Glycoside Hydrolase Family 5 / Subf 8

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (353); Uniprot accession (76); PDB accession (10); 3D entries (6); cryst (0)
| 1 | 2 | 3 | 4 |
Bacteria
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 SGLAU_28405   Streptomyces glaucescens GLA.O AIS01618.1     8
 SHXM_01100   Streptomyces hygroscopicus XM201 AQW47637.1     8
 SIRAN8881   Streptomyces iranensis CDR16057.1     8
 Sle_14000   Streptomyces leeuwenhoekii C34 (= DSM 42122 = NRRL B-24963) CQR60862.1     8
 Sle_59560   Streptomyces leeuwenhoekii C34 (= DSM 42122 = NRRL B-24963) CQR65412.1     8
 SLINC_1228   Streptomyces lincolnensis NRRL 2936 ANS63452.1     8
 β-mannanase (ManA;SlMan) 3.2.1.78 Streptomyces lividans 1326 AAA26710.2 P51529   8
 SLIV_35170   Streptomyces lividans TK24 AIJ17911.1     8
 SLIV_06970 (CelA)   Streptomyces lividans TK24 AIJ12409.1     8
 B1H29_02170   Streptomyces pactum ACT12 AQS65900.1     8
 Sfla_4025   Streptomyces pratensis ATCC 33331 ADW05439.1 C9NFU2   8
 SPRI_0552   Streptomyces pristinaespiralis HCCB 10218 ALC18858.1     8
 SPRI_0824   Streptomyces pristinaespiralis HCCB 10218 ALC19130.1     8
 M271_44965   Streptomyces rapamycinicus NRRL 5491 AGP60361.1     8
 TUE45_06438 (Mana_2)   Streptomyces reticuli CUW31689.1     8
 A4G23_00338 (Mana_3)   Streptomyces rubrolavendulae MJM4426 AOT57549.1     8
 SCAB_78881   Streptomyces scabiei 87.22 CBG74852.1 C9ZCR3   8
 SCAB_82021   Streptomyces scabiei 87.22 CBG75158.1 C9YU29   8
 A7J05_02570   Streptomyces silaceus ACCC40021 APY84783.1     8
 CGL27_05725   Streptomyces sp. 11-1-2 ASQ92711.1     8
 SAMN05428941_6359   Streptomyces sp. 2114.2 SDT78278.1     8
 SAMN05428941_0608   Streptomyces sp. 2114.2 SDS50526.1     8
 SAMN05444521_8314   Streptomyces sp. 3124.6 SHI71357.1     8
 NI25_01330   Streptomyces sp. CCM_MD2014 AIV32327.1     8
 AS200_38935   Streptomyces sp. CdTB01 ALV37404.1     8
 AA958_33630   Streptomyces sp. CNQ-509 AKH86353.1     8
 F750_2698   Streptomyces sp. PAMC 26508 AGJ55179.1     8
 QR97_21190   Streptomyces sp. PBH53 AKN71965.1     8
 A4E84_04775   Streptomyces sp. S10(2016) AMW08869.1     8
 β-1,4-mannanase (Man5S27) 3.2.1.78 Streptomyces sp. S27 ADK91085.1 E2F4D4   8
 β-1,4-mannanase   Streptomyces sp. s6-204 ABY90130.1 B0ZSE6   8
 CAG99_02395   Streptomyces sp. SCSIO 03032 ARQ67834.1     8
 β-mannanase (SACTE_2347) 3.2.1.78 Streptomyces sp. SirexAA-E AEN10237.1   4FK9[A] 8
 β-mannanase (Man;StMan) 3.2.1.78 Streptomyces thermolilacinus NBRC14274 BAK26781.1   3WSU[A,B]
4Y7E[A,B]
8
 β-mannanase (ManII;StManII) 3.2.1.78 Streptomyces thermoluteus NBRC 14269 BAM62868.1     8
 SVEN_6894   Streptomyces venezuelae ATCC 10712 CCA60180.1     8
 SVEN_6905   Streptomyces venezuelae ATCC 10712 CCA60191.1     8
 Strvi_5490   Streptomyces violaceusniger Tu 4113 AEM85012.1     8
 SXIM_49310   Streptomyces xiamenensis 318 AKG46315.1     8
 Sros_0934   Streptosporangium roseum DSM 43021 ACZ83938.1 D2B807   8
 TERTU_4344   Teredinibacter turnerae T7901 ACR11348.1 C5BIG0   8
 TERTU_2894   Teredinibacter turnerae T7901 ACR13797.1 C5BNA8   8
 endomannanase (Man5A) 3.2.1.78 Thermobifida cellulosilytica TB100 AHB89703.1     8
 exo-β-D-mannanase   Thermobifida fusca BCRC1914 AID15578.1     8
 endomannanase, partial (fragment)   Thermobifida fusca CECT 3323 AKJ70979.1     8
 β-mannanase (Man) (partial) 3.2.1.78 Thermobifida fusca KW3 CAA06924.1 Q9ZF13 2MAN[A]
3MAN[A]
1BQC[A]
8
 endomannanase (TM51_04883) (Man5A) 3.2.1.78 Thermobifida fusca TM51 AHB89702.1     8
 β-mannanase (Man;TfMan;Tfu-man;Tfu_0900) 3.2.1.78 Thermobifida fusca YX AAZ54938.1 Q47RH9   8
 endomannanase (Man5A)   Thermobifida halotolerans YIM90462 AHB89704.1     8
 Tbis_0925   Thermobispora bispora DSM 43833 ADG87649.1 D6Y754   8
 VAB18032_13185   Verrucosispora maris AB-18-032 AEB43751.1     8
 AL536_06080   Vibrio fluvialis ATCC 33809 AMF93023.1     8
 vfu_B00526   Vibrio furnissii NCTC 11218 ADT88758.1     8
 BSQ33_10390   Vibrio gazogenes ATCC 43942 ASA57159.1     8
 β-mannanase (ManA) 3.2.1.78 Vibrio sp. MA-138 BAA25188.1 O69347   8
 AKJ12_09710   Xanthomonas arboricola pv. juglandis Xaj 417 AKU50026.1     8
 XAC1796   Xanthomonas axonopodis pv. citri str. 306 AAM36659.1
NP_642123.1
Q8PLK1   8
 XACM_1819   Xanthomonas axonopodis pv. citrumelo F1 AEO42095.1     8
 XAC29_09020   Xanthomonas axonopodis Xac29-1 AGH77288.1     8
 XB05_04035   Xanthomonas campestris 17 AKC78007.1     8
 AAW18_08870   Xanthomonas campestris pv. campestris 17 ALE68568.1     8
 AEA01_11715   Xanthomonas campestris pv. campestris 4013 AKS20523.1     8
 AEA00_11550   Xanthomonas campestris pv. campestris ICMP 21080 AKS16497.1     8
 endo-β-1,4-mannanase (ManA;XC_2458)   Xanthomonas campestris pv. campestris str. 8004 AAY49508.1 Q4UTW5   8
 endo-β-1,4-mannosidase (ManA;XCC1778) 3.2.1.78 Xanthomonas campestris pv. campestris str. ATCC 33913 AAM41068.1
NP_637144.1
Q8P9S0   8
 xcc-b100_2486 (ManA)   Xanthomonas campestris pv. campestris str. B100 CAP51846.1 Q8P9S0   8
 XCR_2021   Xanthomonas campestris pv. raphani 756C AEL06909.1     8
 XCV1826   Xanthomonas campestris pv. vesicatoria str. 85-10 AOY65436.1
CAJ23503.1
Q3BUK6   8
 AB890_09100   Xanthomonas citri pv. citri jx-6 AKM24907.1     8
 BJD09_07000   Xanthomonas citri pv. citri LH201 APR24002.1     8
 BI316_10975   Xanthomonas citri pv. citri LH276 APR19979.1     8
 BI315_22910   Xanthomonas citri pv. citri LJ207-7 APR17238.1     8
 BI314_15315   Xanthomonas citri pv. citri LL074-4 APR11329.1     8
 A9D66_09630   Xanthomonas citri pv. glycines str. 12-2 ARV22849.1     8
 BHE84_14980   Xanthomonas citri pv. glycines str. 8ra AOY63331.1     8
 BGK55_12365   Xanthomonas citri pv. malvacearum MSCT AOL21669.1     8
 XcvCFBP7111P_14665   Xanthomonas citri pv. vignicola CFBP7111 ASK92568.1     8
 XcvCFBP7113P_13085   Xanthomonas citri pv. vignicola CFBP7113 ASL01161.1     8
 J152_01948   Xanthomonas citri subsp. citri 5208 AJZ39612.1     8
 J151_01952   Xanthomonas citri subsp. citri A306 AJD68390.1     8
 XCAW_02609   Xanthomonas citri subsp. citri Aw12879 AGI08391.1     8
 J165_02617   Xanthomonas citri subsp. citri AW13 AJZ44727.1     8
 J166_02619   Xanthomonas citri subsp. citri AW14 AJZ49344.1     8
 J167_02618   Xanthomonas citri subsp. citri AW15 AJZ53963.1     8
 J168_02618   Xanthomonas citri subsp. citri AW16 AJZ66758.1     8
 J170_01943   Xanthomonas citri subsp. citri BL18 AJZ35142.1     8
 J171_01945   Xanthomonas citri subsp. citri FB19 AJZ30679.1     8
 J154_01942   Xanthomonas citri subsp. citri gd2 AJZ26252.1     8
 J155_01942   Xanthomonas citri subsp. citri gd3 AJZ21826.1     8
 J156_01942   Xanthomonas citri subsp. citri jx4 AJZ17402.1     8
 J157_01942   Xanthomonas citri subsp. citri jx5 AJZ12973.1     8
 J172_01943   Xanthomonas citri subsp. citri mf20 AJZ08511.1     8
 J162_01940   Xanthomonas citri subsp. citri MN10 AJZ04080.1     8
 J163_01940   Xanthomonas citri subsp. citri MN11 AJY99656.1     8
 J164_01940   Xanthomonas citri subsp. citri MN12 AJY95232.1     8
 J169_01949   Xanthomonas citri subsp. citri NT17 AJY90770.1     8
 B7L65_14570   Xanthomonas citri subsp. citri TX160042 ARR17990.1     8
 B7L66_12885   Xanthomonas citri subsp. citri TX160149 ARR13012.1     8
 B7L67_22060   Xanthomonas citri subsp. citri TX160197 ARR23898.1     8
 J158_01940   Xanthomonas citri subsp. citri UI6 AJY86337.1     8
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