Activities in Sub Family	Endo-β-1,4-mannanase (EC 3.2.1.78);
Mechanism	Retaining e
Clan	GH-A
3D Structure Status	( β / α ) 8 barrel
Catalytic Nucleophile/Base	Glu (experimental)
Catalytic Proton Donor	Glu (experimental)
Note	Once known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resources	CAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)	MEGAZYME; NZYTech; PROZOMIX;
Statistics	GenBank accession (10); Uniprot accession (37); PDB accession (10); 3D entries (6); cryst (0)

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Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D	Subf
O7542_17390		Micromonospora sp. WMMC264	WBB83150.1			8
GKC29_25675		Micromonospora sp. WMMC415	QGN49881.1			8
O7622_12970		Micromonospora sp. WMMD1076	WFF09395.1			8
O7602_20045		Micromonospora sp. WMMD1128	WBB72016.1			8
O7617_03840		Micromonospora sp. WMMD1155	WFE49510.1			8
O7633_29855		Micromonospora sp. WMMD712	WFE60778.1			8
O7625_16295		Micromonospora sp. WMMD714	WFE64735.1			8
O7606_10165		Micromonospora sp. WMMD882	WBB81690.1			8
O7616_13505		Micromonospora sp. WMMD964	WFF03695.1			8
O7613_03825		Micromonospora sp. WMMD975	WFE34527.1			8
O7612_09815		Micromonospora sp. WMMD987	WFE97135.1			8
O7619_12520		Micromonospora sp. WMMD998	WFE39200.1			8
CSH63_15660		Micromonospora tulbaghiae CNY-010	AYF28867.1			8
GA0070619_0948		Micromonospora zamorensis DSM 45600	SCG40320.1			8
Mycsm_06519		Mycobacterium sp. JS623	AGB26659.1			8
Mycsm_06521		Mycobacterium sp. JS623	AGB26661.1			8
β-mannanase		Niallia circulans	AAS48170.1			8
β-mannanase (TM1)	3.2.1.78	Niallia circulans	AAT39478.1	Q6IUP2		8
β-mannanase (Man1;ManB48)	3.2.1.78	Niallia circulans CGMCC 1416	AAX87002.1	Q49HI4		8
β-mannanase (Man5A)	3.2.1.78	Niallia circulans CGMCC1554	AAX87003.1	Q0IJR6		8
β-mannanase (G)	3.2.1.78	Niallia circulans K-1	BAA25878.1	O66185		8
β-mannanase (MANPN11) (fragment)	3.2.1.78	Niallia nealsonii PN-11	AGU71466.2 AGU71466.1 AGU71466.3	T1Z249		8
L8T27_022755		Niallia sp. Man26	UPO90836.1			8
KGD83_13295		Nocardiopsis akebiae HDS12	QUX31373.1			8
B005_5164 (fragment)		Nocardiopsis alba ATCC BAA-2165	AFR10886.1			8
KGD84_13735		Nocardiopsis changdeensis Mg02	QUX25221.1			8
KGD84_02750		Nocardiopsis changdeensis Mg02	QUX23331.1			8
CGQ36_15825		Nocardiopsis dassonvillei HZNU_N_1	ASU58942.1			8
A9R04_15630		Nocardiopsis dassonvillei NOCA502F	APC36031.1			8
KGD82_15110		Nocardiopsis eucommiae HDS5	QVJ00172.1			8
NE857_15070		Nocardiopsis exhalans JCM11759T	USY22811.1			8
HUT17_02855		Nocardiopsis flavescens NA01583	QKW32020.1			8
PV789_16695		Nocardiopsis sp. DZFXJ 01	WDZ88610.1			8
K1J57_23190		Nocardiopsis sp. MT53	QYX35608.1			8
K1J57_12200		Nocardiopsis sp. MT53	QYX39273.1			8
Nocox_38655 (Mana2)		Nonomuraea coxensis DSM 45129	QYC45281.1			8
OIE67_52290		Nonomuraea fuscirosea NBC 01801	WSA52505.1			8
BN4615_P10778		Nonomuraea gerenzanensis ATCC 39727	SBP01262.1			8
LCN96_52040		Nonomuraea gerenzanensis L70	UBU19121.1			8
mannan endo-1, 4-β-mannosidase		Nonomuraea jabiensis	BBB03671.1			8
GBF35_48645		Nonomuraea nitratireducens WYY166	QFY13395.1			8
GBF35_49840		Nonomuraea nitratireducens WYY166	QFY13598.1			8
HGI30_05340		Paenibacillus albicereus UniB2	QJC54217.1			8
P9222_24040 (fragment)		Paenibacillus amylolyticus Sample9_7	WFR61475.1			8
P9222_24035 (fragment)		Paenibacillus amylolyticus Sample9_7	WFR61474.1			8
OGI70_10680		Paenibacillus amylolyticus SQR-21	WFA87337.1			8
V6668_13700		Paenibacillus amylolyticus Y5S-7	WWP23177.1			8
AR543_12180		Paenibacillus bovis BD3526	ANF96694.1			8
HUB94_22805		Paenibacillus cellulosilyticus KACC 14175	QKS47268.1			8
PGRAT_09255		Paenibacillus graminis DSM 15220	AIQ67798.1			8
SK066_13515		Paenibacillus hunanensis Y9	WPP39644.1			8
BBD41_27510		Paenibacillus ihbetae IHBB 9852	ANY76761.1			8
B4V02_01115		Paenibacillus kribbensis AM49	ASR45403.1			8
PQ456_02900		Paenibacillus kyungheensis KACC 18744	WCT56499.1			8
EIM92_14910		Paenibacillus lentus DSM 25539	AZK47289.1			8
PM3016_3709		Paenibacillus mucilaginosus 3016	AFC30528.1			8
B2K_19295		Paenibacillus mucilaginosus K02	AFH62834.1			8
ERY13_18750		Paenibacillus mucilaginosus KN-18	WFA19155.1			8
KNP414_04275		Paenibacillus mucilaginosus KNP414	AEI42807.1			8
KCX80_18340		Paenibacillus mucilaginosus PM12	WDM30988.1			8
AASFL403_16240		Paenibacillus nuruki AASFL403	CAJ1316768.1			8
CD191_19740		Paenibacillus odorifer CBA7130	AWV34670.1			8
PODO_19980		Paenibacillus odorifer DSM 15391	AIQ75360.1			8
KET34_14895		Paenibacillus pabuli E1	UPK46629.1			8
ABE82_20505		Paenibacillus peoriae HS311	ALA44923.1			8
ABE82_03090		Paenibacillus peoriae HS311	ALA40572.1			8
RBB83_03355		Paenibacillus peoriae JJ21	WVX11650.1			8
RBB83_21785		Paenibacillus peoriae JJ21	WVX10044.1			8
MLD56_03340		Paenibacillus peoriae ZBSF16	UMY55507.1			8
MLD56_12180		Paenibacillus peoriae ZBSF16	UMY57148.1			8
QPK24_13685		Paenibacillus polygoni C31	WIV17477.1			8
G7L40_05315		Paenibacillus polymyxa 2020	QPK57288.1			8
G7L40_22475		Paenibacillus polymyxa 2020	QPK60304.1			8
QNH38_03195		Paenibacillus polymyxa ACCC03434	WHX36472.1			8
QNH38_12790		Paenibacillus polymyxa ACCC03434	WHX33474.1			8
VK72_21225		Paenibacillus polymyxa ATCC 15970	APQ62216.1			8
VK72_03240		Paenibacillus polymyxa ATCC 15970	APQ57839.1			8
CUU60_19495		Paenibacillus polymyxa ATCC 842	UOD87249.1			8
CUU60_02395		Paenibacillus polymyxa ATCC 842	UOD84095.1			8
CPY53_01665		Paenibacillus polymyxa C12	UNL92334.1			8
CPY53_17905		Paenibacillus polymyxa C12	UNL95286.1			8
SKN87_03435		Paenibacillus polymyxa C2	WPQ57523.1			8
SKN87_13105		Paenibacillus polymyxa C2	WPQ54546.1			8
LK13_00505		Paenibacillus polymyxa CF05	AIY07141.1			8
LK13_16140		Paenibacillus polymyxa CF05	AIY09978.1			8
DI243_12515		Paenibacillus polymyxa CJX518	QOH62161.1			8
DI243_03220		Paenibacillus polymyxa CJX518	QOH60481.1			8
X809_02830		Paenibacillus polymyxa CR1	AHC18250.1			8
X809_21705		Paenibacillus polymyxa CR1	AHC21581.1			8
G7035_22535		Paenibacillus polymyxa DSM 36	QPK55218.1			8
G7035_05315		Paenibacillus polymyxa DSM 36	QPK52202.1			8
U3G77_15640		Paenibacillus polymyxa DSM 365	WRL59590.1			8
U3G77_24840		Paenibacillus polymyxa DSM 365	WRL61273.1			8
PPE_00597		Paenibacillus polymyxa E681	ADM68451.1			8
LAZ93_03205		Paenibacillus polymyxa EB4 G3	UBS87882.1			8
LAZ93_12310		Paenibacillus polymyxa EB4 G3	UBS84964.1			8
C1A50_2657		Paenibacillus polymyxa HY96-2	AUS26824.1			8
C1A50_0666		Paenibacillus polymyxa HY96-2	AUS24857.1			8
AOU00_15710		Paenibacillus polymyxa J	AOK91139.1			8
MF622_004120		Paenibacillus polymyxa K 1.14	URJ59471.1 URJ59471.3			8
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