Polysaccharide Lyase Family 8

Activities in Family	Exo-β-1,4-glucuronan lyase (EC 4.2.2.-); Exo-hyaluronate lyase (EC 4.2.2.-); Hyaluronate lyase (EC 4.2.2.1); Xanthan lyase (EC 4.2.2.12); Chondroitinase B (EC 4.2.2.19); Poly(β-mannuronate) lyase / M-specific alginate lyase (EC 4.2.2.3); Chondroitin AC lyase (EC 4.2.2.5); Heparin lyase / heparin lyase I (EC 4.2.2.7);
Mechanism	b-elimination
3D Structure Status	( α / α ) ₆ toroid + anti-parallel β-sheet
Commercial Enzyme Provider(s)	MEGAZYME; PROZOMIX;
Statistics	GenBank accession (4807); Uniprot accession (30); PDB accession (54); 3D entries (13); cryst (1)

Summary

Download PL8 (5166) Taxonomic display Structure (13 - 1 cryst) Characterized (33)

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Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D	Subf
I3J06_06535		Streptomyces clavuligerus F1D7	QPL74649.1
BB341_06495		Streptomyces clavuligerus F613-1	ANW17892.1
hyaluronate lyase (PL8Hyal;SCO5534;SC1C2.15)	4.2.2.1	Streptomyces coelicolor A3(2)	CAA19982.1 NP_629668.1	O86516	2WCO[A] 2WDA[A] 2X03[A,B]
FQ762_28575		Streptomyces coelicolor A3(2) CFB_NBC_0001	QFI47993.1
JCM4020_56510		Streptomyces coelicolor JCM 4020	BDD75031.1
HCU77_28015		Streptomyces coelicolor M1154/pAMX4/pGP1416	QKN71411.1
RE436_27710		Streptomyces coelicolor M22	WMT38356.1
CP976_30575		Streptomyces coeruleorubidus ATCC 13740	QEV30601.1
PV963_32680		Streptomyces coeruleorubidus DM	WDV54781.1
R5U08_07570		Streptomyces coeruleorubidus WT-48	WOT34014.1
RFN52_28595		Streptomyces collinus CGMCC 4.1623	WMX67112.1
HGI09_17890		Streptomyces collinus L2	UJA14479.1
HGI10_46230		Streptomyces collinus SQ	UJA10657.1
B446_25985		Streptomyces collinus Tu 365	AGS72005.1
QU709_11630		Streptomyces coralus SX92	WLW51984.1
EJ357_32680		Streptomyces cyaneochromogenes MK-45	AZQ37626.1
R2B67_00610		Streptomyces cyaneofuscatus 89-2-2	WOP07118.1
SJX93_35125		Streptomyces cyaneofuscatus NEB1061	WRO14543.1
TU94_23365		Streptomyces cyaneogriseus subsp. noncyanogenus NMWT 1	AJP05849.1
S1361_27505 (XlY)		Streptomyces cyanogenus S136	QTE01110.1
D9753_10340		Streptomyces dangxiongensis Z022	AYN39236.1
BN159_2862		Streptomyces davaonensis JCM 4913	CCK27241.1
BN159_0958		Streptomyces davaonensis JCM 4913	CCK25337.1
L3078_32175		Streptomyces deccanensis KCTC 19241	ULR53566.1
K7C20_26190		Streptomyces decoyicus NRRL 2666	QZY18305.1
NEH16_03190		Streptomyces drozdowiczii MDA8-470	UZK53264.1
M4V62_10665		Streptomyces durmitorensis MS405	UQT55514.1
M4V62_07500		Streptomyces durmitorensis MS405	UQT54952.1
M4V62_03810		Streptomyces durmitorensis MS405	UQT54275.1
RI138_31555		Streptomyces durocortorensis C11-1	WNF31014.1
OJ254_01650		Streptomyces endophytica HNM0140	UZJ29423.1
PS783_25715		Streptomyces enissocaesilis NBF 715	WDI20793.1
IM697_35535		Streptomyces ferrugineus CCTCC AA2014009	QOV35332.1
EIZ62_08725		Streptomyces ficellus NRRL 8067	QGV82553.1
K7395_00515		Streptomyces filamentosus L30	USC45307.1
QUY26_02005		Streptomyces flavofungini TRM90047	WJV44413.1
QUY26_35460		Streptomyces flavofungini TRM90047	WJV50347.1
J4032_09595		Streptomyces formicae 1H-GS9	UNM11765.1
J4032_28265		Streptomyces formicae 1H-GS9	UNM14841.1
J4032_28270		Streptomyces formicae 1H-GS9	UNM14842.1
J4032_11885		Streptomyces formicae 1H-GS9	UNM12145.1
J4032_19970		Streptomyces formicae 1H-GS9	UNM16610.1
KY5_6364		Streptomyces formicae KY5	ATL31382.1
KY5_5711		Streptomyces formicae KY5	ATL30729.1
D3X13_07480		Streptomyces fradiae NKZ-259	AYA16082.1
HUT09_33350		Streptomyces fulvissimus NA06532	QKW47048.1
H4W23_28340		Streptomyces gardneri ATCC 15439	QPK48168.1
IAG43_30120		Streptomyces genisteinicus CRPJ-33	QNP66762.1
IAG43_17360		Streptomyces genisteinicus CRPJ-33	QNP64506.1
B1H19_28315		Streptomyces gilvosporeus F607	ARF57580.1
SGLAU_23805		Streptomyces glaucescens GLA.O	AIS00710.1
WQO_33115		Streptomyces globisporus C-1027	ALU97766.1
DIJ69_00490		Streptomyces globisporus TFH56	AWL84572.1
GCM10017557_23350		Streptomyces glomeroaurantiacus JCM 4677	BCL27476.1
test1122_22970		Streptomyces gobiensis 1_25	UGY94307.1
SGFS_040030		Streptomyces graminofaciens A-8890	BBC32709.1
AVL59_08750		Streptomyces griseochromogenes ATCC 14511	ANP56378.1
HEP81_00629		Streptomyces griseofuscus DSM 40191	QNT90965.1
DWG14_02529 (XlY)		Streptomyces griseorubiginosus 3E-1	AYC38300.1
ELQ87_11925		Streptomyces griseoviridis F1-27	AZS84910.1
DDJ31_27380		Streptomyces griseoviridis K61	QCN88237.1
hyaluronidase hya (probable fragment)		Streptomyces griseus	BAA78618.1
SGR_291 (fragment)		Streptomyces griseus subsp. griseus NBRC 13350	BAG17120.1
K9S39_14835		Streptomyces halobius 3_2	UQA92938.1
HUT13_12565		Streptomyces harbinensis NA02264	QKV69520.1
CEB94_28975		Streptomyces hawaiiensis ATCC 12236	QCD60817.1
J2N69_29830		Streptomyces huasconensis D23	UFQ20414.1
J2N69_32955		Streptomyces huasconensis D23	UFQ19390.1
DWB77_06490 (Xly_3)		Streptomyces hundungensis BH38	AYG84277.1
DWB77_06443 (Xly_2)		Streptomyces hundungensis BH38	AYG84230.1
DWB77_02354 (Xly_1)		Streptomyces hundungensis BH38	AYG80223.1
HOK021_58510		Streptomyces hygroscopicus HOK021	BDH14672.1
V8J11_07450		Streptomyces hygroscopicus subsp. hygroscopicus DSM 41954	WXA05601.1
V8J11_04015		Streptomyces hygroscopicus subsp. hygroscopicus DSM 41954	WXA04961.1
SHJG_6645		Streptomyces hygroscopicus subsp. jinggangensis 5008	AEY91912.1
SHJGH_6405		Streptomyces hygroscopicus subsp. jinggangensis TL01	AGF66068.1
SHL15_5279		Streptomyces hygroscopicus subsp. limoneus KCTC 1717	ALO96352.1
SHXM_00913		Streptomyces hygroscopicus XM201	AQW47450.1
RFN58_30025		Streptomyces iakyrus CGMCC 4.1912	WVG05068.1
ABB07_02650		Streptomyces incarnatus NRRL 8089	AKJ08961.1
KI385_31415		Streptomyces inhibens NRRL30439	UKY52872.1
SIRAN9078		Streptomyces iranensis	CDR16573.1
RI060_11845		Streptomyces janthinus JCM 4387	WND17983.1
CP970_04240		Streptomyces kanamyceticus ATCC 12853	QEU90217.1
CP970_12530		Streptomyces kanamyceticus ATCC 12853	QEU91597.1
CP970_09185		Streptomyces kanamyceticus ATCC 12853	QEU91030.1
KJK29_09930		Streptomyces koelreuteriae MG62	QWB22878.1
P8A22_02080		Streptomyces laculatispora Mut2	WLQ38934.1
P8A22_10750		Streptomyces laculatispora Mut2	WLQ45257.1
P8A22_03890		Streptomyces laculatispora Mut2	WLQ39242.1
P8A22_36685		Streptomyces laculatispora Mut2	WLQ44948.1
SLA_5431		Streptomyces laurentii ATCC 31255	BAU86309.1
SLAV_04325 (XlY)		Streptomyces lavendulae subsp. lavendulae CCM 3239	ATZ22773.1
J3S85_30250		Streptomyces lavenduligriseus Tu901	WDM15414.1
J3S85_03815		Streptomyces lavenduligriseus Tu901	WDM10753.1
Sle_21210		Streptomyces leeuwenhoekii C34 (= DSM 42122 = NRRL B-24963)	CQR61582.1
HA039_09355		Streptomyces liangshanensis QMT-12	QIQ02492.1
STRLI_002333		Streptomyces libani subsp. libani DSM 40555	WAT96495.1
Srufu_022930		Streptomyces libani subsp. rufus NBRC 15424	BCK68340.1
JEQ17_14750		Streptomyces liliifuscus ZYC-3	QQM40611.1
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