Activities in Sub Family	Endo-β-1,4-mannanase (EC 3.2.1.78);
Mechanism	Retaining e
Clan	GH-A
3D Structure Status	( β / α ) 8 barrel
Catalytic Nucleophile/Base	Glu (experimental)
Catalytic Proton Donor	Glu (experimental)
Note	Once known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resources	CAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)	MEGAZYME; NZYTech; PROZOMIX;
Statistics	GenBank accession (10); Uniprot accession (37); PDB accession (10); 3D entries (6); cryst (0)

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Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D	Subf
HUT05_42710		Streptomyces chartreusis NA02069	QKZ23485.1			8
STRCI_003602		Streptomyces cinnabarinus DSM 40467	WAZ22351.1			8
SCO6234 (ManA2;SC2H4.16)		Streptomyces coelicolor A3(2)	CAA20610.1 NP_630335.1			8
SCO0554 (ManA;SCF11.34c)		Streptomyces coelicolor A3(2)	CAD55266.1 CAB57406.1 CAB59611.1 NP_733506.1			8
FQ762_02730		Streptomyces coelicolor A3(2) CFB_NBC_0001	QFI40816.1			8
FQ762_32210		Streptomyces coelicolor A3(2) CFB_NBC_0001	QFI46062.1			8
JCM4020_63920		Streptomyces coelicolor JCM 4020	BDD75772.1			8
JCM4020_05340		Streptomyces coelicolor JCM 4020	BDD69914.1			8
HCU77_31510		Streptomyces coelicolor M1154/pAMX4/pGP1416	QKN69620.1			8
HCU77_02550		Streptomyces coelicolor M1154/pAMX4/pGP1416	QKN64494.1			8
RE436_02610		Streptomyces coelicolor M22	WMT31356.1			8
RE436_31280		Streptomyces coelicolor M22	WMT36648.1			8
CP976_04755		Streptomyces coeruleorubidus ATCC 13740	QEV23521.1			8
PV963_04975		Streptomyces coeruleorubidus DM	WDV49754.1			8
R5U08_33230		Streptomyces coeruleorubidus WT-48	WOT38725.1			8
RFN52_04010		Streptomyces collinus CGMCC 4.1623	WMX62553.1			8
QU709_39455		Streptomyces coralus SX92	WLW57073.1			8
EJ357_42890		Streptomyces cyaneochromogenes MK-45	AZQ39351.1			8
TU94_04450		Streptomyces cyaneogriseus subsp. noncyanogenus NMWT 1	AJP00836.1			8
D9753_01445		Streptomyces dangxiongensis Z022	AYN37844.1			8
BN159_5046		Streptomyces davaonensis JCM 4913	CCK29425.1			8
L3078_06945		Streptomyces deccanensis KCTC 19241	ULR55875.1			8
L3078_05450		Streptomyces deccanensis KCTC 19241	ULR55853.1			8
NEH16_20200		Streptomyces drozdowiczii MDA8-470	UZK56113.1			8
PS783_35050		Streptomyces enissocaesilis NBF 715	WDI22516.1			8
IM697_26915		Streptomyces ferrugineus CCTCC AA2014009	QOV33815.1			8
F0344_02440		Streptomyces finlayi NBSH44	QNE73622.1			8
CP974_01765		Streptomyces fradiae ATCC 10745 = DSM 40063	QEV10945.1			8
RYQ63_12190		Streptomyces fradiae FIMYZ-003	WOI60600.1			8
β-1,4-mannase		Streptomyces fradiae k11	ADK91084.1			8
D3X13_01425		Streptomyces fradiae NKZ-259	AYA15097.1			8
J5J01_20495		Streptomyces fradiae ZXY017	UQS29330.1			8
HUT09_34945		Streptomyces fulvissimus NA06532	QKW47771.1			8
CNQ36_04175		Streptomyces fungicidicus TXX3120	AYL34687.1			8
CP966_00930		Streptomyces galilaeus ATCC 14969	QEU63996.1			8
IAG43_25030		Streptomyces genisteinicus CRPJ-33	QNP65869.1			8
IAG43_24805		Streptomyces genisteinicus CRPJ-33	QNP67578.1			8
SGLAU_25530		Streptomyces glaucescens GLA.O	AIS01044.1			8
SGLAU_28405		Streptomyces glaucescens GLA.O	AIS01618.1			8
SGFS_096010		Streptomyces graminofaciens A-8890	BBC38307.1			8
UBV09_03805		Streptomyces griseoincarnatus HNS054	WPW17877.1			8
DWG14_07307 (Mana_2)		Streptomyces griseorubiginosus 3E-1	AYC43001.1			8
ELQ87_35630		Streptomyces griseoviridis F1-27	AZS88981.1			8
DDJ31_03625		Streptomyces griseoviridis K61	QCN84174.1			8
HUT13_24845		Streptomyces harbinensis NA02264	QKV71638.1			8
CEB94_05270		Streptomyces hawaiiensis ATCC 12236	QCD54324.1			8
DWB77_00472 (Mana_1)		Streptomyces hundungensis BH38	AYG78365.1			8
SHXM_01100		Streptomyces hygroscopicus XM201	AQW47637.1			8
RFN58_05125		Streptomyces iakyrus CGMCC 4.1912	WVG00483.1			8
SIRAN8881		Streptomyces iranensis	CDR16057.1			8
RI060_38590		Streptomyces janthinus JCM 4387	WND22901.1			8
KJK29_35640		Streptomyces koelreuteriae MG62	QWB27515.1			8
P8A22_24920		Streptomyces laculatispora Mut2	WLQ42890.1			8
J3S85_01345		Streptomyces lavenduligriseus Tu901	WDM10304.1			8
J3S85_05470		Streptomyces lavenduligriseus Tu901	WDM11044.1			8
Sle_14000		Streptomyces leeuwenhoekii C34 (= DSM 42122 = NRRL B-24963)	CQR60862.1			8
Sle_59560		Streptomyces leeuwenhoekii C34 (= DSM 42122 = NRRL B-24963)	CQR65412.1			8
JEQ17_05165		Streptomyces liliifuscus ZYC-3	QQM46492.1			8
GJU35_06515		Streptomyces lincolnensis B48	QMV05338.1			8
SLCG_1219		Streptomyces lincolnensis LC-G	AXG52374.1			8
SLINC_1228		Streptomyces lincolnensis NRRL 2936	ANS63452.1			8
β-mannanase (ManA;SlMan)	3.2.1.78	Streptomyces lividans 1326	AAA26710.2	P51529		8
SLITK23_61650		Streptomyces lividans TK23	BDE42920.1			8
SLITK23_05010		Streptomyces lividans TK23	BDE37256.1			8
SLIV_35170		Streptomyces lividans TK24	AIJ17911.1			8
SLIV_06970 (CelA)		Streptomyces lividans TK24	AIJ12409.1			8
DNK48_40770		Streptomyces malaysiensis DSM 4137	QDL75937.1 ATL80796.1			8
R8789_41135		Streptomyces malaysiensis NA3722	WPB95060.1			8
LC193_26335		Streptomyces marincola SCSIO 64649	UCM91177.1			8
LC193_21905		Streptomyces marincola SCSIO 64649	UCM90370.1			8
POD33_31370		Streptomyces moderatus DT446	WCH96399.1			8
CP967_21920		Streptomyces nitrosporeus ATCC 12769	QEU74297.1			8
CP967_01465		Streptomyces nitrosporeus ATCC 12769	QEU70798.1			8
B1H29_02170		Streptomyces pactum ACT12	AQS65900.1			8
DVK44_32610		Streptomyces paludis GSSD-12	AXG81675.1			8
OHB35_05200		Streptomyces phaeochromogenes NBC 01752	WSD21369.1			8
OG931_04795		Streptomyces phaeochromogenes NBC_00186	WRZ35951.1			8
F9278_05380		Streptomyces phaeolivaceus GY16	QFQ95700.1			8
NFX46_23810		Streptomyces phaeoluteigriseus Qhu-M197	USQ89666.1			8
CP972_04820		Streptomyces prasinus ATCC 13879	QEV05093.1			8
V3O62_03690		Streptomyces prasinus WY33	WVU02908.1			8
Sfla_4025		Streptomyces pratensis ATCC 33331	ADW05439.1			8
SPRI_0552		Streptomyces pristinaespiralis HCCB 10218	ALC18858.1			8
SPRI_0824		Streptomyces pristinaespiralis HCCB 10218	ALC19130.1			8
H3L99_34195		Streptomyces pristinaespiralis PR11	QMU18007.1			8
H3L99_32835		Streptomyces pristinaespiralis PR11	QMU18766.1			8
A4E84_04775		Streptomyces qaidamensis S10(2016)	AMW08869.1			8
LIV37_45730		Streptomyces rapamycinicus NRRL 5491	UTP35939.1			8
M271_44965		Streptomyces rapamycinicus NRRL 5491	AGP60361.1			8
TUE45_06438 (Mana_2)		Streptomyces reticuli	CUW31689.1			8
TR631_34835		Streptomyces rochei D21E05	WQC16733.1			8
P7W03_33170		Streptomyces rochei JK1	WMC90170.1			8
RBH85_02360		Streptomyces rochei S32	WMI55758.1			8
IAG44_36480		Streptomyces roseirectus CRXT-G-22	QNP74420.1			8
IAG44_39250		Streptomyces roseirectus CRXT-G-22	QNP74875.1			8
A4G23_00338 (Mana_3)		Streptomyces rubrolavendulae MJM4426	AOT57549.1			8
SCAB_78881		Streptomyces scabiei 87.22	CBG74852.1			8
SCAB_82021		Streptomyces scabiei 87.22	CBG75158.1			8
A7J05_02570		Streptomyces silaceus ACCC40021	APY84783.1			8
I1A49_06385		Streptomyces solisilvae HNM0141	QPI54600.1			8
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