Glycoside Hydrolase Family 5 / Subf 8

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (353); Uniprot accession (76); PDB accession (10); 3D entries (6); cryst (0)
| 1 | 2 | 3 | 4 |
Bacteria
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 AHOG_12310 (Mana1)   Actinoalloteichus hoggarensis DSM 45943 ASO20105.1     8
 TL08_12195   Actinoalloteichus hymeniacidonis HPA177(T) (=DSM 45092(T)) AOS63253.1     8
 UA74_13020   Actinoalloteichus sp. ADI127-7 APU14662.1     8
 UA75_13100   Actinoalloteichus sp. GBA129-24 APU20630.1     8
 SAMN04489716_4311   Actinoplanes derwentensis DSM 43941 SDT52805.1     8
 SAMN04489716_3740   Actinoplanes derwentensis DSM 43941 SDT42643.1     8
 AFR_18915   Actinoplanes friuliensis DSM 7358 AGZ42057.1     8
 AMIS_23050   Actinoplanes missouriensis 431 BAL87525.1     8
 AMIS_40420   Actinoplanes missouriensis 431 BAL89262.1     8
 L083_5388   Actinoplanes sp. N902-109 AGL18898.1     8
 Amir_1830   Actinosynnema mirum DSM 43827 ACU35778.1 C6WE35   8
 Amir_4152   Actinosynnema mirum DSM 43827 ACU38007.1 C6WH88   8
 CNX65_20775   Actinosynnema pretiosum X47 ATE55417.1     8
 CNX65_09135   Actinosynnema pretiosum X47 ATE53439.1     8
 β-1,4-mannanase   Alicyclobacillus acidocaldarius AAT47714.1     8
 glycosyl hydrolase family 5_8 and glycosyl hydrolase family 6 domain-containing protein   Alteromonadaceae bacterium Bs02 AIF91556.1     8
 glycosyl hydrolase family 5_8 domain-containing protein, partial   Alteromonadaceae bacterium Bs08 AIF91546.1     8
 glycosyl hydrolase family 5_8 domain-containing protein   Alteromonadaceae bacterium Bs12 AIF91534.1     8
 AXY_08250   Amphibacillus xylanus NBRC 15112 BAM46957.1     8
 B737_7302   Amycolatopsis mediterranei RB AGT87963.1     8
 RAM_38105   Amycolatopsis mediterranei S699 AEK46088.1
AFO80835.1
    8
 AMED_7413   Amycolatopsis mediterranei U32 ADJ49127.1 D8I9G0   8
 SD37_16955   Amycolatopsis orientalis B-37 ANN17163.1     8
 β-mannanase   Bacillus circulans AAS48170.1 Q6QHT4   8
 β-mannanase (TM1) 3.2.1.78 Bacillus circulans AAT39478.1 Q6IUP2   8
 β-mannanase (Man1;ManB48) 3.2.1.78 Bacillus circulans CGMCC 1416 AAX87002.1 Q49HI4   8
 β-mannanase (Man5A) 3.2.1.78 Bacillus circulans CGMCC1554 AAX87003.1 Q0IJR6   8
 β-mannanase (G) 3.2.1.78 Bacillus circulans K-1 BAA25878.1 O66185   8
 BC8716_04830   Bacillus clausii DSM 8716 AST98531.1     8
 DB29_01746   Bacillus clausii ENTPro ALA52574.1     8
 ABC0320   Bacillus clausii KSM-K16 BAD62862.1 Q5WL93   8
 β-mannanase (MANPN11) (fragment) 3.2.1.78 Bacillus nealsonii PN-11 AGU71466.2
AGU71466.1
AGU71466.3
    8
 Sequence 16 from patent US 6566114   Bacillus sp. AAQ31841.1     8
 β-mannanase   Bacillus sp. AAQ31834.1     8
 Sequence 22 from patent US 6566114   Bacillus sp. AAQ31844.1     8
 Sequence 12 from patent US 6566114   Bacillus sp. AAI12 AAQ31839.1     8
 Sequence 20 from patent US 7183093 (fragment)   Bacillus sp. AAI12 ABP12275.1     8
 β-mannanase (Amn5) (Man5A) 3.2.1.78 Bacillus sp. JAMB-602 BAD99527.1 Q4W8M3 1WKY[A] 8
 β-mannanase (ManA;MAN330) (Man5A) 3.2.1.78 Bacillus sp. N16-5 AAT06599.1
AML27065.1
Q5YEX6 3JUG[A] 8
 BAA6_1442   Bifidobacterium animalis A6 AJD34555.1     8
 BGL50_07200   Bifidobacterium animalis BL3 ASL78238.1     8
 EN10_07335   Bifidobacterium animalis RH AIA33432.1     8
 BLA_0648   Bifidobacterium animalis subsp. lactis AD011 ACL28941.1 B8DWU0   8
 BLAC_07295   Bifidobacterium animalis subsp. lactis ATCC 27673 AGW85630.1     8
 W7Y_1448   Bifidobacterium animalis subsp. lactis B420 AFJ17159.1     8
 BIF_00941   Bifidobacterium animalis subsp. lactis BB-12 ADC84837.1 D3R6V5   8
 GU89_07345   Bifidobacterium animalis subsp. lactis BF052 AJD89158.1     8
 W91_1479   Bifidobacterium animalis subsp. lactis Bi-07 AFJ18748.1     8
 ManN   Bifidobacterium animalis subsp. lactis BI07 BAH23806.1 B9X294   8
 Balac_1450 3.2.1.78 Bifidobacterium animalis subsp. lactis Bl-04 ACS46797.1 C6A9J9   8
 Bl12_1362   Bifidobacterium animalis subsp. lactis Bl12 AGO52880.1     8
 BLC1_1405   Bifidobacterium animalis subsp. lactis BLC1 AEN77175.1     8
 BALAC2494_01288   Bifidobacterium animalis subsp. lactis CNCM I-2494 AEK30917.1     8
 Balat_1450   Bifidobacterium animalis subsp. lactis DSM 10140 ACS48364.1 C6AFP1   8
 U723_07350   Bifidobacterium animalis subsp. lactis KLDS2.0603 AJC77114.1     8
 BalV_1405   Bifidobacterium animalis subsp. lactis V9 ADG33993.1 D5TIR7   8
 β-1,4-mannanase (ManA) 3.2.1.78 Caldibacillus cellulovorans AAF22274.1 Q9RFX5   8
 bifunctional mannanase / endoglucanase (CbMan5A/Cel44A;Athe_1859;Cbes_1859;ORF1946) (Man5A-Cel44A) 3.2.1.4
3.2.1.78
Caldicellulosiruptor bescii DSM 6725 ACM60947.1 B9MKT9   8
 bifunctional cellulase / β-mannanase (CelC-ManB;CbCel9B/Man5A;Athe_1865;Cbes_1865;Orf1952) (Cel9B-Man5A) 3.2.1.4
3.2.1.78
Caldicellulosiruptor bescii DSM 6725 ACM60953.1 B9MKU5   8
 Athe_1866 (CelB;CbMan5C/Cel5A) (Man5C-Cel5A) 3.2.1.4 Caldicellulosiruptor bescii DSM 6725 ACM60954.1 B9MKU6   8
 Calkro_0851   Caldicellulosiruptor kronotskyensis 2002 ADQ45728.1 E4SDB9   8
 Calkro_0854   Caldicellulosiruptor kronotskyensis 2002 ADQ45730.1 E4SDC1   8
 Calkro_0856 (fragment)   Caldicellulosiruptor kronotskyensis 2002 ADQ45732.1 E4SDC3   8
 COB47_1669   Caldicellulosiruptor obsidiansis OB47 ADL42950.1 D9TFI0   8
 bifunctional β-mannanase / endo-β-1,4-glucanase (ManA) 3.2.1.4
3.2.1.78
Caldicellulosiruptor saccharolyticus AAA71887.1
AAA72861.1
P22533   8
 Csac_1077 (ManA)   Caldicellulosiruptor saccharolyticus DSM 8903 ABP66691.1 A4XIF6   8
 Csac_1080 (ManB) (fragment)   Caldicellulosiruptor saccharolyticus DSM 8903 ABP66694.1 A4XIF9   8
 CA608_04095   Caulobacter vibrioides CB2 ATC23771.1     8
 Cfla_2811   Cellulomonas flavigena DSM 20109 ADG75696.1 D5UJQ8   8
 Celgi_2637   Cellulomonas gilvus ATCC 13127 AEI13136.1     8
 CBP52_10310   Cellulomonas sp. PSBB021 ASR55418.1     8
 CBR64_11685   Cellulosimicrobium cellulans PSBB019 ARU52036.1     8
 CBR64_01715   Cellulosimicrobium cellulans PSBB019 ARU50408.1     8
 CBR64_01710   Cellulosimicrobium cellulans PSBB019 ARU50407.1     8
 endo-β-1,4-mannanase (ManB)   Cellulosimicrobium cellulans YB-43 AQQ16388.1     8
 β-1,4-mannanase (ManH) 3.2.1.78 Cellulosimicrobium sp. HY-13 AEE43708.1     8
 endo-β-1,4-mannanase 5A (CjMan5A;CJA_3338) (Man5A) 3.2.1.78 Cellvibrio japonicus Ueda107 ACE84673.1
AAO31759.1
B3PF24
Q840C2
  8
 endo-β-1,4-mannanase 5B (CJA_2475) (Man5B) 3.2.1.78 Cellvibrio japonicus Ueda107 AAO31760.1
ACE84941.1
B3PKK7
Q840C1
  8
 CBR65_07645   Cellvibrio sp. PSBB006 ARU29988.1     8
 CM240_1811   Clostridium bornimense M2/40 CDM68969.1     8
 NPD4_1214   Clostridium butyricum CDC_51208 APF25044.1     8
 ATD26_04905   Clostridium butyricum JKY6D1 ALS16221.1     8
 ATN24_06355   Clostridium butyricum KNU-L09 ALP89769.1     8
 BBB49_04985   Clostridium butyricum TK520 AOR93452.1     8
 AZ909_04800   Clostridium butyricum TOA ANF13383.1     8
 CSACC_27090 (Mana_2)   Clostridium saccharobutylicum BAS/B3/SW/136 AQS00885.1     8
 CLSA_c27120   Clostridium saccharobutylicum DSM 13864 AGX43683.1     8
 CLOSACC_27090 (Mana_2)   Clostridium saccharobutylicum NCP 195 AQS14868.1     8
 CLOSC_27020 (Mana_2)   Clostridium saccharobutylicum NCP 200 AQR90981.1     8
 CLOBY_27680 (Mana_2)   Clostridium saccharobutylicum NCP 258 AQS10623.1     8
 CYFUS_003189   Cystobacter fuscus DSM 52655 ATB37764.1     8
 EUS_11000   [Eubacterium] siraeum 70/3 CBK96294.1 D4JT75   8
 ES1_20220   [Eubacterium] siraeum V10Sc8a CBL34898.1 D4MMB5   8
 MY04_5412   Flammeovirga sp. MY04 ANQ52744.1     8
 β-mannanase   Flammeovirga yaeyamensis MY04 / CGMCC2777 ACY02072.1 D0PR29   8
 YC6258_04979 (fragment)   Gynuella sunshinyii YC6258 AJQ97011.1     8
 YC6258_03986   Gynuella sunshinyii YC6258 AJQ96022.1     8
 HCH_00087   Hahella chejuensis KCTC 2396 ABC27008.1 Q2SQR6   8
 I598_1980 (Mana_1)   Isoptericola dokdonensis DS-3 ANC31527.1     8
 Jden_2229   Jonesia denitrificans DSM 20603 ACV09866.1 C7R1N1   8
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