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Polysaccharide Lyase Family 8

Activities in FamilyExo-β-1,4-glucuronan lyase (EC 4.2.2.-);
Exo-hyaluronate lyase (EC 4.2.2.-);
Hyaluronate lyase (EC 4.2.2.1);
Xanthan lyase (EC 4.2.2.12);
Chondroitinase B (EC 4.2.2.19);
Poly(β-mannuronate) lyase / M-specific alginate lyase (EC 4.2.2.3);
Chondroitin AC lyase (EC 4.2.2.5);
Heparin lyase / heparin lyase I (EC 4.2.2.7);
Mechanism b-elimination
3D Structure Status( α / α ) 6 toroid + anti-parallel β-sheet
Commercial Enzyme Provider(s)MEGAZYME; PROZOMIX;
Statistics GenBank accession (4733); Uniprot accession (30); PDB accession (54); 3D entries (13); cryst (1)
Summary
Download PL8 (5091) Taxonomic display Structure (13 - 1 cryst) Characterized (33)
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 Subf
 xanthan lyase (BXL; Xly) 4.2.2.12 Bacillus sp. GL1 BAB21059.1 Q9AQS0
1J0M[A] 2.30
1J0N[A] 2.40
1X1H[A] 2.30
1X1I[A] 1.80
1X1J[A] unknown-(1-4)-D-1-deoxy-GlcpA
 2.10
2E22[A] β-D-Manp
 2.40
2E24[A] 2.15
 chondroitin sulfate ABC lyase 4.2.2.19
4.2.2.5		 Bacteroides thetaiotaomicron WAL2926 ABV21364.1 C5G6D7
2Q1F[A,B] 2.85
2
 exo-hyaluronate lyase (HylB; HYL-IB/II; PPA0380) 4.2.2.- Cutibacterium acnes KPA171202 AAT82132.1 P0CZ01
8FNX[A] 2.10
8G0O[A,B] 2.10
 hyaluronate lyase (HylA;HMPREF0675_3415) 4.2.2.1 Cutibacterium acnes SK137 ADD99051.1  
8FYG[A,B] 2.05
 chondroitin AC lyase (partial) 4.2.2.1
4.2.2.5		 Paenarthrobacter aurescens   P84141
1RWA[A] 1.30
1RWC[A] α-L-4-deoxy-IdopA-(1-3)-β-D-GlcpNAc
 1.90
1RWF[A] α-L-4-deoxy-IdopA-(1-3)-β-D-GalpNAc4SO3-(1-4)-β-D-GlcpA-(1-3)-β-D-Galp4SO3
 1.45
1RWG[A] α-L-4-deoxy-IdopA-(1-3)-β-D-GalpNAc4SO3-(1-4)-β-D-GlcpA-(1-3)-β-D-Galp4SO3
 1.50
1RWH[A] α-L-4-deoxy-IdopA-(1-3)-β-D-GalpNAc4SO3-(1-4)-β-D-GlcpA-(1-3)-β-D-Galp4SO3
 1.25
1RW9[A] 1.35
 xanthan lyase (PXL) 4.2.2.12 Paenibacillus nanensis 62047 / Paenibacillus sp. 62047 AXR85425.1 A0A3S7RW91
A0A493R6T1
6F2P[A] 2.60
 chondroitin AC lyase (CslA;ChnAC;Phep_0786) 4.2.2.5 Pedobacter heparinus DSM 2366 ACU03008.1
AAC83383.1		 Q59288
1CB8[A] 1.90
1HM2[A] α-L-IdopA-(1-3)-β-D-GalpNAc4SO3-(1-4)-α-L-IdopA-(1-3)-β-D-GalpNAc4SO3
 2.00
1HM3[A] β-D-GlcpA-(1-3)-β-D-GlcpNAc
 2.10
1HMU[A] α-L-4-deoxy-IdopA-(1-3)-β-D-GalpNAc4SO3
 2.00
1HMW[A] β-D-4-deoxy-GlcpA-(1-3)-β-D-GalpNAc4SO3-(1-4)-β-D-GlcpA-(1-3)-β-D-GalpNAc6SO3
 2.30
3
 chondroitin ABC lyase I / chondroitinase ABC (ChABC) 4.2.2.19
4.2.2.5		 Proteus vulgaris 2109195A
ABE23097.1
ACN04689.1
ACQ12496.1
ACQ12497.1
ACW17440.1
ACW17441.1
ACY01450.1		 P59807
1HN0[A] 1.90
7EIP[A] 1.88
7EIQ[A] α-L-4-deoxy-IdopA-(1-3)-β-D-GalpNAc4SO3
β-D-4-deoxy-GlcpA-(1-3)-β-D-GalpNAc4SO3
 1.80
7EIR[A] α-L-4-deoxy-IdopA-(1-3)-β-D-GalpNAc6SO3
β-D-4-deoxy-GlcpA-(1-3)-β-D-GalpNAc6SO3
 1.92
7EIS[A] α-L-4-deoxy-IdopA-(1-3)-β-D-GalpNAc
β-D-4-deoxy-GlcpA-(1-3)-β-D-GalpNAc
 2.50
7YKE[A] β-D-4-deoxy-GlcpA-(1-3)-β-D-GalpNAc4SO36SO3
 1.88
2
 chondroitin AC lyase II (ChACII) 4.2.2.5 Proteus vulgaris ATCC 6896 AAB43333.1
ABU46331.1		 C7S340
cryst    
2
 hyaluronate lyase (HylB;SaHyl;Gbs1270) 4.2.2.1 Streptococcus agalactiae NEM316 CAD46929.1
AAA56749.1
NP_735714.1		 Q53591
1F1S[A] 2.10
1I8Q[A] β-D-4-deoxy-GlcpA-(1-3)-β-D-GlcpNAc
 2.20
1LXM[A] β-D-GalpA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc
 2.20
1
 hyaluronate lyase (HysA) 4.2.2.1 Streptococcus pneumoniae R6 AAK99090.1
AAA53685.1
AAA53686.1
AAT16666.1
ACK14456.1
ACW45175.1
NP_357880.1		 Q54873
Q8CWU3
1C82[A] α-L-4-deoxy-IdopA-(1-3)-β-D-GlcpNAc
 1.70
1EGU[A] 1.56
1F9G[A] 2.00
1LOH[A] β-D-GalpA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc
 2.00
1LXK[A] β-D-GlcpA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc
 1.53
1N7N[A] 1.55
1N7O[A] 1.50
1N7P[A] 1.55
1N7Q[A] β-D-GalpA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc
 2.30
1N7R[A] β-D-GalpA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-3)-β-D-GlcpNAc
 2.20
1OJM[A] α-L-4-deoxy-IdopA-(1-3)-β-D-GalpNAc
 1.78
1OJN[A] 1.60
1OJO[A] 1.75
1OJP[A] 1.90
1W3Y[A] 1.65
2BRP[A] 2.0
2BRV[X] 3.3
2BRW[A,B] 2.8
1
 hyaluronate lyase (PL8Hyal;SCO5534;SC1C2.15) 4.2.2.1 Streptomyces coelicolor A3(2) CAA19982.1
NP_629668.1		 O86516
2WCO[A] β-D-4-deoxy-GlcpA-(1-3)-β-D-GlcpNAc
 1.94
2WDA[A] α-L-4-deoxy-IdopA-(1-3)-β-D-GalpNAc4SO3
 2.30
2X03[A,B] 2.30
Eukaryota
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 Subf
 mannuronic acid specific lyase (PsMan8A) (Man8A) 4.2.2.3 Paradendryphiella salina VYG66350.1 A0A5Q5AD67
7R2X[A,B] 3.35
4
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