Polysaccharide Lyase Family 8

Activities in Familyhyaluronate lyase (EC 4.2.2.1); chondroitin AC lyase (EC 4.2.2.5); xanthan lyase (EC 4.2.2.12); chondroitin ABC lyase (EC 4.2.2.20)
3D Structure Status( α / α ) 6 barrel + anti-parallel β-sheet
Commercial Enzyme Provider(s)MEGAZYME; PROZOMIX;
Statistics GenBank accession (1231); Uniprot accession (198); PDB accession (44); 3D entries (9); cryst (1)
All (1151) Archaea (1) Bacteria (1148) Eukaryota (2) Structure (9 - 1 cryst) Characterized (27)
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 hyaluronidase (Hyl;HAase-B) (partial) 4.2.2.1 Bacillus sp. A50 AHB61202.1    
 xanthan lyase (Xly) 4.2.2.12 Bacillus sp. GL1 BAB21059.1 Q9AQS0 1J0M[A]
1J0N[A]
1X1H[A]
1X1I[A]
1X1J[A]
2E22[A]
2E24[A]
 chondroitin sulfate lyase AC (CslA) 4.2.2.5 Bacteroides stercoris HJ-15 ABW87764.1 A9Y5J0   3
 BT3324 4.2.2.20 Bacteroides thetaiotaomicron VPI-5482 AAO78430.1
NP_812236.1
Q8A2I1   2
 chondroitin sulfate ABC lyase 4.2.2.20 Bacteroides thetaiotaomicron WAL2926 ABV21364.1 C5G6D7 2Q1F[A,B] 2
 hyaluronate lyase (Hyase) 4.2.2.1 Cutibacterium acnes AAA51650.1 P0CZ00
Q59634
 
 chondroitin AC lyase (CslA;ChonAC) 4.2.2.5 Flavobacterium columnare G4 AAX07421.1 Q5EC33   3
 chondroitin AC lyase (partial) 4.2.2.1
4.2.2.5
Paenarthrobacter aurescens   P84141 1RWA[A]
1RWC[A]
1RWF[A]
1RWG[A]
1RWH[A]
1RW9[A]
 xanthan lyase (XalA) 4.2.2.12 Paenibacillus alginolyticus XL-1 AAG24953.1 Q9F8Q9  
 chondroitin AC lyase (CslA;ChnAC;Phep_0786) 4.2.2.5 Pedobacter heparinus DSM 2366 ACU03008.1
AAC83383.1
Q59288 1CB8[A]
1HM2[A]
1HM3[A]
1HMU[A]
1HMW[A]
3
 PPA0380 (hyaluronate lyase) 4.2.2.1 Propionibacterium acnes KPA171202 AAT82132.1 P0CZ01  
 chondroitin ABC lyase I / chondroitinase ABC (ChABC) 4.2.2.20 Proteus vulgaris 2109195A
ABE23097.1
ACN04689.1
ACQ12496.1
ACQ12497.1
ACW17440.1
ACW17441.1
ACY01450.1
P59807 1HN0[A] 2
 chondroitin ABC lyase II (ChABCII) 4.2.2.20 Proteus vulgaris ATCC 6896 AAB43333.1
ABU46331.1
  cryst 2
 hyaluronate lyase (HysA) 4.2.2.1 Staphylococcus aureus 8325-4 AAA82984.1 Q59801   1
 hyaluronate lyase (HylB) 4.2.2.1 Streptococcus agalactiae 4755 CAA75865.1 O86478   1
 hyaluronate lyase (HylB;SaHyl;Gbs1270) 4.2.2.1 Streptococcus agalactiae NEM316 CAD46929.1
AAA56749.1
NP_735714.1
Q53591 1F1S[A]
1I8Q[A]
1LXM[A]
1
 hyaluronate lyase 4.2.2.1 Streptococcus constellatus subsp. constellatus ATCC 27823 AAK67165.1 Q934I5   1
 hyaluronidase (Hyl) 4.2.2.1 Streptococcus equi subsp. zooepidemicus CVCC23362 ABV69920.1 A8HJR5   1
 hyaluronate lyase 4.2.2.1 Streptococcus intermedius ATCC 27335 AAK67167.1 Q934I4   1
 hyaluronate lyase (HysA) 4.2.2.1 Streptococcus pneumoniae R6 AAK99090.1
AAA53685.1
AAA53686.1
AAT16666.1
ACK14456.1
ACW45175.1
NP_357880.1
Q8CWU3 1C82[A]
1EGU[A]
1F9G[A]
1LOH[A]
1LXK[A]
1N7N[A]
1N7O[A]
1N7P[A]
1N7Q[A]
1N7R[A]
1OJM[A]
1OJN[A]
1OJO[A]
1OJP[A]
1W3Y[A]
2BRP[A]
2BRV[X]
2BRW[A,B]
1
 hyaluronate lyase (Hyl;SpHyl;SP0314) 4.2.2.1 Streptococcus pneumoniae TIGR4 AAK74491.1
NP_344851.1
Q54873   1
 hyaluronate lyase (HylA) 4.2.2.1 Streptococcus pyogenes AAF29533.1 Q9L7W9   1
 HylA 4.2.2.1 Streptococcus suis P5/11/88 CAC87663.1 Q8VLQ7   1
 hyaluronidase (HylA) 4.2.2.1 Streptococcus suis SEROTYPE 7 CAC87662.1 Q8VLQ8   1
 hyaluronate lyase (PL8Hyal;SCO5534;SC1C2.15) 4.2.2.1 Streptomyces coelicolor A3(2) CAA19982.1
NP_629668.1
O86516 2WCO[A]
2WDA[A]
2X03[A,B]
 VFA0994 4.2.2.1 Vibrio fischeri ES114 AAW88064.1 Q5DYT2  
 glycosaminoglycan lyase / eliminase (HCLase) 4.2.2.1
4.2.2.5
Vibrio sp. FC509 AIL54323.1    
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