Activities in Sub Family	Endo-β-1,4-mannanase (EC 3.2.1.78);
Mechanism	Retaining e
Clan	GH-A
3D Structure Status	( β / α ) 8 barrel
Catalytic Nucleophile/Base	Glu (experimental)
Catalytic Proton Donor	Glu (experimental)
Note	Once known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resources	CAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)	MEGAZYME; NZYTech; PROZOMIX;
Statistics	GenBank accession (10); Uniprot accession (37); PDB accession (10); 3D entries (6); cryst (0)

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Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D	Subf
PYR72_40545		Streptomyces sp. VNUA24	WEH19633.1			8
DMB38_35530		Streptomyces sp. WAC 06738	AZM50398.1			8
O7599_00625		Streptomyces sp. WMMC500	WBB61098.1			8
KV381_03610		Streptomyces sp. WY228	QXQ95506.1			8
IPZ77_02785		Streptomyces sp. XC 2026	QQN76494.1			8
β-mannanase (Man;StMan)	3.2.1.78	Streptomyces thermolilacinus NBRC14274	BAK26781.1	F5HR99	3WSU[A,B] 4Y7E[A,B]	8
β-mannanase (ManII;StManII)	3.2.1.78	Streptomyces thermoluteus NBRC 14269	BAM62868.1	K4PWK0		8
SVEN_6894		Streptomyces venezuelae ATCC 10712	CCA60180.1 QES02884.1			8
SVEN_6905		Streptomyces venezuelae ATCC 10712	CCA60191.1 QES02892.1			8
N6Q81_32360		Streptomyces vinaceusdrappus AC-40	UXI82419.1			8
R2E43_36355		Streptomyces violaceoruber CGMCC 4.1801	WOZ02640.1			8
R2E43_07170		Streptomyces violaceoruber CGMCC 4.1801	WOY97229.1			8
Strvi_5490		Streptomyces violaceusniger Tu 4113	AEM85012.1			8
CP969_06640		Streptomyces viridosporus T7A ATCC 39115	QEU84399.1			8
SXIM_49310		Streptomyces xiamenensis 318	AKG46315.1			8
Sros_0934		Streptosporangium roseum DSM 43021	ACZ83938.1			8
DKM19_02655		Streptosporangium sp. caverna	AWS40398.1			8
WKI14_13020		Teredinibacter turnerae SR01903	WYH48026.1			8
WKI14_19445		Teredinibacter turnerae SR01903	WYH49252.1			8
WKW49_18925		Teredinibacter turnerae SR02026	WYH53255.1			8
WKW49_12625		Teredinibacter turnerae SR02026	WYH52057.1			8
TERTU_4344		Teredinibacter turnerae T7901	ACR11348.1			8
TERTU_2894		Teredinibacter turnerae T7901	ACR13797.1			8
WKI13_08375		Teredinibacter turnerae T7902	WYH46958.1			8
WKI13_01235		Teredinibacter turnerae T7902	WYH45597.1			8
glycosyl hydrolase family 5_8 and glycosyl hydrolase family 6 domain-containing protein		Teredinibacter waterburyi	AIF91556.1			8
mannan endo-1,4-beta mannosidase		Thermobifida alba AHK119	BBA57841.1			8
FOF52_01230		Thermobifida alba DSM 43795	UPT19756.1			8
endomannanase (Man5ATc) (Man5A)	3.2.1.78	Thermobifida cellulosilytica TB100	AHB89703.1	A0A0A7A855		8
β-mannanase (Tfm)	3.2.1.78	Thermobifida fusca BCRC1914	AID15578.1	A0A068CD09		8
endomannanase (Man5ATa)(fragment)		Thermobifida fusca CECT 3323	AKJ70979.1			8
β-mannanase Q1.1 (Man) (partial)	3.2.1.78	Thermobifida fusca KW3	CAA06924.1	Q9ZF13	2MAN[A] 3MAN[A] 1BQC[A]	8
endomannanase (Man5ATf; TM51_04883) (Man5A)	3.2.1.78	Thermobifida fusca TM51	AHB89702.1	R9FGU8		8
IM867_08845		Thermobifida fusca UPMC 901	QOS57566.1			8
β-mannanase (Man; TfMan; Tfu-man; Tfu_0900)	3.2.1.78	Thermobifida fusca YX	AAZ54938.1	Q47RH9		8
NI17_001840		Thermobifida halotolerans DSM 44931	UOE20020.1			8
endomannanase (Man5ATh) (Man5A)	3.2.1.78	Thermobifida halotolerans YIM90462	AHB89704.1	A0A0A7A809		8
Tbis_0925		Thermobispora bispora DSM 43833	ADG87649.1			8
CYL17_06560		Thermobispora bispora ZC4	QSI47563.1			8
RM788_07720		Umezawaea sp. Da 62-37	WNV88170.1			8
HZI73_02995		Vallitalea pronyensis FatNI3	QUI25581.1			8
HUT12_09535		Verrucosispora sp. NA02020	QKW13015.1			8
O3597_16835		Verrucosispora sp. WMMA2044	WBB46848.1			8
O7597_20605		Verrucosispora sp. WMMC514	WBB89399.1			8
O7624_07445		Verrucosispora sp. WMMD1129	WFE44180.1			8
O7601_14915		Verrucosispora sp. WMMD573	WBB57245.1			8
PYE67_13480		Vibrio aestuarianus U17	WGK87139.1			8
PYE51_17975		Vibrio aestuarianus U29	WGK83245.1			8
VCSRO45_2972 (Man5A)		Vibrio cholerae RIMD 2214283	BCK15352.1			8
VCSRO51_2936 (Man5A) (fragment)		Vibrio cholerae RIMD 2214289	BCK22497.1			8
AL536_06080		Vibrio fluvialis ATCC 33809	AMF93023.1			8
KKIDH5335_31840 (fragment)		Vibrio fluvialis IDH05335	BEI24852.1			8
FIU11_17750		Vibrio furnissii FDAARGOS_777	QDC94577.1			8
vfu_B00526		Vibrio furnissii NCTC 11218	ADT88758.1			8
IUJ52_20985		Vibrio furnissii PartQ-Vfurnissii-RM8376	UON50018.1			8
QSU95_21445		Vibrio furnissii VFBJ05	WJG23581.1			8
BSQ33_10390		Vibrio gazogenes ATCC 43942	ASA57159.1			8
MKS89_01330		Vibrio gazogenes PB1	USP14015.1			8
RND59_04515		Vibrio ruber HNIBRBA4764	WNJ96366.1			8
β-mannanase (ManA)	3.2.1.78	Vibrio sp. MA-138	BAA25188.1	O69347		8
Vspart_00311 (Mana_1)		Vibrio spartinae 3.6	QMV13106.1			8
X12_002322		Xanthomonas arboricola isolate Xanthomonas sp. CPBF 796	CAD2258427.1			8
X12_002362		Xanthomonas arboricola isolate Xanthomonas sp. CPBF 1567	CAD7347286.1			8
X12_002593		Xanthomonas arboricola isolate Xanthomonas sp. CPBF 1483	CAD7350179.1			8
X12_002181		Xanthomonas arboricola isolate Xanthomonas sp. CPBF 237	CAD2257978.1			8
X12_001907		Xanthomonas arboricola isolate Xanthomonas sp. CPBF 122	CAD2246131.1			8
X12_001957		Xanthomonas arboricola isolate Xanthomonas sp. CPBF 1586	CAD7380638.1			8
X12_001977		Xanthomonas arboricola isolate Xanthomonas sp. CPBF 554	CAD7380679.1			8
X12_001969		Xanthomonas arboricola isolate Xanthomonas sp. CPBF 1514	CAD7380640.1			8
XA1311A_18330 (Man5A)		Xanthomonas arboricola 1311a	CAE6757592.1			8
XA1314C_18220 (Man5A)		Xanthomonas arboricola 1314c	CAE6757550.1			8
XAC301_26770 (Man5A)		Xanthomonas arboricola pv. corylina 301	CAE6792633.1			8
ICA18_13315		Xanthomonas arboricola pv. corylina A7	QUI82891.1			8
CFBP1159_24720 (Man5A)		Xanthomonas arboricola pv. corylina CFBP 1159	CAE6783942.1			8
KP021_12800		Xanthomonas arboricola pv. corylina CFBP 1846	UQQ09121.1			8
CFBP6600_26730 (Man5A)		Xanthomonas arboricola pv. corylina CFBP 6600	CAE6793354.1			8
KPG65_17600		Xanthomonas arboricola pv. corylina IVIA 3978	UQQ14286.1			8
XSP_001805		Xanthomonas arboricola pv. juglandis	CAD0324607.1			8
KP727_12970		Xanthomonas arboricola pv. juglandis IVIA 1317	UQQ04617.1			8
KP728_21885		Xanthomonas arboricola pv. juglandis IVIA 2499	UQQ00511.1			8
AKJ12_09710		Xanthomonas arboricola pv. juglandis Xaj 417	AKU50026.1			8
F6Y24_22335		Xanthomonas arboricola pv. pruni 15-088	QEX79326.1			8
KQR53_19535		Xanthomonas arboricola pv. pruni CITA 33	UQP93675.1			8
KP026_01250		Xanthomonas arboricola pv. pruni IVIA 2626.1	UQQ06869.1			8
K9U01_12285		Xanthomonas arboricola pv. pruni R1	UJO02614.1			8
K9U02_16375		Xanthomonas arboricola pv. pruni T1	UJO07533.1			8
L1B16_00940		Xanthomonas arboricola pv. pruni Xcp1	UJY94755.1			8
LZZ50_11295		Xanthomonas arboricola YchA	UOS97159.1			8
Xcom_10105		Xanthomonas axonopodis pv. commiphoreae LMG26789	AYO95325.1			8
XAV_09575		Xanthomonas axonopodis pv. vasculorum NCPPB 796	QKD86610.1			8
XAC29_09020		Xanthomonas axonopodis Xac29-1	AGH77288.1			8
JH307_09290		Xanthomonas campestris 10-16	WDK33330.1			8
JH302_09490		Xanthomonas campestris 11-19	WDJ91497.1			8
XB05_04035		Xanthomonas campestris 17	AKC78007.1			8
JH273_20775		Xanthomonas campestris 3054	WDK02147.1			8
JH280_09295		Xanthomonas campestris 5053	WDI95400.1			8
JH314_09130		Xanthomonas campestris CFBP5824	WDJ03540.1			8
QMY63_14630		Xanthomonas campestris GBBC 3077	WHO87343.1			8
QMY62_12450		Xanthomonas campestris GBBC 3139	WHO91151.1			8
IFJ81_12255		Xanthomonas campestris M28	QOF03674.1			8
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