Polysaccharide Lyase Family 8

Activities in Family	Exo-β-1,4-glucuronan lyase (EC 4.2.2.-); Exo-hyaluronate lyase (EC 4.2.2.-); Hyaluronate lyase (EC 4.2.2.1); Xanthan lyase (EC 4.2.2.12); Chondroitinase B (EC 4.2.2.19); Poly(β-mannuronate) lyase / M-specific alginate lyase (EC 4.2.2.3); Chondroitin AC lyase (EC 4.2.2.5); Heparin lyase / heparin lyase I (EC 4.2.2.7);
Mechanism	b-elimination
3D Structure Status	( α / α ) ₆ toroid + anti-parallel β-sheet
Commercial Enzyme Provider(s)	MEGAZYME; PROZOMIX;
Statistics	GenBank accession (4871); Uniprot accession (33); PDB accession (54); 3D entries (13); cryst (1)

Summary

Download PL8 (5315) Taxonomic display Structure (13 - 1 cryst) Characterized (34)


Bacteria
Protein Name	EC#	Reference	Organism	GenBank	Uniprot	PDB/3D	Subf
hyaluronidase (Hyl; HAase-B)	4.2.2.1	pubmed	Bacillus sp. A50	AHB61202.1	W5RSC1
xanthan lyase (BXL; Xly)	4.2.2.12	pubmed	Bacillus sp. GL1	BAB21059.1	Q9AQS0	1J0M[A] 1J0N[A] 1X1H[A] 1X1I[A] 1X1J[A] 2E22[A] 2E24[A]
chondroitin sulfate lyase AC (CslA)	4.2.2.5	pubmed	Bacteroides stercoris HJ-15	ABW87764.1	A9Y5J0		3
chondroitin-sulfate lyase (BT_3324; BT3324)	4.2.2.5	pubmed	Bacteroides thetaiotaomicron VPI-5482	AAO78430.1 NP_812236.1	Q8A2I1		2
chondroitin-sulfate lyase (CsuB; BT_3350; BT3350)	4.2.2.5	pubmed	Bacteroides thetaiotaomicron VPI-5482	AAO78456.1 AAA99039.1 NP_812262.1	Q45773 Q8A2F5		2
chondroitin sulfate ABC lyase	4.2.2.5 4.2.2.19	doi doi	Bacteroides thetaiotaomicron WAL2926	ABV21364.1	C5G6D7	2Q1F[A,B]	2
exo-hyaluronate lyase (HylB; HYL-IB/II; PPA0380)	4.2.2.-	pubmed	Cutibacterium acnes KPA171202	AAT82132.1	P0CZ01	8FNX[A] 8G0O[A,B]
hyaluronate lyase (HylA;HMPREF0675_3415)	4.2.2.1	pubmed	Cutibacterium acnes SK137	ADD99051.1		8FYG[A,B]
chondroitin AC lyase (CslA;ChonAC)	4.2.2.5	pubmed	Flavobacterium columnare G4	AAX07421.1	Q5EC33		3
chondroitin lyase A (CslA; C6N29_05590)	4.2.2.5	pubmed	Flavobacterium columnare MS-FC-4	PTD13951.1			3
xanthan lyase (AB663_001102)	4.2.2.12	pubmed	Microbacterium sp. XT11	ALX66168.1
heparinase (Hep)	4.2.2.7	pubmed	Niallia circulans	BAB91369.1	Q8KKH9		2
chondroitin AC lyase (partial)	4.2.2.1 4.2.2.5	pubmed pubmed	Paenarthrobacter aurescens		P84141	1RWA[A] 1RWC[A] 1RWF[A] 1RWG[A] 1RWH[A] 1RW9[A]
xanthan lyase (XL; XalA)	4.2.2.12	pubmed	Paenibacillus alginolyticus XL-1	AAG24953.1	Q9F8Q9
xanthan lyase (PXL)	4.2.2.12	pubmed	Paenibacillus nanensis 62047 / Paenibacillus sp. 62047	AXR85425.1	A0A3S7RW91 A0A493R6T1	6F2P[A]
chondroitin AC lyase (CslA;ChnAC;Phep_0786)	4.2.2.5	pubmed	Pedobacter heparinus DSM 2366	ACU03008.1 AAC83383.1	Q59288	1CB8[A] 1HM2[A] 1HM3[A] 1HMU[A] 1HMW[A]	3
chondroitin ABC lyase I / chondroitinase ABC (ChABC)	4.2.2.5 4.2.2.19	pubmed pubmed	Proteus vulgaris	2109195A ABE23097.1 ACN04689.1 ACQ12496.1 ACQ12497.1 ACW17440.1 ACW17441.1 ACY01450.1	P59807	1HN0[A] 7EIP[A] 7EIQ[A] 7EIR[A] 7EIS[A] 7YKE[A]	2
chondroitin AC lyase II (ChACII)	4.2.2.5	pubmed	Proteus vulgaris ATCC 6896	AAB43333.1 ABU46331.1	C7S340	cryst	2
hyaluronate lyase (HysA)	4.2.2.1	pubmed	Staphylococcus aureus 8325-4	AAA82984.1	Q59801		1
hyaluronate lyase (HylB)	4.2.2.1	pubmed	Streptococcus agalactiae 4755	CAA75865.1	O86478		1
hyaluronate lyase (HylB;SaHyl;Gbs1270)	4.2.2.1	pubmed	Streptococcus agalactiae NEM316	CAD46929.1 AAA56749.1 NP_735714.1	Q53591	1F1S[A] 1I8Q[A] 1LXM[A]	1
hyaluronate lyase	4.2.2.1	pubmed	Streptococcus constellatus subsp. constellatus ATCC 27823	AAK67165.1	Q934I5		1
hyaluronidase (Hyl)	4.2.2.1	doi	Streptococcus equi subsp. zooepidemicus CVCC23362	ABV69920.1	A8HJR5		1
hyaluronate lyase	4.2.2.1	pubmed	Streptococcus intermedius ATCC 27335	AAK67167.1	Q934I4		1
hyaluronate lyase (HysA)	4.2.2.1	pubmed	Streptococcus pneumoniae R6	AAK99090.1 AAA53685.1 AAA53686.1 AAT16666.1 ACK14456.1 ACW45175.1 NP_357880.1	Q54873 Q8CWU3	1C82[A] 1EGU[A] 1F9G[A] 1LOH[A] 1LXK[A] 1N7N[A] 1N7O[A] 1N7P[A] 1N7Q[A] 1N7R[A] 1OJM[A] 1OJN[A] 1OJO[A] 1OJP[A] 1W3Y[A] 2BRP[A] 2BRV[X] 2BRW[A,B]	1
hyaluronate lyase (Hyl;SpHyl;SP0314)	4.2.2.1	pubmed	Streptococcus pneumoniae TIGR4	AAK74491.1 NP_344851.1	Q54873		1
hyaluronate lyase (HylA)	4.2.2.1	pubmed	Streptococcus pyogenes	AAF29533.1	Q9L7W9		1
HylA	4.2.2.1	pubmed	Streptococcus suis P5/11/88	CAC87663.1	Q8VLQ7		1
hyaluronidase (HylA)	4.2.2.1	pubmed	Streptococcus suis SEROTYPE 7	CAC87662.1	Q8VLQ8		1
hyaluronate lyase (PL8Hyal;SCO5534;SC1C2.15)	4.2.2.1	pubmed	Streptomyces coelicolor A3(2)	CAA19982.1 NP_629668.1	O86516	2WCO[A] 2WDA[A] 2X03[A,B]
hyaluronan/chondroitin sulphate lyase (HCLase)	4.2.2.1 4.2.2.5	pubmed pubmed	Vibrio sp. FC509	AUX13101.1	A0A2L0E6P5
glycosaminoglycan lyase / eliminase (HCLase)	4.2.2.1 4.2.2.5	pubmed pubmed	Vibrio sp. FC509	AIL54323.1	A0A077ERI8
Eukaryota
Protein Name	EC#	Reference	Organism	GenBank	Uniprot	PDB/3D	Subf
mannuronic acid specific lyase (PsMan8A) (Man8A)	4.2.2.3	pubmed	Paradendryphiella salina	VYG66350.1	A0A5Q5AD67	7R2X[A,B]	4
exo-β-1,4-glucuronan lyase (TpPL8A; A9Z42_0065330)	4.2.2.-	pubmed	Trichoderma parareesei	OTA05836.1	A0A2H2ZV03		4
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