Glycoside Hydrolase Family 5 / Subf 8

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (353); Uniprot accession (76); PDB accession (10); 3D entries (6); cryst (0)
| 1 | 2 | 3 | 4 |
Bacteria
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 Jden_2228   Jonesia denitrificans DSM 20603 ACV09865.1 C7R1N0   8
 CEP80_07175   Jonesia denitrificans FDAARGOS_301 ASE08942.1     8
 CEP80_07170   Jonesia denitrificans FDAARGOS_301 ASE08941.1     8
 BBK82_37940   Lentzea guizhouensis DHS C013 ANZ43360.1     8
 BBK82_42255   Lentzea guizhouensis DHS C013 ANZ41596.1     8
 BBK82_33585   Lentzea guizhouensis DHS C013 ANZ40233.1     8
 Mahau_1112   Mahella australiensis 50-1 BON AEE96309.1     8
 A3224_13320   Microbulbifer thermotolerans DAU221 AMX03424.1     8
 Micau_1708   Micromonospora aurantiaca ATCC 27029 ADL45263.1 D9SZY1   8
 GA0070611_0099   Micromonospora auratinigra DSM 44815 SBT37134.1     8
 GA0070612_5795   Micromonospora chokoriensis DSM 45160 SCF27982.1     8
 GA0070607_0868   Micromonospora coriariae DSM 44875 SCE72877.1     8
 GA0070614_4950   Micromonospora coxensis DSM 45161 SCG72161.1     8
 GA0070609_4089   Micromonospora echinaurantiaca DSM 43904 SCG65882.1     8
 GA0070610_3872   Micromonospora echinofusca DSM 43913 SCG17558.1     8
 GA0070618_0252   Micromonospora echinospora DSM 43816 SCE69983.1     8
 GA0070618_4986   Micromonospora echinospora DSM 43816 SCF29942.1     8
 GA0070621_0505   Micromonospora narathiwatensis DSM 45248 SBT38821.1     8
 GA0070621_1600   Micromonospora narathiwatensis DSM 45248 SBT42754.1     8
 GA0074696_4903   Micromonospora purpureochromogenes DSM 43821 SCF36577.1     8
 GA0070623_1979   Micromonospora rifamycinica DSM 44983 SCG51897.1     8
 GA0074704_2434   Micromonospora siamensis DSM 45097 SCG50027.1     8
 ML5_1968   Micromonospora sp. L5 ADU07496.1 D3CFW4   8
 GA0070619_0948   Micromonospora zamorensis DSM 45600 SCG40320.1     8
 Mycsm_06519   Mycobacterium sp. JS623 AGB26659.1     8
 Mycsm_06521   Mycobacterium sp. JS623 AGB26661.1     8
 B005_5164 (fragment)   Nocardiopsis alba ATCC BAA-2165 AFR10886.1     8
 CGQ36_15825   Nocardiopsis dassonvillei HZNU_N_1 ASU58942.1     8
 A9R04_15630   Nocardiopsis dassonvillei NOCA502F APC36031.1     8
 BN4615_P10778   Nonomuraea gerenzanensis ATCC 39727 SBP01262.1     8
 BKM31_49460   Nonomuraea sp. ATCC 55076 AQZ68439.1     8
 AR543_12180   Paenibacillus bovis BD3526 ANF96694.1     8
 PGRAT_09255   Paenibacillus graminis DSM 15220 AIQ67798.1     8
 BBD41_27510   Paenibacillus ihbetae IHBB 9852 ANY76761.1     8
 B4V02_01115   Paenibacillus kribbensis AM49 ASR45403.1     8
 PM3016_3709   Paenibacillus mucilaginosus 3016 AFC30528.1     8
 B2K_19295   Paenibacillus mucilaginosus K02 AFH62834.1     8
 KNP414_04275   Paenibacillus mucilaginosus KNP414 AEI42807.1     8
 PODO_19980   Paenibacillus odorifer DSM 15391 AIQ75360.1     8
 ABE82_20505   Paenibacillus peoriae HS311 ALA44923.1     8
 ABE82_03090   Paenibacillus peoriae HS311 ALA40572.1     8
 VK72_21225   Paenibacillus polymyxa ATCC 15970 APQ62216.1     8
 VK72_03240   Paenibacillus polymyxa ATCC 15970 APQ57839.1     8
 LK13_00505   Paenibacillus polymyxa CF05 AIY07141.1     8
 LK13_16140   Paenibacillus polymyxa CF05 AIY09978.1     8
 X809_02830   Paenibacillus polymyxa CR1 AHC18250.1     8
 X809_21705   Paenibacillus polymyxa CR1 AHC21581.1     8
 PPE_00597   Paenibacillus polymyxa E681 ADM68451.1 E0RFB6   8
 AOU00_15710   Paenibacillus polymyxa J AOK91139.1     8
 PPM_2466 (CelN)   Paenibacillus polymyxa M1 CCC85403.1     8
 PPM_0613 (Mana3)   Paenibacillus polymyxa M1 CCC83550.1     8
 RE92_08635   Paenibacillus polymyxa Sb3-1 AJE51127.1     8
 RE92_23915   Paenibacillus polymyxa Sb3-1 AJE53897.1     8
 PPSC2_c2748   Paenibacillus polymyxa SC2 ADO56715.1 E3E630   8
 PPSC2_c0660   Paenibacillus polymyxa SC2 ADO54643.1 E3EGK4   8
 PPSQR21_006420   Paenibacillus polymyxa SQR-21 SQR21 AHM64305.1     8
 PPSQR21_025410   Paenibacillus polymyxa SQR-21 SQR21 AHM66183.1     8
 PPYC1_21305   Paenibacillus polymyxa YC0136 APB72758.1     8
 PPYC2_23520   Paenibacillus polymyxa YC0573 APB77737.1     8
 PRIO_1944   Paenibacillus riograndensis SBR5 CQR54354.1     8
 β-mannanase   Paenibacillus sp. A1 ACU30843.1 C7FFF2   8
 β-1,4-mannanase (ManB)   Paenibacillus sp. CH-3 AEX60762.1     8
 H70357_25710   Paenibacillus sp. FSL H7-0357 AIQ19732.1     8
 P40081_26410   Paenibacillus sp. FSL P4-0081 AIQ31305.1     8
 ASL14_08775 (fragment)   Paenibacillus sp. IHB B 3084 ALP36244.1     8
 endoglucanase (EG5A)   Paenibacillus sp. IHB B 3084 AHA61670.1
ALP37050.1
    8
 CIC07_01570   Paenibacillus sp. RUD330 ASS64945.1     8
 PSTEL_01805   Paenibacillus stellifer DSM 14472 AIQ62043.1     8
 HPL003_05715   Paenibacillus terrae HPL-003 AET57908.1     8
 BS614_17280   Paenibacillus xylanexedens PAMC 22703 APO45595.1     8
 CIK06_09835   Plantactinospora sp. KBS50 ASW54425.1     8
 β-1,4-mannanase (AmnA)   Pseudomonas sp. ND137 BAB79290.2 Q8RR71   8
 Rumal_1363   Ruminococcus albus 7 = DSM 20455 ADU21877.1 E0L9P6   8
 Rumal_2599   Ruminococcus albus 7 = DSM 20455 ADU23074.1 E0L8X6   8
 RBI_I00637 (ManA)   Ruminococcus bicirculans 80/3 CCO04360.1     8
 β-mannanase (GH5C;RUM_21650) (Man5A) 3.2.1.78 Ruminococcus champanellensis 18P13 = JCM 17042 CBL18180.1 D4LEY5   8
 RfGH5-1/2   Ruminococcus flavefaciens WP_009984467.1     8
 Sde_0064 (Man5N)   Saccharophagus degradans 2-40 ABD79328.1 Q21PQ1   8
 Sde_0656 (Man5O)   Saccharophagus degradans 2-40 ABD79918.1 Q21N11   8
 β-mannanase (Man5A) 3.2.1.78 Salipaludibacillus agaradhaerens AAN27517.1
AAN27518.1
AAQ31837.1
AAQ79152.1
AAQ79153.1
ABC13790.1
ABC13791.1
  2WHJ[A]
2WHL[A]
8
 STHERM_c12480   Spirochaeta thermophila DSM 6192 ADN02189.1 E0RTF8   8
 Spith_1286   Spirochaeta thermophila DSM 6578 AEJ61551.1     8
 SGGB_0206 (GmuG)   Streptococcus gallolyticus subsp. gallolyticus ATCC 43143 BAK27103.1     8
 SGGBAA2069_c01800   Streptococcus gallolyticus subsp. gallolyticus ATCC BAA-2069 CBZ47352.1     8
 BTR42_00825   Streptococcus gallolyticus subsp. gallolyticus DSM 16831 AQP41170.1     8
 GALLO_0162   Streptococcus gallolyticus UCN34 CBI12654.1 D3HC62   8
 AU079_01000 (fragment)   Streptococcus infantarius ICDDRB-NRC-S5 ALT81993.1     8
 SAM23877_4871 (ManA)   Streptomyces ambofaciens ATCC 23877 AKZ57916.1     8
 SAM23877_6969   Streptomyces ambofaciens ATCC 23877 AKZ60014.1     8
 SAMR0614   Streptomyces ambofaciens ATCC 23877 CAJ88324.1 A0ACW9   8
 SAM40697_4389   Streptomyces ambofaciens DSM 40697 ANB08347.1     8
 SAM40697_6286   Streptomyces ambofaciens DSM 40697 ANB10239.1     8
 BV401_06615   Streptomyces autolyticus CGMCC0516 AQA16021.1     8
 SBI_09150   Streptomyces bingchenggensis BCW-1 ADI12268.1 D7C3Q2   8
 SCO6234 (ManA2;SC2H4.16)   Streptomyces coelicolor A3(2) CAA20610.1
NP_630335.1
O86599   8
 SCO0554 (ManA;SCF11.34c)   Streptomyces coelicolor A3(2) CAD55266.1
CAB57406.1
CAB59611.1
NP_733506.1
Q8CK53   8
 TU94_04450   Streptomyces cyaneogriseus subsp. noncyanogenus NMWT 1 AJP00836.1     8
 BN159_5046   Streptomyces davawensis JCM 4913 CCK29425.1     8
 β-1,4-mannase   Streptomyces fradiae k11 ADK91084.1     8
 SGLAU_25530   Streptomyces glaucescens GLA.O AIS01044.1     8
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