575.1 Q9F0N9  
 β-glucosidase (SBGL) 3.2.1.21 Novosphingobium sp. GX9 AGS08637.1    
 β-glucosidase (OENOO_34001) 3.2.1.21 Oenococcus oeni ATCC BAA-1163 EAV39986.1
ZP_01543735.1		 A0NHN3  
 isoprimeverose-producing oligoxyloglucan hydrolase (IPase) 3.2.1.120 Oerskovia sp. Y1 BAM08953.1    
 β-glucosidase (PstG;PSTG) 3.2.1.21 Paenibacillus relictisesami BAJ09393.1 D6RVX0  
 β-glucosidase (BglY) 3.2.1.21 Paenibacillus sp. C7 AAX35883.1 Q58PF3  
 glucocerebrosidase 3.2.1.45 Paenibacillus sp. TS12 BAC16750.1 Q8GAT9  
 β-glucosidase (BglA) 3.2.1.21 Paenibacillus xylanilyticus KJ-03 AFC68969.1    
 exo-1,4-β-glucosidase 3.2.1.21 Prevotella albensis M384 CAC07184.1 Q9F3Y0  
 exo-β-1,4-glucosidase (CdxA;Orf0348;00348-GPBOY) 3.2.1.21
3.2.1.74		 Prevotella bryantii B14 AAA86753.2
AAA86753.1		 Q59716  
 β-xylosidase (Orf00398;00398-GPBOY) (Xyl3A) 3.2.1.37 Prevotella bryantii B14 ADD92014.1    
 β-xylosidase (Orf0911;00911-GPBOY) (Xyl3B) 3.2.1.37 Prevotella bryantii B14 ADD92015.1    
 β-xylosidase (Orf0975;00975-GPBOY) (Xyl3C) 3.2.1.37 Prevotella bryantii B14 ADD92016.1    
 β-xylosidase / α-L-arabinofuranosidase (Xyl3A; PRU_2730) (Xyl3A) 3.2.1.37
3.2.1.55		 Prevotella ruminicola 23 ACN78955.1
ADE82109.1		 D5EY15  
 β-N-acetylglucosaminidase A (Cht60) 3.2.1.52 Pseudoalteromonas piscicida O-7 BAA04223.1
I39596		 P48823  
 exo-1,3/1,4-β-glucanase (GluA;ExoP) 3.2.1.- Pseudoalteromonas sp. BB1 ABC88234.1 Q0QJA3 3F93[A,B,C,D]
3F94[A]
3RRX[A]
3USZ[A]
3UT0[A,B,C,D]
 β-N-acetylglucosaminidase (NagZ;PA3005) 3.2.1.52 Pseudomonas aeruginosa PAO1 AAG06393.1
NP_251695.1		 Q9HZK0 5G1M[A,B]
5G2M[A,B]
5G3R[A,B]
5G5K[A,B]
5G5U[A,B]
5G6T[A,B]
5LY7[A,B]
 β-glucosidase (BglPC28;BglG1537b) 3.2.1.21 Pseudonocardia sp. Gsoil1536 AGA60134.1    
 β-xylosidase (XynB3;Theth_0138) 3.2.1.37 Pseudothermotoga thermarum DSM 5069 AEH50242.1    
 β-glucosidase (possible fragment) 3.2.1.21 Rhizobium leguminosarum bv. trifolii AAM93475.1 Q7X201  
 β-N-acetylhexosaminidase (RRR_05655) 3.2.1.52 Rickettsia rickettsii str. R AJG33435.1    
 xylan β-1,4-xylosidase (RiXyl3A;ROSINTL182_08202) (Xyl3A) 3.2.1.37 Roseburia intestinalis L1-82 EEU99897.1    
 β-galactosidase (RIL182_00213;ROSINTL182_07684;Bglb_2) 3.2.1.- Roseburia intestinalis L1-82 VCV20358.1
EEV00398.1		    
 β-glucosidase (RIL182_00212;ROSINTL182_07685;Bglb_1) 3.2.1.21 Roseburia intestinalis L1-82 VCV20357.1
EEV00399.1		    
 β-glucosidase (GluA) 3.2.1.21 Ruminococcus albus 7 AAC05445.1 O66050  
 β-xylosidase 3A (Xyl3A) 3.2.1.37 Ruminococcus albus 8 AEE64772.1
ZP_08159508.1		    
 β-1,3-glucosidase (Ra1595;CUS_7631) 3.2.1.58 Ruminococcus albus 8 EGC01435.1
ZP_08160757.1		    
 β-glucosidase (Bgl) 3.2.1.21 Ruminococcus albus ATCC27210 CAA33461.1 P15885  
 β-N-acetylglucosaminidase 3C (HexC; Sde_1790) (Hex3C) 3.2.1.52 Saccharophagus degradans 2-40 DAA01340.1
ABD81050.1
ACG81708.1		 Q7PC47  
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