Polysaccharide Lyase Family 8

Known Activities	hyaluronate lyase (EC 4.2.2.1); chondroitin AC lyase (EC 4.2.2.5); xanthan lyase (EC 4.2.2.12); chondroitin ABC lyase (EC 4.2.2.20)
3D Structure Status	( α / α ) ₆ barrel + anti-parallel β-sheet
External resources	InterPro; PFAM;
Commercial Enzyme Provider(s)	MEGAZYME; PROZOMIX;
Statistics	GenBank accession (361); Uniprot accession (191); PDB accession (44); 3D entries (9); cryst (1)

Summary

All (301) Archaea (1) Bacteria (300) Structure (9 - 1 cryst) Characterized (26) Subfamilies (166)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D	Subf
chondroitin AC lyase	4.2.2.1 4.2.2.5	Arthrobacter aurescens		P84141	1RW9[A] 1RWA[A] 1RWC[A] 1RWF[A] 1RWG[A] 1RWH[A]
xanthan lyase (Xly)	4.2.2.12	Bacillus sp. GL1	BAB21059.1	Q9AQS0	1J0M[A] 1J0N[A] 1X1H[A] 1X1I[A] 1X1J[A] 2E22[A] 2E24[A]
chondroitin sulfate lyase AC (CslA)	4.2.2.5	Bacteroides stercoris HJ-15	ABW87764.1	A9Y5J0		3
BT3324	4.2.2.20	Bacteroides thetaiotaomicron VPI-5482	AAO78430.1 NP_812236.1	Q8A2I1		2
chondroitin sulfate ABC lyase	4.2.2.20	Bacteroides thetaiotaomicron WAL2926	ABV21364.1	C5G6D7	2Q1F[A,B]	2
chondroitin AC lyase (CslA)	4.2.2.5	Flavobacterium columnare G4	AAX07421.1	Q5EC33		3
xanthan lyase (XalA)	4.2.2.12	Paenibacillus alginolyticus XL-1	AAG24953.1	Q9F8Q9
chondroitin AC lyase (CslA;ChnAC;Phep_0786)	4.2.2.5	Pedobacter heparinus DSM 2366	AAC83383.1 ACU03008.1	Q59288	1CB8[A] 1HM2[A] 1HM3[A] 1HMU[A] 1HMW[A]	3
hyaluronate lyase (Hyase)	4.2.2.1	Propionibacterium acnes	AAA51650.1	Q59634
PPA0380 (hyaluronate lyase)	4.2.2.1	Propionibacterium acnes KPA171202	AAT82132.1
chondroitin ABC lyase I	4.2.2.20	Proteus vulgaris	2109195A ABE23097.1 ACN04689.1 ACQ12496.1 ACQ12497.1 ACW17440.1 ACW17441.1 ACY01450.1	P59807	1HN0[A]	2
chondroitin ABC lyase II (ChABCII)	4.2.2.20	Proteus vulgaris ATCC 6896	AAB43333.1 ABU46331.1		cryst	2
hyaluronate lyase (HysA)	4.2.2.1	Staphylococcus aureus 8325-4	AAA82984.1	Q59801		1
hyaluronate lyase (HylB)	4.2.2.1	Streptococcus agalactiae 4755	CAA75865.1	O86478		1
hyaluronate lyase	4.2.2.1	Streptococcus agalactiae TYPE III / GBS 3502	AAA56749.1	Q53591	1F1S[A] 1I8Q[A] 1LXM[A]	1
hyaluronate lyase	4.2.2.1	Streptococcus constellatus subsp. constellatus ATCC 27823	AAK67165.1	Q934I5		1
hyaluronidase (Hyl)	4.2.2.1	Streptococcus equi subsp. zooepidemicus CVCC23362	ABV69920.1	A8HJR5		1
hyaluronate lyase	4.2.2.1	Streptococcus intermedius ATCC 27335	AAK67167.1	Q934I4		1
hyaluronate lyase (HysA)	4.2.2.1	Streptococcus pneumoniae R6	AAA53685.1 AAA53686.1 AAK99090.1 AAT16666.1 ACK14456.1 ACW45175.1 NP_357880.1	Q8CWU3	1C82[A] 1EGU[A] 1F9G[A] 1LOH[A] 1LXK[A] 1N7N[A] 1N7O[A] 1N7P[A] 1N7Q[A] 1N7R[A] 1OJM[A] 1OJN[A] 1OJO[A] 1OJP[A] 1W3Y[A] 2BRP[A] 2BRV[X] 2BRW[A,B]	1
hyaluronate lyase (SP0314)	4.2.2.1	Streptococcus pneumoniae TIGR4	AAK74491.1 NP_344851.1	Q54873.2		1
hyaluronate lyase (HylA)	4.2.2.1	Streptococcus pyogenes	AAF29533.1	Q9L7W9		1
HylA (fragment)	4.2.2.1	Streptococcus suis	ADF49630.1 CAC87664.1	Q8VLQ6
HylA	4.2.2.1	Streptococcus suis P5/11/88	CAC87663.1	Q8VLQ7		1
hyaluronidase (HylA)	4.2.2.1	Streptococcus suis SEROTYPE 7	CAC87662.1	Q8VLQ8		1
hyaluronate lyase (PL8Hyal;SCO5534;SC1C2.15)	4.2.2.1	Streptomyces coelicolor A3(2)	CAA19982.1 NP_629668.1	O86516	2WCO[A] 2WDA[A] 2X03[A,B]
VFA0994	4.2.2.1	Vibrio fischeri ES114	AAW88064.1	Q5DYT2

Footnotes

Experimental characterization exclusively covers enzyme activities at present. If you are aware of any missing experimental characterization that should be mentioned here, we encourage you to send your comment and support of the experimental evidence, including an electronic copy or appropriate link to the support material (i.e., article(s), thesis, database, etc), to cazy@afmb.univ-mrs.fr.