Polysaccharide Lyase Family 8

Activities in Familyhyaluronate lyase (EC 4.2.2.1); chondroitin AC lyase (EC 4.2.2.5); xanthan lyase (EC 4.2.2.12); chondroitin ABC lyase (EC 4.2.2.20)
3D Structure Status( α / α ) 6 barrel + anti-parallel β-sheet
Commercial Enzyme Provider(s)MEGAZYME; PROZOMIX;
Statistics GenBank accession (1231); Uniprot accession (198); PDB accession (44); 3D entries (9); cryst (1)
All (1151) Archaea (1) Bacteria (1148) Eukaryota (2) Structure (9 - 1 cryst) Characterized (27)
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
Subf
 xanthan lyase (Xly) 4.2.2.12 Bacillus sp. GL1 BAB21059.1 Q9AQS0
1J0M[A] 2.30
1J0N[A] 2.40
1X1H[A] 2.30
1X1I[A] 1.80
1X1J[A] unknown-(1-4)-D-1-deoxy-GlcpA
2.10
2E22[A] β-D-Manp
2.40
2E24[A] 2.15
 chondroitin sulfate ABC lyase 4.2.2.20 Bacteroides thetaiotaomicron WAL2926 ABV21364.1 C5G6D7
2Q1F[A,B] 2.85
2
 chondroitin AC lyase (partial) 4.2.2.1
4.2.2.5
Paenarthrobacter aurescens   P84141
1RWA[A] 1.30
1RWC[A] α-L-4-deoxy-IdopA-(1-3)-β-D-GlcpNAc
1.90
1RWF[A] α-L-4-deoxy-IdopA-(1-3)-β-D-GalpNAc4SO3-(1-4)-β-D-GlcpA-(1-3)-β-D-Galp4SO3
1.45
1RWG[A] α-L-4-deoxy-IdopA-(1-3)-β-D-GalpNAc4SO3-(1-4)-β-D-GlcpA-(1-3)-β-D-Galp4SO3
1.50
1RWH[A] α-L-4-deoxy-IdopA-(1-3)-β-D-GalpNAc4SO3-(1-4)-β-D-GlcpA-(1-3)-β-D-Galp4SO3
1.25
1RW9[A] 1.35
 chondroitin AC lyase (CslA;ChnAC;Phep_0786) 4.2.2.5 Pedobacter heparinus DSM 2366 ACU03008.1
AAC83383.1
Q59288
1CB8[A] 1.90
1HM2[A] α-L-IdopA-(1-3)-β-D-GalpNAc4SO3-(1-4)-α-L-IdopA-(1-3)-β-D-GalpNAc4SO3
2.00
1HM3[A] β-D-GlcpA-(1-3)-β-D-GlcpNAc
2.10
1HMU[A] α-L-4-deoxy-IdopA-(1-3)-β-D-GalpNAc4SO3
2.00
1HMW[A] β-D-4-deoxy-GlcpA-(1-3)-β-D-GalpNAc4SO3-(1-4)-β-D-GlcpA-(1-3)-β-D-GalpNAc6SO3
2.30
3
 chondroitin ABC lyase I / chondroitinase ABC (ChABC) 4.2.2.20 Proteus vulgaris 2109195A
ABE23097.1
ACN04689.1
ACQ12496.1
ACQ12497.1
ACW17440.1
ACW17441.1
ACY01450.1
P59807
1HN0[A] 1.90
2
 chondroitin ABC lyase II (ChABCII) 4.2.2.20 Proteus vulgaris ATCC 6896 AAB43333.1
ABU46331.1
 
cryst    
2
 hyaluronate lyase (HylB;SaHyl;Gbs1270) 4.2.2.1 Streptococcus agalactiae NEM316 CAD46929.1
AAA56749.1
NP_735714.1
Q53591
1F1S[A] 2.10
1I8Q[A] β-D-4-deoxy-GlcpA-(1-3)-β-D-GlcpNAc
2.20
1LXM[A] β-D-GalpA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc
2.20
1
 hyaluronate lyase (HysA) 4.2.2.1 Streptococcus pneumoniae R6 AAK99090.1
AAA53685.1
AAA53686.1
AAT16666.1
ACK14456.1
ACW45175.1
NP_357880.1
Q8CWU3
1C82[A] α-L-4-deoxy-IdopA-(1-3)-β-D-GlcpNAc
1.70
1EGU[A] 1.56
1F9G[A] 2.00
1LOH[A] β-D-GalpA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc
2.00
1LXK[A] β-D-GlcpA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc
1.53
1N7N[A] 1.55
1N7O[A] 1.50
1N7P[A] 1.55
1N7Q[A] β-D-GalpA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc
2.30
1N7R[A] β-D-GalpA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc
2.20
1OJM[A] α-L-4-deoxy-IdopA-(1-3)-β-D-GalpNAc
1.78
1OJN[A] 1.60
1OJO[A] 1.75
1OJP[A] 1.90
1W3Y[A] 1.65
2BRP[A] 2.0
2BRV[X] 3.3
2BRW[A,B] 2.8
1
 hyaluronate lyase (PL8Hyal;SCO5534;SC1C2.15) 4.2.2.1 Streptomyces coelicolor A3(2) CAA19982.1
NP_629668.1
O86516
2WCO[A] β-D-4-deoxy-GlcpA-(1-3)-β-D-GlcpNAc
1.94
2WDA[A] α-L-4-deoxy-IdopA-(1-3)-β-D-GalpNAc4SO3
2.30
2X03[A,B] 2.30
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